DK3600354T3 - Generering af terapeutiske celler ved hjælp af ekstracellulære komponenter fra målorganer - Google Patents

Generering af terapeutiske celler ved hjælp af ekstracellulære komponenter fra målorganer Download PDF

Info

Publication number
DK3600354T3
DK3600354T3 DK18720454.0T DK18720454T DK3600354T3 DK 3600354 T3 DK3600354 T3 DK 3600354T3 DK 18720454 T DK18720454 T DK 18720454T DK 3600354 T3 DK3600354 T3 DK 3600354T3
Authority
DK
Denmark
Prior art keywords
target organs
therapeutic cells
extracellular components
generating therapeutic
generating
Prior art date
Application number
DK18720454.0T
Other languages
Danish (da)
English (en)
Inventor
Eric G Schmuck
John A Kink
Amish N Raval
Peiman Hematti
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of DK3600354T3 publication Critical patent/DK3600354T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/33—Fibroblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C12N2500/84—Undefined extracts from animals from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
DK18720454.0T 2017-03-31 2018-03-30 Generering af terapeutiske celler ved hjælp af ekstracellulære komponenter fra målorganer DK3600354T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2018628 2017-03-31
PCT/US2018/025371 WO2018183825A1 (en) 2017-03-31 2018-03-30 Generation of therapeutic cells using extracellular components of target organs

Publications (1)

Publication Number Publication Date
DK3600354T3 true DK3600354T3 (da) 2023-10-30

Family

ID=58548819

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18720454.0T DK3600354T3 (da) 2017-03-31 2018-03-30 Generering af terapeutiske celler ved hjælp af ekstracellulære komponenter fra målorganer

Country Status (7)

Country Link
US (2) US11760975B2 (https=)
EP (1) EP3600354B1 (https=)
JP (2) JP7249951B2 (https=)
AU (1) AU2018243554C1 (https=)
CA (1) CA3058437A1 (https=)
DK (1) DK3600354T3 (https=)
WO (1) WO2018183825A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2949083C (en) 2014-05-18 2023-10-10 Children's Medical Center Corporation Methods and compositions relating to exosomes
US11738046B2 (en) 2017-11-03 2023-08-29 Wisconsin Alumni Research Foundation Macrophage cell therapy to treat orthopedic injury
US10876753B2 (en) 2018-02-12 2020-12-29 Watsco Ventures Llc Integrated sensor and service port for HVAC equipment or HVAC system
CN112334190B (zh) 2018-04-30 2024-09-20 儿童医学中心公司 间充质基质细胞外排体及其用途
CA3099042A1 (en) * 2018-05-09 2019-11-14 Children's Medical Center Corporation Mesenchymal stromal cell exosome -treated monocytes and uses thereof
US12350293B2 (en) 2019-03-08 2025-07-08 Niigata University Induction method for macrophage, anti-inflammatory macrophage-inducing agent, and pharmaceutical composition
US20230071393A1 (en) * 2020-04-16 2023-03-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Matrix bound vesicles (mbv) for treatment of acute respiratory distress syndrome
EP3984527A1 (en) 2020-10-13 2022-04-20 Ludwig-Maximilians-Universität München Nano-in-micro encapsulated sirna dry powder, method for producing the same and use of a powder formulation as a pharmaceutical dosage form, in particular for pulmonary delivery
US20220127579A1 (en) * 2020-10-22 2022-04-28 Wisconsin Alumni Research Foundation Use of Toll-Like Receptor 4 Agonists to Treat Inflammation and Tissue Injury
WO2023003775A2 (en) * 2021-07-21 2023-01-26 The Regents Of The University Of California Human ipsc-derived macrophages for liver repair and regeneration
EP4398948A4 (en) * 2021-09-07 2025-07-09 Wisconsin Alumni Res Found CARDIAC FIBROBLAST-DERIVED EXTRACELLULAR MATRIX

