JP2021138636A - Composition for health promotion, and medicine or food and beverage containing the composition for health promotion - Google Patents

Abstract

To provide a composition for health promotion capable of improving health to prevent a disease which is supposed to be caused by active oxygen, compared with a conventional composition which uses only astaxanthin as a main active ingredient; and to provide a medicine or a food and beverage containing the composition for health promotion.SOLUTION: A composition for health promotion contains astaxanthin and edible silicon. The content of the edible silicon may be larger than the content of the astaxanthin. The content of the astaxanthin may be 0.10 wt.% or more and 0.30 wt.% or less. The composition for health promotion is contained in a medicine or a food and beverage.SELECTED DRAWING: None

Description

The present invention relates to a health-promoting composition and a pharmaceutical product or food or drink containing the health-promoting composition.

Various health-promoting compositions have been developed to promote health.
As such a composition, for example, Patent Document 1 discloses a composition containing only astaxanthin as a main active ingredient.

When astaxanthin is taken into the body, it exerts an antioxidant effect and is thought to improve and prevent diseases caused by active oxygen.

Japanese Unexamined Patent Publication No. 2005-27589

There may be individual differences in the effectiveness of astaxanthin.
Therefore, even if a composition containing only astaxanthin as a main active ingredient is ingested, there is a risk that it is not possible to improve or prevent a disease caused by active oxygen.

The present invention has been made in view of the above problems, and can improve and prevent diseases caused by active oxygen as compared with conventional compositions containing only astaxanthin as a main active ingredient. An object of the present invention is to provide a health-promoting composition and a drug or food or drink containing the health-promoting composition.

In order to achieve the above object, the health-promoting composition of the present invention contains astaxanthin and edible silicon.

For example, the content of the edible silicon may be higher than the content of the astaxanthin.

For example, the content of the astaxanthin may be 0.10% by mass or more and 0.30% by mass or less.

The pharmaceutical product or food or drink of the present invention contains the above-mentioned health-promoting composition.

According to the present invention, a health-promoting composition capable of improving and preventing a disease caused by active oxygen, and a health-promoting composition, as compared with a conventional composition containing only astaxanthin as a main active ingredient. Pharmaceuticals or foods and drinks containing the composition for use can be provided.

Hereinafter, the health-promoting composition according to the embodiment of the present invention will be described.

The health-promoting composition of the present invention contains astaxanthin and edible silicon as active ingredients.

Astaxanthin is 3,3'-dihydroxy-β, β-carotene-4, 4'-dione.
Astaxanthin contains three optical isomers (3R, 3'R), (3R, 3'S), and (3S, 3'S) based on the configuration of the hydroxy group at the 3,3'position. exist. In addition, astaxanthin has four kinds of geometric isomers based on the conjugated double bond cis-trans.
The health-promoting composition of the present invention may contain any of these three optical isomers and four geometric isomers.

Astaxanthin may be of natural origin or may be artificially synthesized.

Naturally-derived astaxanthin is not particularly limited, but for example, algae such as Haematococcus algae, yeasts such as red yeast Faffia, crustaceans such as shrimp and crab, fish such as salmon and Thailand, Paracoccus sp. N81106 and Brevundimas sp. Bacteria such as SD212, Schizochytrium sp. Examples thereof include astaxanthin extracted from labyrinthula such as KH105.

In particular, since it is considered that a relatively large amount of astaxanthin is accumulated in Haematococcus algae, naturally-derived astaxanthin is preferably extracted from Haematococcus algae.
Examples of Haematococcus algae include Haematococcus plvialis such as UTEX2505, Haematococcus lacustris Haematococcus lacustris Haematococcus lacustris, UTEX LB1758, and Haematococcus LB1758. Haematococcus capensis, Haematococcus deroebakensis such as UTEX 55, and the like.

The method for extracting astaxanthin from a natural product is not particularly limited, and examples thereof include a method in which a natural product is crushed, astaxanthin is extracted from the crushed product with an organic solvent, and the organic solvent used for the extraction is removed. Be done.
Examples of the organic solvent used for extraction include acetone, ether, ethanol, methanol and a mixture thereof.

The artificially synthesized astaxanthin is not particularly limited, and may be astaxanthin synthesized by a known method.
A known method is, for example, a method for producing astaxanthin disclosed in Japanese Patent Application Laid-Open No. 07-118227, which is an aprotic polarity of a specific oxaziridine compound on canthaxanthin dimetal enolate at a low temperature. Examples thereof include a method of adding a solution of a solvent, further adding an acidic substance, and separating unreacted canthaxanthin from the resulting reaction solution at a low temperature.

