JP2020512373A5 - - Google Patents

Download PDF

Info

Publication number
JP2020512373A5
JP2020512373A5 JP2019553478A JP2019553478A JP2020512373A5 JP 2020512373 A5 JP2020512373 A5 JP 2020512373A5 JP 2019553478 A JP2019553478 A JP 2019553478A JP 2019553478 A JP2019553478 A JP 2019553478A JP 2020512373 A5 JP2020512373 A5 JP 2020512373A5
Authority
JP
Japan
Prior art keywords
alkyl
amine
phenyl
compound
benzodiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019553478A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020512373A (ja
JP7674811B2 (ja
Filing date
Publication date
Priority claimed from GBGB1705263.0A external-priority patent/GB201705263D0/en
Application filed filed Critical
Publication of JP2020512373A publication Critical patent/JP2020512373A/ja
Publication of JP2020512373A5 publication Critical patent/JP2020512373A5/ja
Priority to JP2022082769A priority Critical patent/JP7589191B2/ja
Priority to JP2024107135A priority patent/JP2024153639A/ja
Application granted granted Critical
Publication of JP7674811B2 publication Critical patent/JP7674811B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019553478A 2017-03-31 2018-04-03 新規の阻害剤 Active JP7674811B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022082769A JP7589191B2 (ja) 2017-03-31 2022-05-20 新規の阻害剤
JP2024107135A JP2024153639A (ja) 2017-03-31 2024-07-03 新規の阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1705263.0 2017-03-31
GBGB1705263.0A GB201705263D0 (en) 2017-03-31 2017-03-31 Novel inhibitors
PCT/EP2018/058391 WO2018178384A1 (en) 2017-03-31 2018-04-03 Novel inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022082769A Division JP7589191B2 (ja) 2017-03-31 2022-05-20 新規の阻害剤

Publications (3)

Publication Number Publication Date
JP2020512373A JP2020512373A (ja) 2020-04-23
JP2020512373A5 true JP2020512373A5 (https=) 2021-05-20
JP7674811B2 JP7674811B2 (ja) 2025-05-12

Family

ID=58682483

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019553478A Active JP7674811B2 (ja) 2017-03-31 2018-04-03 新規の阻害剤
JP2022082769A Active JP7589191B2 (ja) 2017-03-31 2022-05-20 新規の阻害剤
JP2024107135A Pending JP2024153639A (ja) 2017-03-31 2024-07-03 新規の阻害剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022082769A Active JP7589191B2 (ja) 2017-03-31 2022-05-20 新規の阻害剤
JP2024107135A Pending JP2024153639A (ja) 2017-03-31 2024-07-03 新規の阻害剤

Country Status (13)

