JP6775976B2 - Topical preparation for reducing skin friction - Google Patents

Description

The present invention relates to an external preparation for reducing skin friction. More specifically, the present invention relates to an external preparation for reducing skin friction, which can reduce friction on the skin by forming a film on the skin.

In daily life, the skin is stimulated by friction with external objects. Such irritation to the skin not only causes discomfort, but can also cause various symptoms on the skin. For example, as a symptom caused by friction against the skin, there are a symptom such as a rash caused by tightening underwear, a bed sore, and a shoe slip. In addition, when an accessory such as a ring is attached, it may be difficult to attach or detach due to friction with the finger. Therefore, various methods for dealing with problems caused by friction applied to the skin have been conventionally proposed.

For example, Patent Document 1 discloses that shoe rubbing can be prevented by using a foot cover (deformed sock) having a friction imparting body attached to the inner surface of the heel contact portion. However, a body-wearing device such as Patent Document 1 has a drawback that the skin part other than the part that receives physical stimulation due to friction is covered, so that the feeling of use is poor and the part on which the body-wearing tool is worn is bulky. There is.

Further, for example, in Patent Document 2, a seal in which a plurality of strip-shaped tape pieces are stuck and fixed in parallel on an adhesive layer surface formed on one surface of a sheet body at appropriate intervals is provided on a skin portion where shoe rubbing has occurred. It has been reported that by attaching it to the paper, it is possible to prevent the shoes from rubbing. However, a sheet-like material such as Patent Document 2 is inflexible and difficult to apply to a range of motion such as joints, and also has a feeling of tension (feeling that the skin is pulled) at the time of application, which gives a feeling of use. It has the drawback of being bad.

On the other hand, conventionally, a technique for reducing skin friction by directly forming a film on the skin has not been known.

Japanese Unexamined Patent Publication No. 10-292206 Japanese Unexamined Patent Publication No. 2013-275614

An object of the present invention is to provide an external preparation for reducing skin friction that can reduce friction on the skin.

As a result of diligent studies to solve the above problems, the present inventor has come up with a new idea of reducing skin friction by forming a film directly on the skin. Then, as a result of diligent studies on an external preparation that forms a film directly on the skin, at least one alcohol selected from the group consisting of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol, and 2 to 2 carbon atoms. An external preparation containing an ester of a monocarboxylic acid of 4 and a monohydric alcohol having 1 to 5 carbon atoms and nitrocellulose can form a film having a high friction reducing effect on the skin, and is useful as an external preparation for reducing skin friction. I found that. The present inventor has also found that by further adding a specific component such as panthenol to the external preparation, the feeling of tension during use can be reduced and the feeling of use is improved. The present invention has been completed by further studies based on these findings.

That is, the present invention provides the inventions of the following aspects.
Item 1. (A) At least one alcohol selected from the group consisting of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol, (B) monocarboxylic acids having 2 to 4 carbon atoms and monohydric alcohols having 1 to 5 carbon atoms. An external preparation for reducing skin friction, which comprises an ester of (C) and (C) nitrocellulose.
Item 2. The component (A) is at least one selected from the group consisting of ethanol, isopropanol, and benzyl alcohol, and the component (B) is at least one selected from the group consisting of ethyl acetate and butyl acetate. Item 2. The external preparation for reducing skin friction according to Item 1.
Item 3. Further, item 1 or 2 includes (D) at least one selected from the group consisting of glycyrrhizic acids, tocopherols, panthenol, vitamin C, vitamin A, pyridoxines, allantoins, and azulene. The above-mentioned external preparation for reducing skin friction.
Item 4. Item 8. The external preparation for reducing skin friction according to any one of Items 1 to 3, which is for preventing shoe rubbing.

The external preparation for reducing skin friction of the present invention can suppress defects due to friction applied to the skin by forming a film having a high friction reducing effect on the skin.

Further, in a preferred embodiment of the external preparation for reducing skin friction of the present invention, a feeling of tension during use (a feeling of pulling the skin when a film is formed on the skin) can be suppressed, so that the range of motion of joints and the like can be suppressed. Even if it is applied to the range of motion of joints or the like or the foot, it can follow the movement of the body, suppress tearing or peeling, and give a good feeling of use.

