JP2020502230A5 - - Google Patents

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Publication number
JP2020502230A5
JP2020502230A5 JP2019534197A JP2019534197A JP2020502230A5 JP 2020502230 A5 JP2020502230 A5 JP 2020502230A5 JP 2019534197 A JP2019534197 A JP 2019534197A JP 2019534197 A JP2019534197 A JP 2019534197A JP 2020502230 A5 JP2020502230 A5 JP 2020502230A5
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JP
Japan
Prior art keywords
methyl
pyridyl
amine
isopropyl
ethoxy
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JP2019534197A
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English (en)
Japanese (ja)
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JP2020502230A (ja
JP7074758B2 (ja
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Priority claimed from PCT/EP2017/083721 external-priority patent/WO2018115067A1/en
Publication of JP2020502230A publication Critical patent/JP2020502230A/ja
Publication of JP2020502230A5 publication Critical patent/JP2020502230A5/ja
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Publication of JP7074758B2 publication Critical patent/JP7074758B2/ja
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JP2019534197A 2016-12-22 2017-12-20 PDE1阻害剤としてのピラゾロ[3,4-b]ピリジン及びイミダゾ[1,5-b]ピリダジン Active JP7074758B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201600784 2016-12-22
DKPA201600784 2016-12-22
DKPA201700404 2017-07-06
DKPA201700404 2017-07-06
PCT/EP2017/083721 WO2018115067A1 (en) 2016-12-22 2017-12-20 Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors

Publications (3)

Publication Number Publication Date
JP2020502230A JP2020502230A (ja) 2020-01-23
JP2020502230A5 true JP2020502230A5 (US06244707-20010612-C00010.png) 2021-01-28
JP7074758B2 JP7074758B2 (ja) 2022-05-24

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ID=60812077

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Application Number Title Priority Date Filing Date
JP2019534197A Active JP7074758B2 (ja) 2016-12-22 2017-12-20 PDE1阻害剤としてのピラゾロ[3,4-b]ピリジン及びイミダゾ[1,5-b]ピリダジン

Country Status (23)

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US (2) US10351561B2 (US06244707-20010612-C00010.png)
EP (1) EP3558988B1 (US06244707-20010612-C00010.png)
JP (1) JP7074758B2 (US06244707-20010612-C00010.png)
KR (1) KR20190095301A (US06244707-20010612-C00010.png)
CN (1) CN110099901B (US06244707-20010612-C00010.png)
AU (1) AU2017384481A1 (US06244707-20010612-C00010.png)
BR (1) BR112018017067A2 (US06244707-20010612-C00010.png)
CA (1) CA3046588A1 (US06244707-20010612-C00010.png)
CL (1) CL2019001669A1 (US06244707-20010612-C00010.png)
CO (1) CO2019005538A2 (US06244707-20010612-C00010.png)
CR (1) CR20190302A (US06244707-20010612-C00010.png)
DO (1) DOP2019000169A (US06244707-20010612-C00010.png)
EC (1) ECSP19043790A (US06244707-20010612-C00010.png)
ES (1) ES2882335T3 (US06244707-20010612-C00010.png)
IL (1) IL267561A (US06244707-20010612-C00010.png)
JO (1) JOP20190126A1 (US06244707-20010612-C00010.png)
MX (1) MX2019007509A (US06244707-20010612-C00010.png)
PE (1) PE20191323A1 (US06244707-20010612-C00010.png)
PH (1) PH12019501324A1 (US06244707-20010612-C00010.png)
RU (1) RU2019116251A (US06244707-20010612-C00010.png)
TW (1) TW201829405A (US06244707-20010612-C00010.png)
WO (1) WO2018115067A1 (US06244707-20010612-C00010.png)
ZA (1) ZA201904236B (US06244707-20010612-C00010.png)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JOP20190126A1 (ar) 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
CN111465410B (zh) 2017-12-14 2022-10-25 H.隆德贝克有限公司 包括施用1h-吡唑并[4,3-b]吡啶的组合治疗
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
TW201927784A (zh) 2017-12-20 2019-07-16 丹麥商H 朗德貝克公司 作為pde1抑制劑之大環
WO2019121840A1 (en) 2017-12-20 2019-06-27 H. Lundbeck A/S Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors
US10766893B2 (en) 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326379B1 (en) 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
ES2319797T3 (es) * 2004-07-05 2009-05-12 Astellas Pharma Inc. Derivados de pirazolopiridina.
ATE430746T1 (de) 2004-10-19 2009-05-15 Smithkline Beecham Cork Ltd Crf-rezeptor-antagonisten und zugehörige verfahren
JP5837278B2 (ja) 2006-12-05 2015-12-24 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 新規使用
CA2680625C (en) 2007-03-14 2016-02-23 Ranbaxy Laboratories Limited Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
WO2009067607A2 (en) * 2007-11-20 2009-05-28 Memory Pharmaceuticals Corporation Combinations of pde4 inhibitors and antipsychotics for the treatment of psychotic disorders
MA32940B1 (fr) * 2008-12-06 2012-01-02 Intra Cellular Therapies Inc Composes organiques
EP2828253A1 (en) 2012-03-19 2015-01-28 Abide Therapeutics, Inc. Carbamate compounds and of making and using same
TW201533043A (zh) 2013-04-18 2015-09-01 Lundbeck & Co As H 作爲lrrk2抑制劑的芳基吡咯并吡啶衍生化合物
WO2016042775A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic derivative
US20160083391A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic piperazine derivative
US20160083400A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
TW201629064A (zh) 2014-10-10 2016-08-16 H 朗德貝克公司 作爲pde1抑制劑之三唑並吡酮
US20180044343A1 (en) 2015-03-16 2018-02-15 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic imidazolo derivative
US20160311831A1 (en) 2015-04-22 2016-10-27 H. Lundbeck A/S Imidazotriazinones as PDE1 Inhibitors
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JOP20190126A1 (ar) 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
TW201927784A (zh) 2017-12-20 2019-07-16 丹麥商H 朗德貝克公司 作為pde1抑制劑之大環
US10766893B2 (en) 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

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