JP2020100608A - Nutritional supplement, and medicine or food/drink containing the nutritional supplement - Google Patents
Nutritional supplement, and medicine or food/drink containing the nutritional supplement Download PDFInfo
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- JP2020100608A JP2020100608A JP2018241714A JP2018241714A JP2020100608A JP 2020100608 A JP2020100608 A JP 2020100608A JP 2018241714 A JP2018241714 A JP 2018241714A JP 2018241714 A JP2018241714 A JP 2018241714A JP 2020100608 A JP2020100608 A JP 2020100608A
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- nutritional supplement
- nucleic acid
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Abstract
Description
本発明は、栄養補助剤、及び当該栄養補助剤を含む医薬品又は飲食品に関する。 The present invention relates to a nutritional supplement, and a pharmaceutical product or food or drink containing the nutritional supplement.
健康や美容を保持増進させる栄養補助食品が、種々開発されている。
このような栄養補助食品として、例えば特許文献１に、核酸のみを主要な有効成分とする核酸食品が開示されている。
Various nutritional supplements for maintaining and improving health and beauty have been developed.
As such a dietary supplement, for example, Patent Document 1 discloses a nucleic acid food containing only nucleic acid as a main active ingredient.
食品中の核酸は、体内に取り入れられると、ヌクレオシドや遊離塩基にまで分解されて、核酸の再合成に利用されると考えられている。
そして、再合成された核酸の成分は、抗酸化作用を奏し、体内の活性酸素の過剰な増加を抑制すると考えられている。
Nucleic acid in food is considered to be used for resynthesis of nucleic acid when taken into the body, it is decomposed into nucleoside and free base.
The resynthesized nucleic acid component is believed to exert an antioxidant effect and suppress an excessive increase in active oxygen in the body.
体内の活性酸素の過剰な増加が抑制されると、動脈硬化、心筋梗塞、癌、糖尿病等の病気の発症が抑制され、また、シミ、シワなどの増加が抑制されると考えられている。 It is considered that when an excessive increase in active oxygen in the body is suppressed, the onset of diseases such as arteriosclerosis, myocardial infarction, cancer and diabetes is suppressed, and an increase in spots and wrinkles is suppressed.
食品中の核酸の全てが、体内で核酸の再合成に利用されるわけではない。
そのため、核酸食品を摂取しても、体内の活性酸素の過剰な増加を抑制できない虞がある。
Not all of the nucleic acids in food are utilized in the body for nucleic acid resynthesis.
Therefore, even if the nucleic acid food is ingested, it may not be possible to suppress an excessive increase in active oxygen in the body.
本発明は、上記問題点に鑑みてなされたものであり、従来よりも体内の活性酸素の過剰な増加を抑制することが可能な栄養補助剤、及び当該栄養補助剤を含む医薬品又は飲食品を提供することを目的とする。 The present invention has been made in view of the above problems, a nutritional supplement capable of suppressing an excessive increase in active oxygen in the body more than before, and a drug or food or drink containing the nutritional supplement. The purpose is to provide.
上記目的を達成するため、本発明の栄養補助剤は、核酸と、食用珪素と、を含有する。 To achieve the above object, the nutritional supplement of the present invention contains a nucleic acid and edible silicon.
例えば、さらに、ヌクレオシド、ヌクレオチド、アデニン、グアニン、シトシン、ウラシル及びチミンの少なくとも１つ以上を含有してもよい。 For example, it may further contain at least one or more of nucleoside, nucleotide, adenine, guanine, cytosine, uracil and thymine.
例えば、前記核酸は、デオキシリボ核酸ナトリウム及びリボ核酸であり、
前記デオキシリボ核酸ナトリウムの含有量は、３０〜３２質量％であり、
前記リボ核酸の含有量は、３０〜３２質量％であり、
前記食用珪素の含有量は、１〜４質量％であってもよい。
For example, the nucleic acids are sodium deoxyribonucleic acid and ribonucleic acid,
The content of deoxyribonucleic acid sodium is 30 to 32% by mass,
The content of the ribonucleic acid is 30 to 32% by mass,
The content of the edible silicon may be 1 to 4% by mass.
本発明の医薬品又は飲食品は、前記栄養補助剤を含む。 The medicine or food or drink of the present invention contains the nutritional supplement.
