JP2020099418A - External preparation with membrane formability - Google Patents

Abstract

To provide an external preparation with membrane formability, which has excellent coatability allowing a sufficient amount to be applied at a lick, even accommodated in a container equipped with a small brush having a prescribed size.SOLUTION: An external preparation with membrane formability comprising (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, (C) nitrocellulose, and (D) tocopherol and/or a derivative thereof is accommodated in a container having a vessel body and a lid part equipped with an application member entering the inside of the vessel body. The application member has a grip part and a brush part disposed at an end of the grip part. The length of the brush part from the base end to the tip end is 11 to 13 mm, and the tip width is 1.5 to 4.5 mm. The external preparation has excellent coatability allowing a sufficient amount to be applied at a lick.SELECTED DRAWING: None

Description

The present invention relates to a film-forming external preparation. More specifically, the present invention relates to a film-forming external preparation which is thickened so that good coatability can be obtained even with a small brush.

BACKGROUND ART Bandages are known as hygiene materials for preventing skin injured parts such as cracks, cracks, peelings, and cuts from invading bacteria and infection. Adhesive bandages are a tape-type adhesive bandage type in which a gauze or absorbent pad is attached to the center of a tape base material laminated with an adhesive, and a liquid adhesive bandage that is liquid before use but forms a film when applied to the skin. Be separated. Among them, the liquid adhesive plaster does not use an adhesive and the physical irritation at the time of peeling is alleviated.Furthermore, by selectively applying it to the damaged site, a film according to the size and shape of the damaged site can be obtained. Since it can be formed, it has attracted attention as a supplement to the above-mentioned drawbacks of tape-shaped bandages.

Conventionally, nitrocellulose has been used as a film-forming component in liquid adhesive plasters, and various pharmaceutical formulations of liquid adhesive plasters using nitrocellulose have been reported. For example, Patent Document 1 discloses a film guard preparation prepared by dissolving nitrocellulose in 3-methylbutyl acetate, isobutyl acetate or acetone, and further adding ethyl alcohol to prepare the preparation.

On the other hand, a liquid adhesive plaster having a formulation different from the above has also been reported. For example, in Patent Document 2, for the purpose of alleviating irritation at the time of application, about 1 to 40 mass% of a hydrophobic polysaccharide and about A skin protectant comprising 60-99 wt% volatile hydrophobic solvent is disclosed. Patent Document 2 describes that a volatile hydrophobic solvent has excellent properties in terms of coatability in addition to alleviating irritation, and as an auxiliary agent that can further improve coatability, Viscosity modifiers such as vegetable oils, animal oils, diisopropyl adipate, menthol, camphor, glycerol triacetate, cholesterol, cholesterol derivatives, fumed silica, bentonite and other clay derivatives are disclosed.

JP, 2008-105979, A JP, 2014-204832, A

In order for the film formed on the skin by the liquid bandage to exhibit the protective function originally required for the bandage, it must be applied in a sufficient amount to form a film. The present inventor has focused on a liquid adhesive plaster of a type which is housed in a container with a brush and applied with a brush in order to obtain good coatability on the skin. However, unlike a liquid adhesive plaster of the type applied with a brush, unlike a liquid adhesive plaster of the type housed in a tube container, it is difficult to apply a sufficient amount with one application. In addition, if it is stored in a container equipped with a small brush for the purpose of making it easier to apply to a skin site with a relatively complicated surface shape or a skin site with a relatively small wound, the amount of liquid that the brush can hold is inevitable. On the contrary, there was a problem that it was more difficult to apply a sufficient amount with one coating. Also, for parts with a relatively complex surface shape or parts with a relatively small wound, there are many movements on a daily basis such as fingers, it is easy to be exposed to various external factors, and the pain to the wound is particularly sensitive. Since there are many parts such as, there is a great adverse effect caused by the difficulty of applying a sufficient amount with one application.

Therefore, it is an object of the present invention to provide a film-forming external preparation which has excellent coatability and can be applied in a sufficient amount in a single application while being contained in a container equipped with a small-sized brush.

As a result of diligent studies, the present inventors have (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, and ( A film-forming external preparation containing C) nitrocellulose, which has not been known as a thickener for a film-forming external preparation (D) tocopherol and/or a derivative thereof (hereinafter, also referred to as tocopherols). It was found that the formulation for external use thickens the film-forming external preparation unexpectedly, and a sufficient amount can be easily applied with one application even with a small-sized brush. The present invention has been completed by further studies based on this finding.