The external preparation for reducing skin friction of the present invention contains at least one alcohol selected from the group consisting of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol (hereinafter, may be referred to as component (A)). , An ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms (hereinafter, may be referred to as a component (B)) and nitrocellulose (hereinafter, referred to as a component (C)). It is characterized by containing (may be). Hereinafter, the external preparation for reducing skin friction of the present invention will be described in detail.

(A) Monohydric alcohol having 1 to 4 carbon atoms and / or benzyl alcohol The external preparation for reducing skin friction of the present invention is at least one selected from the group consisting of monohydric alcohol having 1 to 4 carbon atoms and benzyl alcohol. Contains alcohol.

The type of monohydric alcohol having 1 to 4 carbon atoms is not particularly limited, and examples thereof include methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, and tert-butanol.

Among these alcohols, monohydric alcohols and benzyl alcohols having 2 to 4 carbon atoms are preferable, ethanol, isopropanol, n-butanol and benzyl alcohol are more preferable, and ethanol, isopropanol and benzyl alcohol are particularly preferable.

In the external preparation for reducing skin friction of the present invention, as the component (A), one of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol may be used alone, or two or more thereof may be combined. May be used.

From the viewpoint of forming a film having an even more excellent friction reducing action on the skin, a preferred embodiment of the component (A) is a monohydric alcohol having 1 to 4 carbon atoms or a monohydric alcohol having 1 to 4 carbon atoms. And benzyl alcohol; more preferably at least one of ethanol and isopropanol, or at least one of ethanol and isopropanol and benzyl alcohol; particularly preferably a combination of isopropanol and benzyl alcohol. In particular, when a monohydric alcohol having 1 to 4 carbon atoms and a benzyl alcohol are used in combination as the component (A), a film having an even more excellent friction reducing effect can be formed on the skin and with water. It is possible to suppress whitening and gelation of the film due to contact, and it is also possible to have good properties.

When a monovalent alcohol having 1 to 4 carbon atoms and a benzyl alcohol are used in combination as the component (A), the ratio thereof is not particularly limited, but for example, 1 part by weight of the monovalent alcohol having 1 to 4 carbon atoms is used. Benzyl alcohol is 0.05 to 2 parts by weight, preferably 0.05 to 1.25 parts by weight, more preferably 0.05 to 0.77 parts by weight, still more preferably 0.06 to 0.56 parts by weight. Can be mentioned.

The content of the component (A) in the external preparation for reducing skin friction of the present invention is not particularly limited, but is, for example, 10 to 70% by weight, preferably 15 to 65% by weight, and more preferably 18 to 60% by weight. , Especially preferably 25 to 60% by weight. When the component (A) satisfies the above content, it becomes possible to form a film having an even more excellent friction reducing action on the skin. Further, when the component (A) satisfies the content and also contains the component (D) described later, it is possible to more effectively reduce the feeling of tension during use.

(B) Ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms The external preparation for reducing skin friction of the present invention contains a monocarboxylic acid having 2 to 4 carbon atoms and 1 to 5 carbon atoms. Contains an ester of 5 monohydric alcohol. "Ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms" means one molecule of monocarboxylic acid having 2 to 4 carbon atoms and one molecule of monohydric alcohol having 1 to 5 carbon atoms. Is an ester-bonded compound.

The type of monocarboxylic acid having 2 to 4 carbon atoms constituting the ester is not particularly limited, and examples thereof include acetic acid, lactic acid, propionic acid, butyric acid and the like. Among these monocarboxylic acids, a monocarboxylic acid having 2 or 3 carbon atoms is preferable, and acetic acid and lactic acid are more preferable.

The type of monohydric alcohol having 1 to 5 carbon atoms constituting the ester is not particularly limited, but for example, methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, tert. -Butanol, benzyl alcohol, 1-pentanol, 3-methyl-1-butanol, 2-methyl-1-butanol, 2,2dimethyl-1-propanol, 2-pentanol, 3-methyl-2-butanol, 3 -Pentanol and 2-methyl-2-butanol can be mentioned. Among these alcohols, preferred are methanol, ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol, benzyl alcohol, and more preferably ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol. Can be mentioned.