本発明によれば、従来よりも体内の活性酸素の過剰な増加を抑制することが可能な栄養補助剤、及び当該栄養補助剤を含む医薬品又は飲食品を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the nutritional supplement which can suppress the excessive increase of the active oxygen in the body more than before, and the pharmaceutical or food/beverage products containing the said nutritional supplement can be provided.
以下、本発明の実施の形態に係る栄養補助剤について説明する。 Hereinafter, the nutritional supplement according to the embodiment of the present invention will be described.
本発明の栄養補助剤は、有効成分として、核酸と、食用珪素と、を含有する。 The nutritional supplement of the present invention contains a nucleic acid and edible silicon as active ingredients.
核酸は、五炭糖、リン酸及び塩基から構成された複数のヌクレオチドが、ホスホジエステル結合で連結した高分子である。
核酸は、特に限定されず、例えばデオキシリボ核酸（ＤＮＡ）、デオキシリボ核酸ナトリウム（ＤＮＡ−Ｎａ）及びリボ核酸（ＲＮＡ）を挙げることができる。本発明の栄養補助剤は、必要に応じて、これらの１以上の核酸を含有してもよい。
Nucleic acid is a polymer in which a plurality of nucleotides composed of pentose, phosphate and base are linked by a phosphodiester bond.
The nucleic acid is not particularly limited, and examples thereof include deoxyribonucleic acid (DNA), sodium deoxyribonucleic acid (DNA-Na), and ribonucleic acid (RNA). The nutritional supplement of the present invention may optionally contain one or more of these nucleic acids.
また、核酸は、天然由来のものであってもよく、人工的に合成されたものであってもよい。
天然由来の核酸としては、特に限定されないが、例えばサケ、マス、ニシン、サバ、タラ等の魚類の白子に含まれる核酸、家畜等の哺乳動物の乳腺等に含まれる核酸、植物や酵母に含まれる核酸等を挙げることができる。
また、人工的に合成された核酸としては、β−シアノエチルホスフォロアミダイト法、ＤＮＡ固相合成法等により合成されたＤＮＡ、及び、ＲＮＡポリメラーゼを用いる酵素法により合成されたＲＮＡ等を挙げることができる。
The nucleic acid may be naturally derived or artificially synthesized.
The naturally-occurring nucleic acid is not particularly limited, but includes, for example, salmon, trout, herring, mackerel, nucleic acid contained in fish spores such as cod, nucleic acid contained in mammary glands of mammals such as livestock, and plants and yeasts. Nucleic acid and the like.
Examples of artificially synthesized nucleic acids include DNA synthesized by the β-cyanoethyl phosphoramidite method, DNA solid-phase synthesis method and the like, and RNA synthesized by the enzymatic method using RNA polymerase. it can.
また、核酸は、市販のものであってもよい。
市販の核酸としては、特に限定されないが、例えば、大和化成株式会社から販売されている「ＤＮＡ−Ｎａ」及び「ＲＮＡ」などが挙げられる。
The nucleic acid may be commercially available.
The commercially available nucleic acid is not particularly limited, and examples thereof include “DNA-Na” and “RNA” sold by Daiwa Kasei Co., Ltd.
ここで、大和化成株式会社から販売されている「ＤＮＡ−Ｎａ」及び「ＲＮＡ」の製品規格は、それぞれ以下の表１及び表２の通りである。 Here, the product standards of "DNA-Na" and "RNA" sold by Daiwa Kasei Co., Ltd. are as shown in Tables 1 and 2 below.
本発明の栄養補助剤の製造工程において、このような市販の核酸製品を用いることにより、核酸を人工的に合成して利用する場合などと比較して、その製造工程を簡略化することができる。 By using such a commercially available nucleic acid product in the production process of the nutritional supplement of the present invention, the production process can be simplified as compared with the case of artificially synthesizing and utilizing a nucleic acid. ..
食用珪素は、非晶質珪素であり、例えば、食物由来の珪素や、鉱物由来の珪素が挙げられる。
食物由来の珪素としては、穀類、野菜類、海藻類などに含まれる珪素が挙げられる。
穀類としては、例えば、麦、玄米、白米、トウモロコシである。
野菜類としては、例えば、ゴボウ、大根、人参である。
海藻類としては、例えば、昆布、ワカメである。
穀類、野菜類、海藻類などの食物は、粉砕された状態で、本発明の栄養補助剤に含有されていてもよい。
Edible silicon is amorphous silicon, and examples thereof include food-derived silicon and mineral-derived silicon.