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011013452A (es) * 2009-07-02 2012-04-30 Ith Immune Therapy Holdings Ab Tratamiento de cancer basado en exosomas.
US8647678B2 (en) * 2009-08-24 2014-02-11 Wisconsin Alumni Research Foundation Anti-inflammatory macrophages and uses thereof
US8802144B2 (en) 2011-08-25 2014-08-12 Wisconsin Alumni Research Foundation 3-dimensional cardiac fibroblast derived extracellular matrix
WO2015031376A1 (en) * 2013-08-26 2015-03-05 The Trustees Of Columbia University In The City Of New York Scaffolds containing cytokines for tissue engineering
US10624930B2 (en) 2014-06-10 2020-04-21 Mesoblast International Sarl Treatment of immune disorders
US10166254B2 (en) 2014-09-19 2019-01-01 Wisconsin Alumni Research Foundation Use of mesenchymal stem cell-educated macrophages to treat and prevent graft versus host disease and radiation-induced injury
EP3204117A4 (en) * 2014-10-06 2018-05-09 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
KR20180015187A (ko) 2015-06-03 2018-02-12 위스콘신 얼럼나이 리서어치 화운데이션 심장 섬유모세포-유래된 세포외 기질 및 허혈성 질환 또는 손상의 치료를 위한 이의 주사 가능한 제형
US11738046B2 (en) 2017-11-03 2023-08-29 Wisconsin Alumni Research Foundation Macrophage cell therapy to treat orthopedic injury

Also Published As

Publication number Publication date
WO2018183825A1 (en) 2018-10-04
US20230407256A1 (en) 2023-12-21
EP3600354A1 (en) 2020-02-05
JP2023052043A (ja) 2023-04-11
AU2018243554B2 (en) 2024-02-15
JP2020511999A (ja) 2020-04-23
AU2018243554A1 (en) 2019-10-17
CA3058437A1 (en) 2018-10-04
US11760975B2 (en) 2023-09-19
JP7249951B2 (ja) 2023-03-31
EP3600354B1 (en) 2023-09-20
US20180282698A1 (en) 2018-10-04
JP7419490B2 (ja) 2024-01-22
AU2018243554C1 (en) 2025-01-30

Similar Documents

Publication Publication Date Title
DK3600354T3 (da) Generering af terapeutiske celler ved hjælp af ekstracellulære komponenter fra målorganer
DK3704230T3 (da) Fremgangsmåde til generering af terapeutiske sammensætninger af modificerede celler
EP3829494C0 (en) IMPLANTS
IL275882A (en) Electrosurgical generator
DK3653617T3 (da) Fremgangsmåde til fremstillingen af (s)-nikotin fra myosmin
DK3169772T3 (da) Generering af en mesenchymal stromacellebank ud af de poolede mononukleære celler fra flere knoglemarvsdonorer
EP3641665A4 (en) RECHARGEABLE SURGICAL CARTRIDGE SET
EP3302356A4 (en) BALLOON-SUPPORTED RELEASE OF AN ENDOLUMINAL PROTECTION
GB2574795B (en) Generating virtual representations
PT3903182T (pt) Linguagem de solução natural
EP3784148C0 (en) IMPLANTS
EP3609409C0 (en) SURGICAL SIMULATION SYSTEM
EP3761963A4 (en) SURGICAL REPAIR TRANSPLANT
EP3407924A4 (en) ELECTRIC BEADS IRRADIATED OSTEOINDUCTIVE BONE IMPLANT
IL281287A (en) Tissue repair by activated cells
EP3692254C0 (en) IMPROVED TURBINE GENERATOR ASSEMBLY
EP3853984A4 (en) Energy generation
DK3721072T3 (da) System til generering af elektrisk energi ud fra havets bølgebevægelse
EP4144386C0 (en) BONE GRAFT SUBSTITUTE
UA37226S (uk) Генератор
DK3544420T3 (da) Anvendelse af sammensætninger til organ-/vævskonservering
CA188703S (fr) Générateur de vapeur
EP3727193A4 (en) FABRIC REPAIR LAMINATES
EP3727486A4 (en) FABRIC REPAIR LAMINATES
DK3136956T3 (da) Fremgangsmåde til at bestemme fysiologiske parametre fra sternumknoglen