Country Link
US (3) US11339152B2 (https=)
EP (1) EP3601269A1 (https=)
JP (3) JP7674811B2 (https=)
KR (2) KR20250002689A (https=)
CN (2) CN117024352A (https=)
AU (2) AU2018246382C1 (https=)
CA (2) CA3221839A1 (https=)
EA (1) EA201992120A1 (https=)
GB (1) GB201705263D0 (https=)
IL (3) IL297534A (https=)
MX (2) MX2019011544A (https=)
WO (1) WO2018178384A1 (https=)
ZA (1) ZA201905811B (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2536650A (en) 2015-03-24 2016-09-28 Augmedics Ltd Method and system for combining video-based and optic-based augmented reality in a near eye display
US12521201B2 (en) 2017-12-07 2026-01-13 Augmedics Ltd. Spinous process clamp
US12458411B2 (en) 2017-12-07 2025-11-04 Augmedics Ltd. Spinous process clamp
US11980507B2 (en) 2018-05-02 2024-05-14 Augmedics Ltd. Registration of a fiducial marker for an augmented reality system
FI3861001T3 (fi) * 2018-10-05 2024-01-03 Pfizer Booria sisältäviä PDE4-inhibiittoreita
US11766296B2 (en) 2018-11-26 2023-09-26 Augmedics Ltd. Tracking system for image-guided surgery
KR20210113648A (ko) * 2019-01-06 2021-09-16 소마젠 인크 Ｈｔｒａ 저해제 및 ｃａｇａ 저해제 및 이의 용도
US11980506B2 (en) 2019-07-29 2024-05-14 Augmedics Ltd. Fiducial marker
US12178666B2 (en) 2019-07-29 2024-12-31 Augmedics Ltd. Fiducial marker
US11382712B2 (en) 2019-12-22 2022-07-12 Augmedics Ltd. Mirroring in image guided surgery
KR102433502B1 (ko) * 2020-01-17 2022-08-18 재단법인 대구경북첨단의료산업진흥재단 신규 화합물, 이의 제조방법 및 이의 용도
ES3010543T3 (en) * 2020-01-17 2025-04-03 Daegu Gyeongbuk Medical Innovation Found Novel compound, preparation method thereof, and use thereof
US11389252B2 (en) 2020-06-15 2022-07-19 Augmedics Ltd. Rotating marker for image guided surgery
US12239385B2 (en) 2020-09-09 2025-03-04 Augmedics Ltd. Universal tool adapter
US12502163B2 (en) 2020-09-09 2025-12-23 Augmedics Ltd. Universal tool adapter for image-guided surgery
WO2022086920A1 (en) * 2020-10-20 2022-04-28 Blacksmith Medicines, Inc. Glutaminyl-peptide cyclotransferase like (qpctl) protein inhibitors and uses thereof
EP4259617B1 (en) * 2020-12-10 2024-10-23 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
US11896445B2 (en) 2021-07-07 2024-02-13 Augmedics Ltd. Iliac pin and adapter
US12150821B2 (en) 2021-07-29 2024-11-26 Augmedics Ltd. Rotating marker and adapter for image-guided surgery
EP4387552A4 (en) 2021-08-18 2025-04-30 Augmedics Ltd. AUGMENTED REALITY SURGICAL SYSTEM USING DEPTH SENSING
CN117567435A (zh) * 2022-01-30 2024-02-20 上海市第十人民医院 谷氨酰胺环化酶抑制剂及其应用
WO2023205173A1 (en) * 2022-04-20 2023-10-26 Blacksmith Medicines, Inc. Substituted piperidines and substituted tetrahydropyridines as immune-modulating compounds
EP4511809A4 (en) 2022-04-21 2026-03-11 Augmedics Ltd Systems and methods for medical image visualization
CN114560817B (zh) * 2022-04-25 2022-10-25 北京大学第三医院（北京大学第三临床医学院） 一种用于抑制纤维化的小分子药物及其应用
AR130003A1 (es) * 2022-08-03 2024-10-23 Boehringer Ingelheim Int Derivados de piperidinilpiridinilcarbonitrilo como inhibidores de glutaminil-péptido ciclotransferasa y proteína tipo glutaminil-péptido ciclotransferasa
EP4587881A1 (en) 2022-09-13 2025-07-23 Augmedics Ltd. Augmented reality eyewear for image-guided medical intervention
WO2024131742A1 (zh) * 2022-12-20 2024-06-27 深圳湾实验室 一种靶向usp1的小分子抑制剂及其应用
JP2026501078A (ja) 2022-12-22 2026-01-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルタミニルペプチドサイクロトランスフェラーゼ及びグルタミニルペプチドサイクロトランスフェラーゼ様タンパク質の阻害剤としてのフェニルピペリジン誘導体
KR20250157401A (ko) 2023-03-13 2025-11-04 베링거 인겔하임 인터내셔날 게엠베하 글루타미닐-펩타이드 사이클로트랜스퍼라제 및 글루타미닐-펩타이드 사이클로트랜스퍼라제 유사 단백질의 억제제로서의 페닐피페리딘 유도체
TW202523321A (zh) 2023-08-04 2025-06-16 德商百靈佳殷格翰國際股份有限公司 作為麩醯胺醯基肽環轉移酶及麩醯胺醯基肽環轉移酶樣蛋白之抑制劑的哌啶基吡啶基甲腈衍生物
US20250059166A1 (en) 2023-08-04 2025-02-20 Boehringer Ingelheim International Gmbh Piperidinylpyridinylcarbonitrile derivatives as inhibitors of glutaminyl-peptide cyclotransferase and glutaminyl-peptide cyclotransferase like protein
WO2025036713A1 (en) 2023-08-14 2025-02-20 Boehringer Ingelheim International Gmbh Piperidinylpyridinylcarbonitrile derivatives as inhibitors of glutaminyl-peptide cyclotransferase and glutaminyl-peptide cyclotransferase like protein
CN117538462B (zh) * 2024-01-10 2024-03-26 地奥集团成都药业股份有限公司 一种氨氯地平贝那普利胶囊有关物质的检测方法
WO2025240620A1 (en) * 2024-05-14 2025-11-20 Pronovo Therapeutics Inc. Selective dual agonists of muscarinic 1 and 4 receptors and therapeutic uses thereof