Examples of food-derived silicon include silicon contained in grains, vegetables, seaweeds, and the like.
Examples of grains include wheat, brown rice, white rice, and corn.
Examples of vegetables include burdock, radish, and carrot.
Examples of seaweeds are kelp and seaweed.
Foods such as grains, vegetables, and seaweeds may be contained in the nutritional supplement of the present invention in a pulverized state.
鉱物由来の珪素としては、水晶から抽出した珪素が挙げられる。 Examples of silicon derived from minerals include silicon extracted from quartz.
また、食用珪素は、市販の食用珪素であってもよく、例えば、株式会社ＡＰＡコーポレーションから販売されている水溶性珪素「ｕｍｏ（登録商標）」に含まれている珪素が挙げられる。 The edible silicon may be commercially available edible silicon, and examples thereof include silicon contained in water-soluble silicon “umo (registered trademark)” sold by APA Corporation.
また、食用珪素は、単体の珪素であってもよいし、例えば二酸化珪素のように化合物中の珪素であってもよい。 The edible silicon may be silicon alone or silicon in a compound such as silicon dioxide.
食用珪素は、人体に摂取されると、腸管から吸収されて、細胞中のミトコンドリアを活性化しつつ、体内の活性酸素の過剰な増加を防ぐ。
つまり、食用珪素を摂取すると、その抗酸化作用により、体内の活性酸素の過剰な増加を抑制することができる。
When edible silicon is ingested by the human body, it is absorbed from the intestinal tract to activate mitochondria in cells and prevent an excessive increase in active oxygen in the body.
That is, when edible silicon is ingested, its antioxidative effect can suppress an excessive increase in active oxygen in the body.
このような本発明の栄養補助剤によれば、核酸の成分による抗酸化作用に加え、食用珪素による抗酸化作用が得られる。
そのため、本発明の栄養補助剤を摂取することで、核酸のみを主要な有効成分とする核酸食品を摂取する場合と比較して、体内の活性酸素の過剰な増加を抑制することができる。
なお、核酸の成分による抗酸化作用には、核酸の成分であるプリン体が代謝されて生成する尿酸による抗酸化作用が含まれる。
According to the nutritional supplement of the present invention as described above, in addition to the antioxidant action of the nucleic acid component, the antioxidant action of edible silicon is obtained.
Therefore, by ingesting the nutritional supplement of the present invention, it is possible to suppress an excessive increase in active oxygen in the body as compared with the case of ingesting a nucleic acid food containing only nucleic acid as a main active ingredient.
The antioxidative action of the nucleic acid component includes the antioxidative action of uric acid produced by the metabolism of purine which is a nucleic acid component.
また、核酸は、新陳代謝を促す作用を奏すると考えられている。そのため、本発明の栄養補助剤を摂取することで、肥満などを予防することが可能になると考えられる。 In addition, nucleic acids are considered to exert an action of promoting metabolism. Therefore, it is considered that obesity and the like can be prevented by ingesting the nutritional supplement of the present invention.
ここで、本発明の栄養補助剤に含まれる核酸及び食用珪素の含有量は、特に限定されない。
ただし、より高い効果を得るために、本発明の栄養補助剤の総質量に基づく核酸及び食用珪素の含有量は、それぞれ、６０〜７０質量％及び１〜４質量％であることが好ましい。
この場合、本発明の栄養補助剤の総質量に基づく核酸の含有量は、デオキシリボ核酸ナトリウムとリボ核酸との組み合わせで、６０〜７０質量％としてもよい。
そして、例えば、本発明の核酸を、デオキシリボ核酸ナトリウム及びリボ核酸とし、本発明の栄養補助剤の総質量に基づくデオキシリボ核酸ナトリウム、リボ核酸及び食用珪素の含有量を、それぞれ３０〜３２質量％、３０〜３２質量％及び１〜４質量％としてもよい。
Here, the contents of nucleic acid and edible silicon contained in the nutritional supplement of the present invention are not particularly limited.
However, in order to obtain higher effects, the contents of nucleic acid and edible silicon based on the total mass of the nutritional supplement of the present invention are preferably 60 to 70% by mass and 1 to 4% by mass, respectively.
In this case, the content of the nucleic acid based on the total mass of the nutritional supplement of the present invention may be 60 to 70 mass% in the combination of sodium deoxyribonucleic acid and ribonucleic acid.
