JP2020511999A5 - - Google Patents
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- JP2020511999A5 JP2020511999A5 JP2019553818A JP2019553818A JP2020511999A5 JP 2020511999 A5 JP2020511999 A5 JP 2020511999A5 JP 2019553818 A JP2019553818 A JP 2019553818A JP 2019553818 A JP2019553818 A JP 2019553818A JP 2020511999 A5 JP2020511999 A5 JP 2020511999A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- tissue
- population
- macrophages
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 27
- 210000002540 macrophage Anatomy 0.000 claims description 21
- 210000004027 cell Anatomy 0.000 claims description 16
- 210000001519 tissue Anatomy 0.000 claims description 14
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 10
- 210000001054 cardiac fibroblast Anatomy 0.000 claims description 10
- 210000001808 exosome Anatomy 0.000 claims description 10
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 8
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 8
- 210000002744 extracellular matrix Anatomy 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims description 6
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims description 6
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 4
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 4
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 4
- 108090001005 Interleukin-6 Proteins 0.000 claims description 4
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims description 4
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims description 4
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims description 4
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 4
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims description 4
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 3
- 206010019280 Heart failures Diseases 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 210000002798 bone marrow cell Anatomy 0.000 claims description 2
- 210000004958 brain cell Anatomy 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 210000003890 endocrine cell Anatomy 0.000 claims description 2
- 239000010408 film Substances 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 210000004392 genitalia Anatomy 0.000 claims description 2
- 210000005003 heart tissue Anatomy 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 210000003292 kidney cell Anatomy 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 210000005229 liver cell Anatomy 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 210000005265 lung cell Anatomy 0.000 claims description 2
- 210000001616 monocyte Anatomy 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 210000004927 skin cell Anatomy 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022205718A JP7419490B2 (ja) | 2017-03-31 | 2022-12-22 | 標的臓器の細胞外構成成分を使用する治療用細胞の作製 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2018628 | 2017-03-31 | ||
| NL2018628 | 2017-03-31 | ||
| PCT/US2018/025371 WO2018183825A1 (en) | 2017-03-31 | 2018-03-30 | Generation of therapeutic cells using extracellular components of target organs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022205718A Division JP7419490B2 (ja) | 2017-03-31 | 2022-12-22 | 標的臓器の細胞外構成成分を使用する治療用細胞の作製 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511999A JP2020511999A (ja) | 2020-04-23 |
| JP2020511999A5 true JP2020511999A5 (https=) | 2021-05-06 |
| JP7249951B2 JP7249951B2 (ja) | 2023-03-31 |
Family
ID=58548819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553818A Active JP7249951B2 (ja) | 2017-03-31 | 2018-03-30 | 標的臓器の細胞外構成成分を使用する治療用細胞の作製 |
| JP2022205718A Active JP7419490B2 (ja) | 2017-03-31 | 2022-12-22 | 標的臓器の細胞外構成成分を使用する治療用細胞の作製 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022205718A Active JP7419490B2 (ja) | 2017-03-31 | 2022-12-22 | 標的臓器の細胞外構成成分を使用する治療用細胞の作製 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11760975B2 (https=) |
| EP (1) | EP3600354B1 (https=) |
| JP (2) | JP7249951B2 (https=) |
