JP2020501516A5 - - Google Patents
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- Publication number
- JP2020501516A5 JP2020501516A5 JP2019522647A JP2019522647A JP2020501516A5 JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5 JP 2019522647 A JP2019522647 A JP 2019522647A JP 2019522647 A JP2019522647 A JP 2019522647A JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- mouse
- gene segments
- light chain
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 111
- 108060003951 Immunoglobulin Proteins 0.000 claims description 54
- 102000018358 immunoglobulin Human genes 0.000 claims description 54
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 23
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 23
- 238000003780 insertion Methods 0.000 claims description 22
- 230000037431 insertion Effects 0.000 claims description 22
- 239000003623 enhancer Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 18
- 210000004602 germ cell Anatomy 0.000 claims description 14
- 108091092724 Noncoding DNA Proteins 0.000 claims description 10
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 claims description 9
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 claims description 9
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 7
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 108020004414 DNA Proteins 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 48
- 241000699670 Mus sp. Species 0.000 claims 6
- 241001529936 Murinae Species 0.000 claims 2
- 108700031127 mouse Adam6a Proteins 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 241000283984 Rodentia Species 0.000 description 81
- 210000004027 cell Anatomy 0.000 description 5
- 239000000427 antigen Substances 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417845P | 2016-11-04 | 2016-11-04 | |
| US62/417,845 | 2016-11-04 | ||
| US201762567932P | 2017-10-04 | 2017-10-04 | |
| US62/567,932 | 2017-10-04 | ||
| PCT/US2017/060006 WO2018128691A1 (en) | 2016-11-04 | 2017-11-03 | Non-human animals having an engineered immunoglobulin lambda light chain locus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036180A Division JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020501516A JP2020501516A (ja) | 2020-01-23 |
| JP2020501516A5 true JP2020501516A5 (enrdf_load_stackoverflow) | 2020-12-10 |
| JP6884860B2 JP6884860B2 (ja) | 2021-06-09 |
Family
ID=62025924
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522647A Active JP6884860B2 (ja) | 2016-11-04 | 2017-11-03 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2021036180A Withdrawn JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2022109658A Active JP7386292B2 (ja) | 2016-11-04 | 2022-07-07 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2023023312A Withdrawn JP2023053400A (ja) | 2016-11-04 | 2023-02-17 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036180A Withdrawn JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2022109658A Active JP7386292B2 (ja) | 2016-11-04 | 2022-07-07 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2023023312A Withdrawn JP2023053400A (ja) | 2016-11-04 | 2023-02-17 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Country Status (26)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012018610A2 (en) | 2010-07-26 | 2012-02-09 | Trianni, Inc. | Transgenic animals and methods of use |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| CN104202971B (zh) * | 2012-02-01 | 2016-07-06 | 瑞泽恩制药公司 | 表达包含vl结构域的重链的人源化啮齿动物的制备方法 |
| EP3384030A4 (en) | 2015-12-03 | 2019-07-03 | Trianni, Inc. | IMPROVED IMMUNOGLULINIVITY |
| CN114369157A (zh) | 2016-11-04 | 2022-04-19 | 瑞泽恩制药公司 | 具有经工程化的免疫球蛋白λ轻链基因座的非人类动物 |
| IL277353B2 (en) | 2018-03-24 | 2025-05-01 | Regeneron Pharma | Non-human animals genetically modified to produce therapeutic antibodies against peptide-MHC complexes, methods for their preparation and uses thereof |