Then, for example, the nucleic acid of the present invention is deoxyribonucleic acid sodium and ribonucleic acid, and the content of deoxyribonucleic acid sodium, ribonucleic acid and edible silicon based on the total mass of the nutritional supplement of the present invention is 30 to 32% by mass respectively. It may be 30 to 32% by mass and 1 to 4% by mass.
なお、本発明は、上記実施の形態に限定されず、種々の変形及び応用が可能である。 The present invention is not limited to the above-mentioned embodiment, and various modifications and applications are possible.
例えば、本発明の栄養補助剤は、有効成分として、さらに、ヌクレオシド及びヌクレオチドの少なくとも１つ以上を含んでもよい。 For example, the nutritional supplement of the present invention may further contain at least one or more of nucleosides and nucleotides as an active ingredient.
ヌクレオシドは、プリン塩基やピリミジン塩基等の塩基と糖とが結合した化合物の総称である。ヌクレオシドは、特に限定されず、例えばアデノシン、デオキシアデノシン、グアノシン、デオキシグアノシン、５−メチルウリジン、チミジン、ウリジン、デオキシウリジン、シチジン、デオキシシチジンを挙げることができる。
本発明の栄養補助剤は、必要に応じて、これらの１つ以上のヌクレオシドを含有してもよい。
Nucleoside is a general term for compounds in which a sugar is bound to a base such as a purine base or a pyrimidine base. The nucleoside is not particularly limited, and examples thereof include adenosine, deoxyadenosine, guanosine, deoxyguanosine, 5-methyluridine, thymidine, uridine, deoxyuridine, cytidine, and deoxycytidine.
The nutritional supplement of the present invention may optionally contain one or more of these nucleosides.
ヌクレオチドは、ヌクレオシドの糖部分にリン酸が結合した化合物である。 Nucleotides are compounds in which a phosphate is bound to the sugar portion of a nucleoside.
また、本発明の栄養補助剤は、有効成分として、さらに、ヌクレオシド、ヌクレオチド及び核酸のいずれかの構成成分である塩基を含んでもよい。
当該塩基は、特に限定されないが、例えばアデニン、グアニン、シトシン、ウラシル、チミンを挙げることができる。
本発明の栄養補助剤は、必要に応じて、これらの少なくとも１つ以上の塩基を含有してもよい。
The nutritional supplement of the present invention may further contain, as an active ingredient, a base which is a constituent of any one of nucleoside, nucleotide and nucleic acid.
The base is not particularly limited, but examples thereof include adenine, guanine, cytosine, uracil, and thymine.
The nutritional supplement of the present invention may contain at least one or more of these bases, if necessary.
すなわち、本発明の栄養補助剤は、有効成分として、さらに、ヌクレオシド、ヌクレオチド、アデニン、グアニン、シトシン、ウラシル及びチミンの少なくとも１つ以上を含有してもよい。
なお、ヌクレオシド、ヌクレオチド、アデニン、グアニン、シトシン、ウラシル及びチミンは、天然由来のものであってもよく、公知の方法で人工的に合成されたものであってもよい。
天然由来のヌクレオシド、ヌクレオチド、アデニン、グアニン、シトシン、ウラシル及びチミンとしては、特に限定されないが、例えばサケ、マス、ニシン、サバ、タラ等の魚類の白子、家畜等の哺乳動物の乳腺、及び植物や酵母に含まれるものを挙げることができる。
That is, the nutritional supplement of the present invention may further contain, as an active ingredient, at least one or more of nucleoside, nucleotide, adenine, guanine, cytosine, uracil and thymine.
The nucleoside, nucleotide, adenine, guanine, cytosine, uracil and thymine may be of natural origin or artificially synthesized by a known method.
Naturally-occurring nucleosides, nucleotides, adenine, guanine, cytosine, uracil and thymine are not particularly limited, but include, for example, salmon, trout, herring, mackerel, cod, etc. And those contained in yeast.
ヌクレオシド、ヌクレオチド、アデニン、グアニン、シトシン、ウラシル及びチミンは、体内に取り入れられると、核酸の再合成に利用されると考えられる。そして、再合成された核酸の成分が、抗酸化作用を奏し、体内の活性酸素の過剰な増加を抑制すると考えられる。
そのため、本発明の栄養補助剤が、核酸及び食用珪素と、ヌクレオシド、ヌクレオチド、アデニン、グアニン、シトシン、ウラシル及びチミンの少なくとも１つ以上と、を含有することで、さらに体内の活性酸素の過剰な増加を抑制することが可能になると考えられる。
Nucleosides, nucleotides, adenines, guanines, cytosines, uracils and thymines, when taken into the body, are thought to be available for resynthesis of nucleic acids. It is considered that the resynthesized nucleic acid component exerts an antioxidant effect and suppresses an excessive increase in active oxygen in the body.
