JP2020501538A - インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ - Google Patents

インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ Download PDF

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JP2020501538A
JP2020501538A JP2019529228A JP2019529228A JP2020501538A JP 2020501538 A JP2020501538 A JP 2020501538A JP 2019529228 A JP2019529228 A JP 2019529228A JP 2019529228 A JP2019529228 A JP 2019529228A JP 2020501538 A JP2020501538 A JP 2020501538A
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nucleic acid
cell
gene
sequence
acid sequence
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JP2020501538A5 (enExample
Inventor
ロスカ，ボトンド
ユエットナー，ジョゼフィーヌ
テイシェイラ，ミゲル
Original Assignee
フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ
フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ
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Publication of JP2020501538A publication Critical patent/JP2020501538A/ja
Publication of JP2020501538A5 publication Critical patent/JP2020501538A5/ja
Priority to JP2022002979A priority Critical patent/JP2022050590A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2019529228A 2016-12-01 2017-11-29 インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ Pending JP2020501538A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022002979A JP2022050590A (ja) 2016-12-01 2022-01-12 インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16201749.5 2016-12-01
EP16201749 2016-12-01
PCT/EP2017/080829 WO2018099975A1 (en) 2016-12-01 2017-11-29 Synpi, a promoter for the specific expression of genes in interneurons

Related Child Applications (1)

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JP2022002979A Division JP2022050590A (ja) 2016-12-01 2022-01-12 インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ

Publications (2)

Publication Number Publication Date
JP2020501538A true JP2020501538A (ja) 2020-01-23
JP2020501538A5 JP2020501538A5 (enExample) 2021-01-14

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JP2019529228A Pending JP2020501538A (ja) 2016-12-01 2017-11-29 インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ
JP2022002979A Withdrawn JP2022050590A (ja) 2016-12-01 2022-01-12 インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ

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JP2022002979A Withdrawn JP2022050590A (ja) 2016-12-01 2022-01-12 インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ

Country Status (5)

Country Link
US (1) US20190376083A1 (enExample)
EP (1) EP3548094A1 (enExample)
JP (2) JP2020501538A (enExample)
CN (1) CN110072558A (enExample)
WO (1) WO2018099975A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011516091A (ja) 2008-04-18 2011-05-26 ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ 失明の治療のための新規な治療用ツールおよび方法
US10941417B2 (en) 2015-04-30 2021-03-09 Friedrich Miescher Institute For Biomedical Research Promoter for the specific expression of genes in Müller cells
ES2926677T3 (es) 2015-09-15 2022-10-27 Friedrich Miescher Institute For Biomedical Res Herramientas y métodos terapéuticos novedosos para tratar la ceguera mediante el direccionamiento a los fotorreceptores
US11254934B2 (en) 2015-10-14 2022-02-22 Friedrich Miescher Institute For Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
US10994026B2 (en) 2015-12-03 2021-05-04 Friedrich Miescher Institute For Biomedical Research SynP160, a promoter for the specific expression of genes in rod photoreceptors
CA3006952A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp161, a promoter for the specific expression of genes in rod photoreceptors
WO2017093936A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp162, a promoter for the specific expression of genes in rod photoreceptors
WO2017093931A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp159, a promoter for the specific expression of genes in rod photoreceptors
AU2017354086C1 (en) 2016-11-02 2021-05-06 Friedrich Miescher Institute For Biomedical Research SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells
US11371060B2 (en) 2017-02-08 2022-06-28 Friedrich Miescher Institute For Biomedical Research SYNP88, a promoter for the specific expression of genes in retinal ganglion cells
CR20200210A (es) 2017-11-15 2020-09-23 Friedrich Miescher Institute For Biomedical Res Promotor especìfico de las cèlulas del epitelio pigmentario retinal en primates
BR112020010928A2 (pt) 2017-11-30 2020-11-24 Friedrich Miescher Institute For Biomedical Research synpiii, um promotor para a expressão de gene específica em epitélio de pigmento retinal

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519584A (ja) * 2002-10-31 2006-08-31 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｎｓにおけるｃｒｈ応答性遺伝子
WO2013068413A1 (en) * 2011-11-08 2013-05-16 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Rod cell-specific promoter
US20130195763A1 (en) * 2012-01-27 2013-08-01 Charles F. Landry Methods and compositions for improving sleep and memory

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011516091A (ja) * 2008-04-18 2011-05-26 ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ 失明の治療のための新規な治療用ツールおよび方法
US20110098346A1 (en) * 2008-05-19 2011-04-28 Agency For Science, Technology And Research Nucleic acid molecule and method of targeting gene expression to gliomas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519584A (ja) * 2002-10-31 2006-08-31 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｎｓにおけるｃｒｈ応答性遺伝子
WO2013068413A1 (en) * 2011-11-08 2013-05-16 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Rod cell-specific promoter
US20130195763A1 (en) * 2012-01-27 2013-08-01 Charles F. Landry Methods and compositions for improving sleep and memory

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DEVELOPMENT, vol. 121, no. 6, JPN6021039832, June 1995 (1995-06-01), pages 1719 - 1730, ISSN: 0004760202 *
NEUROSCI RES., vol. 68, no. 2, JPN6021039836, October 2010 (2010-10-01), pages 94 - 102, ISSN: 0004760203 *

Also Published As

Publication number Publication date
CN110072558A (zh) 2019-07-30
EP3548094A1 (en) 2019-10-09
WO2018099975A1 (en) 2018-06-07
JP2022050590A (ja) 2022-03-30
US20190376083A1 (en) 2019-12-12

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