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0640599B1 (en) * 1993-08-26 1998-03-04 Ono Pharmaceutical Co., Ltd. 4-Aminopyrimidine derivatives
US6262059B1 (en) 1995-06-07 2001-07-17 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with quinazoline derivatives
US7642278B2 (en) * 2001-07-03 2010-01-05 Novartis Vaccines And Diagnostics, Inc. Indazole benzimidazole compounds
US7064215B2 (en) * 2001-07-03 2006-06-20 Chiron Corporation Indazole benzimidazole compounds
US8673924B2 (en) * 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
WO2005004818A2 (en) * 2003-07-09 2005-01-20 Imclone Systems Incorporated Heterocyclic compounds and their use as anticancer agents
EP1781659B1 (en) * 2003-07-16 2008-11-05 Janssen Pharmaceutica N.V. Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors
DE602005001931T2 (de) * 2004-01-12 2008-04-24 Applied Research Systems Ars Holding N.V. Thiazolderivate und deren verwendung
US7875624B2 (en) * 2004-02-20 2011-01-25 Novartis Vaccines And Diagnostics, Inc. Modulating and measuring cellular adhesion
EP1768984B1 (en) * 2004-07-16 2010-10-20 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as aurora kinase inhibitors
BRPI0514094A (pt) * 2004-08-02 2008-05-27 Osi Pharm Inc composto, composição, e, método de tratamento de distúrbio hiperproliferativo
GB0520958D0 (en) * 2005-10-14 2005-11-23 Cyclacel Ltd Compound
WO2007067537A1 (en) * 2005-12-07 2007-06-14 Osi Pharmaceuticals, Inc. Pyrrolopyridine kinase inhibiting compounds
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
TW200808739A (en) * 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
US7893058B2 (en) * 2006-05-15 2011-02-22 Janssen Pharmaceutica Nv Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
US7683176B2 (en) * 2006-07-14 2010-03-23 Chemocentryx, Inc. Triazolyl pyridyl benzenesulfonamides
CA2673003A1 (en) * 2006-12-22 2008-07-03 Novartis Ag Quinazolines for pdk1 inhibition
CA2672518A1 (en) * 2006-12-22 2008-07-03 Novartis Ag Organic compounds and their uses
JP5675343B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としての尿素誘導体
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
US8530480B2 (en) * 2007-09-04 2013-09-10 The Scripps Research Institute Substituted pyrimidinyl-amines as protein kinase inhibitors
TWI409265B (zh) * 2008-08-20 2013-09-21 Merck Sharp & Dohme 經取代之吡啶及嘧啶衍生物及彼等於治療病毒感染之用途
AU2009289238B2 (en) * 2008-09-04 2014-09-04 Vivoryon Therapeutics N.V. Novel inhibitors
JP5934645B2 (ja) * 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2011107530A2 (en) * 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) * 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) * 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
AU2011328237A1 (en) * 2010-11-09 2013-05-23 Cellzome Limited Pyridine compounds and aza analogues thereof as TYK2 inhibitors
HRP20172006T1 (hr) * 2010-11-10 2018-02-09 Genentech, Inc. Derivati pirazol-aminopiridina kao lrrk2-modulatori
US8785459B2 (en) * 2011-12-27 2014-07-22 Development Center For Biotechnology Quinazoline compounds as kinase inhibitors
RU2637947C2 (ru) * 2012-05-03 2017-12-08 Дженентек, Инк. Производные пиразоламинопиримидина в качестве модуляторов обогащенной лейциновыми повторами киназы 2
RU2015118647A (ru) * 2012-11-20 2017-01-10 Дженентек, Инк. Аминопиримидиновые соединения в качестве ингибиторов содержащих т790м мутантных egfr
US9512115B2 (en) * 2013-03-15 2016-12-06 Probiodrug Ag Inhibitors
MA40957A (fr) * 2014-10-09 2017-09-19 Biomarin Pharm Inc Inhibiteurs de biosynthèse d'héparane sulfate pour traiter des maladies
JP2018515612A (ja) * 2015-05-13 2018-06-14 セルビタ スプウカ アクツィーナ 置換キノキサリン誘導体
EP3334733A1 (en) * 2015-08-10 2018-06-20 Pfizer Inc 3-indol substituted derivatives, pharmaceutical compositions and methods for use
JP7114076B2 (ja) * 2015-12-22 2022-08-08 シャイ・セラピューティクス・エルエルシー がん及び炎症性疾患の処置のための化合物
US10034861B2 (en) * 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

Similar Documents

Publication Publication Date Title
JP2020512373A5 (https=)
IL307911A (en) New inhibitors
ES2358863T3 (es) Hetarilanilinas como moduladores de beta-amiloide.
JP5378532B2 (ja) 複素環γ−セクレターゼモジュレーター
KR101179087B1 (ko) 인간 단백질 티로신 포스파타아제 억제제 및 이용 방법
JP4261914B2 (ja) 新規ベンジルピペリジン化合物
US20100298340A1 (en) Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies
EP3331864A2 (en) 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
JP2010524893A5 (https=)
JP2010524896A5 (https=)
JP2012502006A5 (https=)
JP2013521325A5 (https=)
PE20090297A1 (es) Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogenesis
JP2010524899A5 (https=)
JP2013521260A5 (https=)
JP2010511013A5 (https=)
CA2371274A1 (en) Selective npy (y5) antagonists
JP2010524895A5 (https=)
CA2553705A1 (en) 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them
JP2010509284A5 (https=)
JP2003532730A (ja) 細胞増殖抑制剤として有用な１，１−ジオキソイソチアゾリジンを持つインダゾール
JP2015509510A5 (https=)
EA022420B1 (ru) Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5)
JP2010524898A5 (https=)
WO2007063925A1 (ja) ２－アミノベンズアミド誘導体