Therefore, the dietary supplement of the present invention contains nucleic acid and edible silicon and at least one or more of nucleoside, nucleotide, adenine, guanine, cytosine, uracil and thymine, so that the excess of active oxygen in the body is further increased. It is considered that the increase can be suppressed.
本発明の栄養補助剤に、ヌクレオシド、ヌクレオチド、アデニン、グアニン、シトシン、ウラシル及びチミンのいずれか１つ以上を含有させる場合、その含有量は、特に限定されない。 When the nutritional supplement of the present invention contains any one or more of nucleoside, nucleotide, adenine, guanine, cytosine, uracil and thymine, the content thereof is not particularly limited.
また、本発明の栄養補助剤は、必要に応じて、さらに、核酸や食用珪素とは関連しない成分であって、抗酸化作用を奏する成分を含んでもよい。
このような抗酸化作用を奏する成分は、特に限定されないが、例えばセレン酵母、コエンザイムＱ１０、ビタミンＣ、レスベラトロール、ローヤルゼリー及びクエン酸などが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの抗酸化作用を奏する成分の少なくとも１つ以上を含有してもよい。
In addition, the nutritional supplement of the present invention may further contain a component that is not related to nucleic acids or edible silicon and that exhibits an antioxidant action, if necessary.
The component exhibiting such an antioxidant action is not particularly limited, and examples thereof include selenium yeast, coenzyme Q10, vitamin C, resveratrol, royal jelly, and citric acid.
The nutritional supplement of the present invention may contain at least one or more of these components having an antioxidant action, if necessary.
そして、本発明の栄養補助剤に、セレン酵母、コエンザイムＱ１０、ビタミンＣ、レスベラトロール、ローヤルゼリー及びクエン酸を含有させる場合、それらの含有量は、特に限定されない。
例えば、下記の表３に示す通り、本発明の栄養補助剤について、本発明の栄養補助剤の総質量に基づくＤＮＡ−Ｎａ（核酸）、ＲＮＡ（核酸）、食用珪素（珪素パウダー）、セレン酵母、コエンザイムＱ１０、ビタミンＣ、レスベラトロール、ローヤルゼリー及びクエン酸の含有量を、それぞれ、３１．２５０質量％、３１．２５０質量％、１．２５０質量％、０．８２５質量％、０．１２５０質量％、１．２５０質量％、０．２５０質量％、１．２５０質量％及び１．２５０質量％としてもよい。
When the nutritional supplement of the present invention contains selenium yeast, coenzyme Q10, vitamin C, resveratrol, royal jelly and citric acid, their contents are not particularly limited.
For example, as shown in Table 3 below, regarding the nutritional supplement of the present invention, DNA-Na (nucleic acid), RNA (nucleic acid), edible silicon (silicon powder), and selenium yeast based on the total mass of the nutritional supplement of the present invention. , Coenzyme Q10, vitamin C, resveratrol, royal jelly and citric acid content of 31.250% by mass, 31.250% by mass, 1.250% by mass, 0.825% by mass, 0.1250% by mass, respectively. %, 1.250% by mass, 0.250% by mass, 1.250% by mass and 1.250% by mass.
ここで、上記の表３に示す本発明の栄養補助剤１５００ｍｇ中に含まれる成分は、下記の表４の通りである。 Here, the components contained in 1500 mg of the nutritional supplement of the present invention shown in Table 3 above are as shown in Table 4 below.
また、本発明の栄養補助剤は、必要に応じて、賦形剤、ｐＨ調整剤、清涼化剤、懸濁化剤、コーティング剤、着色剤、結合剤、滑沢剤、界面活性剤などを含有してもよい。 In addition, the nutritional supplement of the present invention may include an excipient, a pH adjuster, a cooling agent, a suspending agent, a coating agent, a coloring agent, a binder, a lubricant, a surfactant, etc. May be included.