Further, astaxanthin may be commercially available.
Commercially available astaxanthin is not particularly limited, but for example, "astaxanthin-LS1" sold by Oryza Yuka Co., Ltd., "astaxanthin powder" sold by Bioactives Japan Co., Ltd., Fuji Chemical Industries, Ltd. "Astaryl (registered trademark)" sold by.
In particular, in the present invention, when commercially available astaxanthin is used, it is preferable to use "astaxanthin-LS1" sold by Oryza Yuka Co., Ltd. in consideration of the contained components and the like.

The edible silicon is amorphous silicon, and examples thereof include silicon derived from food and silicon derived from minerals.
Examples of food-derived silicon include silicon contained in cereals, vegetables, seaweeds, and the like.
Examples of cereals are wheat, brown rice, white rice, and corn.
Examples of vegetables include burdock, radish, and carrot.
Examples of seaweeds include kelp and wakame seaweed.
Foods such as cereals, vegetables, and seaweeds may be contained in the health-promoting composition of the present invention in a crushed state.

Examples of mineral-derived silicon include silicon extracted from quartz.

Further, the edible silicon may be commercially available edible silicon, and examples thereof include silicon contained in the water-soluble silicon "umo (registered trademark)" sold by APA Corporation.

Further, the edible silicon may be a simple substance of silicon, or may be silicon in a compound such as silicon dioxide.

When edible silicon is ingested by the human body, it is absorbed from the intestinal tract and activates mitochondria in cells while preventing an excessive increase in active oxygen in the body.
That is, when edible silicon is ingested, its antioxidant action makes it possible to improve and prevent diseases caused by active oxygen.

According to such a health-promoting composition of the present invention, in addition to the antioxidant action of astaxanthin, the antioxidant action of edible silicon can be obtained.
Therefore, by ingesting the health-promoting composition of the present invention, the disease caused by active oxygen can be further improved and compared with the case of ingesting the composition containing only astaxanthin as a main active ingredient. It becomes possible to prevent.

Diseases caused by active oxygen are not particularly limited, and examples thereof include diseases such as arteriosclerosis, myocardial infarction, cancer, diabetes, and rough skin.

Here, the contents of astaxanthin and edible silicon contained in the health-promoting composition of the present invention are not particularly limited.
However, it is preferable that the content of edible silicon is higher than the content of astaxanthin.
This will make it possible to further improve and prevent diseases caused by active oxygen.

The content of astaxanthin based on the total mass of the health-promoting composition of the present invention is preferably 0.01% by mass or more and 0.50% by mass or less, and 0.10% by mass or more and 0.30% by mass or less. The following is more preferable, and 0.2% by mass is most preferable.
As a result, when the health-promoting composition of the present invention is ingested, it becomes possible to improve and prevent a disease caused by active oxygen without making the peculiar odor of astaxanthin felt as much as possible.
The content of astaxanthin based on the total mass of the health-promoting composition of the present invention is preferably 0.01% by mass or more and 0.50% by mass or less, and therefore, for example, 0.02% by mass or 0.04. Mass%, 0.06% by mass, 0.08% by mass, 0.12% by mass, 0.14% by mass, 0.16% by mass, 0.18% by mass, 0.22% by mass, 0.24% by mass , 0.26% by mass, 0.28% by mass, 0.32% by mass, 0.34% by mass, 0.36% by mass, 0.38% by mass, 0.40% by mass, 0.42% by mass, 0 Includes .44% by weight, 0.46% by weight and 0.48% by weight.

The present invention is not limited to the above embodiment, and various modifications and applications are possible.

For example, the health-promoting composition of the present invention may further contain a component that is not related to astaxanthin or edible silicon and has an antioxidant effect, if necessary.
The components having such an antioxidant effect are not particularly limited, but for example, γ-orizanol, alpha lipoic acid, catechins, flavonoids, coenzyme Q10, vitamin C, vitamin E, enzogenol, royal jelly, uric acid, citric acid and the like. Can be mentioned.
The health-promoting composition of the present invention may contain at least one or more of these antioxidant components, if necessary.

