JP2020506962A5 - - Google Patents

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Publication number
JP2020506962A5
JP2020506962A5 JP2019560066A JP2019560066A JP2020506962A5 JP 2020506962 A5 JP2020506962 A5 JP 2020506962A5 JP 2019560066 A JP2019560066 A JP 2019560066A JP 2019560066 A JP2019560066 A JP 2019560066A JP 2020506962 A5 JP2020506962 A5 JP 2020506962A5
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JP
Japan
Prior art keywords
seq
hla
antibody
neoantigen
cancer cells
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JP2019560066A
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English (en)
Japanese (ja)
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JP7303750B2 (ja
JP2020506962A (ja
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Priority claimed from PCT/US2018/015086 external-priority patent/WO2018140525A1/en
Publication of JP2020506962A publication Critical patent/JP2020506962A/ja
Publication of JP2020506962A5 publication Critical patent/JP2020506962A5/ja
Priority to JP2023102868A priority Critical patent/JP2023134503A/ja
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Publication of JP7303750B2 publication Critical patent/JP7303750B2/ja
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JP2019560066A 2017-01-24 2018-01-24 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物 Active JP7303750B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023102868A JP2023134503A (ja) 2017-01-24 2023-06-22 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762449954P 2017-01-24 2017-01-24
US62/449,954 2017-01-24
US201762460585P 2017-02-17 2017-02-17
US62/460,585 2017-02-17
PCT/US2018/015086 WO2018140525A1 (en) 2017-01-24 2018-01-24 Methods and compositions for targeting a complex comprising non-classical hla-i and neoantigen in cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023102868A Division JP2023134503A (ja) 2017-01-24 2023-06-22 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物

Publications (3)

Publication Number Publication Date
JP2020506962A JP2020506962A (ja) 2020-03-05
JP2020506962A5 true JP2020506962A5 (OSRAM) 2021-03-04
JP7303750B2 JP7303750B2 (ja) 2023-07-05

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ID=62979691

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019560066A Active JP7303750B2 (ja) 2017-01-24 2018-01-24 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物
JP2023102868A Pending JP2023134503A (ja) 2017-01-24 2023-06-22 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物

Family Applications After (1)

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JP2023102868A Pending JP2023134503A (ja) 2017-01-24 2023-06-22 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物

Country Status (5)

