JP2020500875A5 - - Google Patents
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- Publication number
- JP2020500875A5 JP2020500875A5 JP2019529533A JP2019529533A JP2020500875A5 JP 2020500875 A5 JP2020500875 A5 JP 2020500875A5 JP 2019529533 A JP2019529533 A JP 2019529533A JP 2019529533 A JP2019529533 A JP 2019529533A JP 2020500875 A5 JP2020500875 A5 JP 2020500875A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- hexahydro
- dimethoxy
- isobutyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 isoquinolin-2-yl Chemical group 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 8
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims description 8
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 7
- 208000028017 Psychotic disease Diseases 0.000 claims description 5
- 230000000155 isotopic effect Effects 0.000 claims description 5
- 208000022610 schizoaffective disease Diseases 0.000 claims description 5
- 201000000980 schizophrenia Diseases 0.000 claims description 5
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 2
- GEJDGVNQKABXKG-CFKGEZKQSA-N [(2r,3r,11br)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1h-benzo[a]quinolizin-2-yl] (2s)-2-amino-3-methylbutanoate Chemical compound C1CN2C[C@@H](CC(C)C)[C@H](OC(=O)[C@@H](N)C(C)C)C[C@@H]2C2=C1C=C(OC)C(OC)=C2 GEJDGVNQKABXKG-CFKGEZKQSA-N 0.000 claims description 2
- 231100000871 behavioral problem Toxicity 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 14
- HPZNBNITYLLYBM-UHFFFAOYSA-N CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.NC(C(=O)ON1CC2=CC=CC=C2C=C1)C(C)C Chemical compound CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.NC(C(=O)ON1CC2=CC=CC=C2C=C1)C(C)C HPZNBNITYLLYBM-UHFFFAOYSA-N 0.000 claims 2
- 239000007963 capsule composition Substances 0.000 claims 1
- 239000007916 tablet composition Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 8
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022189060A JP2023015405A (ja) | 2016-12-02 | 2022-11-28 | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
| JP2025010365A JP2025071099A (ja) | 2016-12-02 | 2025-01-24 | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662429652P | 2016-12-02 | 2016-12-02 | |
| US62/429,652 | 2016-12-02 | ||
| PCT/US2017/064196 WO2018102673A1 (en) | 2016-12-02 | 2017-12-01 | Use of valbenazine for treating schizophrenia or schizoaffective disorder |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022189060A Division JP2023015405A (ja) | 2016-12-02 | 2022-11-28 | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500875A JP2020500875A (ja) | 2020-01-16 |
| JP2020500875A5 true JP2020500875A5 (enExample) | 2021-01-21 |
| JPWO2018102673A5 JPWO2018102673A5 (enExample) | 2022-04-08 |
Family
ID=60703209
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529533A Withdrawn JP2020500875A (ja) | 2016-12-02 | 2017-12-01 | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
| JP2022189060A Withdrawn JP2023015405A (ja) | 2016-12-02 | 2022-11-28 | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
| JP2025010365A Pending JP2025071099A (ja) | 2016-12-02 | 2025-01-24 | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022189060A Withdrawn JP2023015405A (ja) | 2016-12-02 | 2022-11-28 | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
| JP2025010365A Pending JP2025071099A (ja) | 2016-12-02 | 2025-01-24 | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20200078352A1 (enExample) |
