US20180311147A1 - Self-adhesive film for teeth - Google Patents
Self-adhesive film for teeth Download PDFInfo
- Publication number
- US20180311147A1 US20180311147A1 US16/025,702 US201816025702A US2018311147A1 US 20180311147 A1 US20180311147 A1 US 20180311147A1 US 201816025702 A US201816025702 A US 201816025702A US 2018311147 A1 US2018311147 A1 US 2018311147A1
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- US
- United States
- Prior art keywords
- process according
- carboxymethyl cellulose
- copolymer
- mixture
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Definitions
- the present invention relates to film-shaped preparations which are pressure-sensitive adhesive to teeth, gums or the oral mucosa and which are suitable for cosmetic or medical treatment of the teeth, especially the tooth necks, and of the gums.
- the present invention relates to a process for the manufacture of such film-shaped preparations.
- Products for cleaning one's mouth and for active substance delivery having the form of pastes, creams or mouth rinses have long since been known and have been available on the market. These products include tooth pastes and creams which have a cleaning effect, protect against caries, are desensitizing, or have a bleaching effect. Also known are creams, gels and ointments that are applied in the oral region for treating local illnesses and disorders such as anti-inflammatory remedies, analgesic remedies and/or tonics.
- film-shaped, flat-shaped or strip-shaped oral application forms too, have been commercially available and are used for cosmetic or therapeutic purposes.
- application forms include, for example, the Listerine Pocket-Paks® by Pfizer or the “Teeth Whitestrips” by Procter & Gamble.
- Such application forms are as a rule based on films made up of water-soluble polymers which on use disintegrate rather quickly and are therefore not suitable for a longer-lasting treatment.
- a disadvantage here is that there are limitations to preparing a completely dissolved formulation of lipophile, poorly water-soluble active substances or of active substances that are sensitive to water.
- the object of the present invention was thus to provide a mono- or multilayered, water-soluble or at least partially water-swellable film-shaped material which has good adhesion to teeth, gums or the oral mucosa, which is suitable as active substance carrier, and which does not already disintegrate with in a few seconds. More particularly, the object is to provide a film-shaped material of the afore-mentioned type which enables administration of water-insoluble or water-sensitive active substances.
- This object is achieved by providing a mono or multilayered, pressure-sensitive-adhesive, film-shaped preparation which contains at least one polymethyl vinyl ether-maleic acid anhydride copolymer, polyvinyl acetate and/or at least one copolymer of the polyvinyl acetate with vinyl alcohol esters of fatty acids, as well as at least one cosmetic and/or pharmaceutical active substance.
- the content of polymethyl vinyl ether-maleic acid anhydride copolymer in the film-shaped, pressure sensitive adhesive preparations is 5 to 35%-wt.
- the content of polyvinyl acetate and/or of the copolymer(s) of the polyvinyl acetate with vinyl alcohol esters of fatty acids in the film-shaped, pressure-sensitive-adhesive preparations preferably amounts to 4 to 35%-wt.
- the film-shaped, pressure-sensitive adhesive preparations in addition have a content of at least one cosmetic and/or pharmaceutical active substance which is determined by the nature of the illness or by the cosmetic needs.
- the active substance is preferably a poorly water-soluble active substance or a water-sensitive active substance.
- poorly water-soluble active substances is understood to mean such active substances as have a solubility in water of less than 1 g/l. These include, for example, griseofulvin, estradiol and vitamin D 3 .
- the water-sensitive active substances include those active substances, the aqueous solution of which looses more than 0.1% of its active substance content within 24 hours at room temperature due to decomposition of the active substance.
- the water-sensitive active substances include, for example, acetylsalicylic acid andiodine.
- the film-shaped, pressure-sensitive adhesive preparation in addition contains carboxymethyl cellulose and/or one of its salts.
- the content of carboxymethyl cellulose or of one of its salts in the preparation amounts to 5 to 35%-wt.
- the various, water-soluble and/or water-swellable polymers are mixed with at least one active substance in solutions containing organic solvents as main component. This mixture is used to coat a substrate, and the coated substrate is dried, optionally by application of heat.
