JP2020511135A5 - - Google Patents
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- Publication number
- JP2020511135A5 JP2020511135A5 JP2019549581A JP2019549581A JP2020511135A5 JP 2020511135 A5 JP2020511135 A5 JP 2020511135A5 JP 2019549581 A JP2019549581 A JP 2019549581A JP 2019549581 A JP2019549581 A JP 2019549581A JP 2020511135 A5 JP2020511135 A5 JP 2020511135A5
- Authority
- JP
- Japan
- Prior art keywords
- library
- nucleic acid
- encodes
- polynucleotides
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 31
- 108091033319 polynucleotide Proteins 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 22
- 239000002157 polynucleotide Substances 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 108020004705 Codon Proteins 0.000 claims 12
- 238000009826 distribution Methods 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000002194 synthesizing effect Effects 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000002703 mutagenesis Methods 0.000 claims 4
- 231100000350 mutagenesis Toxicity 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000009828 non-uniform distribution Methods 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 241000203069 Archaea Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000005754 cellular signaling Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023011285A JP7696937B2 (ja) | 2017-03-15 | 2023-01-27 | デノボ合成されたコンビナトリアル核酸ライブラリー |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471723P | 2017-03-15 | 2017-03-15 | |
| US62/471,723 | 2017-03-15 | ||
| US201762578326P | 2017-10-27 | 2017-10-27 | |
| US62/578,326 | 2017-10-27 | ||
| PCT/US2018/022487 WO2018170164A1 (en) | 2017-03-15 | 2018-03-14 | De novo synthesized combinatorial nucleic acid libraries |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023011285A Division JP7696937B2 (ja) | 2017-03-15 | 2023-01-27 | デノボ合成されたコンビナトリアル核酸ライブラリー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511135A JP2020511135A (ja) | 2020-04-16 |
| JP2020511135A5 true JP2020511135A5 (https=) | 2021-04-22 |
| JP7335165B2 JP7335165B2 (ja) | 2023-08-29 |
Family
ID=63523968
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549581A Active JP7335165B2 (ja) | 2017-03-15 | 2018-03-14 | デノボ合成されたコンビナトリアル核酸ライブラリー |
| JP2023011285A Active JP7696937B2 (ja) | 2017-03-15 | 2023-01-27 | デノボ合成されたコンビナトリアル核酸ライブラリー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023011285A Active JP7696937B2 (ja) | 2017-03-15 | 2023-01-27 | デノボ合成されたコンビナトリアル核酸ライブラリー |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20180282721A1 (https=) |
| EP (1) | EP3596258A4 (https=) |
| JP (2) | JP7335165B2 (https=) |
| KR (2) | KR102607157B1 (https=) |
| CN (2) | CN110914486B (https=) |
| AU (2) | AU2018234624B2 (https=) |
| CA (1) | CA3056386A1 (https=) |
| GB (1) | GB2575576A (https=) |
| IL (1) | IL269288A (https=) |
| SG (1) | SG11201908489XA (https=) |
| WO (1) | WO2018170164A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201600853UA (en) | 2013-08-05 | 2016-03-30 | Twist Bioscience Corp | De novo synthesized gene libraries |
| US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| EP3350314A4 (en) | 2015-09-18 | 2019-02-06 | Twist Bioscience Corporation | OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF |
| KR102794025B1 (ko) | 2015-09-22 | 2025-04-09 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
| CN115920796A (zh) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| EP3500672A4 (en) | 2016-08-22 | 2020-05-20 | Twist Bioscience Corporation | DE NOVO SYNTHETIZED NUCLEIC ACID LIBRARIES |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| GB2573069A (en) | 2016-12-16 | 2019-10-23 | Twist Bioscience Corp | Variant libraries of the immunological synapse and synthesis thereof |
| EP4556433A3 (en) | 2017-02-22 | 2025-08-06 | Twist Bioscience Corporation | Nucleic acid based data storage |
| WO2018170169A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| AU2018234624B2 (en) * | 2017-03-15 | 2023-11-16 | Twist Bioscience Corporation | De novo synthesized combinatorial nucleic acid libraries |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| WO2018231872A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| KR102804057B1 (ko) | 2018-01-04 | 2025-05-07 | 트위스트 바이오사이언스 코포레이션 | Dna 기반 디지털 정보 저장 |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| WO2020139871A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| CN113766930B (zh) | 2019-02-26 | 2025-07-22 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
| JP2022522668A (ja) | 2019-02-26 | 2022-04-20 | ツイスト バイオサイエンス コーポレーション | 抗体を最適化するための変異体核酸ライブラリ |
| US11332738B2 (en) | 2019-06-21 | 2022-05-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| JP2022548783A (ja) | 2019-09-23 | 2022-11-21 | ツイスト バイオサイエンス コーポレーション | 単一ドメイン抗体のバリアント核酸ライブラリー |