That is, the present invention provides the inventions of the following modes.
Item 1. (A) Monohydric alcohol having 1 to 4 carbon atoms, (B) Ester of monocarboxylic acid having 2 to 4 carbon atoms and monohydric alcohol having 1 to 5 carbon atoms, (C) Nitrocellulose, and (D) Tocopherol And/or a derivative thereof,
The container is housed in a container having a container body and a lid part having a coating member that enters the container body, and the coating member has a handle portion and a brush portion provided at an end of the handle portion. A film-forming external preparation, characterized in that the length from the base end to the tip of the brush part is 11 to 13 mm and the tip width is 1.5 to 4.5 mm.
Item 2. Item 2. The film-forming external preparation according to Item 1, which is used for application to a finger of a hand.
Item 3. Item 3. The film-forming external preparation according to Item 1 or 2, which is used for application to a wound site of skin.
Item 4. Item 5. The film-forming external preparation according to any one of Items 1 to 3, which has a viscosity of 5000 to 15000 mPa·s.
Item 5. (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, and (C) nitrocellulose,
The container is housed in a container having a container main body and a lid provided with a coating member that enters the inside of the container main body, and the coating member has a handle portion and a brush portion provided at an end of the handle portion. And, in the film-forming external preparation, wherein the length from the base end to the tip of the brush part is 11 to 13 mm and the tip width is 1.5 to 4.5 mm,
(D) A method of increasing the viscosity of a film-forming external preparation, which comprises adding tocopherol and/or a derivative thereof.

ADVANTAGE OF THE INVENTION According to this invention, the film-forming external preparation which has the outstanding applicability which can be apply|coated with a sufficient amount by one application, even if accommodated in the container provided with the small-sized brush is provided.

An example of a lid part provided with an application member is shown typically.

1. Film-Forming External Formulation The film-forming external preparation of the present invention comprises (A) a specific alcohol (hereinafter also referred to as (A) component) and (B) a specific ester (hereinafter also referred to as (B) component). , (C) nitrocellulose (hereinafter, also referred to as (C) component), and (D) tocopherols (hereinafter, also referred to as (D) component), and are contained in a container having a brush portion of a predetermined size. It is characterized by Hereinafter, the film-forming external preparation of the present invention will be described in detail.

(A) Monohydric alcohol having 1 to 4 carbon atoms The film-forming external preparation of the present invention contains a monohydric alcohol having 1 to 4 carbon atoms as the component (A).

The type of monohydric alcohol having 1 to 4 carbon atoms is not particularly limited, but examples thereof include methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, and tert-butanol. Among these alcohols, monohydric alcohols having 2 to 4 carbon atoms are preferable, ethanol, isopropanol, and n-butanol are more preferable, and ethanol and isopropanol are more preferable.

In the film-forming external preparation of the present invention, as the component (A), one kind of monohydric alcohol having 1 to 4 carbon atoms may be used alone, or two or more kinds thereof may be used in combination. Good.

From the viewpoint of obtaining even more excellent coatability, isopropanol is a preferred embodiment of the component (A).

In the film-forming external preparation of the present invention, the content of the component (A) is not particularly limited, but is, for example, 10 to 70% by weight, preferably 15 to 65% by weight, more preferably 30 to 60% by weight, It is more preferably 30 to 60% by weight, and particularly preferably 35 to 60% by weight. By satisfying the content of the component (A), more excellent coatability can be obtained.

(B) Ester of monocarboxylic acid having 2 to 4 carbon atoms and monohydric alcohol having 1 to 5 carbon atoms The film-forming external preparation of the present invention comprises, as the component (B), monocarboxylic acid having 2 to 4 carbon atoms. And an ester of a monohydric alcohol having 1 to 5 carbon atoms. "Ester of monocarboxylic acid having 2 to 4 carbon atoms and monohydric alcohol having 1 to 5 carbon atoms" means 1 molecule of monocarboxylic acid having 2 to 4 carbon atoms and 1 molecule of monohydric alcohol having 1 to 5 carbon atoms. Is a compound having an ester bond.

The type of monocarboxylic acid having 2 to 4 carbon atoms that constitutes the ester is not particularly limited, and examples thereof include acetic acid, lactic acid, propionic acid, and butyric acid. Among these monocarboxylic acids, monocarboxylic acids having 2 or 3 carbon atoms are preferable, and acetic acid and lactic acid are more preferable.

