JP2020509024A5 - - Google Patents

Info

Publication number

JP2020509024A5

JP2020509024A5 JP2019547135A JP2019547135A JP2020509024A5 JP 2020509024 A5 JP2020509024 A5 JP 2020509024A5 JP 2019547135 A JP2019547135 A JP 2019547135A JP 2019547135 A JP2019547135 A JP 2019547135A JP 2020509024 A5 JP2020509024 A5 JP 2020509024A5

Authority

JP

Japan

Prior art keywords

medicament according

chemotherapy

pertuzumab

trastuzumab

cyclophosphamide

Prior art date

2018-02-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 claims 14
• 238000002512 chemotherapy Methods 0.000 claims 10
• 229960002087 pertuzumab Drugs 0.000 claims 7
• 229960000575 trastuzumab Drugs 0.000 claims 6
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 4
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
• 229960004397 cyclophosphamide Drugs 0.000 claims 4
• 229940123237 Taxane Drugs 0.000 claims 3
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 3
• 230000002980 postoperative effect Effects 0.000 claims 3
• 238000002560 therapeutic procedure Methods 0.000 claims 3
• AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 2
• HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 2
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
• 229930012538 Paclitaxel Natural products 0.000 claims 2
• PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 claims 2
• 150000004056 anthraquinones Chemical class 0.000 claims 2
• 229960003668 docetaxel Drugs 0.000 claims 2
• 229960004679 doxorubicin Drugs 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 229960001904 epirubicin Drugs 0.000 claims 2
• 229960002949 fluorouracil Drugs 0.000 claims 2
• 229960001592 paclitaxel Drugs 0.000 claims 2
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 101150029707 ERBB2 gene Proteins 0.000 claims 1
• 208000007433 Lymphatic Metastasis Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 108091008039 hormone receptors Proteins 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 208000030776 invasive breast carcinoma Diseases 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
• 230000004083 survival effect Effects 0.000 claims 1
• 230000003442 weekly effect Effects 0.000 claims 1