JP2020504112A5 - - Google Patents
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- JP2020504112A5 JP2020504112A5 JP2019533594A JP2019533594A JP2020504112A5 JP 2020504112 A5 JP2020504112 A5 JP 2020504112A5 JP 2019533594 A JP2019533594 A JP 2019533594A JP 2019533594 A JP2019533594 A JP 2019533594A JP 2020504112 A5 JP2020504112 A5 JP 2020504112A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fab
- variable region
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000035693 Fab Effects 0.000 claims description 152
- 102000004965 antibodies Human genes 0.000 claims description 102
- 108090001123 antibodies Proteins 0.000 claims description 102
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 18
- 239000011780 sodium chloride Substances 0.000 claims description 18
- 210000003958 Hematopoietic Stem Cells Anatomy 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 11
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims description 10
- 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 claims description 10
- 206010000871 Acute monocytic leukaemia Diseases 0.000 claims description 8
- 206010000880 Acute myeloid leukaemia Diseases 0.000 claims description 8
- 208000009721 Leukemia, Monocytic, Acute Diseases 0.000 claims description 8
- 208000008456 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Diseases 0.000 claims description 8
- 208000007046 Leukemia, Myeloid, Acute Diseases 0.000 claims description 8
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 8
- 201000005510 acute lymphocytic leukemia Diseases 0.000 claims description 8
- 201000006934 chronic myeloid leukemia Diseases 0.000 claims description 8
- 201000010874 syndrome Diseases 0.000 claims description 8
- 206010020243 Hodgkin's disease Diseases 0.000 claims description 6
- 239000002254 cytotoxic agent Substances 0.000 claims description 6
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 6
- 230000003211 malignant Effects 0.000 claims description 6
- 206010061598 Immunodeficiency Diseases 0.000 claims description 5
- 201000003793 myelodysplastic syndrome Diseases 0.000 claims description 5
- CIORWBWIBBPXCG-JZTFPUPKSA-N Amanitin Chemical compound O=C1N[C@@H](CC(N)=O)C(=O)N2CC(O)C[C@H]2C(=O)N[C@@H](C(C)[C@@H](O)CO)C(=O)N[C@@H](C2)C(=O)NCC(=O)N[C@@H](C(C)CC)C(=O)NCC(=O)N[C@H]1CS(=O)C1=C2C2=CC=C(O)C=C2N1 CIORWBWIBBPXCG-JZTFPUPKSA-N 0.000 claims description 4
- 206010003816 Autoimmune disease Diseases 0.000 claims description 4
- 201000006743 Hodgkin's lymphoma Diseases 0.000 claims description 4
- 208000000389 T-Cell Leukemia Diseases 0.000 claims description 4
- 108010044540 auristatin Proteins 0.000 claims description 4
- 210000004027 cells Anatomy 0.000 claims description 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 201000009277 hairy cell leukemia Diseases 0.000 claims description 4
- 201000002138 hematopoietic system disease Diseases 0.000 claims description 4
- 206010002967 Aplastic anaemia Diseases 0.000 claims description 3
- 206010010356 Congenital anomaly Diseases 0.000 claims description 3
- 206010062018 Inborn error of metabolism Diseases 0.000 claims description 3
- 208000008466 Metabolic Disease Diseases 0.000 claims description 3
- 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 claims description 2
- 208000003950 B-Cell Lymphoma Diseases 0.000 claims description 2
- 206010053138 Congenital aplastic anaemia Diseases 0.000 claims description 2
- 206010011401 Crohn's disease Diseases 0.000 claims description 2
- 206010012818 Diffuse large B-cell lymphoma Diseases 0.000 claims description 2
- 206010061850 Extranodal marginal zone B-cell lymphoma (MALT type) Diseases 0.000 claims description 2
- 201000004939 Fanconi anemia Diseases 0.000 claims description 2
- 206010018048 Gaucher's disease Diseases 0.000 claims description 2
- 230000036499 Half live Effects 0.000 claims description 2
- 206010021460 Immunodeficiency syndrome Diseases 0.000 claims description 2