- the content of polymethyl vinyl ether-maleic acid anhydride copolymer is preferably 5 to 35%-wt., and the content of polyvinyl acetate and/or the copolymer(s) of the polyvinyl acetate with vinyl alcohol esters of fatty acids is preferably 4 to 35%-wt., in each case relative to the solids content.
- polymethyl vinyl ether-maleic acid anhydride copolymers sold under the name of Gantrez by the firm of ISP, and the polyvinyl acetates designated as 0 VINNAPAS or their copolymers with vinyl alcohol esters of fatty acids of the firm of Wacker Polymer Systems, Burghausen, have proved to be particularly suitable in accordance with the present invention.
- any solvents which dissolve the polymethyl vinyl ether-maleic acid anhydride copolymers and polyvinyl acetate or its copolymers with vinyl alcohol esters of fatty-acids may be used as the organic solvents which, in the method according to the invention, are contained in the solution as the main component thereof.
- these organic solvents those are used with preference which also mix with water since by adding small amounts of water; e.g. of 1 to 5%-wt., the dissolving power for the polymers and the active substance/active substances can be adapted to the given requirements.
- Particular preference is given to those organic solvents which permit addition of the active substance dissolved in ethanol or in an ethanol-water mixture.
- the especially preferred organic solvent is selected from the group comprising methyl ethyl ketone, ethyl acetate, ethanol, acetone and mixtures thereof.
- the consistency and/or tackiness of the resultant film-shaped preparations can be adapted to the demands placed on the product by altering the mixing ratio of ethanol and methyl ethyl ketone.
- Solvent mixtures containing an ethanol portion of 5 to 20%-wt., relative to the total solvent, have proved advantageous.
- carboxymethyl cellulose and/or at least one of its salts is added to the polymer mixture.
- carboxymethyl cellulose or at least one of its salts, relative to the solids content is added to the polymer mixture.
- At least one polymethyl vinyl ether-maleic acid anhydride copolymer and polyvinyl acetate and/or at least one copolymer of the vinyl acetate with vinyl alcohol esters of fatty acids, together with at least one active substance and, optionally, carboxymethyl cellulose and/or at least one of its salts, are mixed in a solution containing one or several organic solvents as its main component.
- the resultant compound is applied in liquid form to a support and freed from the solvent mixture, so that a film having a layer thickness of 4 to 2000 pm, preferably 40 to 500 pm, and particularly preferably 60 to 250 pm, is obtained.
- Multilayer, pressure-sensitive-adhesive film-shaped preparations with which it is possible to achieve, for example, an improved adhesion of the preparation to teeth, can be prepared, for example, by hot lamination, by coating already existent layers with further solvent-containing compounds, as described hereinabove in connection with the manufacture of a monolayer film, or by other processes known to those skilled in the art.
- Pieces having a size appropriate to the respective given purposes are then punched out from the film or laminate.
- the process according to the present invention results in film-shaped preparations which adhere to teeth, gums or the oral mucosa, which do not already disintegrate within a few seconds, and by means of which water-insoluble and even water-sensitive active substances can be administered. These preparations may advantageously be utilized for medical or cosmetic treatments.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
Abstract
Description
- This application is a divisional of U.S. patent application Ser. No. 11/664,949, filed Apr. 9, 2007, which is a National Stage application of International Patent Application No. PCT/EP2005/010749, filed Oct. 6, 2005, which claims priority to German Patent Application No. DE 10 2004 049 740.0 filed Oct. 13, 2004. Each of U.S. patent application Ser. No. 11/664,949; International Patent Application No. PCT/EP2005/010749; and German Patent Application No. DE 10 2004 049 740.0 are hereby incorporated by reference herein in their entirety.
- The present invention relates to film-shaped preparations which are pressure-sensitive adhesive to teeth, gums or the oral mucosa and which are suitable for cosmetic or medical treatment of the teeth, especially the tooth necks, and of the gums. In addition, the present invention relates to a process for the manufacture of such film-shaped preparations.
- Products for cleaning one's mouth and for active substance delivery having the form of pastes, creams or mouth rinses have long since been known and have been available on the market. These products include tooth pastes and creams which have a cleaning effect, protect against caries, are desensitizing, or have a bleaching effect. Also known are creams, gels and ointments that are applied in the oral region for treating local illnesses and disorders such as anti-inflammatory remedies, analgesic remedies and/or tonics.