The type of monohydric alcohol having 1 to 5 carbon atoms that constitutes the ester is not particularly limited, but examples thereof include methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, and tert. -Butanol, benzyl alcohol, 1-pentanol, 3-methyl-1-butanol, 2-methyl-1-butanol, 2,2 dimethyl-1-propanol, 2-pentanol, 3-methyl-2-butanol, 3 -Pentanol and 2-methyl-2-butanol are mentioned. Among these alcohols, preferably methanol, ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol, benzyl alcohol, more preferably ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol. Are listed.

Specific examples of the ester include methyl acetate, ethyl acetate, propyl acetate (n-propyl acetate), isopropyl acetate, butyl acetate (n-butyl acetate), sec-butyl acetate, isobutyl acetate, pentyl acetate (acetic acid 1- Pentyl), ethyl lactate, butyl lactate, isoamyl acetate (3-methylbutyl acetate), ethyl butyrate, ethyl propionate and the like. Among these, ethyl acetate, butyl acetate, and ethyl lactate are preferable as the ester, and ethyl acetate and butyl acetate are more preferable, from the viewpoint of obtaining even more excellent coatability.

In the film-forming external preparation of the present invention, as the component (B), one kind of the above-mentioned esters may be used alone, or two or more kinds may be used in combination. For example, by using, as the component (B), two or more kinds of esters having different boiling points in combination, the film forming rate of the film forming external preparation of the present invention can be appropriately adjusted. For example, when the above ester having a boiling point of less than 100° C. (for example, ethyl acetate) and the above ester having a boiling point of 100° C. or more (for example, butyl acetate) are used together, and the ratio of the above ester having a boiling point of less than 100° C. is set to be high. The film formation rate can be increased, and the film formation rate can be decreased by setting the ratio of the ester having a boiling point of less than 100° C. to be low.

As a suitable example of the component (B), ethyl acetate and butyl acetate are used in combination, and 0.05 to 0.5 parts by weight, preferably 0.07 to 0.4, of butyl acetate is used per 1 part by weight of ethyl acetate. Part by weight, more preferably 0.1 to 0.3 parts by weight may be satisfied. By using ethyl acetate and butyl acetate together in such a ratio, it becomes possible to form a film at an appropriate film formation rate when applied to the skin.

In the film-forming external preparation of the present invention, the content of the component (B) is not particularly limited, and may be appropriately set according to the type of the component (B), the film-forming rate to be provided, and the like. 25 to 65% by weight, preferably 25 to 60% by weight, more preferably 30 to 55% by weight, still more preferably 33 to 52% by weight.

In the film-forming external preparation of the present invention, the ratio of the component (B) to the component (A) may be appropriately set within a range satisfying the respective contents of these two components. For example, the component (A) The amount of the component (B) is 0.2 to 10 parts by weight per 1 part by weight.

As a ratio of the component (B) to the component (A), the component (B) is preferably 0.3 to 5 parts by weight, more preferably 1 part by weight of the component (A), from the viewpoint of obtaining even more excellent coatability. Is 0.4 to 3 parts by weight, more preferably 0.5 to 2 parts by weight, and particularly preferably 0.6 to 1.5 parts by weight.

(C) Nitrocellulose The film-forming external preparation of the present invention contains nitrocellulose as the component (C). Nitrocellulose serves as a base for the film that forms on the skin.

The nitrocellulose used in the present invention is not particularly limited in its molecular weight, nitrogen content and the like as long as it can form a film on the skin.

Further, in the film-forming external preparation of the present invention, pyroxylin can be used as the nitrocellulose. Pyroxyline is one in which nitrocellulose is moistened with a solvent, and specific examples thereof include a mixture of about 70% by weight of nitrocellulose and about 30% by weight of isopropanol. In the present invention, commercially available pyroxylin can be used as the component (C). Specific examples of commercially available pyroxylin include T.I. N. C. Industrial Co. , RS 1/32 sec, RS 1/16 sec, RS 1/8 sec, RS 1/8 L sec, RS 1/8 H sec, RS 1/4 sec, RS 1/4 H sec, RS 1/2 sec, RS 1 sec, RS 5-6 sec, RS 10-15 sec, RS 15-20 sec, RS 30-40 sec, RS 60-80 sec, RS 120 sec, RS 150 sec, RS 300 sec. , RS 500 sec, RS 800 sec, RS 1200 sec, RS 2000 sec; RS 1/16, RS 1/8, RS 1/4, RS 1/2, RS 1, RS 2, RS 5 manufactured by Korea CNC Ltd. , RS 7, RS 20, RS 60, RS 120, RS 500, RS 1000, RS 2000 and the like. These may be used alone or in combination of two or more. In the present invention, when pyroxylin is used as the component (C), the monohydric alcohol having 1 to 4 carbon atoms contained in the pyroxylin constitutes a part of the component (A).