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims description 2
- 208000002551 Irritable Bowel Syndrome Diseases 0.000 claims description 2
- 208000006404 Large Granular Lymphocytic Leukemia Diseases 0.000 claims description 2
- 241000990101 Leucochloridium Species 0.000 claims description 2
- 206010025135 Lupus erythematosus Diseases 0.000 claims description 2
- 208000006557 Lymphoma, B-Cell, Marginal Zone Diseases 0.000 claims description 2
- 208000003002 Lymphoma, T-Cell, Peripheral Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 201000003791 MALT lymphoma Diseases 0.000 claims description 2
- 206010026798 Mantle cell lymphomas Diseases 0.000 claims description 2
- 210000000138 Mast Cells Anatomy 0.000 claims description 2
- 102000009030 Member 1 Subfamily D ATP Binding Cassette Transporter Human genes 0.000 claims description 2
- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 claims description 2
- 206010028093 Mucopolysaccharidosis Diseases 0.000 claims description 2
- 208000002678 Mucopolysaccharidosis Diseases 0.000 claims description 2
- 206010028372 Muscular weakness Diseases 0.000 claims description 2
- 206010029592 Non-Hodgkin's lymphomas Diseases 0.000 claims description 2
- 206010025310 Other lymphomas Diseases 0.000 claims description 2
- 102100012341 PIGA Human genes 0.000 claims description 2
- 101700037337 PIGA Proteins 0.000 claims description 2
- 108010084592 Saporins Proteins 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 201000008717 T-cell large granular lymphocyte leukemia Diseases 0.000 claims description 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims description 2
- 206010047115 Vasculitis Diseases 0.000 claims description 2
- 201000011452 adrenoleukodystrophy Diseases 0.000 claims description 2
- 201000006966 adult T-cell leukemia Diseases 0.000 claims description 2
- 201000009446 chronic granulomatous disease Diseases 0.000 claims description 2
- 238000003776 cleavage reaction Methods 0.000 claims description 2
- 230000003750 conditioning Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000003444 follicular lymphoma Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- -1 maytansinoid Proteins 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 230000036473 myasthenia Effects 0.000 claims description 2
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims description 2
- 201000007923 peripheral T-cell lymphoma Diseases 0.000 claims description 2
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims description 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims description 2
- 201000002367 primary immunodeficiency disease Diseases 0.000 claims description 2
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 claims 3
- 210000000601 Blood Cells Anatomy 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 210000004494 Erythroblasts Anatomy 0.000 claims 1
- 206010020718 Hyperplasia Diseases 0.000 claims 1
- 208000003669 Immune Deficiency Disease Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000009999 Tuberous Sclerosis Diseases 0.000 claims 1
- 230000002068 genetic Effects 0.000 claims 1
- 230000000527 lymphocytic Effects 0.000 claims 1
- 201000009251 multiple myeloma Diseases 0.000 claims 1
- 230000000242 pagocytic Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 17
- XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 6
- 235000018417 cysteine Nutrition 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000006011 modification reaction Methods 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 230000000875 corresponding Effects 0.000 description 2
- 208000007502 Anemia Diseases 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 206010015037 Epilepsy Diseases 0.000 description 1
- 206010020244 Hodgkin's disease nodular sclerosis Diseases 0.000 description 1
- 206010024324 Leukaemias Diseases 0.000 description 1