- For some years, film-shaped, flat-shaped or strip-shaped oral application forms, too, have been commercially available and are used for cosmetic or therapeutic purposes. These application forms include, for example, the Listerine Pocket-Paks® by Pfizer or the “Teeth Whitestrips” by Procter & Gamble. Such application forms are as a rule based on films made up of water-soluble polymers which on use disintegrate rather quickly and are therefore not suitable for a longer-lasting treatment.
- In addition, products are known that consist of several layers, such as those disclosed in U.S. Pat. No. 6,582,708, which, however, include only one flexible layer and which, due to their overall thickness of up to 3 mm, are disturbing and unpleasant in the mouth.
- The recipes and methods used in the manufacture of the known film-shaped application forms, for the most part, start from water or from water-containing alcoholic polymer solutions. A disadvantage here is that there are limitations to preparing a completely dissolved formulation of lipophile, poorly water-soluble active substances or of active substances that are sensitive to water.
- The object of the present invention was thus to provide a mono- or multilayered, water-soluble or at least partially water-swellable film-shaped material which has good adhesion to teeth, gums or the oral mucosa, which is suitable as active substance carrier, and which does not already disintegrate with in a few seconds. More particularly, the object is to provide a film-shaped material of the afore-mentioned type which enables administration of water-insoluble or water-sensitive active substances.
- This object is achieved by providing a mono or multilayered, pressure-sensitive-adhesive, film-shaped preparation which contains at least one polymethyl vinyl ether-maleic acid anhydride copolymer, polyvinyl acetate and/or at least one copolymer of the polyvinyl acetate with vinyl alcohol esters of fatty acids, as well as at least one cosmetic and/or pharmaceutical active substance.
- Preferably, the content of polymethyl vinyl ether-maleic acid anhydride copolymer in the film-shaped, pressure sensitive adhesive preparations is 5 to 35%-wt.
- The content of polyvinyl acetate and/or of the copolymer(s) of the polyvinyl acetate with vinyl alcohol esters of fatty acids in the film-shaped, pressure-sensitive-adhesive preparations preferably amounts to 4 to 35%-wt. The film-shaped, pressure-sensitive adhesive preparations in addition have a content of at least one cosmetic and/or pharmaceutical active substance which is determined by the nature of the illness or by the cosmetic needs. The active substance is preferably a poorly water-soluble active substance or a water-sensitive active substance.
- It should be appreciated that the term “poorly water-soluble active substances” is understood to mean such active substances as have a solubility in water of less than 1 g/l. These include, for example, griseofulvin, estradiol and vitamin D3.
- The water-sensitive active substances include those active substances, the aqueous solution of which looses more than 0.1% of its active substance content within 24 hours at room temperature due to decomposition of the active substance. The water-sensitive active substances include, for example, acetylsalicylic acid andiodine.
- In a particularly preferred embodiment, the film-shaped, pressure-sensitive adhesive preparation in addition contains carboxymethyl cellulose and/or one of its salts. The content of carboxymethyl cellulose or of one of its salts in the preparation amounts to 5 to 35%-wt.
- To manufacture the film-shaped preparations, which are pressure-sensitive adhesive on teeth, gums or the oral mucosa, the various, water-soluble and/or water-swellable polymers are mixed with at least one active substance in solutions containing organic solvents as main component. This mixture is used to coat a substrate, and the coated substrate is dried, optionally by application of heat.
- The advantages of the invention arise especially where mixtures of polymethyl vinyl ether-maleic acid anhydride co-polymers with polyvinyl acetate, or with copolymers of the latter with vinyl alcohol esters of fatty acids are used.
- The content of polymethyl vinyl ether-maleic acid anhydride copolymer is preferably 5 to 35%-wt., and the content of polyvinyl acetate and/or the copolymer(s) of the polyvinyl acetate with vinyl alcohol esters of fatty acids is preferably 4 to 35%-wt., in each case relative to the solids content.
- The polymethyl vinyl ether-maleic acid anhydride copolymers sold under the name of Gantrez by the firm of ISP, and the polyvinyl acetates designated as 0VINNAPAS or their copolymers with vinyl alcohol esters of fatty acids of the firm of Wacker Polymer Systems, Burghausen, have proved to be particularly suitable in accordance with the present invention.