In the film-forming external preparation of the present invention, the content of the component (C) is not particularly limited as long as it can form a film on the skin, but is, for example, 3.5 to 14% by weight, preferably 5 to 11% by weight, and more preferably 7 to 9.5% by weight.

(D) Tocopherols The film-forming external preparation of the present invention contains tocopherols as the component (D). By containing the component (D), the skin-forming external preparation can be thickened, thereby allowing a sufficient amount of liquid to be retained even with a small brush, and as a result, a sufficient amount can be applied with one application. It is possible to obtain excellent coating properties. The tocopherols are at least one of tocopherol and a derivative of tocopherol.

Tocopherol is a known ingredient also known as Vitamin E. The tocopherol used in the present invention may be in a d-form or a dl-form, and may have any of α, β, γ and δ structures. As the tocopherol used in the present invention, specifically, d-α-tocopherol, d-β-tocopherol, d-γ-tocopherol, d-δ-tocopherol, 1-α-tocopherol, 1-β-tocopherol, Examples thereof include l-γ-tocopherol, l-δ-tocopherol, and a mixture thereof such as dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol and dl-δ-tocopherol.

The derivative of tocopherol is a component having the same skeleton as tocopherol and obtained by adding a substituent to tocopherol.

Like the tocopherol, the derivative of tocopherol used in the present invention may be in the d-form or the dl-form, and may be in the structure of α, β, γ or δ.

The derivative of tocopherol is not particularly limited as long as it is pharmaceutically acceptable, and examples thereof include an ester of tocopherol and an organic acid. Specific examples of the ester of tocopherol and organic acid include tocopherol acetate ester, tocopherol nicotinate ester, tocopherol succinate ester, and tocopherol linolenic acid ester. These tocopherol derivatives may be used alone or in combination of two or more.

These components (D) are not particularly limited in their raw materials, production methods, purification methods, etc., and those isolated and purified by themselves from animals or the like may be used, or commercially available products may be used. Commercially available products of the component (D) are manufactured or sold by Riken Vitamin Co., Ltd., Eisai Co., Ltd., Eisai Food Chemical Co., Ltd., DSM Nutrition Japan Co., Ltd., Tama Seikagaku Co., Ltd., Okami Kagaku Co., Ltd., etc. The products are listed.

Among these components (D), tocopherol derivatives are preferable, and tocopherol acetate ester is more preferable, from the viewpoint of obtaining even more excellent coatability.

In the film-forming external preparation of the present invention, the content of the component (D) is not particularly limited and may be appropriately set according to the thickening effect to be imparted, for example, 0.01 to 10% by weight. , Preferably 0.1 to 5% by weight, more preferably 0.5 to 4% by weight, particularly preferably 1 to 3% by weight.

As a ratio of the component (D) to the component (C), the component (D) is preferably used, and preferably 0.01 to 1 part by weight, per 1 part by weight of the component (C) from the viewpoint of obtaining further excellent coatability. , More preferably 0.05 to 0.5 parts by weight, and further preferably 0.1 to 0.3 parts by weight.

Other Components The film-forming external preparation of the present invention may further contain a solvent such as water, acetone, ethyl methyl ketone, diethyl ether or the like, if necessary, within a range that does not impair the effects of the present invention. However, a solvent other than the components (A) and (B) may impair the transparency of the coating or may easily cause clouding or gelation of the coating due to contact with water. When blending a solvent other than the component and the component (B), it is necessary to consider such characteristics. In addition, diethyl ether requires caution in handling during production due to its ignitability due to its high volatility, and can also cause solidification due to drying during storage, a characteristic odor, etc. When blending ether, it is required to consider such characteristics. The content of the solvent other than the components (A) and (B) in the film-forming external preparation of the present invention is, for example, preferably about 4% by weight or less, particularly about 2% by weight or less.