Country Link
US (1) US20190071502A1 (OSRAM)
EP (1) EP3573997A4 (OSRAM)
JP (2) JP7303750B2 (OSRAM)
CN (1) CN110809580A (OSRAM)
WO (1) WO2018140525A1 (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201501017D0 (en) 2014-12-23 2015-03-04 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers
PL3545965T3 (pl) 2014-12-23 2021-12-27 Immatics Biotechnologies Gmbh Nowe peptydy i kombinacja peptydów do stosowania w immunoterapii względem raka komórek wątroby (hcc) i innych rodzajów raka
EP3539552A1 (en) * 2018-03-16 2019-09-18 Deutsches Rheuma-Forschungszentrum Berlin Activation and expansion of nkg2c+ nk cells
AU2019309948A1 (en) * 2018-07-23 2021-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
AU2019371417A1 (en) * 2018-11-01 2021-06-17 Berkeley Lights, Inc. Methods for assaying biological cells in a microfluidic device
AU2020312163A1 (en) 2019-07-05 2022-02-17 Intellexon Gmbh HLA-H in medicine and diagnostics
CN110491450B (zh) * 2019-08-23 2023-05-16 深圳市新合生物医疗科技有限公司 肿瘤新生抗原预测平台及其应用
US20220363767A1 (en) * 2019-10-25 2022-11-17 Intellexon Gmbh Hla-h, hla-j, hla-l, hla-v and hla-y as therapeutic and diagnostic targets
US12312412B2 (en) 2020-05-19 2025-05-27 Amgen Inc. MAGEB2 binding constructs
US10981996B1 (en) * 2020-06-01 2021-04-20 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
US10981997B1 (en) * 2020-06-01 2021-04-20 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
US11976120B2 (en) * 2020-06-01 2024-05-07 Boehringer Ingelheim International Gmbh Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
CN115698088A (zh) * 2020-06-30 2023-02-03 和铂医药(上海)有限责任公司 免疫细胞衔接器多特异性结合蛋白及其制备和应用
CN115667316A (zh) * 2020-06-30 2023-01-31 和铂医药(上海)有限责任公司 Fab-HCAb结构的结合蛋白
WO2022002033A1 (zh) * 2020-06-30 2022-01-06 和铂医药(上海)有限责任公司 具有H2L2与HCAb结构的结合蛋白
CA3192845A1 (en) * 2020-09-15 2022-03-24 Barton F. Haynes Antibodies that target hla-e-host peptide complexes and uses thereof
EP4388012A4 (en) * 2021-08-20 2025-09-17 Univ Duke ANTIBODIES TARGETING HLA-E-HOST PEPTIDE COMPLEXES AND THEIR USES
US20250136669A1 (en) * 2021-12-15 2025-05-01 Teikyo Heisei University Vhh antibody
JP2025533851A (ja) * 2022-10-05 2025-10-09 ティースキャン セラピューティクス インコーポレイテッド Ｍａｇｅａ１免疫原性ペプチド、ｍａｇｅａ１免疫原性ペプチドを認識する結合性タンパク質、及びその使用
WO2024084091A1 (en) * 2022-10-21 2024-04-25 Medizinische Universität Wien Materials and methods to treat epstein-barr virus (ebv) and ebv-induced diseases
AR133120A1 (es) * 2023-09-22 2025-08-27 Regeneron Pharma Métodos para obtener moléculas de anticuerpos que se unen a una interfaz péptido-mhc
GB202316281D0 (en) * 2023-10-24 2023-12-06 Replay Holdings Inc Methods and compositions for modulating immune cell activity in cellular therapy
WO2026024596A1 (en) * 2024-07-22 2026-01-29 The Children's Hospital Of Philadelphia Methods of stimulating an immune response

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199902553T2 (xx) * 1997-04-14 2000-03-21 Micromet Gesellschaft F�R Biomedizinische Forschung Mbh �nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�.
JP2001519143A (ja) * 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション 可溶性の一本鎖ｔ細胞レセプタータンパク質
GB9725764D0 (en) * 1997-12-04 1998-02-04 Isis Innovation HLA-E binding
EP1276896B1 (en) * 2000-04-28 2010-07-21 Mannkind Corporation Epitope synchronization in antigen presenting cells
CN101663047B (zh) 2007-02-23 2014-07-09 纽约哥伦比亚大学理事会 通过激活或阻断HLA-E/Qa-1限制性CD8+T细胞调控途径来治疗免疫疾病的方法
EP2144935A2 (en) * 2007-03-29 2010-01-20 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
GB201003198D0 (en) * 2010-02-25 2010-04-14 Arab Biotechnology Company Compositions and methods for the treatment of cancer
MX2013001305A (es) * 2010-08-05 2013-03-20 Hoffmann La Roche Proteina de fusion de citoquina anti-viral de anticuerpo anti-mhc.
US9290541B2 (en) * 2011-11-18 2016-03-22 Board Of Regents, The University Of Texas System TCL1 peptides for immunotherapy
US10656156B2 (en) * 2012-07-05 2020-05-19 Mepur Ravindranath Diagnostic and therapeutic potential of HLA-E monospecific monoclonal IgG antibodies directed against tumor cell surface and soluble HLA-E
AU2014358191B2 (en) * 2013-12-04 2020-12-24 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
GB201505305D0 (en) * 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
NL2014935B1 (en) * 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
KR20180012850A (ko) * 2015-06-24 2018-02-06 유레카 쎄라퓨틱스, 인코포레이티드 Ny-eso-1 펩티드/mhc 복합체를 표적화하는 구축물 및 그의 용도
EP3475706B1 (en) * 2016-06-27 2021-08-11 Juno Therapeutics, Inc. Mhc-e restricted epitopes, binding molecules and related methods and uses

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