- Any solvents which dissolve the polymethyl vinyl ether-maleic acid anhydride copolymers and polyvinyl acetate or its copolymers with vinyl alcohol esters of fatty-acids may be used as the organic solvents which, in the method according to the invention, are contained in the solution as the main component thereof. Of these organic solvents, those are used with preference which also mix with water since by adding small amounts of water; e.g. of 1 to 5%-wt., the dissolving power for the polymers and the active substance/active substances can be adapted to the given requirements. Particular preference is given to those organic solvents which permit addition of the active substance dissolved in ethanol or in an ethanol-water mixture. The especially preferred organic solvent is selected from the group comprising methyl ethyl ketone, ethyl acetate, ethanol, acetone and mixtures thereof.
- The consistency and/or tackiness of the resultant film-shaped preparations can be adapted to the demands placed on the product by altering the mixing ratio of ethanol and methyl ethyl ketone. Solvent mixtures containing an ethanol portion of 5 to 20%-wt., relative to the total solvent, have proved advantageous.
- To manufacture a preferred embodiment enabling a particularly successful adhesion of the film-shaped preparations on the teeth, gums and/or oral mucosa, carboxymethyl cellulose and/or at least one of its salts is added to the polymer mixture.
- Preferably, 5 to 35%-wt. of carboxymethyl cellulose or at least one of its salts, relative to the solids content, is added to the polymer mixture.
- To manufacture the preparation according to the invention, at least one polymethyl vinyl ether-maleic acid anhydride copolymer and polyvinyl acetate and/or at least one copolymer of the vinyl acetate with vinyl alcohol esters of fatty acids, together with at least one active substance and, optionally, carboxymethyl cellulose and/or at least one of its salts, are mixed in a solution containing one or several organic solvents as its main component. The resultant compound is applied in liquid form to a support and freed from the solvent mixture, so that a film having a layer thickness of 4 to 2000 pm, preferably 40 to 500 pm, and particularly preferably 60 to 250 pm, is obtained.
- Multilayer, pressure-sensitive-adhesive film-shaped preparations, with which it is possible to achieve, for example, an improved adhesion of the preparation to teeth, can be prepared, for example, by hot lamination, by coating already existent layers with further solvent-containing compounds, as described hereinabove in connection with the manufacture of a monolayer film, or by other processes known to those skilled in the art.
- Pieces having a size appropriate to the respective given purposes are then punched out from the film or laminate.
- The process according to the present invention results in film-shaped preparations which adhere to teeth, gums or the oral mucosa, which do not already disintegrate within a few seconds, and by means of which water-insoluble and even water-sensitive active substances can be administered. These preparations may advantageously be utilized for medical or cosmetic treatments.
- 5 g of a 33.3% solution (%-wt.) of a vinyl acetate-based polymer in methyl ethyl ketone and 3 g of a 15% solution (%-wt.) of polymethyl vinyl ether-maleic acid anhydride (=copolymer of methyl vinyl ether and maleic acid anhydride) in ethyl acetate were added together and homogenized. This resulted in a solution which was spread at various coating thicknesses and, subsequently, dried. This yielded flexible films which adhered both to the oral mucosa and to the teeth.