Furthermore, the film-forming external preparation of the present invention may optionally contain a medicinal component other than the component (D) within a range that does not impair the effects of the present invention. Such medicinal ingredients include, for example, anti-inflammatory agents, local anesthetics, analgesics, antihistamines, bactericides, antifungal agents, vitamins, moisturizers, whitening agents, tissue repair agents, skin protectants, keratin softeners. , Topical stimulants, antipruritics, astringents, ultraviolet protective agents, silicone gels, herbal medicine extracts, amino acids, minerals and the like.

In addition, the film-forming external preparation of the present invention is a thickening agent other than the component (D), a buffering agent, a chelating agent, an antioxidant, a stabilizer, if necessary, within a range that does not impair the effects of the present invention. , Emulsifiers, plasticizers, preservatives, fragrances, cooling agents, colorants, dispersants, superplasticizers, thickeners, adsorbents, moisturizers, humectants, moisturizers, antistatic agents, etc. May be included.

The plasticizer is not particularly limited as long as it is pharmaceutically acceptable, but includes, for example, vegetable oils, esters of mono-, di- or tricarboxylic acids having 5 to 22 carbon atoms and monohydric alcohols having 1 to 9 carbon atoms, terpenoids. , Polyhydric alcohols, glycerin fatty acid esters, mineral oils, polyethers, polyesters, etc., preferably vegetable oils, esters of mono-, di- or tricarboxylic acids having 5 to 22 carbon atoms and monohydric alcohols having 1 to 9 carbon atoms. , Terpenoids, and more preferably terpenoids.

As the vegetable oil, specifically, castor oil, cottonseed oil, soybean oil, sesame oil, almond oil, fennel oil, corn oil, olive oil, orange oil, chamomile oil, cinnamon oil, wheat malt oil, safflower oil, perilla oil , Citronella oil, ginger oil, spearmint oil, rice oil, clove oil, camellia oil, turpentine oil, spruce oil, rapeseed oil, peppermint oil, cedar oil, sunflower oil, bergamot oil, coconut oil, eucalyptus oil, peanut oil, Examples include lavender oil, egg yolk oil, lemon oil, rose oil, funnel oil, and chamomile oil. These vegetable oils may be used alone or in combination of two or more.

Specific examples of the ester of mono-, di- or tricarboxylic acid having 5 to 22 carbon atoms and monohydric alcohol having 1 to 9 carbon atoms include isopropyl palmitate, isopropyl myristate, isopropyl stearate, ethyl linoleate and linoleic acid. Isopropyl, dimethyl phthalate, diethyl phthalate, dipropyl phthalate, dibutyl phthalate, dioctyl phthalate, diisobutyl adipate, diisopropyl adipate, diisononyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dibutyl sebacate, Examples include triethyl citrate, tributyl citrate, acetyl tributyl citrate and the like. These esters may be used alone or in combination of two or more.

Specific examples of the terpenoid include camphor, menthol, borneol, cineol, anethole, limonene, eugenol, geraniol, peppermint oil and the like, and camphor is preferable. These terpenoids may be used alone or in combination of two or more.

These plasticizers may be used alone or in combination of two or more.

When the plasticizer is contained in the film-forming external preparation of the present invention, the content thereof is not particularly limited and may be, for example, more than 0% by weight and 10% by weight or less. From the viewpoint of obtaining a more excellent effect of improving the release of the active ingredient, it is preferably more than 0% by weight and 6% by weight or less, more preferably 0.5 to 3% by weight, further preferably 0.5 to 2% by weight. ..

Formulation Form The form of the skin cleansing composition of the present invention is not particularly limited as long as it is a viscous liquid at room temperature, that is, a semisolid form (gel form, paste form). Since the skin cleansing composition of the present invention is effectively thickened, it is possible to hold a sufficient amount of liquid even with a small brush, and as a result, an excellent application capable of applying a sufficient amount with one application. Makes it possible to gain sex.

The specific viscosity of the skin cleansing composition of the present invention is preferably 5000 to 15000 mPa·s, more preferably 5500 to 13000 mPa·s, and further preferably 6000 to 12000 mPas, from the viewpoint of obtaining even better coatability. .S, particularly preferably 7,000 to 11,000 mPa.s. Here, the viscosity is a value measured by a B-type viscometer (spindle No. 3, 12 rpm) at 20 to 22°C.

