JP2020510050A - がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 - Google Patents
がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 Download PDFInfo
- Publication number
- JP2020510050A JP2020510050A JP2019549569A JP2019549569A JP2020510050A JP 2020510050 A JP2020510050 A JP 2020510050A JP 2019549569 A JP2019549569 A JP 2019549569A JP 2019549569 A JP2019549569 A JP 2019549569A JP 2020510050 A JP2020510050 A JP 2020510050A
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- cancer
- csf
- oncovex
- mgm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/763—Herpes virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023066170A JP7654708B2 (ja) | 2017-03-15 | 2023-04-14 | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
| JP2025043270A JP2025094078A (ja) | 2017-03-15 | 2025-03-18 | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471875P | 2017-03-15 | 2017-03-15 | |
| US62/471,875 | 2017-03-15 | ||
| PCT/US2018/022442 WO2018170133A1 (en) | 2017-03-15 | 2018-03-14 | Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023066170A Division JP7654708B2 (ja) | 2017-03-15 | 2023-04-14 | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020510050A true JP2020510050A (ja) | 2020-04-02 |
| JP2020510050A5 JP2020510050A5 (https=) | 2021-04-22 |
Family
ID=61913527
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549569A Pending JP2020510050A (ja) | 2017-03-15 | 2018-03-14 | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
| JP2023066170A Active JP7654708B2 (ja) | 2017-03-15 | 2023-04-14 | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
| JP2025043270A Pending JP2025094078A (ja) | 2017-03-15 | 2025-03-18 | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023066170A Active JP7654708B2 (ja) | 2017-03-15 | 2023-04-14 | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
| JP2025043270A Pending JP2025094078A (ja) | 2017-03-15 | 2025-03-18 | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20200009204A1 (https=) |
| EP (1) | EP3595690A1 (https=) |
| JP (3) | JP2020510050A (https=) |
| CN (1) | CN110461346A (https=) |
| AU (2) | AU2018235944B2 (https=) |
| CA (1) | CA3056392A1 (https=) |
| MA (1) | MA51630A (https=) |
| MX (3) | MX2019010797A (https=) |
| WO (1) | WO2018170133A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6457940B2 (ja) * | 2012-08-30 | 2019-01-23 | アムジエン・インコーポレーテツド | 単純ヘルペスウイルスおよび免疫チェックポイント阻害薬を使用して、メラノーマを治療するための方法 |
| CA3071599A1 (en) * | 2017-08-07 | 2019-02-14 | Amgen Inc. | Treatment of triple negative breast cancer or colorectal cancer with liver metastases with an anti pd-l1 antibody and an oncolytic virus |
| CN110833622A (zh) * | 2018-08-17 | 2020-02-25 | 北京奥源和力生物技术有限公司 | 用于治疗癌症的组合及其治疗用途 |
| TWI894357B (zh) * | 2020-09-18 | 2025-08-21 | 大陸商成都美杰賽爾生物科技有限公司 | 溶瘤病毒與經改造的免疫細胞聯合治療腫瘤 |
| CA3207359A1 (en) | 2021-02-05 | 2022-08-11 | Cecile Chartier-Courtaud | Adjuvant therapy for cancer |
| WO2022252185A1 (zh) | 2021-06-03 | 2022-12-08 | 上海允英生物医药科技有限公司 | 溶瘤病毒载体及其应用 |
| TW202321458A (zh) * | 2021-09-22 | 2023-06-01 | 瑞典商生物創新國際公司 | 新穎抗體組合及其用途 |
| US12129634B2 (en) * | 2022-08-23 | 2024-10-29 | Vetta, Llc | Sink system |
| CN115463161A (zh) * | 2022-09-15 | 2022-12-13 | 广东天普生化医药股份有限公司 | 一种溶瘤病毒在制备治疗骨肉瘤的药物组合物中的应用 |
| CN116271052B (zh) * | 2022-11-11 | 2025-07-04 | 上海市普陀区中心医院 | 溶瘤病毒vg161或与免疫检查点抑制剂联用在治疗胃癌中的应用 |
| WO2024207425A1 (en) * | 2023-04-07 | 2024-10-10 | Virogin Biotech (Shanghai) Ltd. | Combination of recombinant oncolytic virus and checkpoint inhibitor for the treatment of cancer |
| CN120648657A (zh) * | 2024-03-08 | 2025-09-16 | 上海锦斯生物技术有限公司 | 一种修饰的溶瘤病毒及其组合物 |
| CN119524123A (zh) * | 2024-11-08 | 2025-02-28 | 北京肿瘤医院(北京大学肿瘤医院) | 溶瘤病毒联合pd-1单抗在制备黑色素瘤治疗药物中的应用 |
| CN119792537B (zh) * | 2025-01-22 | 2025-10-21 | 常州大学 | 利巴韦林与pd-1抑制剂联合用药物组合物及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015526525A (ja) * | 2012-08-30 | 2015-09-10 | アムジエン・インコーポレーテツド | 単純ヘルペスウイルスおよび免疫チェックポイント阻害薬を使用して、メラノーマを治療するための方法 |