Claims (16)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/025,702 US20180311147A1 (en) | 2004-10-13 | 2018-07-02 | Self-adhesive film for teeth |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004049740.0 | 2004-10-13 | ||
DE102004049740A DE102004049740B4 (en) | 2004-10-13 | 2004-10-13 | Self-adhesive tooth foil and method for producing the dental foil |
PCT/EP2005/010749 WO2006040059A1 (en) | 2004-10-13 | 2005-10-06 | Self-adhesive dental floss |
US66494907A | 2007-04-09 | 2007-04-09 | |
US16/025,702 US20180311147A1 (en) | 2004-10-13 | 2018-07-02 | Self-adhesive film for teeth |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/664,949 Division US10039711B2 (en) | 2004-10-13 | 2005-10-06 | Self-adhesive film for teeth |
PCT/EP2005/010749 Division WO2006040059A1 (en) | 2004-10-13 | 2005-10-06 | Self-adhesive dental floss |
Publications (1)
Publication Number | Publication Date |
---|---|
US20180311147A1 true US20180311147A1 (en) | 2018-11-01 |
Family
ID=35501103
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/664,949 Active 2028-11-29 US10039711B2 (en) | 2004-10-13 | 2005-10-06 | Self-adhesive film for teeth |
US16/025,702 Abandoned US20180311147A1 (en) | 2004-10-13 | 2018-07-02 | Self-adhesive film for teeth |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/664,949 Active 2028-11-29 US10039711B2 (en) | 2004-10-13 | 2005-10-06 | Self-adhesive film for teeth |
Country Status (16)
Country | Link |
---|---|
US (2) | US10039711B2 (en) |
EP (1) | EP1799183B1 (en) |
JP (1) | JP5179184B2 (en) |
KR (1) | KR101168463B1 (en) |
CN (1) | CN101035500B (en) |
AU (1) | AU2005293842B2 (en) |
BR (1) | BRPI0516326B1 (en) |
CA (1) | CA2583574C (en) |
DE (1) | DE102004049740B4 (en) |
ES (1) | ES2410354T3 (en) |
IL (1) | IL182513A (en) |
MX (1) | MX2007004240A (en) |
NZ (1) | NZ554540A (en) |
RU (1) | RU2362541C2 (en) |
WO (1) | WO2006040059A1 (en) |
ZA (1) | ZA200702235B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0922690A2 (en) * | 2008-12-04 | 2016-01-05 | Swedish Pharma Ab | bioadhesive plaster |
US20120244197A1 (en) * | 2009-11-24 | 2012-09-27 | Basf Se | Film-Like Pharmaceutical Dosage Forms |
MX2012008381A (en) * | 2010-01-29 | 2012-08-15 | Colgate Palmolive Co | Dental strip for administration of oral treatment. |
KR101328162B1 (en) * | 2011-06-27 | 2013-11-13 | 조선대학교산학협력단 | fluorine agent of tape type using biodegradable polymers and manufacturing method thereof |
WO2017161408A1 (en) | 2016-03-24 | 2017-09-28 | Sdi Limited | Dental adhesive compositions |
CN105943405B (en) * | 2016-05-05 | 2018-09-11 | 刘玉艳 | It is sustained fluorine ion PPC remineralization films and preparation method thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB785119A (en) * | 1954-09-23 | 1957-10-23 | Distillers Co Yeast Ltd | Pressure sensitive adhesives |
DE1289594C2 (en) * | 1966-10-31 | 1973-10-11 | PRESSURE SENSITIVE, MELT APPLICABLE ADHESIVES | |
DE3407279A1 (en) * | 1984-02-28 | 1985-08-29 | Gebrüder Kömmerling Kunststoffwerke GmbH, 6780 Pirmasens | SELF-ADHESIVE, REDISPENSABLE ADHESIVE MIXTURE AND SELF-ADHESIVE FILM CONTAINING IT TO PROTECT SENSITIVE SURFACES |
JPS61249472A (en) * | 1985-04-27 | 1986-11-06 | 日東電工株式会社 | Bandage in oral cavity and its production |
JPS61249473A (en) * | 1985-04-27 | 1986-11-06 | 日東電工株式会社 | Bandage in oral cavity and its production |
EP0200508B1 (en) * | 1985-04-27 | 1991-10-02 | Nitto Denko Corporation | Adhesive oral bandages and oral pharmaceutical preparations |
JPH0710769B2 (en) * | 1986-04-25 | 1995-02-08 | 日東電工株式会社 | Oral formulation |