Method for producing film-forming external preparation The film-forming external preparation of the present invention comprises the above components (A) to (D) and, if necessary, the above-mentioned other solvent, medicinal components, additives and the like in desired amounts. It is prepared by

Method of using the film-forming external preparation The film-forming external preparation of the present invention is a small brush designed to have a predetermined size attached to a container (the length from the base end to the tip of the brush portion is 11 to 13 mm, the tip is It is used as a so-called liquid adhesive plaster by applying it to a skin site with a width of 1.5 to 4.5 mm). The film-forming external preparation of the present invention is thickened so as to maintain a sufficient amount of liquid even with a small brush, and it is possible to obtain excellent coatability capable of applying a sufficient amount even with a single application, and thus small. It is used by applying to a skin site suitable for application with a brush.

On the skin site to which the film-forming external preparation of the present invention is applied, a sufficient amount can be applied even with one application, so that a film having a sufficient thickness can be easily formed, and thereby the skin site can be well protected. ..

The skin site to which the film-forming external preparation of the present invention is applied may be a skin site suitable for application with a small brush, for example, a skin site having a relatively complex surface shape or a skin having a relatively small wound. Parts. More specifically, examples of the skin site to which the film-forming external preparation of the present invention is applied include limbs, more preferably fingers. In particular, since the fingers of the hand often move on a daily basis and are easily exposed to various external factors, when applied to the fingers of the hand, even a single coating forms a film of sufficient thickness, and It is preferable that the film is not broken by external factors or external factors, and that a better protective effect can be obtained.

Further, as the skin site to which the film-forming external preparation of the present invention is applied, a wound site of skin is also preferably mentioned. Examples of the wound area of the skin include cracks, cracks, cuts, peels, and other areas where irritation is caused by thinning or loss of the stratum corneum. At these sites, when the film-forming external preparation is applied, irritation due to a solvent or physical irritation due to the application action is inevitably felt. Since the film-forming external preparation of the present invention can be applied in a sufficient amount even with one coating, it is not necessary to repeatedly coat it. That is, when it is applied to a wounded part of the skin, it is preferable in that the irritation at the time of application can be minimized without repetitive irritation and pain can be reduced. In particular, the fingers of the hand are not only susceptible to wounds due to external factors, but are also more susceptible to pain at the wound site. For this reason, when applied to a wound of a finger of a hand, it is more preferable from the viewpoint of reducing pain by minimizing irritation at the time of application.

Container The film-forming external preparation of the present invention is contained in a container provided with a brush designed to have a predetermined size. The container has a container main body and a lid portion including an application member that enters the inside of the container main body. The material of the container body is not particularly limited, and examples thereof include metals and resins. From the viewpoint of stability of the contained preparation, metal is preferable. The lid may be configured to be able to seal the opening of the container body. The material of the lid is not particularly limited, but is preferably resin from the viewpoint of hermeticity.

FIG. 1 shows an example of a lid portion provided with a coating member. As shown in FIG. 1, the lid 10 is provided with a coating member 20. The coating member 20 has a handle portion 21 and a brush portion 22 provided at an end portion (one end) of the handle portion 21, and the other end of the handle portion 21 has an opening portion of the container body of the lid portion 10. It is fixed to the inner wall that opposes. This allows the application member 20 to enter the inside of the container body when the lid is closed, and the brush portion 22 of the application member 20 is impregnated in the film-forming external preparation inside the container body.

The brush unit 22 is configured such that a hair bundle is fixed to one end of the handle unit 21. The bristles of the brush part 22 and the handle 21 may be made of different materials (for example, different resins), and the root of the bunch may be embedded (planted) in one end of the handle 21 and fixed. The bunch of the brush portion 22 and the handle portion 21 may be integrally molded with resin. As for the size of the brush portion 22, the length L from the base end (fixed end of the hair bundle) to the tip (free end of the hair bundle) is 11 to 13 mm and the width of the tip (free end width of the hair bundle) W1 in front view. Is designed to be 1.5 to 4.5 mm. Preferably, the length L from the base end to the tip is designed to be 11.5 to 12.5 mm, and the tip width W1 is designed to be 1.8 to 4.2 mm. In the present invention, the tip width W1 refers to the tip width in a dry state where the brush portion does not hold the film-forming external preparation. A brush of such a small size, by nature, cannot hold a sufficient amount of liquid because it can hold a small amount of liquid. However, since the film-forming external preparation of the present invention is effectively thickened, even a brush designed to have such a small size can hold a sufficient amount of liquid, and as a result, Therefore, it becomes possible to obtain excellent coating properties that a sufficient amount can be coated with one coating.