| IL277355B2 (en) | 2018-03-26 | 2025-01-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| MX2021009855A (es) | 2019-02-22 | 2021-09-10 | Regeneron Pharma | Roedores que tienen canales de sodio modificados geneticamente y metodos de uso de los mismos. |
| CN114554841B (zh) * | 2019-07-01 | 2024-06-11 | 特里安尼公司 | 转基因哺乳动物及其使用方法 |
| EP4158034A4 (en) * | 2020-06-02 | 2024-07-03 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with common light chain immunoglobulin locus |
| KR20230066386A (ko) | 2020-09-11 | 2023-05-15 | 리제너론 파마슈티칼스 인코포레이티드 | 항원 특이적 항체의 확인 및 제조 |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| CA3197426A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| MX2023007401A (es) | 2020-12-23 | 2023-07-06 | Regeneron Pharma | Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos. |
| GB202217978D0 (en) * | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2124967C (en) * | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CA2847885C (en) | 2001-11-30 | 2022-03-22 | Amgen Fremont Inc. | Transgenic animals bearing human ig.lambda. light chain genes |
| AU2004257292A1 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| WO2007143168A2 (en) | 2006-06-02 | 2007-12-13 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| CA3038954A1 (en) | 2008-09-30 | 2010-04-08 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
| US20110314563A1 (en) * | 2008-12-18 | 2011-12-22 | Kingdon Craig R | Antibody production |
| DK2792236T4 (da) * | 2009-07-08 | 2023-05-15 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011115476A1 (en) | 2010-03-17 | 2011-09-22 | N.V. Nutricia | Infant nutrition for improving fatty acid composition of brain membranes later in life |
| PL2480676T3 (pl) | 2010-06-22 | 2016-10-31 | Mysz wykazująca ekspresję hybrydowego łańcucha lekkiego immunoglobuliny | |
| HUE062552T2 (hu) | 2011-02-25 | 2023-11-28 | Regeneron Pharma | ADAM6 egerek |
| RU2743589C2 (ru) | 2011-10-17 | 2021-02-20 | Регенерон Фармасьютикалс, Инк. | Мыши с ограниченной тяжелой цепью иммуноглобулина |
| US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| TR201903439T4 (tr) * | 2011-12-20 | 2019-04-22 | Regeneron Pharma | İnsanlaştırılmış hafif zincirli fareler. |
| MY178882A (en) * | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| CN109913495B (zh) | 2013-02-20 | 2022-11-25 | 瑞泽恩制药公司 | 大鼠的遗传修饰 |
| US9788534B2 (en) * | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| SG10201802295XA (en) * | 2013-10-01 | 2018-04-27 | Kymab Ltd | Animal Models and Therapeutic Molecules |
| WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| MX385689B (es) | 2014-06-06 | 2025-03-18 | Regeneron Pharma | Métodos y composiciones para modificar un locus dirigido. |
| ES2781323T3 (es) | 2014-06-23 | 2020-09-01 | Regeneron Pharma | Montaje de ADN mediado por nucleasas |
| SG10201913829YA (en) | 2014-11-21 | 2020-03-30 | Regeneron Pharma | METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATION USING PAIRED GUIDE RNAs |
| CA2971213C (en) | 2014-12-19 | 2023-09-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification through single-step multiple targeting |
| CN114369157A (zh) | 2016-11-04 | 2022-04-19 | 瑞泽恩制药公司 | 具有经工程化的免疫球蛋白λ轻链基因座的非人类动物 |
-
2017
- 2017-11-03 CN CN202210050898.8A patent/CN114369157A/zh active Pending
- 2017-11-03 KR KR1020237002504A patent/KR102658529B1/ko active Active
- 2017-11-03 FI FIEP22164751.4T patent/FI4082334T3/fi active
- 2017-11-03 ES ES17863293T patent/ES2823305T3/es active Active
- 2017-11-03 JP JP2019522647A patent/JP6884860B2/ja active Active
- 2017-11-03 MX MX2019005256A patent/MX385857B/es unknown
- 2017-11-03 ES ES22164751T patent/ES3035365T3/es active Active
- 2017-11-03 PL PL22164751.4T patent/PL4082334T3/pl unknown
- 2017-11-03 AU AU2017391167A patent/AU2017391167B2/en active Active
