CN110461346A - 溶瘤病毒单独或与检查点抑制剂组合用于治疗癌症的用途 - Google Patents

溶瘤病毒单独或与检查点抑制剂组合用于治疗癌症的用途 Download PDF

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Publication number
CN110461346A
CN110461346A CN201880017970.9A CN201880017970A CN110461346A CN 110461346 A CN110461346 A CN 110461346A CN 201880017970 A CN201880017970 A CN 201880017970A CN 110461346 A CN110461346 A CN 110461346A
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tumor
cancer
csf
oncovex
cell
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P.J.贝尔特兰
C.比尔斯
K.库克
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Amgen Inc
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Amgen Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201880017970.9A 2017-03-15 2018-03-14 溶瘤病毒单独或与检查点抑制剂组合用于治疗癌症的用途 Pending CN110461346A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762471875P 2017-03-15 2017-03-15
US62/471875 2017-03-15
PCT/US2018/022442 WO2018170133A1 (en) 2017-03-15 2018-03-14 Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer

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CN110461346A true CN110461346A (zh) 2019-11-15

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CN201880017970.9A Pending CN110461346A (zh) 2017-03-15 2018-03-14 溶瘤病毒单独或与检查点抑制剂组合用于治疗癌症的用途

Country Status (9)

Country Link
US (2) US20200009204A1 (https=)
EP (1) EP3595690A1 (https=)
JP (3) JP2020510050A (https=)
CN (1) CN110461346A (https=)
AU (2) AU2018235944B2 (https=)
CA (1) CA3056392A1 (https=)
MA (1) MA51630A (https=)
MX (3) MX2019010797A (https=)
WO (1) WO2018170133A1 (https=)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104704002A (zh) * 2012-08-30 2015-06-10 安姆根有限公司 使用单纯疱疹病毒和免疫检查点抑制剂治疗黑色素瘤的方法
CN110833622A (zh) * 2018-08-17 2020-02-25 北京奥源和力生物技术有限公司 用于治疗癌症的组合及其治疗用途
WO2022057904A1 (zh) * 2020-09-18 2022-03-24 成都美杰赛尔生物科技有限公司 溶瘤病毒与经改造的免疫细胞联合治疗肿瘤
CN115463161A (zh) * 2022-09-15 2022-12-13 广东天普生化医药股份有限公司 一种溶瘤病毒在制备治疗骨肉瘤的药物组合物中的应用
WO2024207425A1 (en) * 2023-04-07 2024-10-10 Virogin Biotech (Shanghai) Ltd. Combination of recombinant oncolytic virus and checkpoint inhibitor for the treatment of cancer
US12129634B2 (en) * 2022-08-23 2024-10-29 Vetta, Llc Sink system
CN119524123A (zh) * 2024-11-08 2025-02-28 北京肿瘤医院(北京大学肿瘤医院) 溶瘤病毒联合pd-1单抗在制备黑色素瘤治疗药物中的应用
CN119792537A (zh) * 2025-01-22 2025-04-11 常州大学 利巴韦林与pd-1抑制剂联合用药物组合物及其应用
WO2025185740A1 (zh) * 2024-03-08 2025-09-12 上海锦斯生物技术有限公司 一种修饰的溶瘤病毒及其组合物

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CA3071599A1 (en) * 2017-08-07 2019-02-14 Amgen Inc. Treatment of triple negative breast cancer or colorectal cancer with liver metastases with an anti pd-l1 antibody and an oncolytic virus
CA3207359A1 (en) 2021-02-05 2022-08-11 Cecile Chartier-Courtaud Adjuvant therapy for cancer
WO2022252185A1 (zh) 2021-06-03 2022-12-08 上海允英生物医药科技有限公司 溶瘤病毒载体及其应用
TW202321458A (zh) * 2021-09-22 2023-06-01 瑞典商生物創新國際公司 新穎抗體組合及其用途
CN116271052B (zh) * 2022-11-11 2025-07-04 上海市普陀区中心医院 溶瘤病毒vg161或与免疫检查点抑制剂联用在治疗胃癌中的应用

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104704002A (zh) * 2012-08-30 2015-06-10 安姆根有限公司 使用单纯疱疹病毒和免疫检查点抑制剂治疗黑色素瘤的方法
CN104704002B (zh) * 2012-08-30 2022-05-10 安姆根有限公司 使用单纯疱疹病毒和免疫检查点抑制剂治疗黑色素瘤的方法
CN110833622A (zh) * 2018-08-17 2020-02-25 北京奥源和力生物技术有限公司 用于治疗癌症的组合及其治疗用途
WO2022057904A1 (zh) * 2020-09-18 2022-03-24 成都美杰赛尔生物科技有限公司 溶瘤病毒与经改造的免疫细胞联合治疗肿瘤
US12129634B2 (en) * 2022-08-23 2024-10-29 Vetta, Llc Sink system
CN115463161A (zh) * 2022-09-15 2022-12-13 广东天普生化医药股份有限公司 一种溶瘤病毒在制备治疗骨肉瘤的药物组合物中的应用
WO2024207425A1 (en) * 2023-04-07 2024-10-10 Virogin Biotech (Shanghai) Ltd. Combination of recombinant oncolytic virus and checkpoint inhibitor for the treatment of cancer
WO2025185740A1 (zh) * 2024-03-08 2025-09-12 上海锦斯生物技术有限公司 一种修饰的溶瘤病毒及其组合物
CN119524123A (zh) * 2024-11-08 2025-02-28 北京肿瘤医院(北京大学肿瘤医院) 溶瘤病毒联合pd-1单抗在制备黑色素瘤治疗药物中的应用
CN119792537A (zh) * 2025-01-22 2025-04-11 常州大学 利巴韦林与pd-1抑制剂联合用药物组合物及其应用
CN119792537B (zh) * 2025-01-22 2025-10-21 常州大学 利巴韦林与pd-1抑制剂联合用药物组合物及其应用

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US20260102446A1 (en) 2026-04-16
JP2023089171A (ja) 2023-06-27
JP2020510050A (ja) 2020-04-02
MX2019010797A (es) 2019-10-24
AU2024202086A1 (en) 2024-04-18
JP2025094078A (ja) 2025-06-24
AU2018235944B2 (en) 2024-01-04
WO2018170133A1 (en) 2018-09-20
US20200009204A1 (en) 2020-01-09
MX2025001102A (es) 2025-03-07
JP7654708B2 (ja) 2025-04-01
EP3595690A1 (en) 2020-01-22
CA3056392A1 (en) 2018-09-20
MX2024006614A (es) 2024-06-19
AU2018235944A1 (en) 2019-09-26
MA51630A (fr) 2020-01-22

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