JP2020506710A5 - - Google Patents
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- JP2020506710A5 JP2020506710A5 JP2019542436A JP2019542436A JP2020506710A5 JP 2020506710 A5 JP2020506710 A5 JP 2020506710A5 JP 2019542436 A JP2019542436 A JP 2019542436A JP 2019542436 A JP2019542436 A JP 2019542436A JP 2020506710 A5 JP2020506710 A5 JP 2020506710A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- cell
- acid molecule
- isolated nucleic
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17155193 | 2017-02-08 | ||
| EP17155193.0 | 2017-02-08 | ||
| PCT/IB2018/050696 WO2018146588A1 (en) | 2017-02-08 | 2018-02-05 | Synp88, a promoter for the specific expression of genes in retinal ganglion cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506710A JP2020506710A (ja) | 2020-03-05 |
| JP2020506710A5 true JP2020506710A5 (enExample) | 2021-05-13 |
| JP7112414B2 JP7112414B2 (ja) | 2022-08-03 |
Family
ID=57995117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019542436A Expired - Fee Related JP7112414B2 (ja) | 2017-02-08 | 2018-02-05 | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11371060B2 (enExample) |
| EP (1) | EP3579884A1 (enExample) |
| JP (1) | JP7112414B2 (enExample) |
| CN (1) | CN110392582A (enExample) |
| WO (1) | WO2018146588A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101970013B (zh) | 2008-04-18 | 2014-11-05 | 诺瓦提斯研究基金会弗里德里克·米谢尔生物医学研究所 | 治疗失明的新型治疗工具和方法 |
| WO2016174624A1 (en) | 2015-04-30 | 2016-11-03 | Friedrich Miescher Institute For Biomedical Research | Promoter for the specific expression of genes in müller cells |
| JP6898920B2 (ja) | 2015-09-15 | 2021-07-07 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 光受容器のターゲッティングにより失明を治療するための新規な治療用ツールおよび方法 |
| EP3362101B1 (en) | 2015-10-14 | 2021-05-19 | Friedrich Miescher Institute for Biomedical Research | Promoter for the specific expression of genes in retinal endothelial cells |
| EP3383440B1 (en) | 2015-12-03 | 2021-06-30 | Friedrich Miescher Institute for Biomedical Research | Synp162, a promoter for the specific expression of genes in rod photoreceptors |
| ES2909444T3 (es) | 2015-12-03 | 2022-05-06 | Friedrich Miescher Institute For Biomedical Res | Synp159, un promotor para la expresión específica de genes en los fotorreceptores de los bastones |
| CA3006952A1 (en) | 2015-12-03 | 2017-06-08 | Friedrich Miescher Institute For Biomedical Research | Synp161, a promoter for the specific expression of genes in rod photoreceptors |
| CN108474001B (zh) | 2015-12-03 | 2022-04-08 | 弗里德里克·米谢尔生物医学研究所 | SynP160，用于基因在视杆光感受器中特异性表达的启动子 |
| AU2017354086C1 (en) | 2016-11-02 | 2021-05-06 | Friedrich Miescher Institute For Biomedical Research | SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells |
| CN110392582A (zh) * | 2017-02-08 | 2019-10-29 | 弗里德里克·米谢尔生物医学研究所 | 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP88 |
| AU2018369975B2 (en) | 2017-11-15 | 2022-05-19 | Friedrich Miescher Institute For Biomedical Research | Primate retinal pigment epithelium cell-specific promoter |
| KR20200091432A (ko) | 2017-11-30 | 2020-07-30 | 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 | 망막 색소 상피에서의 유전자의 특이적 발현을 위한 프로모터 SynPIII |
| CN110857440B (zh) * | 2018-08-23 | 2021-02-19 | 武汉纽福斯生物科技有限公司 | 重组人ⅱ型线粒体动力蛋白样gtp酶基因序列及其应用 |
| EP3870709A1 (en) * | 2018-10-25 | 2021-09-01 | Friedrich Miescher Institute for Biomedical Research | Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes |
| JP2022512780A (ja) * | 2018-10-25 | 2022-02-07 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターＳｙｎＰ１９４（ＰｒｏＢ１５） |
| US20230293730A1 (en) * | 2020-08-05 | 2023-09-21 | Hangzhou Exegenesis Bio Ltd. | Nucleic acid constructs and uses thereof for treating spinal muscular atrophy |
| US12234472B2 (en) | 2021-10-18 | 2025-02-25 | Regeneron Pharmaceuticals, Inc. | Eukaryotic cells comprising adenovirus-associated virus polynucleotides |
| CN117625619B (zh) * | 2023-12-05 | 2024-11-12 | 云舟生物科技(广州)股份有限公司 | 核酸分子及其作为特异启动子的应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070161031A1 (en) * | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
| EP1891976A1 (en) | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| CN101970013B (zh) | 2008-04-18 | 2014-11-05 | 诺瓦提斯研究基金会弗里德里克·米谢尔生物医学研究所 | 治疗失明的新型治疗工具和方法 |
| EP2888368A1 (en) * | 2012-08-27 | 2015-07-01 | Friedrich Miescher Institute for Biomedical Research | Retinal off circuit-specific promoter |
| WO2015118507A1 (en) | 2014-02-10 | 2015-08-13 | Friedrich Miescher Institute For Biomedical Research | Aii retinal amacrine cell-specific promoter |
| ES2748282T3 (es) | 2014-02-11 | 2020-03-16 | Friedrich Miescher Institute For Biomedical Res | Promotor específico de células de Müller |
| WO2016174624A1 (en) | 2015-04-30 | 2016-11-03 | Friedrich Miescher Institute For Biomedical Research | Promoter for the specific expression of genes in müller cells |
