JP2020504074A5 - - Google Patents
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- Publication number
- JP2020504074A5 JP2020504074A5 JP2018566875A JP2018566875A JP2020504074A5 JP 2020504074 A5 JP2020504074 A5 JP 2020504074A5 JP 2018566875 A JP2018566875 A JP 2018566875A JP 2018566875 A JP2018566875 A JP 2018566875A JP 2020504074 A5 JP2020504074 A5 JP 2020504074A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- group
- sulfonamide
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- -1 cyano, hydroxy Chemical group 0.000 claims 13
- 229940124530 sulfonamide Drugs 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 11
- 108091034117 Oligonucleotide Proteins 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 125000003107 substituted aryl group Chemical group 0.000 claims 9
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000004103 aminoalkyl group Chemical group 0.000 claims 8
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000004404 heteroalkyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- VHFVDEXSJFKLDW-UHFFFAOYSA-N OS(S(O)(=O)=O)(S(O)(=O)=O)=O Chemical compound OS(S(O)(=O)=O)(S(O)(=O)=O)=O VHFVDEXSJFKLDW-UHFFFAOYSA-N 0.000 claims 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000004452 carbocyclyl group Chemical group 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 4
- 150000007942 carboxylates Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical group [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438006P | 2016-12-22 | 2016-12-22 | |
| US62/438,006 | 2016-12-22 | ||
| PCT/EP2017/083128 WO2018114710A1 (en) | 2016-12-22 | 2017-12-15 | Coumarin compounds and their uses as fluorescent labels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020504074A JP2020504074A (ja) | 2020-02-06 |
| JP2020504074A5 true JP2020504074A5 (enExample) | 2020-11-12 |
Family
ID=60765630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566875A Pending JP2020504074A (ja) | 2016-12-22 | 2017-12-15 | クマリン化合物および蛍光標識としてのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10214768B2 (enExample) |
| EP (2) | EP3559004B1 (enExample) |
| JP (1) | JP2020504074A (enExample) |
| KR (1) | KR102512190B1 (enExample) |
| CN (1) | CN109476674B (enExample) |
| AU (2) | AU2017379315B2 (enExample) |
| CA (1) | CA3025880C (enExample) |
| ES (1) | ES2954284T3 (enExample) |
| IL (1) | IL263358B (enExample) |
| SG (1) | SG11201810611YA (enExample) |
| WO (1) | WO2018114710A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018114710A1 (en) | 2016-12-22 | 2018-06-28 | Illumina Cambridge Limited | Coumarin compounds and their uses as fluorescent labels |
| LT3860998T (lt) | 2018-10-05 | 2024-06-25 | Annapurna Bio Inc. | Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| NL2023327B1 (en) * | 2019-03-01 | 2020-09-17 | Illumina Inc | Multiplexed fluorescent detection of analytes |
| WO2020178231A1 (en) * | 2019-03-01 | 2020-09-10 | Illumina, Inc. | Multiplexed fluorescent detection of analytes |
| US11421271B2 (en) * | 2019-03-28 | 2022-08-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing using photoswitchable labels |
| CN112794857B (zh) * | 2019-11-13 | 2023-09-19 | 湖南超亟检测技术有限责任公司 | 一种可用于亚铁离子检测的荧光探针及制备和应用 |
| EP4065646A1 (en) | 2019-11-27 | 2022-10-05 | Illumina Cambridge Limited | Cyclooctatetraene containing dyes and compositions |
| CN115297964A (zh) * | 2020-03-10 | 2022-11-04 | 西部数据技术公司 | 用于核酸定序的磁性传感器阵列以及制造及使用其的方法 |
| JP2023531009A (ja) | 2020-06-22 | 2023-07-20 | イルミナ ケンブリッジ リミテッド | ３’アセタールブロッキング基を有するヌクレオシド及びヌクレオチド |
| US11981964B2 (en) | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
| US20220195517A1 (en) * | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Long stokes shift chromenoquinoline dyes and uses in sequencing applications |