賦形剤としては、特に限定されず、例えば、デンプン、乳糖、白糠、ラクトース、微結晶セルロース、スクロース、デキストリン、Ｄ−マンニトール、コーンスターチ、リン酸カルシウム、リン酸水素カルシウム、硫酸カルシウム、カルボキシメチルスターチナトリウム、メタケイ酸有アルミン酸マグネシウム、ポリエチレングリコール、中鎖脂肪酸トリグリセリドなどが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上の賦形剤を含有してもよい。
The excipient is not particularly limited, for example, starch, lactose, white bran, lactose, microcrystalline cellulose, sucrose, dextrin, D-mannitol, corn starch, calcium phosphate, calcium hydrogen phosphate, calcium sulfate, sodium carboxymethyl starch, Examples thereof include magnesium aluminate having metasilicate, polyethylene glycol, and medium chain fatty acid triglyceride.
The nutritional supplement of the present invention may optionally contain one or more of these excipients.
ｐＨ調整剤としては、特に限定されず、例えば、クエン酸、乳酸、リンゴ酸、アスパラギン酸、重曹、水酸化ナトリウム、リン酸水素ナトリウム、水酸化カリウム、水酸化マグネシウムなどが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上のｐＨ調整剤を含有してもよい。
The pH adjuster is not particularly limited, and examples thereof include citric acid, lactic acid, malic acid, aspartic acid, sodium bicarbonate, sodium hydroxide, sodium hydrogen phosphate, potassium hydroxide, magnesium hydroxide and the like.
The nutritional supplement of the present invention may contain one or more of these pH adjusting agents, if necessary.
清涼化剤としては、特に限定されず、例えば、ｌ−メントール、ハッカ水などが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上の清涼化剤を含有してもよい。
The cooling agent is not particularly limited, and examples thereof include l-menthol and peppermint water.
The nutritional supplement of the present invention may optionally contain one or more of these cooling agents.
懸濁化剤としては、特に限定されず、例えば、カルボキシメチルセルロース、ヒドロキシメチルセルロース、ポリビニルアルコール、ポリビニルピロリドン、カオリン、カルメロースナトリウムなどが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上の懸濁化剤を含有してもよい。
The suspending agent is not particularly limited, and examples thereof include carboxymethyl cellulose, hydroxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, kaolin, and carmellose sodium.
The nutritional supplement of the present invention may optionally contain one or more of these suspending agents.
コーティング剤としては、特に限定されず、例えば、ヒドロキシメチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルエチルセルロース、ポリオキシエチレングリコール、セルロースアセテートフタレート、ポリビニルアセタールジエチルアミノアセテート、セルロースアセテートトリメリテート、ポリビニルアセテートフタレート、ヒドロキシプロピルメチルセルロースアセテートサクシネート、ヒドロキシプロピルメチルセルロースフタレート、メタクリレートコポリマーなどが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上のコーティング剤を含有してもよい。
The coating agent is not particularly limited, and examples thereof include hydroxymethyl cellulose, hydroxypropyl cellulose, carboxymethyl ethyl cellulose, polyoxyethylene glycol, cellulose acetate phthalate, polyvinyl acetal diethylaminoacetate, cellulose acetate trimellitate, polyvinyl acetate phthalate, hydroxypropyl methyl cellulose. Examples thereof include acetate succinate, hydroxypropylmethyl cellulose phthalate, and methacrylate copolymer.
The nutritional supplement of the present invention may optionally contain one or more of these coating agents.
着色剤としては、特に限定されず、例えば、タール色素、酸化チタン、ウコン抽出液、リボフラビンなどが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上の着色剤を含有してもよい。
The colorant is not particularly limited, and examples thereof include tar dyes, titanium oxide, turmeric extract, riboflavin and the like.
The nutritional supplement of the present invention may optionally contain one or more of these colorants.
結合剤としては、特に限定されず、例えば、エタノール、プロパノール、ポリビニルアルコール、メチルセルロース、エチルセルロース、カルボキシメチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、ゼラチン、デンプン、ブドウ糖、アラビアゴム、リン酸カルシウム、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステルなどが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上の結合剤を含有してもよい。
The binder is not particularly limited and, for example, ethanol, propanol, polyvinyl alcohol, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, gelatin, starch, glucose, acacia, calcium phosphate, sodium alginate, propylene alginate. Examples thereof include glycol ester.
The nutritional supplement of the present invention may optionally contain one or more of these binders.