| JP6898920B2 (ja) | 2015-09-15 | 2021-07-07 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 光受容器のターゲッティングにより失明を治療するための新規な治療用ツールおよび方法 |
| EP3362101B1 (en) | 2015-10-14 | 2021-05-19 | Friedrich Miescher Institute for Biomedical Research | Promoter for the specific expression of genes in retinal endothelial cells |
| ES2909444T3 (es) | 2015-12-03 | 2022-05-06 | Friedrich Miescher Institute For Biomedical Res | Synp159, un promotor para la expresión específica de genes en los fotorreceptores de los bastones |
| CA3006952A1 (en) | 2015-12-03 | 2017-06-08 | Friedrich Miescher Institute For Biomedical Research | Synp161, a promoter for the specific expression of genes in rod photoreceptors |
| EP3383440B1 (en) | 2015-12-03 | 2021-06-30 | Friedrich Miescher Institute for Biomedical Research | Synp162, a promoter for the specific expression of genes in rod photoreceptors |
| CN108474001B (zh) | 2015-12-03 | 2022-04-08 | 弗里德里克·米谢尔生物医学研究所 | SynP160，用于基因在视杆光感受器中特异性表达的启动子 |
| EP3384036B1 (en) | 2015-12-04 | 2021-02-24 | Sorbonne Université | Promoters and uses thereof |
| US20190209708A1 (en) | 2016-05-17 | 2019-07-11 | Friedrich Miescher Institute For Biomedical Research | Novel therapeutic tools and methods for treating blindness |
| AU2017354086C1 (en) | 2016-11-02 | 2021-05-06 | Friedrich Miescher Institute For Biomedical Research | SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells |
| WO2018099975A1 (en) | 2016-12-01 | 2018-06-07 | Friedrich Miescher Institute For Biomedical Research | Synpi, a promoter for the specific expression of genes in interneurons |
| WO2018099974A1 (en) | 2016-12-01 | 2018-06-07 | Friedrich Miescher Institute For Biomedical Research | Synp107, a promoter for the specific expression of genes in interneurons |
| CN110392582A (zh) | 2017-02-08 | 2019-10-29 | 弗里德里克·米谢尔生物医学研究所 | 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP88 |
| AU2018369975B2 (en) | 2017-11-15 | 2022-05-19 | Friedrich Miescher Institute For Biomedical Research | Primate retinal pigment epithelium cell-specific promoter |
| KR20200091432A (ko) | 2017-11-30 | 2020-07-30 | 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 | 망막 색소 상피에서의 유전자의 특이적 발현을 위한 프로모터 SynPIII |
| CR20200235A (es) | 2017-11-30 | 2020-10-19 | Friedrich Miescher Institute For Biomedical Res | Synp61, un promotor específico de células del epitelio pigmentario retiniano de primates |
| US20210388386A1 (en) | 2018-10-25 | 2021-12-16 | Friedrich Miescher Institute For Biomedical Research | Synp57 (proa14), a promoter for the specific expression of genes in photoreceptors |
| EP3870709A1 (en) | 2018-10-25 | 2021-09-01 | Friedrich Miescher Institute for Biomedical Research | Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes |
| JP2022505516A (ja) | 2018-10-25 | 2022-01-14 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターＳｙｎＰ１７（ＰｒｏＢ１） |
| EP3870242A1 (en) | 2018-10-25 | 2021-09-01 | Friedrich Miescher Institute for Biomedical Research | Synp151 (proc29), a promoter for the specific expression of genes in retinal ganglion cells |
| JP2022512780A (ja) | 2018-10-25 | 2022-02-07 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターＳｙｎＰ１９４（ＰｒｏＢ１５） |
| US20210355505A1 (en) | 2018-10-25 | 2021-11-18 | Friedrich Miescher Institute For Biomedical Research | Synp78 (proa27), a promoter for the specific expression of genes in retinal ganglion cells |
| WO2020152626A1 (en) | 2019-01-24 | 2020-07-30 | Friedrich Miescher Institute For Biomedical Research | Synp166 (proa36), a promoter for the specific expression of genes in photoreceptors |
| US20220090062A1 (en) | 2019-01-24 | 2022-03-24 | Friedrich Miescher Institute For Biomedical Research | Synp66 (proa21), a promoter for the specific expression of genes in retinal ganglion cells |
| EP3914299A1 (en) | 2019-01-24 | 2021-12-01 | Friedrich Miescher Institute for Biomedical Research | Synp5 (proa9), a promoter for the specific expression of genes in retinal ganglion cells |
| US20220119807A1 (en) | 2019-01-24 | 2022-04-21 | Friedrich Miescher Institute For Biomedical Research | Synp35 (proc8), a promoter for the specific expression of genes in retinal ganglion cells |
| SG11202108044YA (en) | 2019-02-25 | 2021-09-29 | Novartis Ag | Compositions and methods to treat bietti crystalline dystrophy |
| WO2020174369A2 (en) | 2019-02-25 | 2020-09-03 | Novartis Ag | Compositions and methods to treat bietti crystalline dystrophy |
-
2018
- 2018-02-05 CN CN201880010380.3A patent/CN110392582A/zh active Pending
- 2018-02-05 JP JP2019542436A patent/JP7112414B2/ja not_active Expired - Fee Related
- 2018-02-05 EP EP18704314.6A patent/EP3579884A1/en not_active Withdrawn
- 2018-02-05 WO PCT/IB2018/050696 patent/WO2018146588A1/en not_active Ceased
- 2018-02-05 US US16/484,252 patent/US11371060B2/en active Active
-
2022
- 2022-05-13 US US17/663,242 patent/US20220267800A1/en not_active Abandoned
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