| US20220195196A1 (en) * | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Alkylpyridinium coumarin dyes and uses in sequencing applications |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195518A1 (en) * | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| CN114671843B (zh) * | 2020-12-24 | 2023-07-04 | 郑州思昆生物工程有限公司 | 一种荧光化合物、荧光修饰核苷酸、试剂盒 |
| US20220396832A1 (en) | 2021-05-20 | 2022-12-15 | Illumina Cambridge Limited | Compositions and methods for sequencing by synthesis |
| US20230304086A1 (en) | 2022-03-28 | 2023-09-28 | Illumina Cambridge Limited | Labeled avidin and methods for sequencing |
| US20230313292A1 (en) * | 2022-03-29 | 2023-10-05 | Illumina Cambridge Limited | Chromenoquinoline dyes and uses in sequencing |
| EP4499870A1 (en) | 2022-03-31 | 2025-02-05 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
| EP4499659A1 (en) | 2022-03-31 | 2025-02-05 | Illumina, Inc. | Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis |
| WO2023232829A1 (en) | 2022-05-31 | 2023-12-07 | Illumina, Inc | Compositions and methods for nucleic acid sequencing |
| CN119213083A (zh) | 2022-09-30 | 2024-12-27 | 伊路米纳有限公司 | 用于减少测序期间的光损伤的组合物和方法 |
| AU2023409219A1 (en) | 2022-12-22 | 2024-10-03 | Illumina, Inc. | Palladium catalyst compositions and methods for sequencing by synthesis |
| US20240229131A1 (en) | 2022-12-22 | 2024-07-11 | Illumina, Inc. | Transition-metal catalyst compositions and methods for sequencing by synthesis |
| US20240271206A1 (en) | 2022-12-27 | 2024-08-15 | Illumina, Inc. | Methods of sequencing using 3' allyl blocked nucleotides |
| AU2024247902A1 (en) | 2023-03-30 | 2024-12-12 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| US20250075269A1 (en) | 2023-08-31 | 2025-03-06 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| US20250215493A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing |
| WO2025184226A1 (en) | 2024-02-28 | 2025-09-04 | Illumina, Inc. | Nucleotides with terminal phosphate capping |
| WO2025188906A1 (en) | 2024-03-08 | 2025-09-12 | Illumina, Inc. | Modified adenosine nucleotides |
| WO2025221895A1 (en) | 2024-04-19 | 2025-10-23 | Illumina, Inc. | Water soluble polymer scaffolds for dye labeling |
| WO2025230914A1 (en) | 2024-04-29 | 2025-11-06 | Illumina, Inc. | Nucleotides with enzyme-triggered self-immolative linkers for sequencing by synthesis |
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| WO2018114710A1 (en) * | 2016-12-22 | 2018-06-28 | Illumina Cambridge Limited | Coumarin compounds and their uses as fluorescent labels |
-
2017
- 2017-12-15 WO PCT/EP2017/083128 patent/WO2018114710A1/en not_active Ceased
- 2017-12-15 AU AU2017379315A patent/AU2017379315B2/en active Active
- 2017-12-15 EP EP17817742.4A patent/EP3559004B1/en active Active
- 2017-12-15 KR KR1020187037384A patent/KR102512190B1/ko active Active
- 2017-12-15 SG SG11201810611YA patent/SG11201810611YA/en unknown
- 2017-12-15 CA CA3025880A patent/CA3025880C/en active Active
- 2017-12-15 CN CN201780042084.7A patent/CN109476674B/zh active Active
- 2017-12-15 ES ES17817742T patent/ES2954284T3/es active Active
- 2017-12-15 JP JP2018566875A patent/JP2020504074A/ja active Pending
- 2017-12-15 EP EP23182481.4A patent/EP4257596A3/en active Pending
- 2017-12-21 US US15/851,014 patent/US10214768B2/en active Active
-
2018
- 2018-11-28 IL IL263358A patent/IL263358B/en active IP Right Grant
-
2019
- 2019-02-22 US US16/282,783 patent/US10533211B2/en active Active
-
2020
- 2020-01-09 US US16/738,560 patent/US10907196B2/en active Active
-
2021
- 2021-01-29 US US17/162,606 patent/US11371078B2/en active Active
-
2022
- 2022-06-14 AU AU2022204153A patent/AU2022204153B2/en active Active
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