| EP (2) | EP4400171A3 (enExample) |
| JP (3) | JP2020500875A (enExample) |
| TW (3) | TW202515564A (enExample) |
| WO (1) | WO2018102673A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3368534T3 (pl) | 2015-10-30 | 2021-07-12 | Neurocrine Biosciences, Inc. | Ditosylan walbenazyny i jego polimorfy |
| CN121045173A (zh) | 2015-12-23 | 2025-12-02 | 纽罗克里生物科学有限公司 | 制备3-异丁基-9,10-二甲氧基-六氢-1H-吡啶并[2,1-a]异喹啉-2-基2-氨基-3-甲基丁酸酯的盐的方法 |
| MX393077B (es) | 2017-01-27 | 2025-03-24 | Neurocrine Biosciences Inc | Métodos para la administración de ciertos inhibidores de proteína transportadora transportador de monoamina vesicular (vmat2). |
| IL301770B2 (en) | 2017-09-21 | 2024-06-01 | Neurocrine Biosciences Inc | High dose valbenazine formulation and related preparations, methods and kits |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| SG11202003194YA (en) | 2017-10-10 | 2020-05-28 | Neurocrine Biosciences Inc | Methods for the administration of certain vmat2 inhibitors |
| WO2019129100A1 (zh) | 2017-12-26 | 2019-07-04 | 苏州科睿思制药有限公司 | 一种Valbenazine二对甲苯磺酸盐的晶型及其制备方法和用途 |
| BR112020024018A2 (pt) * | 2018-06-14 | 2021-02-23 | Neurocrine Biosciences Inc. | compostos inibidores de vmat2, composições e métodos relacionados a eles |
| CN110818705A (zh) * | 2018-08-14 | 2020-02-21 | 苏州鹏旭医药科技有限公司 | 缬苯那嗪的盐型和相应晶型与其制备方法 |
| CN112867491A (zh) | 2018-08-15 | 2021-05-28 | 纽罗克里生物科学有限公司 | 施用某些vmat2抑制剂的方法 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| CN112933055B (zh) * | 2021-03-23 | 2023-01-13 | 安徽九华华源药业有限公司 | 帕利哌酮胃滞留片及其制备方法 |
| EP4362944A1 (en) * | 2021-06-30 | 2024-05-08 | Neurocrine Biosciences, Inc. | Valbenazine for use in the add-on treatment of schizophrenia |
| EP4387679A1 (en) | 2021-08-20 | 2024-06-26 | Neurocrine Biosciences, Inc. | Methods of screening for vmat2 inhibitors |
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| RU2757221C2 (ru) * | 2014-02-07 | 2021-10-12 | Ньюрокрайн Байосайенсиз, Инк. | Фармацевтические композиции, содержащие антипсихотическое лекарственное средство и ингибитор vmat2, и их применение |
| PT3936130T (pt) * | 2014-05-06 | 2024-04-17 | Neurocrine Biosciences Inc | Regime de dosagem de valbenazina para o tratamento de distúrbios de movimento hipercinéticos |
| MX390795B (es) * | 2015-06-23 | 2025-03-21 | Neurocrine Biosciences Inc | Inhibidores de transportador de monoamina vesicular tipo 2 (vmat2) para tratar enfermedades o trastornos neurologicos. |
| PL3368534T3 (pl) * | 2015-10-30 | 2021-07-12 | Neurocrine Biosciences, Inc. | Ditosylan walbenazyny i jego polimorfy |
-
2017
- 2017-12-01 TW TW113125691A patent/TW202515564A/zh unknown
- 2017-12-01 TW TW112107002A patent/TW202345829A/zh unknown
- 2017-12-01 WO PCT/US2017/064196 patent/WO2018102673A1/en not_active Ceased
- 2017-12-01 JP JP2019529533A patent/JP2020500875A/ja not_active Withdrawn
- 2017-12-01 EP EP24163571.3A patent/EP4400171A3/en active Pending
- 2017-12-01 TW TW106142147A patent/TW201827051A/zh unknown
- 2017-12-01 EP EP17817594.9A patent/EP3548027A1/en not_active Withdrawn
- 2017-12-01 US US16/465,779 patent/US20200078352A1/en not_active Abandoned
-
2020
- 2020-06-03 US US16/891,160 patent/US20210113553A1/en not_active Abandoned
-
2022
- 2022-11-28 JP JP2022189060A patent/JP2023015405A/ja not_active Withdrawn
-
2025
- 2025-01-24 JP JP2025010365A patent/JP2025071099A/ja active Pending
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