JP2020513036A5 - - Google Patents
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- JP2020513036A5 JP2020513036A5 JP2020504094A JP2020504094A JP2020513036A5 JP 2020513036 A5 JP2020513036 A5 JP 2020513036A5 JP 2020504094 A JP2020504094 A JP 2020504094A JP 2020504094 A JP2020504094 A JP 2020504094A JP 2020513036 A5 JP2020513036 A5 JP 2020513036A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- substituted
- alkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 61
- 102000004169 proteins and genes Human genes 0.000 claims 56
- 108090000623 proteins and genes Proteins 0.000 claims 56
- 150000003839 salts Chemical class 0.000 claims 38
- 125000003118 aryl group Chemical group 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 125000006693 (C2-C9) heterocyclyl group Chemical group 0.000 claims 22
- 125000004452 carbocyclyl group Chemical group 0.000 claims 21
- 238000000034 method Methods 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 12
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 10
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 7
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- -1 substituted Chemical class 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 102000009658 Peptidylprolyl Isomerase Human genes 0.000 claims 5
- 108010020062 Peptidylprolyl Isomerase Proteins 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 150000003573 thiols Chemical class 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 241000187747 Streptomyces Species 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000000855 fermentation Methods 0.000 claims 2
- 230000004151 fermentation Effects 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 102000004631 Calcineurin Human genes 0.000 claims 1
- 108010042955 Calcineurin Proteins 0.000 claims 1
- 108010077544 Chromatin Proteins 0.000 claims 1
- 102000001493 Cyclophilins Human genes 0.000 claims 1
- 108010068682 Cyclophilins Proteins 0.000 claims 1
- 102000013446 GTP Phosphohydrolases Human genes 0.000 claims 1
- 102000018898 GTPase-Activating Proteins Human genes 0.000 claims 1
- 108091006094 GTPase-accelerating proteins Proteins 0.000 claims 1
- 108091006109 GTPases Proteins 0.000 claims 1
- 102000016285 Guanine Nucleotide Exchange Factors Human genes 0.000 claims 1
- 108010067218 Guanine Nucleotide Exchange Factors Proteins 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 102000004310 Ion Channels Human genes 0.000 claims 1
- 108090000862 Ion Channels Proteins 0.000 claims 1
- 102000005591 NIMA-Interacting Peptidylprolyl Isomerase Human genes 0.000 claims 1
- 108010059419 NIMA-Interacting Peptidylprolyl Isomerase Proteins 0.000 claims 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 claims 1
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims 1
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 210000003483 chromatin Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000006916 protein interaction Effects 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 230000004850 protein–protein interaction Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023149774A JP2023161027A (ja) | 2017-04-05 | 2023-09-15 | 協同的結合に関与する化合物及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762481956P | 2017-04-05 | 2017-04-05 | |
| US62/481,956 | 2017-04-05 | ||
| PCT/US2018/025991 WO2018187401A1 (en) | 2017-04-05 | 2018-04-04 | Compounds that participate in cooperative binding and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023149774A Division JP2023161027A (ja) | 2017-04-05 | 2023-09-15 | 協同的結合に関与する化合物及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020513036A JP2020513036A (ja) | 2020-04-30 |
| JP2020513036A5 true JP2020513036A5 (https=) | 2021-05-13 |
Family
ID=63712657
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020504094A Pending JP2020513036A (ja) | 2017-04-05 | 2018-04-04 | 協同的結合に関与する化合物及びその使用 |
| JP2023149774A Pending JP2023161027A (ja) | 2017-04-05 | 2023-09-15 | 協同的結合に関与する化合物及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023149774A Pending JP2023161027A (ja) | 2017-04-05 | 2023-09-15 | 協同的結合に関与する化合物及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20200199102A1 (https=) |
