JP2020509043A - カンナビノイドアゴニストによる認知症の治療 - Google Patents

カンナビノイドアゴニストによる認知症の治療 Download PDF

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Publication number
JP2020509043A
JP2020509043A JP2019547448A JP2019547448A JP2020509043A JP 2020509043 A JP2020509043 A JP 2020509043A JP 2019547448 A JP2019547448 A JP 2019547448A JP 2019547448 A JP2019547448 A JP 2019547448A JP 2020509043 A JP2020509043 A JP 2020509043A
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Prior art keywords
dementia
compound
use according
group
alkyl
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Japanese (ja)
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JP2020509043A5 (https=
Inventor
プエルタス、ラファエル ロドリゲス
プエルタス、ラファエル ロドリゲス
ビセンテ、イバン マヌエル
ビセンテ、イバン マヌエル
イトゥリサガ、ラウラ ロンバルデロ
イトゥリサガ、ラウラ ロンバルデロ
オベヘロ、アルベルト ジョレンテ
オベヘロ、アルベルト ジョレンテ
ロドリゲス、マルタ モレノ
ロドリゲス、マルタ モレノ
ガルデアサバル、ホナタン マルティネス
ガルデアサバル、ホナタン マルティネス
デ サン ロマン マルティン、エスティバリス ゴンザレス
デ サン ロマン マルティン、エスティバリス ゴンザレス
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Euskal Herriko Unibertsitatea
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Euskal Herriko Unibertsitatea
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Publication of JP2020509043A publication Critical patent/JP2020509043A/ja
Publication of JP2020509043A5 publication Critical patent/JP2020509043A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019547448A 2017-03-02 2018-02-23 カンナビノイドアゴニストによる認知症の治療 Pending JP2020509043A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES201730284A ES2638057B1 (es) 2017-03-02 2017-03-02 Tratamiento de la demencia con agonistas cannabinoides
ESP201730284 2017-03-02
PCT/EP2018/054525 WO2018158150A1 (en) 2017-03-02 2018-02-23 Treatment of dementia with cannabinoid agonists

Publications (2)

Publication Number Publication Date
JP2020509043A true JP2020509043A (ja) 2020-03-26
JP2020509043A5 JP2020509043A5 (https=) 2021-04-08

Family

ID=60043443

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019547448A Pending JP2020509043A (ja) 2017-03-02 2018-02-23 カンナビノイドアゴニストによる認知症の治療

Country Status (5)

Country Link
US (1) US20200016163A1 (https=)
EP (1) EP3589322A1 (https=)
JP (1) JP2020509043A (https=)
ES (1) ES2638057B1 (https=)
WO (1) WO2018158150A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3893673A4 (en) 2018-12-14 2023-05-03 Natural Extraction Systems, LLC COMPOSITIONS AND METHODS RELATED TO ANIONIC CANNABINOID MOLECULES
WO2021084523A2 (en) * 2019-10-31 2021-05-06 Radient Technologies Innovations Inc. Enhancing lifestyle of memory impaired patients using cbd
CA3158673A1 (en) * 2019-11-14 2021-05-20 Douglas G. Metcalf Pharmaceutical compositions comprising cannabinoid anions
US12349706B2 (en) 2020-07-31 2025-07-08 Natural Extraction Systems, LLC Compositions and methods related to excipients and cannabinoid formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009059277A1 (en) * 2007-11-02 2009-05-07 University Of South Florida Synergistic modulation of microglial activation by nicotine and thc
PL2606032T3 (pl) * 2010-08-20 2015-07-31 Univ Washington Through Its Center For Commercialization Kompozycja i sposoby terapii glejakaep

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRITISH JOURNAL OF PHARMACOLOGY, vol. 171, JPN6021045054, 2014, pages 468 - 479, ISSN: 0004798433 *
MOLECULAR PHARMACOLOGY, vol. 79, JPN6021045056, 2011, pages 964 - 973, ISSN: 0004798432 *
THE JOURNAL OF NEUROSCIENCE, vol. 25, no. 8, JPN6021045057, 2005, pages 1904 - 1913, ISSN: 0004798431 *

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Publication number Publication date
ES2638057A1 (es) 2017-10-18
WO2018158150A1 (en) 2018-09-07
US20200016163A1 (en) 2020-01-16
EP3589322A1 (en) 2020-01-08
ES2638057B1 (es) 2018-10-01

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