滑沢剤としては、特に限定されず、例えば、ステアリン酸マグネシウム、ステアリン酸カルシウム、コロイダルシリカ、ショ糖脂肪酸エステル、フマル酸ステアリルナトリウム、タルク、ポリエチレングリコールなどが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上の滑沢剤を含有してもよい。
The lubricant is not particularly limited, and examples thereof include magnesium stearate, calcium stearate, colloidal silica, sucrose fatty acid ester, sodium stearyl fumarate, talc, polyethylene glycol and the like.
The nutritional supplement of the present invention may optionally contain one or more of these lubricants.
界面活性剤としては、特に限定されず、例えば、ラウリル硫酸ナトリウム、ポリソルベート８０、Ｔｗｅｅｎ６０、Ｔｗｅｅｎ８０、ポリオキシエチレン硬化ヒマシ油、モノステアリンサングリセリン、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、プロピレングリコール、モノステアリン酸ソルビタン、モノラウリン酸ソルビタンなどが挙げられる。
本発明の栄養補助剤は、必要に応じて、これらの１以上の界面活性剤を含有してもよい。
The surfactant is not particularly limited, and examples thereof include sodium lauryl sulfate, polysorbate 80, Tween 60, Tween 80, polyoxyethylene hydrogenated castor oil, monostearin sanglycerin, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, Propylene glycol, sorbitan monostearate, sorbitan monolaurate and the like can be mentioned.
The nutritional supplement of the present invention may optionally contain one or more of these surfactants.
また、本発明の栄養補助剤は、医薬品又は飲食品に含まれてもよい。 Moreover, the nutritional supplement of the present invention may be contained in a pharmaceutical product or a food or drink.
医薬品に含まれる場合は、特に限定されないが、例えば、薬学的に許容される担体とともに、錠剤、カプセル剤、液剤、粉末剤、ペースト状剤、ゲル状剤などの形態で人体に投与される。 When it is contained in a medicine, it is not particularly limited, but for example, it is administered to the human body in the form of tablets, capsules, solutions, powders, pastes, gels, etc. together with a pharmaceutically acceptable carrier.
飲食品は、飲料品又は食料品を意味し、特に限定されないが、例えば、果汁飲料、清涼飲料、コーヒー、野菜ジュース、茶、コーヒー、シロップ、食酢、味噌、果物、野菜、穀物、肉、乳製品、菓子、麺、ゼリー、栄養補助食品、機能性食品、健康食品などが挙げられる。 Food and drink means beverages or foods, and is not particularly limited, for example, fruit juice drink, soft drink, coffee, vegetable juice, tea, coffee, syrup, vinegar, miso, fruits, vegetables, grains, meat, milk Examples include products, confectionery, noodles, jellies, dietary supplements, functional foods, and health foods.
Claims (4)
栄養補助剤。 Containing nucleic acid and edible silicon,
Nutritional supplement.
請求項１に記載の栄養補助剤。 Furthermore, it contains at least one or more of nucleoside, nucleotide, adenine, guanine, cytosine, uracil and thymine,
The nutritional supplement according to claim 1.
前記デオキシリボ核酸ナトリウムの含有量は、３０〜３２質量％であり、
前記リボ核酸の含有量は、３０〜３２質量％であり、
前記食用珪素の含有量は、１〜４質量％である、
請求項１又は２のいずれか１項に記載の栄養補助剤。 The nucleic acid is sodium deoxyribonucleic acid and ribonucleic acid,
The content of deoxyribonucleic acid sodium is 30 to 32% by mass,
The content of the ribonucleic acid is 30 to 32% by mass,
The content of the edible silicon is 1 to 4% by mass,
The nutritional supplement according to claim 1.
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| 免疫カラダラボ 商品コード：KAKU01 核酸１５００ＭＧ, JPN6023013036, 23 March 2023 (2023-03-23), ISSN: 0005026448 * |
| 日本珪素医化学 学会 珪素, JPN6023013037, 23 March 2023 (2023-03-23), ISSN: 0005026449 * |
| 硅素Ｑ＆Ａ, JPN6022046936, 28 October 2022 (2022-10-28), ISSN: 0005026447 * |
| 食品工業, vol. 50(18), JPN6022046933, 2007, pages 104 - 116, ISSN: 0005026445 * |
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| JP2022060611A (en) * | 2020-10-05 | 2022-04-15 | 日本セルフメディカル株式会社 | Composition for beauty and health and pharmaceutical product or food or beverage product comprising the same |
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