Specific examples of the ester include methyl acetate, ethyl acetate, propyl acetate (n-propyl acetate), isopropyl acetate, butyl acetate (n-butyl acetate), sec-butyl acetate, isobutyl acetate, and pentyl acetate (1-propyl acetate). Pentyl), ethyl lactate, butyl lactate, isoamyl acetate (3-methylbutyl acetate), ethyl butyrate, ethyl propionate and the like. Among these, ethyl acetate, butyl acetate, ethyl lactate are preferable, and ethyl acetate and butyl acetate are more preferable, as the ester from the viewpoint of forming a film having an even more excellent friction reducing action on the skin. Can be mentioned.

In the external preparation for reducing skin friction of the present invention, as the component (B), one of the esters may be used alone, or two or more thereof may be used in combination. For example, by using two or more kinds of esters having different boiling points in combination as the component (B), the film formation rate of the external preparation for reducing skin friction of the present invention can be appropriately adjusted. For example, when the above ester having a boiling point of less than 100 ° C. (for example, ethyl acetate) and the above ester having a boiling point of 100 ° C. or higher (for example, butyl acetate) are used in combination, the ratio of the above ester having a boiling point of less than 100 ° C. is set high. The film formation rate can be increased, and if the ratio of the ester having a boiling point of less than 100 ° C. is set low, the film formation rate can be decreased.

As a preferable example of the component (B), ethyl acetate and butyl acetate are used in combination, and 0.05 to 0.5 parts by weight of butyl acetate, preferably 0.07 to 0.4 parts by weight, is used per 1 part by weight of ethyl acetate. It is possible to satisfy a ratio of parts by weight, more preferably 0.1 to 0.3 parts by weight. By using ethyl acetate and butyl acetate in combination at such a ratio, it becomes possible to form a film at an appropriate film forming rate when applied to the skin.

In the external preparation for reducing skin friction of the present invention, the content of the component (B) is not particularly limited and may be appropriately set according to the type of the component (B), the film forming speed to be provided, and the like. For example, 25 to 65% by weight, preferably 25 to 60% by weight, more preferably 35 to 55% by weight, based on the total amount of the preparation.

In the external preparation for reducing skin friction of the present invention, the ratio of the component (B) to the component (A) may be appropriately set within a range that satisfies each content of both of these components. For example, (A) The ratio of the component (B) to 0.2 to 10 parts by weight per part by weight of the component can be mentioned.

As a ratio of the component (B) to the component (A), the component (B) is preferably 0 per part by weight of the component (A) from the viewpoint of forming a film having an even more excellent friction reducing effect on the skin. The ratio is .4 to 6 parts by weight, more preferably 0.4 to 5 parts by weight, particularly preferably 0.4 to 3.5 parts by weight, and even more preferably 0.6 to 1.8 parts by weight. .. When such a ratio is satisfied, in addition to being able to form a film having an even better friction-reducing effect on the skin, it is possible to suppress whitening and gelation of the film due to contact with water, resulting in good properties. It will also be possible to prepare. Further, when the component (D) described later is contained while satisfying such a ratio, it is possible to further effectively reduce the feeling of tension.

(C) Nitrocellulose The external preparation for reducing skin friction of the present invention contains nitrocellulose. Nitrocellulose serves as a base for the film formed on the skin.

The nitrocellulose used in the present invention is not particularly limited in its molecular weight, nitrogen content and the like as long as it can form a film on the skin.

Further, in the external preparation for reducing skin friction of the present invention, pyroxylin can also be used as the nitrocellulose. Pyroxylin is a solvent in which nitrocellulose is moistened, and specific examples thereof include a mixture of about 70% by weight of nitrocellulose and about 30% by weight of isopropanol. In the present invention, commercially available pyroxylin can also be used as the component (C). Specific examples of commercially available pyroxylin include T.I. N. C. Industrial Co. , Ltd made RS 1/32 sec, RS 1/16 sec, RS 1/8 sec, RS 1/8 L sec, RS 1/8 H sec, RS 1/4 sec, RS 1/4 H sec, RS 1/2 sec, RS 1 sec, RS 5-6 sec, RS 10-15 sec, RS 15-20 sec, RS 30-40 sec, RS 60-80 sec, RS 120 sec, RS 150 sec, RS 300 sec , RS 500 sec, RS 800 sec, RS 1200 sec, RS 2000 sec; RS 1/16, RS 1/8, RS 1/4, RS 1/2, RS 1, RS 2, RS 5 manufactured by Korea CNC Ltd. , RS 7, RS 20, RS 60, RS 120, RS 500, RS 1000, RS 2000 and the like. These may be used individually by 1 type, and may be used in combination of 2 or more type. In the present invention, when pyroxylin is used as the component (C), the monohydric alcohol having 1 to 4 carbon atoms contained in the pyroxylin constitutes a part of the component (A).