JPH062670B2 (en) * | 1986-08-25 | 1994-01-12 | サンスタ−株式会社 | Oral formulation |
JPH062671B2 (en) * | 1986-08-25 | 1994-01-12 | サンスタ−株式会社 | Oral formulation |
US5173317A (en) * | 1991-10-29 | 1992-12-22 | Wm. Wrigley Jr. Company | Gum compositions containing vinyl laurate/vinyl acetate copolymer |
US5747017A (en) | 1995-05-15 | 1998-05-05 | Lip-Ink International | Lip cosmetic |
CN1158249A (en) * | 1996-02-29 | 1997-09-03 | 上海市牙病中心防治所 | Preparation for oral cavity medicine |
US6582708B1 (en) * | 2000-06-28 | 2003-06-24 | The Procter & Gamble Company | Tooth whitening substance |
JPH11240816A (en) | 1998-02-23 | 1999-09-07 | Hironori Oka | Composition for coating tooth |
DE60137568D1 (en) * | 2000-03-17 | 2009-03-19 | Lg Household & Health Care Ltd | PUNCH TO KNOW THE TEETH |
US6946142B2 (en) * | 2001-06-23 | 2005-09-20 | Lg Household & Healthcare Ltd. | Multi-layer patches for teeth whitening |
US6585997B2 (en) * | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
KR100796385B1 (en) * | 2001-12-29 | 2008-01-22 | 에스케이케미칼주식회사 | Thin-Film type Tooth Whitener |
US20040077498A1 (en) * | 2002-07-01 | 2004-04-22 | Lynch John F. | Agricultural seed having protective coatings |
US20050249678A1 (en) | 2004-05-10 | 2005-11-10 | Mahmoud Hassan | Multilayer tooth whitening strips |
-
2004
- 2004-10-13 DE DE102004049740A patent/DE102004049740B4/en not_active Expired - Fee Related
-
2005
- 2005-10-06 US US11/664,949 patent/US10039711B2/en active Active
- 2005-10-06 NZ NZ554540A patent/NZ554540A/en not_active IP Right Cessation
- 2005-10-06 JP JP2007536049A patent/JP5179184B2/en not_active Expired - Fee Related
- 2005-10-06 CA CA2583574A patent/CA2583574C/en not_active Expired - Fee Related
- 2005-10-06 MX MX2007004240A patent/MX2007004240A/en active IP Right Grant
- 2005-10-06 EP EP05794373.0A patent/EP1799183B1/en not_active Not-in-force
- 2005-10-06 ES ES05794373T patent/ES2410354T3/en active Active
- 2005-10-06 BR BRPI0516326-9A patent/BRPI0516326B1/en not_active IP Right Cessation
- 2005-10-06 KR KR1020077010458A patent/KR101168463B1/en active IP Right Grant
- 2005-10-06 RU RU2007113628/15A patent/RU2362541C2/en active
- 2005-10-06 CN CN2005800339857A patent/CN101035500B/en not_active Expired - Fee Related
- 2005-10-06 AU AU2005293842A patent/AU2005293842B2/en not_active Ceased
- 2005-10-06 WO PCT/EP2005/010749 patent/WO2006040059A1/en active Application Filing
-
2007
- 2007-03-16 ZA ZA2007/02235A patent/ZA200702235B/en unknown
- 2007-04-12 IL IL182513A patent/IL182513A/en active IP Right Grant
-
2018
- 2018-07-02 US US16/025,702 patent/US20180311147A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0516326A (en) | 2008-09-02 |
ZA200702235B (en) | 2008-03-26 |
IL182513A0 (en) | 2007-09-20 |
MX2007004240A (en) | 2007-06-12 |
KR20070084071A (en) | 2007-08-24 |
AU2005293842B2 (en) | 2010-07-22 |
RU2362541C2 (en) | 2009-07-27 |
US10039711B2 (en) | 2018-08-07 |
US20080286317A1 (en) | 2008-11-20 |
EP1799183A1 (en) | 2007-06-27 |
DE102004049740B4 (en) | 2009-08-27 |
KR101168463B1 (en) | 2012-07-27 |
EP1799183B1 (en) | 2013-04-24 |
IL182513A (en) | 2011-08-31 |
ES2410354T3 (en) | 2013-07-01 |
DE102004049740A1 (en) | 2006-04-20 |
CN101035500A (en) | 2007-09-12 |
NZ554540A (en) | 2010-04-30 |
RU2007113628A (en) | 2008-10-27 |
CN101035500B (en) | 2010-07-28 |
JP2008515944A (en) | 2008-05-15 |
CA2583574A1 (en) | 2006-10-20 |
AU2005293842A1 (en) | 2006-04-20 |
BRPI0516326B1 (en) | 2019-10-01 |
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