| WO2016009017A1 (en) * | 2014-07-16 | 2016-01-21 | Institut Gustave-Roussy | Combination of oncolytic virus with immune checkpoint modulators |
| WO2017013419A1 (en) * | 2015-07-20 | 2017-01-26 | Virttu Biologics Limited | Use of oncolytic herpes simplex virus, alone or in combination with immune checkpoint inhibitor, in the treatment of cancer |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770274B1 (en) | 1990-09-14 | 2004-08-03 | The General Hospital Corporation | Viral mutant HSV mediated destruction of neoplastic cells |
| US6699468B1 (en) | 1994-06-23 | 2004-03-02 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
| US5728379A (en) | 1994-06-23 | 1998-03-17 | Georgetown University | Tumor- or cell-specific herpes simplex virus replication |
| US5585096A (en) | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US6207157B1 (en) | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
| US5824318A (en) | 1996-07-24 | 1998-10-20 | American Cyanamid Company | Avirulent herpetic viruses useful as tumoricidal agents and vaccines |
| US6379674B1 (en) | 1997-08-12 | 2002-04-30 | Georgetown University | Use of herpes vectors for tumor therapy |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| EP1141338A4 (en) | 1998-12-31 | 2002-09-25 | Arch Dev Corp | RECOMBINANT HERPES SIMPLEX VIRUS FOR TREATING NEOPLASTIC DISEASES |
| AU2905199A (en) | 1999-03-15 | 2000-10-04 | Trustees Of The University Of Pennsylvania, The | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| US6764675B1 (en) | 1999-06-08 | 2004-07-20 | The Uab Research Foundation | Herpes simplex virus expressing foreign genes and method for treating cancers therewith |
| IL148079A0 (en) | 1999-08-24 | 2002-09-12 | Medarex Inc | Human ctla-4 antibodies and compositions containing the same |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| DE60115600T2 (de) | 2000-01-21 | 2006-07-20 | Biovex Ltd. | Virusstämme für die onkolytische behandlung von krebs |
| CN1286303A (zh) | 2000-08-17 | 2001-03-07 | 上海市农业科学院生物技术研究中心 | 抗人龋齿致病菌蛋白基因及其制备方法 |
| CA2441663C (en) | 2001-03-27 | 2013-01-22 | Medigene, Inc. | Viral vectors and their use in therapeutic methods |
| WO2003042402A2 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| US7731952B2 (en) | 2004-06-24 | 2010-06-08 | New York University | Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| CN101230335B (zh) | 2007-01-22 | 2010-08-11 | 北京奥源和力生物技术有限公司 | 单纯疱疹病毒和重组病毒及宿主细胞及其药物组合物 |
| CN101230334B (zh) | 2007-01-22 | 2011-06-01 | 北京奥源和力生物技术有限公司 | 单纯疱疹病毒和重组病毒及宿主细胞及其药物组合物 |
| HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| KR101814408B1 (ko) | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도 |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| WO2010089411A2 (en) | 2009-02-09 | 2010-08-12 | Universite De La Mediterranee | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| WO2011082400A2 (en) | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体 |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| ES2704632T3 (es) | 2011-09-08 | 2019-03-19 | Univ New York | Virus de herpes simplex oncolítico y sus usos terapéuticos |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| PT3151921T (pt) * | 2014-06-06 | 2019-11-21 | Bristol Myers Squibb Co | Anticorpos contra recetor do fator de necrose tumoral induzido por glicocorticoide e utilizações dos mesmos |
| WO2017120670A1 (en) * | 2016-01-11 | 2017-07-20 | Brian Lichty | Oncolytic virus and checkpoint inhibitor combination therapy |
| PL3426271T3 (pl) * | 2016-03-10 | 2025-11-24 | Cg Oncology, Inc. | Sposoby leczenia guzów litych terapią skojarzoną |
| EP3225253A1 (en) * | 2016-04-01 | 2017-10-04 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor |
| JP2020501589A (ja) * | 2016-12-23 | 2020-01-23 | ウイルツ・バイオロジクス・リミテッド | がんの治療 |
-
2018
- 2018-03-14 JP JP2019549569A patent/JP2020510050A/ja active Pending
- 2018-03-14 US US16/493,376 patent/US20200009204A1/en not_active Abandoned
- 2018-03-14 MX MX2019010797A patent/MX2019010797A/es unknown