- 2017-11-03 SG SG11201903344XA patent/SG11201903344XA/en unknown
- 2017-11-03 PT PT201805082T patent/PT3766343T/pt unknown
- 2017-11-03 CA CA3038720A patent/CA3038720A1/en active Pending
- 2017-11-03 CN CN201780067880.6A patent/CN109996441B/zh active Active
- 2017-11-03 SI SI201731606T patent/SI4082334T1/sl unknown
- 2017-11-03 HU HUE20180508A patent/HUE061980T2/hu unknown
- 2017-11-03 SM SM20200558T patent/SMT202000558T1/it unknown
- 2017-11-03 MA MA044091A patent/MA44091A/fr unknown
- 2017-11-03 BR BR112019008675A patent/BR112019008675A2/pt unknown
- 2017-11-03 EP EP20180508.2A patent/EP3766343B1/en active Active
- 2017-11-03 RU RU2019112589A patent/RU2757665C2/ru active
- 2017-11-03 EP EP25157740.9A patent/EP4567119A2/en active Pending
- 2017-11-03 SM SM20220259T patent/SMT202200259T1/it unknown
- 2017-11-03 RS RS20201205A patent/RS60886B1/sr unknown
- 2017-11-03 PT PT178632931T patent/PT3407709T/pt unknown
- 2017-11-03 DK DK17863293.1T patent/DK3407709T3/da active
- 2017-11-03 LT LTEP22164751.4T patent/LT4082334T/lt unknown
- 2017-11-03 ES ES20180508T patent/ES2915609T3/es active Active
- 2017-11-03 WO PCT/US2017/060006 patent/WO2018128691A1/en active Application Filing
- 2017-11-03 DK DK22164751.4T patent/DK4082334T3/da active
- 2017-11-03 EP EP17863293.1A patent/EP3407709B9/en active Active
- 2017-11-03 SM SM20250204T patent/SMT202500204T1/it unknown
- 2017-11-03 SI SI201731147T patent/SI3766343T1/sl unknown
- 2017-11-03 SG SG10201913483XA patent/SG10201913483XA/en unknown
- 2017-11-03 RU RU2021129958A patent/RU2021129958A/ru unknown
- 2017-11-03 LT LTEP17863293.1T patent/LT3407709T/lt unknown
- 2017-11-03 SI SI201730381T patent/SI3407709T1/sl unknown
- 2017-11-03 EP EP22164751.4A patent/EP4082334B1/en active Active
- 2017-11-03 IL IL266282A patent/IL266282B2/en unknown
- 2017-11-03 HU HUE17863293A patent/HUE052087T2/hu unknown
- 2017-11-03 DK DK20180508.2T patent/DK3766343T3/da active
- 2017-11-03 KR KR1020247012338A patent/KR20240055863A/ko active Pending
- 2017-11-03 MA MA053935A patent/MA53935A/fr unknown
- 2017-11-03 IL IL308197A patent/IL308197A/en unknown
- 2017-11-03 PL PL17863293T patent/PL3407709T3/pl unknown
- 2017-11-03 KR KR1020217034468A patent/KR102492433B1/ko active Active
- 2017-11-03 HR HRP20250695TT patent/HRP20250695T1/hr unknown
- 2017-11-03 HR HRP20201403TT patent/HRP20201403T1/hr unknown
- 2017-11-03 KR KR1020197015717A patent/KR102319069B1/ko active Active
- 2017-11-03 PT PT221647514T patent/PT4082334T/pt unknown
- 2017-11-03 RS RS20220669A patent/RS63390B1/sr unknown
- 2017-11-03 US US15/803,513 patent/US10820582B2/en active Active
- 2017-11-03 RS RS20250535A patent/RS66884B1/sr unknown
- 2017-11-03 LT LTEP20180508.2T patent/LT3766343T/lt unknown
- 2017-11-03 PL PL20180508.2T patent/PL3766343T3/pl unknown
- 2017-11-03 HR HRP20220888TT patent/HRP20220888T1/hr unknown
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2019
- 2019-05-03 MX MX2021010556A patent/MX2021010556A/es unknown
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2020
- 2020-09-24 US US17/031,367 patent/US20210029978A1/en active Pending
- 2020-10-29 CY CY20201101022T patent/CY1123491T1/el unknown
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2021
- 2021-03-08 JP JP2021036180A patent/JP2021090455A/ja not_active Withdrawn
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2022
- 2022-07-07 JP JP2022109658A patent/JP7386292B2/ja active Active
- 2022-08-08 CY CY20221100540T patent/CY1125474T1/el unknown
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2023
- 2023-02-17 JP JP2023023312A patent/JP2023053400A/ja not_active Withdrawn
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2024
- 2024-01-31 AU AU2024200582A patent/AU2024200582A1/en active Pending
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