Further, in a front view, the base end width (fixed end width of the hair bundle) W2 of the brush portion 22 is, for example, 1.5 to 5.5 mm, and preferably 2.5 to 5.2 mm. Further, it is preferable that the tip width W1 is configured to be narrower than the base width W2 from the viewpoint of facilitating application to a finer portion. Each of the bristles forming the bunch may be arranged in a single row over the base width W2 of the brush portion, or may be arranged in a plurality of rows overlapping in the side-viewing direction so that the total number of bristles. May be increased. From the viewpoint of facilitating application even to a finer portion, it is more preferable that each of the hairs forming the hair bundle is arranged in a line over the base width W2. Also in this case, since the total number of hairs constituting the hair bundle is small, the amount of liquid that can be retained is originally small, and a sufficient amount cannot be applied by one application. However, since the film-forming external preparation of the present invention is effectively thickened, a sufficient amount of liquid is retained even if the total number of hairs forming the hair bundle of the brush portion 22 is small. As a result, it becomes possible to obtain excellent coatability capable of coating a sufficient amount with one coating.

2. Method for thickening film-forming external preparation As described above, tocopherol acids are composed of monohydric alcohol having 1 to 4 carbon atoms, monocarboxylic acid having 2 to 4 carbon atoms and monohydric alcohol having 1 to 5 carbon atoms. A film-forming external preparation containing ester and nitrocellulose is attached to a container containing the film-forming external preparation, and a small brush (the length from the base end to the tip is 11 to 13 mm, the tip width is 1 0.5 to 4.5 mm), the viscosity can be increased to the extent that excellent coating properties can be obtained. Therefore, the present invention further includes (A) a monohydric alcohol having 1 to 4 carbon atoms, (B) an ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms, and (C ) Containing nitrocellulose; housed in a container having a container body and a lid portion having a coating member that enters the container body, the coating member being provided at a handle portion and an end portion of the handle portion. A film-forming external preparation having a brush part and having a length from the base end to the tip of the brush part of 11 to 13 mm and a tip width of 1.5 to 4.5 mm; (D) tocopherol And/or a derivative thereof are provided, to provide a method for thickening a film-forming external preparation.

In the present invention, thickening a film-forming external preparation means that a film-forming external preparation containing the components (A), (B), and (C) does not contain the component (D). On the other hand, it means increasing the viscosity to such an extent that excellent coatability can be obtained with a small brush (the length from the base end to the tip is 11 to 13 mm, and the tip width is 1.5 to 4.5 mm). The viscosity at which excellent coating properties can be obtained is, as shown in the examples, a viscosity at which a sufficient amount can be coated with one coating to form a thick film, and preferably a viscosity of about 5000 to 15000 mPa·s. Say.

In the method for thickening the film-forming external preparation, the types and amounts of the components to be used, the form of the film-forming external preparation, the method of use, etc. are as shown in the section “1. Film-forming external preparation”. Is.

Hereinafter, the present invention will be described more specifically with reference to Examples, but the present invention is not limited thereto.

Test example 1
[Preparation of film-forming external preparation]
A film-forming external preparation having the composition shown in Table 1 was prepared. Specifically, the components (A) and (D) are mixed by stirring, the component (C) is added and dispersed therein, and then the component (B) is added and uniformly dissolved by stirring to form a film. An external preparation was obtained. Pyroxyline was used as the nitrocellulose, and the nitrocellulose in the pyroxylin was adjusted to the blending amount shown in the table. As the tocopherol acetate, tocopherol acetate was used in the Japanese Pharmacopoeia.

[Measurement of viscosity]
53.3 g of each prepared film-forming external preparation was filled in a screw tube SV-50A (outer diameter 40 mm, total height 75 mm, manufactured by Maru-M). With a Brookfield B type viscometer (LVDV-II+), spindle No. 3 was used to measure the viscosity of each film-forming external preparation in the screw tube. The measurement conditions were a temperature of 20 to 22° C. and a rotation speed of 12 rpm, and the viscosity was measured 3 minutes after the start of measurement. The results are shown in Table 1.