- 2018-03-14 CN CN201880017970.9A patent/CN110461346A/zh active Pending
- 2018-03-14 WO PCT/US2018/022442 patent/WO2018170133A1/en not_active Ceased
- 2018-03-14 AU AU2018235944A patent/AU2018235944B2/en active Active
- 2018-03-14 EP EP18716700.2A patent/EP3595690A1/en active Pending
- 2018-03-14 MA MA051630A patent/MA51630A/fr unknown
- 2018-03-14 CA CA3056392A patent/CA3056392A1/en active Pending
-
2019
- 2019-09-11 MX MX2025001102A patent/MX2025001102A/es unknown
- 2019-09-11 MX MX2024006614A patent/MX2024006614A/es unknown
-
2023
- 2023-04-14 JP JP2023066170A patent/JP7654708B2/ja active Active
-
2024
- 2024-04-02 AU AU2024202086A patent/AU2024202086A1/en not_active Abandoned
-
2025
- 2025-03-18 JP JP2025043270A patent/JP2025094078A/ja active Pending
- 2025-07-31 US US19/287,666 patent/US20260102446A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015526525A (ja) * | 2012-08-30 | 2015-09-10 | アムジエン・インコーポレーテツド | 単純ヘルペスウイルスおよび免疫チェックポイント阻害薬を使用して、メラノーマを治療するための方法 |
| WO2016009017A1 (en) * | 2014-07-16 | 2016-01-21 | Institut Gustave-Roussy | Combination of oncolytic virus with immune checkpoint modulators |
| WO2017013419A1 (en) * | 2015-07-20 | 2017-01-26 | Virttu Biologics Limited | Use of oncolytic herpes simplex virus, alone or in combination with immune checkpoint inhibitor, in the treatment of cancer |
Non-Patent Citations (6)
| Title |
|---|
| ANN. SURG. ONCOL., 2010, VOL.17, PP.718-730, JPN6022011189, ISSN: 0004947414 * |
| CANCER RES., 2015, VOL.75, 15_SUPPL., ABSTRACT NO.258, JPN6022011190, ISSN: 0004737239 * |
| CANCER SCI., 2016, VOL.107, PP.1373-1379, JPN6022011188, ISSN: 0004947415 * |
| CLINICALTRIALS.GOV., "STUDY OF TALIMOGENE LAHERPAREPVEC IN CHILDREN WITH ADVANCED NON CNS TUMORS", 2, JPN6022011187, ISSN: 0004947416 * |
| GENE THERAPY, 2003, VOL.10, PP.292-303, JPN6022011185, ISSN: 0004737243 * |
| MOLECULAR THERAPY, 2013, VOL.21, NO.5, PP.1014-1023, JPN6022011193, ISSN: 0004737238 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20260102446A1 (en) | 2026-04-16 |
| JP2023089171A (ja) | 2023-06-27 |
| CN110461346A (zh) | 2019-11-15 |
| MX2019010797A (es) | 2019-10-24 |
| AU2024202086A1 (en) | 2024-04-18 |
| JP2025094078A (ja) | 2025-06-24 |
| AU2018235944B2 (en) | 2024-01-04 |
| WO2018170133A1 (en) | 2018-09-20 |
| US20200009204A1 (en) | 2020-01-09 |
| MX2025001102A (es) | 2025-03-07 |
| JP7654708B2 (ja) | 2025-04-01 |
| EP3595690A1 (en) | 2020-01-22 |
| CA3056392A1 (en) | 2018-09-20 |
| MX2024006614A (es) | 2024-06-19 |
| AU2018235944A1 (en) | 2019-09-26 |
| MA51630A (fr) | 2020-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7654708B2 (ja) | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 | |
| US20200078426A1 (en) | Treatment of cancer by infusion of oncolytic herpes simplex virus to the blood | |
| JP6656349B2 (ja) | 単純ヘルペスウイルスおよび免疫チェックポイント阻害薬を使用して、メラノーマを治療するための方法 | |
| JP6954648B2 (ja) | 併用療法による固形腫瘍又はリンパ系腫瘍の治療方法 | |
| RU2702332C2 (ru) | Антитела к в7-н1 и к ctla-4 для лечения немелкоклеточного рака легкого | |
| TWI851676B (zh) | 溶瘤病毒用於治療癌症之用途 | |
| EP3473263A1 (en) | Combined preparations for the treatment of cancer or infection | |
| TWI817958B (zh) | 用於治療肝癌之組合物及方法 | |
| TW202102543A (zh) | 溶瘤病毒在癌症新輔助療法中之用途 | |
| US20140205609A1 (en) | Methods for inducing systemic immune responses to cancer | |
| CN108815188A (zh) | 包含间充质干细胞制剂与免疫检查点抑制剂的肿瘤治疗组合物、试剂盒及其用途 | |
| RU2802962C2 (ru) | Композиции и способы лечения рака печени | |
| WO2022048574A1 (zh) | 一种编码Kras基因突变体的核酸分子 | |
| CN111405906A (zh) | 用于治疗癌症的组合物和方法 | |
| HK1255016A1 (en) | Methods of treating solid or lymphatic tumors by combination therapy | |
| HK1255016B (zh) | 通过组合疗法治疗实体或淋巴肿瘤的方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210312 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210312 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220329 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220623 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220926 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20221220 |