| EP (1) | EP3606492A4 (https=) |
| JP (2) | JP2020513036A (https=) |
| KR (2) | KR20200003803A (https=) |
| CN (1) | CN110831632A (https=) |
| AU (3) | AU2018248417A1 (https=) |
| CA (1) | CA3058953A1 (https=) |
| WO (1) | WO2018187401A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| KR102455171B1 (ko) | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
| EP3247378B8 (en) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
| EP4302834A3 (en) | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| IL269779B2 (en) * | 2017-04-05 | 2026-04-01 | Revolution Medicines Inc | Methods and reagents for the analysis of protein-protein interfaces |
| CA3074690A1 (en) | 2017-09-07 | 2019-03-14 | Revolution Medicines, Inc. | Shp2 inhibitor compositions and methods for treating cancer |
| TW201930292A (zh) | 2017-10-12 | 2019-08-01 | 美商銳新醫藥公司 | 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物 |
| JP7361693B2 (ja) | 2017-12-15 | 2023-10-16 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての多環式化合物 |
| US11691984B2 (en) | 2018-10-12 | 2023-07-04 | The Scripps Research Institute | Compounds and methods for DCAF-mediated protein degradation |
| AU2020377925A1 (en) | 2019-11-04 | 2022-05-05 | Revolution Medicines, Inc. | Ras inhibitors |
| IL322454A (en) | 2019-11-04 | 2025-09-01 | Revolution Medicines Inc | ras inhibitors |
| TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| MX2022006861A (es) | 2019-12-04 | 2022-07-11 | Scripps Research Inst | Agonistas del receptor glp2 y metodos de uso. |
| CA3194067A1 (en) | 2020-09-15 | 2022-03-24 | Revolution Medicines, Inc. | Ras inhibitors |
| KR20240017811A (ko) | 2021-05-05 | 2024-02-08 | 레볼루션 메디슨즈, 인크. | 암의 치료를 위한 ras 억제제 |
| KR20240032010A (ko) | 2021-06-09 | 2024-03-08 | 더 스크립스 리서치 인스티튜트 | 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN115611989B (zh) * | 2022-10-09 | 2023-08-01 | 武汉理工大学 | 机械活化淀粉衍生物抑制剂的优化制备方法及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002503667A (ja) * | 1998-02-13 | 2002-02-05 | プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 新規な二量体化剤、その製造および使用 |
| US7220552B1 (en) * | 1999-11-19 | 2007-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
| DE10146104A1 (de) * | 2001-09-19 | 2003-04-03 | Bayer Ag | Antibakterielle Markrozyklen |
| CN1839150A (zh) * | 2003-07-17 | 2006-09-27 | 麦根克斯有限公司 | 脂肽抗菌衍生物组合物及其应用方法 |
| US9428845B1 (en) * | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| WO2012174489A2 (en) * | 2011-06-15 | 2012-12-20 | The Ohio State University | Small molecule composite surfaces as inhibitors of protein-protein interactions |
| TW201629069A (zh) * | 2015-01-09 | 2016-08-16 | 霍普驅動生物科技股份有限公司 | 參與協同結合之化合物及其用途 |
| EP3247378B8 (en) * | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
| EP4242304A3 (en) * | 2015-10-01 | 2024-02-07 | Revolution Medicines, Inc. | Methods and reagents for analyzing protein-protein interfaces |
-
2018
- 2018-04-04 CA CA3058953A patent/CA3058953A1/en active Pending
- 2018-04-04 KR KR1020197032296A patent/KR20200003803A/ko not_active Ceased
- 2018-04-04 WO PCT/US2018/025991 patent/WO2018187401A1/en not_active Ceased
- 2018-04-04 KR KR1020247006370A patent/KR20240033100A/ko active Pending
- 2018-04-04 US US16/500,702 patent/US20200199102A1/en not_active Abandoned
- 2018-04-04 EP EP18781380.3A patent/EP3606492A4/en active Pending
- 2018-04-04 CN CN201880037178.XA patent/CN110831632A/zh active Pending
- 2018-04-04 AU AU2018248417A patent/AU2018248417A1/en not_active Abandoned
- 2018-04-04 JP JP2020504094A patent/JP2020513036A/ja active Pending
-
2022
- 2022-08-05 AU AU2022211916A patent/AU2022211916A1/en not_active Abandoned
-
2023
- 2023-09-15 JP JP2023149774A patent/JP2023161027A/ja active Pending
-
2024
- 2024-04-10 AU AU2024202332A patent/AU2024202332A1/en active Pending
- 2024-07-29 US US18/787,714 patent/US20250206715A1/en active Pending
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