JP2020503296A5 - - Google Patents
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- Publication number
- JP2020503296A5 JP2020503296A5 JP2019531779A JP2019531779A JP2020503296A5 JP 2020503296 A5 JP2020503296 A5 JP 2020503296A5 JP 2019531779 A JP2019531779 A JP 2019531779A JP 2019531779 A JP2019531779 A JP 2019531779A JP 2020503296 A5 JP2020503296 A5 JP 2020503296A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- foam
- preparation according
- component
- anhydrous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 61
- 238000009472 formulation Methods 0.000 claims description 35
- 239000006260 foam Substances 0.000 claims description 33
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- 239000000839 emulsion Substances 0.000 claims description 24
- 239000003380 propellant Substances 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 19
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims description 17
- 229960004963 mesalazine Drugs 0.000 claims description 16
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 16
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 claims description 15
- 229960004909 aminosalicylic acid Drugs 0.000 claims description 15
- 239000003995 emulsifying agent Substances 0.000 claims description 14
- 150000002632 lipids Chemical class 0.000 claims description 14
- 239000011347 resin Substances 0.000 claims description 14
- 229920005989 resin Polymers 0.000 claims description 14
- 239000004094 surface-active agent Substances 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 10
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 229960002446 octanoic acid Drugs 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 239000000230 xanthan gum Substances 0.000 claims description 8
- 229920001285 xanthan gum Polymers 0.000 claims description 8
- 235000010493 xanthan gum Nutrition 0.000 claims description 8
- 229940082509 xanthan gum Drugs 0.000 claims description 8
- 239000004264 Petrolatum Substances 0.000 claims description 6
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 6
- 229960000541 cetyl alcohol Drugs 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
- 229940066842 petrolatum Drugs 0.000 claims description 6
- 235000019271 petrolatum Nutrition 0.000 claims description 6
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 6
- 229950004959 sorbitan oleate Drugs 0.000 claims description 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 5
- 208000011231 Crohn disease Diseases 0.000 claims description 5
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 4
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 claims description 4
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 4
- 229940075529 glyceryl stearate Drugs 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 4
- 229940096976 rectal foam Drugs 0.000 claims description 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- 239000004479 aerosol dispenser Substances 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940074052 glyceryl isostearate Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 229940048845 polyglyceryl-3 diisostearate Drugs 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 229940012831 stearyl alcohol Drugs 0.000 claims description 2
- 230000008961 swelling Effects 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940072224 asacol Drugs 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 229940100861 polyglyceryl-3 laurate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022129473A JP2022163191A (ja) | 2016-12-16 | 2022-08-16 | 直腸フォーム製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435265P | 2016-12-16 | 2016-12-16 | |
| US62/435,265 | 2016-12-16 | ||
| PCT/IB2017/057954 WO2018109717A1 (en) | 2016-12-16 | 2017-12-14 | Rectal foam formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022129473A Division JP2022163191A (ja) | 2016-12-16 | 2022-08-16 | 直腸フォーム製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020503296A JP2020503296A (ja) | 2020-01-30 |
| JP2020503296A5 true JP2020503296A5 (https=) | 2021-01-28 |
Family
ID=60937825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531779A Pending JP2020503296A (ja) | 2016-12-16 | 2017-12-14 | 直腸フォーム製剤 |
| JP2022129473A Abandoned JP2022163191A (ja) | 2016-12-16 | 2022-08-16 | 直腸フォーム製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022129473A Abandoned JP2022163191A (ja) | 2016-12-16 | 2022-08-16 | 直腸フォーム製剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20190351060A1 (https=) |
| EP (1) | EP3554473A1 (https=) |
| JP (2) | JP2020503296A (https=) |
| KR (1) | KR20190110092A (https=) |
| CN (1) | CN110430869A (https=) |
| AU (1) | AU2017377017A1 (https=) |
| BR (1) | BR112019012122A2 (https=) |
| CA (1) | CA3046938A1 (https=) |
| IL (1) | IL267347A (https=) |
| MX (2) | MX391415B (https=) |
| RU (1) | RU2757275C2 (https=) |
| WO (1) | WO2018109717A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3216267A1 (en) * | 2021-04-22 | 2022-10-27 | Glenn W. Laub | Foam compositions for treating clostridioides difficile infections |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8909559D0 (en) * | 1989-04-26 | 1989-06-14 | Smith Kline French Lab | Pharmaceutical compositions |
| SE9000485D0 (sv) * | 1990-02-09 | 1990-02-09 | Pharmacia Ab | Foamable composition for pharmaceutical use, use thereof and method of treatment |
| IT1243379B (it) * | 1990-07-27 | 1994-06-10 | Giuliani Spa | Composizione farmaceutica adatta alla somministrazione rettale di principi attivi che esplicano un'azione di medicazione a livello del colon prevalentemente di tipo topico |
| FR2713486B1 (fr) * | 1993-12-14 | 1996-02-09 | Scophysa | Nouvelles compositions pour mousses, notamment mousses rectales, et mousses ainsi obtenues. |
| DE4446891A1 (de) | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stabile wäßrige Budesonid-Lösung |
| US7820145B2 (en) * | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US20060018937A1 (en) * | 2002-10-25 | 2006-01-26 | Foamix Ltd. | Steroid kit and foamable composition and uses thereof |
| US20080069779A1 (en) * | 2003-08-04 | 2008-03-20 | Foamix Ltd. | Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof |
| EP1663148A2 (en) * | 2003-08-25 | 2006-06-07 | Foamix Ltd. | Penetrating pharmaceutical foam |
| AU2006298442A1 (en) * | 2005-05-09 | 2007-04-12 | Foamix Ltd. | Saccharide foamable compositions |
| WO2009150530A2 (en) * | 2008-06-11 | 2009-12-17 | Ferring International Center Sa | Novel foam composition |
| EP2140866A1 (en) * | 2008-07-04 | 2010-01-06 | Bayer Schering Pharma Aktiengesellschaft | Oxazolidinones for the treatment of inflammatory conditions of the gastrointestinal tract |
| RU2012126084A (ru) * | 2009-11-23 | 2013-12-27 | Сипла Лимитед | Пенная композиция для местного применения |
-
2017
- 2017-12-14 AU AU2017377017A patent/AU2017377017A1/en not_active Abandoned
- 2017-12-14 JP JP2019531779A patent/JP2020503296A/ja active Pending
- 2017-12-14 RU RU2019119495A patent/RU2757275C2/ru active
- 2017-12-14 EP EP17825956.0A patent/EP3554473A1/en not_active Withdrawn
- 2017-12-14 BR BR112019012122-6A patent/BR112019012122A2/pt not_active IP Right Cessation
- 2017-12-14 US US16/470,077 patent/US20190351060A1/en not_active Abandoned
- 2017-12-14 WO PCT/IB2017/057954 patent/WO2018109717A1/en not_active Ceased
- 2017-12-14 CN CN201780086722.5A patent/CN110430869A/zh active Pending
- 2017-12-14 CA CA3046938A patent/CA3046938A1/en not_active Abandoned
- 2017-12-14 KR KR1020197020401A patent/KR20190110092A/ko not_active Ceased
- 2017-12-14 MX MX2019006924A patent/MX391415B/es unknown
-
2019
- 2019-06-12 MX MX2021016053A patent/MX2021016053A/es unknown
- 2019-06-13 IL IL267347A patent/IL267347A/en unknown
-
2022
- 2022-08-16 JP JP2022129473A patent/JP2022163191A/ja not_active Abandoned
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