| EP4034566A4 (en) | 2019-09-23 | 2024-01-24 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID BANKS FOR CRTH2 |
| BR112022011235A2 (pt) | 2019-12-09 | 2022-12-13 | Twist Bioscience Corp | Bibliotecas de variantes de ácido nucleico para receptores de adenosina |
| MX2022013499A (es) | 2020-04-27 | 2023-01-16 | Twist Bioscience Corp | Bibliotecas de ácidos nucleicos variantes para coronavirus. |
| EP4204460A4 (en) | 2020-08-26 | 2024-09-25 | Twist Bioscience Corporation | METHODS AND COMPOSITIONS RELATING TO GLP1R VARIANTS |
| CN117043171A (zh) | 2020-08-28 | 2023-11-10 | 特韦斯特生物科学公司 | 用于合成的装置和方法 |
| EP4229210A4 (en) | 2020-10-19 | 2025-01-08 | Twist Bioscience Corporation | METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDES USING BOUND NUCLEOTIDES |
| KR20230147617A (ko) | 2021-01-21 | 2023-10-23 | 트위스트 바이오사이언스 코포레이션 | 아데노신 수용체에 관한 방법 및 조성물 |
| EP4314075A4 (en) | 2021-03-24 | 2025-04-09 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID BANKS FOR CD3 |
| WO2022235584A1 (en) | 2021-05-03 | 2022-11-10 | Twist Bioscience Corporation | Variant nucleic acid libraries for glycans |
| US12201857B2 (en) | 2021-06-22 | 2025-01-21 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
| WO2023023285A2 (en) | 2021-08-19 | 2023-02-23 | Twist Bioscience Corporation | Methods and compositions relating to covalently closed nucleic acids |
| US12134656B2 (en) | 2021-11-18 | 2024-11-05 | Twist Bioscience Corporation | Dickkopf-1 variant antibodies and methods of use |
| EP4460516A2 (en) | 2022-01-03 | 2024-11-13 | Twist Bioscience Corporation | Bispecific sars-cov-2 antibodies and methods of use |
| US20230340461A1 (en) * | 2022-02-14 | 2023-10-26 | Twist Bioscience Corporation | Combinatorial dna assembly for multispecific antibodies |
| US20230325641A1 (en) * | 2022-04-07 | 2023-10-12 | Winbond Electronics Corp. | Light source optimization apparatus and light source optimization method |
| CN114694757B (zh) * | 2022-04-20 | 2025-04-18 | 中南民族大学 | Rna序列编码潜力预测方法及系统 |
| WO2025217152A1 (en) * | 2024-04-09 | 2025-10-16 | Octant, Inc. | Methods and systems for identifying functional sites |
| WO2025250626A2 (en) * | 2024-05-28 | 2025-12-04 | Immorna Biotherapeutics Inc. | Mrna composition and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681702A (en) * | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| WO2003014325A2 (en) * | 2001-08-10 | 2003-02-20 | Xencor | Protein design automation for protein libraries |
| EP2078077A2 (en) | 2006-10-04 | 2009-07-15 | Codon Devices, Inc | Nucleic acid libraries and their design and assembly |
| US20090075378A1 (en) * | 2007-02-20 | 2009-03-19 | Anaptysbio, Inc. | Somatic hypermutation systems |
| US8401798B2 (en) * | 2008-06-06 | 2013-03-19 | Dna Twopointo, Inc. | Systems and methods for constructing frequency lookup tables for expression systems |
| US20110082055A1 (en) * | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
| PT2890836T (pt) * | 2012-08-31 | 2019-09-16 | Scripps Research Inst | Métodos relacionados a moduladores de células eucariotóticas |
| SG11201600853UA (en) * | 2013-08-05 | 2016-03-30 | Twist Bioscience Corp | De novo synthesized gene libraries |
| EP3350314A4 (en) * | 2015-09-18 | 2019-02-06 | Twist Bioscience Corporation | OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF |
| AU2018234624B2 (en) * | 2017-03-15 | 2023-11-16 | Twist Bioscience Corporation | De novo synthesized combinatorial nucleic acid libraries |
-
2018
- 2018-03-14 AU AU2018234624A patent/AU2018234624B2/en active Active
- 2018-03-14 US US15/921,479 patent/US20180282721A1/en not_active Abandoned
- 2018-03-14 GB GB1914881.6A patent/GB2575576A/en not_active Withdrawn
- 2018-03-14 JP JP2019549581A patent/JP7335165B2/ja active Active
- 2018-03-14 KR KR1020197029959A patent/KR102607157B1/ko active Active
- 2018-03-14 EP EP18768130.9A patent/EP3596258A4/en active Pending
- 2018-03-14 CN CN201880032556.5A patent/CN110914486B/zh not_active Expired - Fee Related
- 2018-03-14 WO PCT/US2018/022487 patent/WO2018170164A1/en not_active Ceased
- 2018-03-14 CA CA3056386A patent/CA3056386A1/en active Pending
- 2018-03-14 SG SG11201908489X patent/SG11201908489XA/en unknown
- 2018-03-14 CN CN202410055914.1A patent/CN117888207A/zh active Pending
- 2018-03-14 KR KR1020237040300A patent/KR20230163591A/ko not_active Ceased
-
2019
- 2019-09-11 IL IL26928819A patent/IL269288A/en unknown
-
2023
- 2023-01-27 JP JP2023011285A patent/JP7696937B2/ja active Active
-
2024
- 2024-02-16 AU AU2024201012A patent/AU2024201012A1/en not_active Abandoned
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