- 206010049646 Lymphohistiocytosis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010040767 Sjogren's syndrome Diseases 0.000 description 1
- 208000006110 Wiskott-Aldrich Syndrome Diseases 0.000 description 1
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002071 myeloproliferative Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022167563A JP2023015080A (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437622P | 2016-12-21 | 2016-12-21 | |
| US62/437,622 | 2016-12-21 | ||
| US201762520854P | 2017-06-16 | 2017-06-16 | |
| US62/520,854 | 2017-06-16 | ||
| PCT/IB2017/058159 WO2018116178A1 (en) | 2016-12-21 | 2017-12-19 | Antibody drug conjugates for ablating hematopoietic stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022167563A Division JP2023015080A (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504112A JP2020504112A (ja) | 2020-02-06 |
| JP2020504112A5 true JP2020504112A5 (US20040106767A1-20040603-C00005.png) | 2021-02-04 |
| JP7181203B2 JP7181203B2 (ja) | 2022-11-30 |
Family
ID=60957364
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533594A Active JP7181203B2 (ja) | 2016-12-21 | 2017-12-19 | 造血幹細胞を除去するための抗体薬物結合体 |
| JP2022167563A Pending JP2023015080A (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022167563A Pending JP2023015080A (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Country Status (23)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3452492A1 (en) * | 2016-05-05 | 2019-03-13 | Novartis AG | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
| SG11201811290VA (en) * | 2016-06-17 | 2019-01-30 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd117+cells |
| JP2021526525A (ja) * | 2018-06-07 | 2021-10-07 | マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 抗体薬物コンジュゲート（ａｄｃｓ）を用いた治療方法 |
| UY38265A (es) * | 2018-06-20 | 2020-01-31 | Novartis Ag | Conjugados anticuerpo droga para ablación de células madre hematopoyéticas |
| CA3107383A1 (en) * | 2018-07-23 | 2020-01-30 | Magenta Therapeutics, Inc. | Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy |
| CN112739339A (zh) * | 2018-07-23 | 2021-04-30 | 美真达治疗公司 | 抗cd137抗体药物缀合物(adc)在同种异体细胞疗法中的用途 |
| MX2021004231A (es) * | 2018-10-23 | 2021-06-15 | Magenta Therapeutics Inc | Conjugados de anticuerpos y fármacos (caf) con silenciamiento de fc y usos de los mismos. |
| EP3873532A1 (en) * | 2018-10-31 | 2021-09-08 | Novartis AG | Dc-sign antibody drug conjugates |
| EP3817773A4 (en) * | 2018-11-26 | 2021-09-15 | Forty Seven, Inc. | HUMANIZED ANTIBODIES AGAINST C-KIT |
| EP3894387A4 (en) * | 2018-12-12 | 2023-07-19 | Levim Biotech LLP | ACYLATION PROCESSES FOR THE PRODUCTION OF N-SUBSTITUTED PEPTIDES |
| JP2022535527A (ja) * | 2019-06-04 | 2022-08-09 | マジェンタ セラピューティクス インコーポレイテッド | 自己免疫疾患を治療するための方法および組成物 |
| CN112569368A (zh) | 2019-08-07 | 2021-03-30 | 烟台迈百瑞国际生物医药股份有限公司 | 一种抗体药物偶联物及其应用 |
| CN116183899B (zh) * | 2023-04-28 | 2023-06-30 | 天津市协和医药科技集团有限公司 | 一种吖啶酯标记抗体保存液的制备方法 |
Family Cites Families (35)
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| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| CA2109528A1 (en) | 1991-05-01 | 1992-11-02 | Gregory A. Prince | A method for treating infectious respiratory diseases |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| AU2063197A (en) | 1996-03-04 | 1997-09-22 | Massachusetts Institute Of Technology | Materials and methods for enhancing cellular internalization |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| ATE287257T1 (de) | 1997-01-16 | 2005-02-15 | Massachusetts Inst Technology | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| JP2002512624A (ja) | 1997-05-21 | 2002-04-23 | バイオベーション リミテッド | 非免疫原性タンパク質の製造方法 |
| US6673901B2 (en) | 1997-06-12 | 2004-01-06 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
| JP2002518432A (ja) | 1998-06-24 | 2002-06-25 | アドバンスト インハレーション リサーチ，インコーポレイテッド | 吸入器から放出される大多孔性粒子 |
| US7151164B2 (en) | 2002-02-14 | 2006-12-19 | Immunomedics, Inc. | Anti-CD20 antibodies and fusion proteins thereof and methods of use |