[Evaluation of coating properties]
A coating member (coating member A) having a handle portion and a brush portion provided on the end portion (one end) of the handle portion was prepared. The size of the brush portion of the coating member A is 12 mm in the length from the base end to the tip (corresponding to the length L in FIG. 1) and 2 mm in the tip width (corresponding to the tip width W1 in FIG. 1) in a front view. The base width (corresponding to the base width W2 in FIG. 1) is 2 mm. Further, in the coating member A, the hair bundle of the brush portion and the handle portion are made of different resins, the root of the hair bundle is embedded (planted) at one end of the handle portion, and the hair bundle of the brush portion is viewed from the side. It is designed to be fixed in a manner arranged in multiple rows in the direction. The brush portion of the coating member was sufficiently impregnated into each film-forming external preparation filled in the screw tube.

(Evaluation 1: coating amount of one coating)
The brush portion of the application member was pulled out from the film-forming external preparation and applied to the surface of the membrane in a single coating. It should be noted that the one-time application means application by moving the brush part only once in one direction. The same coating was applied 3 times for each film-forming external preparation, and the membranes before and after the coating were weighed by an electronic balance in each of the 3 times, and the difference was averaged to derive the coating amount by one coating. The results are shown in Table 1.

(Evaluation 2: One-coat film state)
The brush part of the application member was pulled up from the film-forming external preparation, and applied to the nail root part of the finger by one application. It should be noted that the one-time application means application by moving the brush part only once in one direction. The state of the coating film after coating was visually observed and judged based on the following criteria. That is, it was evaluated that the thicker the obtained film, the better the film state. The results are shown in Table 1.
⊚: A thick film was obtained.
◯: A slightly thick film was obtained.
Δ: Only a thin film was obtained.
X: No film was obtained.

As is clear from Table 1, in the film-forming external preparation containing the components (A), (B) and (C) (Comparative Example 1), when the film component nitrocellulose was not included (Comparative Example 3). Although a thickening was recognized as compared with the above, the degree of such thickening did not provide excellent coating properties such that a single coating with a small-sized brush could apply a sufficient amount. On the other hand, in the film-forming external preparations (Examples 1 and 2) in which the component (A), the component (B) and the component (C) are further mixed with the tocopherol acetate which is the component (D), the tocopherol acetate ester is used. Although not a thickening component itself (Comparative Example 2), a remarkable thickening effect was observed. Therefore, the coating amount of one coating was remarkably increased, and the film state was also remarkably improved.

Test example 2
The coating property was evaluated in the same manner as in Test Example 1 except that the coating member B was used instead of the coating member A. The size of the brush portion of the coating member B is 12 mm in the length from the base end to the tip (corresponding to the length L in FIG. 1) and the tip width (corresponding to the tip width W1 in FIG. 1) is 4 mm in a front view. The base end width (corresponding to the base end width W2 in FIG. 1) is 5 mm. Further, the coating member B is designed such that the hair bundle and the handle are integrally molded of resin, and the hairs forming the hair bundle are arranged in a line over the base end width of the brush portion. According to the film-forming external preparations of Examples 1 and 2, a remarkable increase in the coating amount of one coating and a remarkable improvement in the film state were also observed.

Claims (5)

(A) Monohydric alcohol having 1 to 4 carbon atoms, (B) Ester of monocarboxylic acid having 2 to 4 carbon atoms and monohydric alcohol having 1 to 5 carbon atoms, (C) Nitrocellulose, and (D) Tocopherol And/or a derivative thereof,
The container is housed in a container having a container body and a lid part having a coating member that enters the container body, and the coating member has a handle portion and a brush portion provided at an end of the handle portion. A film-forming external preparation, characterized in that the length from the base end to the tip of the brush part is 11 to 13 mm and the tip width is 1.5 to 4.5 mm. The film-forming external preparation according to claim 1, which is used for application to fingers of a hand. The film-forming external preparation according to claim 1 or 2, which is used for application to a wound area of skin. The film-forming external preparation according to any one of claims 1 to 3, which has a viscosity of 5,000 to 15,000 mPa·s. (A) monohydric alcohol having 1 to 4 carbon atoms, (B) ester of monocarboxylic acid having 2 to 4 carbon atoms and monohydric alcohol having 1 to 5 carbon atoms, and (C) nitrocellulose,
The container is housed in a container having a container body and a lid part having a coating member that enters the container body, and the coating member has a handle portion and a brush portion provided at an end of the handle portion. And, in the film-forming external preparation, wherein the length from the base end to the tip of the brush part is 11 to 13 mm and the tip width is 1.5 to 4.5 mm,
(D) A method of thickening a film-forming external preparation, which comprises adding tocopherol and/or a derivative thereof.

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