When the health-promoting composition of the present invention contains the above-mentioned γ-orizanol, alpha lipoic acid, catechins, flavonoids, coenzyme Q10, vitamin C, vitamin E, enzogenol, royal jelly, uric acid, citric acid and the like. Their content is not particularly limited.

In addition, the health-promoting composition of the present invention contains excipients, pH adjusters, refreshing agents, suspending agents, coating agents, coloring agents, binders, lubricants, and surfactants, as required. It may contain an agent or the like.

The excipient is not particularly limited, and for example, starch, lactose, white bran, lactose, microcrystalline cellulose, sucrose, dextrin, D-mannitol, corn starch, calcium phosphate, calcium hydrogen phosphate, calcium sulfate, sodium carboxymethyl starch, and the like. Examples thereof include magnesium aluminome with metacalcium, polyethylene glycol, and medium-chain fatty acid triglyceride.
The health-promoting composition of the present invention may contain one or more of these excipients, if necessary.

The pH adjusting agent is not particularly limited, and examples thereof include citric acid, lactic acid, malic acid, aspartic acid, sodium bicarbonate, sodium hydroxide, sodium hydrogenphosphate, potassium hydroxide, magnesium hydroxide and the like.
The health-promoting composition of the present invention may contain one or more of these pH adjusters, if necessary.

The refreshing agent is not particularly limited, and examples thereof include l-menthol and mint water.
The health-promoting composition of the present invention may contain one or more of these refreshing agents, if necessary.

The suspending agent is not particularly limited, and examples thereof include carboxymethyl cellulose, hydroxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, kaolin, and carmellose sodium.
The health-promoting composition of the present invention may contain one or more of these suspending agents, if necessary.

The coating agent is not particularly limited, and for example, hydroxymethyl cellulose, hydroxypropyl cellulose, carboxymethyl ethyl cellulose, polyoxyethylene glycol, cellulose acetate phthalate, polyvinyl acetal diethylamino acetate, cellulose acetate trimellitate, polyvinyl acetate phthalate, hydroxypropyl methyl cellulose. Examples thereof include acetate succinate, hydroxypropyl methylcellulose phthalate, and methacrylate copolymer.
The health-promoting composition of the present invention may contain one or more of these coating agents, if necessary.

The colorant is not particularly limited, and examples thereof include tar dye, titanium oxide, turmeric extract, and riboflavin.
The health-promoting composition of the present invention may contain one or more of these colorants, if necessary.

The binder is not particularly limited, and for example, ethanol, propanol, polyvinyl alcohol, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, gelatin, starch, glucose, gum arabic, calcium phosphate, sodium alginate, propylene alginate. Glycol ester and the like can be mentioned.
The health-promoting composition of the present invention may contain one or more of these binders, if necessary.

The lubricant is not particularly limited, and examples thereof include magnesium stearate, calcium stearate, colloidal silica, sucrose fatty acid ester, sodium stearyl fumarate, talc, and polyethylene glycol.
The health-promoting composition of the present invention may contain one or more of these lubricants, if necessary.

The surfactant is not particularly limited, and for example, sodium lauryl sulfate, polysorbate 80, Tween 60, Tween 80, polyoxyethylene hydrogenated castor oil, monostearic acid sanglycerin, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, etc. Examples thereof include propylene glycol, sorbitan monostearate, and sorbitan monolaurate.
The health-promoting composition of the present invention may contain one or more of these surfactants, if necessary.

In addition, the health-promoting composition of the present invention may be contained in a pharmaceutical product or a food or drink.

When it is contained in a pharmaceutical product, it is administered to the human body in the form of tablets, capsules, liquids, powders, pastes, gels and the like together with a pharmaceutically acceptable carrier, for example.

Food and drink means beverages or foodstuffs, and is not particularly limited, for example, fruit juice drinks, soft drinks, coffee, vegetable juices, tea, coffee, syrup, vinegar, miso, fruits, vegetables, grains, meat, milk. Products, confectionery, noodles, jellies, nutritional supplements, functional foods, health foods, etc. can be mentioned.

Claims (4)

Containing astaxanthin and edible silicon,
Composition for health promotion. The content of the edible silicon is higher than the content of the astaxanthin.
The health-promoting composition according to claim 1. The content of astaxanthin is 0.10% by mass or more and 0.30% by mass or less.
The health-promoting composition according to claim 1 or 2. A drug or food or drink containing the health-promoting composition according to any one of claims 1 to 3.