| WO2003048731A2 (en) | 2001-12-03 | 2003-06-12 | Abgenix, Inc. | Antibody categorization based on binding characteristics |
| AU2003245752A1 (en) * | 2002-06-28 | 2004-01-19 | Bio Transplant, Inc. | Process for promoting graft acceptance by depletion of hematopoietic stem cells |
| KR20110091598A (ko) | 2003-03-24 | 2011-08-11 | 지모제넥틱스, 인코포레이티드 | 항-ｉｌ-22ｒａ 항체 및 결합 파트너 및 염증에 있어서의 사용 방법 |
| TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之ｃ-ｋｉｔ抗體 |
| ES2642205T3 (es) | 2006-11-03 | 2017-11-15 | The Board Of Trustees Of The Leland Stanford Junior University | Inmunoempobrecimiento selectivo de un nicho de células madre endógenas para injerto |
| EP2711018A1 (en) | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
| WO2012103165A2 (en) | 2011-01-26 | 2012-08-02 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
| NZ630363A (en) | 2012-07-25 | 2018-09-28 | Celldex Therapeutics Inc | Anti-kit antibodies and uses thereof |
| MX2015010146A (es) | 2013-02-08 | 2016-05-31 | Novartis Ag | Sitios especificos para modificar anticuerpos para hacer inmunoconjugados. |
| AP2015008656A0 (en) | 2013-03-15 | 2015-08-31 | Novartis Ag | Antibody drug conjugates |
| US20170021033A1 (en) | 2014-03-12 | 2017-01-26 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
| CA2951368A1 (en) | 2014-06-13 | 2015-12-17 | Novartis Ag | Auristatin derivatives and conjugates thereof |
| US10786578B2 (en) * | 2014-08-05 | 2020-09-29 | Novartis Ag | CKIT antibody drug conjugates |
| EP3215519A1 (en) * | 2014-11-06 | 2017-09-13 | Novartis AG | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
| CA2982115A1 (en) * | 2015-04-06 | 2016-10-13 | President And Fellows Of Harvard College | Compositions and methods for non-myeloablative conditioning |
| EP3310813A1 (en) * | 2015-06-17 | 2018-04-25 | Novartis AG | Antibody drug conjugates |
| SG11201811290VA (en) * | 2016-06-17 | 2019-01-30 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd117+cells |
-
2017
- 2017-06-16 JO JOP/2019/0155A patent/JOP20190155A1/ar unknown
- 2017-12-19 TW TW106144615A patent/TWI778994B/zh active
- 2017-12-19 CN CN201780079504.9A patent/CN110099697B/zh active Active
- 2017-12-19 JP JP2019533594A patent/JP7181203B2/ja active Active
- 2017-12-19 EA EA201991526A patent/EA201991526A1/ru unknown
- 2017-12-19 MX MX2019007582A patent/MX2019007582A/es unknown
- 2017-12-19 TW TW111133640A patent/TW202300524A/zh unknown
- 2017-12-19 BR BR112019012483A patent/BR112019012483A2/pt unknown
- 2017-12-19 MY MYPI2019003457A patent/MY193985A/en unknown
- 2017-12-19 US US16/470,897 patent/US11357864B2/en active Active
- 2017-12-19 EP EP17829033.4A patent/EP3558389A1/en active Pending
- 2017-12-19 PE PE2019001291A patent/PE20191539A1/es unknown
- 2017-12-19 MA MA047231A patent/MA47231A/fr unknown
- 2017-12-19 KR KR1020197020530A patent/KR20190099238A/ko not_active Application Discontinuation
- 2017-12-19 CA CA3045592A patent/CA3045592A1/en active Pending
- 2017-12-19 KR KR1020247016376A patent/KR20240093751A/ko unknown
- 2017-12-19 CU CU2019000061A patent/CU24644B1/es unknown
- 2017-12-19 CR CR20190296A patent/CR20190296A/es unknown
- 2017-12-19 WO PCT/IB2017/058159 patent/WO2018116178A1/en active Application Filing
- 2017-12-19 CN CN202311642832.9A patent/CN117653740A/zh active Pending
- 2017-12-19 AU AU2017383458A patent/AU2017383458C1/en active Active
- 2017-12-19 IL IL300567A patent/IL300567A/en unknown
-
2019
- 2019-06-13 PH PH12019501330A patent/PH12019501330A1/en unknown
- 2019-06-18 IL IL267478A patent/IL267478B2/en unknown
- 2019-06-19 CO CONC2019/0006455A patent/CO2019006455A2/es unknown
- 2019-06-20 CL CL2019001745A patent/CL2019001745A1/es unknown
- 2019-06-21 EC ECSENADI201944625A patent/ECSP19044625A/es unknown
-
2022
- 2022-06-06 US US17/833,077 patent/US20220305134A1/en active Pending
- 2022-10-19 JP JP2022167563A patent/JP2023015080A/ja active Pending
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