| AU (1) | AU2018243554C1 (https=) |
| CA (1) | CA3058437A1 (https=) |
| DK (1) | DK3600354T3 (https=) |
| WO (1) | WO2018183825A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2949083C (en) | 2014-05-18 | 2023-10-10 | Children's Medical Center Corporation | Methods and compositions relating to exosomes |
| US11738046B2 (en) | 2017-11-03 | 2023-08-29 | Wisconsin Alumni Research Foundation | Macrophage cell therapy to treat orthopedic injury |
| US10876753B2 (en) | 2018-02-12 | 2020-12-29 | Watsco Ventures Llc | Integrated sensor and service port for HVAC equipment or HVAC system |
| CN112334190B (zh) | 2018-04-30 | 2024-09-20 | 儿童医学中心公司 | 间充质基质细胞外排体及其用途 |
| CA3099042A1 (en) * | 2018-05-09 | 2019-11-14 | Children's Medical Center Corporation | Mesenchymal stromal cell exosome -treated monocytes and uses thereof |
| US12350293B2 (en) | 2019-03-08 | 2025-07-08 | Niigata University | Induction method for macrophage, anti-inflammatory macrophage-inducing agent, and pharmaceutical composition |
| US20230071393A1 (en) * | 2020-04-16 | 2023-03-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Matrix bound vesicles (mbv) for treatment of acute respiratory distress syndrome |
| EP3984527A1 (en) | 2020-10-13 | 2022-04-20 | Ludwig-Maximilians-Universität München | Nano-in-micro encapsulated sirna dry powder, method for producing the same and use of a powder formulation as a pharmaceutical dosage form, in particular for pulmonary delivery |
| US20220127579A1 (en) * | 2020-10-22 | 2022-04-28 | Wisconsin Alumni Research Foundation | Use of Toll-Like Receptor 4 Agonists to Treat Inflammation and Tissue Injury |
| WO2023003775A2 (en) * | 2021-07-21 | 2023-01-26 | The Regents Of The University Of California | Human ipsc-derived macrophages for liver repair and regeneration |
| EP4398948A4 (en) * | 2021-09-07 | 2025-07-09 | Wisconsin Alumni Res Found | CARDIAC FIBROBLAST-DERIVED EXTRACELLULAR MATRIX |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011013452A (es) * | 2009-07-02 | 2012-04-30 | Ith Immune Therapy Holdings Ab | Tratamiento de cancer basado en exosomas. |
| US8647678B2 (en) * | 2009-08-24 | 2014-02-11 | Wisconsin Alumni Research Foundation | Anti-inflammatory macrophages and uses thereof |
| US8802144B2 (en) | 2011-08-25 | 2014-08-12 | Wisconsin Alumni Research Foundation | 3-dimensional cardiac fibroblast derived extracellular matrix |
| WO2015031376A1 (en) * | 2013-08-26 | 2015-03-05 | The Trustees Of Columbia University In The City Of New York | Scaffolds containing cytokines for tissue engineering |
| US10624930B2 (en) | 2014-06-10 | 2020-04-21 | Mesoblast International Sarl | Treatment of immune disorders |
| US10166254B2 (en) | 2014-09-19 | 2019-01-01 | Wisconsin Alumni Research Foundation | Use of mesenchymal stem cell-educated macrophages to treat and prevent graft versus host disease and radiation-induced injury |
| EP3204117A4 (en) * | 2014-10-06 | 2018-05-09 | Cedars-Sinai Medical Center | Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells |
| KR20180015187A (ko) | 2015-06-03 | 2018-02-12 | 위스콘신 얼럼나이 리서어치 화운데이션 | 심장 섬유모세포-유래된 세포외 기질 및 허혈성 질환 또는 손상의 치료를 위한 이의 주사 가능한 제형 |
| US11738046B2 (en) | 2017-11-03 | 2023-08-29 | Wisconsin Alumni Research Foundation | Macrophage cell therapy to treat orthopedic injury |
-
2018
- 2018-03-30 WO PCT/US2018/025371 patent/WO2018183825A1/en not_active Ceased
- 2018-03-30 US US15/941,409 patent/US11760975B2/en active Active
- 2018-03-30 CA CA3058437A patent/CA3058437A1/en active Pending
- 2018-03-30 AU AU2018243554A patent/AU2018243554C1/en active Active
- 2018-03-30 DK DK18720454.0T patent/DK3600354T3/da active
- 2018-03-30 EP EP18720454.0A patent/EP3600354B1/en active Active
- 2018-03-30 JP JP2019553818A patent/JP7249951B2/ja active Active
-
2022
- 2022-12-22 JP JP2022205718A patent/JP7419490B2/ja active Active
-
2023
- 2023-08-17 US US18/451,617 patent/US20230407256A1/en active Pending
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