In the external preparation for reducing skin friction of the present invention, the content of the component (C) is not particularly limited as long as a film can be formed on the skin, but is preferably 3.5 to 14% by weight, for example. When pyroxylin, which is a mixture of 70% by weight of nitrocellulose and 30% by weight of isopropanol, is used, the pyroxylin content is 5 to 20% by weight, preferably 8 to 16% by weight. ).

(D) Ingredients that reduce the tension of the film formed on the skin The external preparation for reducing skin friction of the present invention contains glycyrrhizic acids, tocopherols, and panthenol in addition to the above components (A) to (C). , Vitamin Cs, Vitamin As, Pyridoxines, Allantoins, and Azulene may contain at least one selected from the group (hereinafter, may be referred to as component (D)). By containing these (D) components, it is possible to reduce the feeling of tension caused by the film formed on the skin, and even if it is applied to the range of motion of joints and the feet, it can follow the movement of the body, and it is torn or peeled off. It can be suppressed.

Glycyrrhizic acids are glycyrrhizinic acid, derivatives thereof, and salts thereof. Specifically, glycyrrhizinic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, glycerin glycyrrhetinate, stearyl glycyrrhetinate, and pyridoxin glycyrrhetinate. And so on. Among these glycyrrhizic acids, glycyrrhizic acid, dipotassium glycyrrhizinate and glycyrrhetinic acid are preferable. These glycyrrhizic acids may be used alone or in combination of two or more.

Tocopherols are tocopherols and derivatives thereof, and specifically, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, Examples thereof include tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, tocopherol (linoleic acid / oleic acid) and the like. Among these tocopherols, tocopherol acetate is preferable. These tocopherols may be used alone or in combination of two or more.

Pantenols are pantenols, derivatives thereof, and salts thereof. Specifically, pantenol, pantothenyl ethyl ether, alkaline earth metal pantothenate (for example, calcium salt, etc.), alkali metal pantothenate. Examples thereof include salts (for example, sodium salts and the like), acetylpantothenyl ethyl ether and the like. Among these panthenol types, panthenol is preferable. These panthenol types may be used alone or in combination of two or more.

Vitamin Cs are ascorbic acid, derivatives thereof, and salts thereof, and specifically, ascorbic acid and ascorbic acid monoalkyl esters (for example, ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid monoolate). , Tetrahexyl decanoate ascorbyl, etc.), Ascorbic acid dialkyl ester (eg, ascorbic acid distearate, ascorbic acid dipalmitate, ascorbic acid diolate), ascorbic acid trialkyl ester (eg, ascorbic acid tristearate, ascorbic acid tripalmitate, ascorbin) Acid triolate, etc.) and the like. These vitamin Cs may be used alone or in combination of two or more.

Vitamin A is vitamin A and its derivatives, and specifically, retinol, retinal, retinoic acid, 3-dehydroretinol, 3-dehydroretinal, 3-dehydroretinoic acid, hydrogenated retinol, retinol palmitate, Examples thereof include retinol propionate, retinol linoleate, and retinol acetate. These vitamin As may be used alone or in combination of two or more.

Vitamin B6s are vitamin B6, derivatives thereof, and salts thereof. Specifically, pyridoxine, pyridoxal, pyridoxamine, and inorganic acid salts thereof (for example, hydrochloride, sulfate, nitrate, hydrobromic acid). Salts, phosphates, etc.) and the like. These vitamin B6s may be used alone or in combination of two or more.

The allantoins are allantoin and its derivatives, and specific examples thereof include allantoin, allantoin chlorohydroxyaluminum, and allantoinhydroxyaluminum. These allantoins may be used alone or in combination of two or more.

Azulene species are azulene, derivatives thereof, and salts thereof. Specifically, azulene, guaiazulene, guaizulene sulfonic acid, azulene sulfonic acid, sodium azulene sulfonate, 1,4-dimethyl-7-isopropylazulene- Examples include 3-sulfonic acid. These azulene species may be used alone or in combination of two or more.

Among these (D) components, pantenols and tocopherols are preferable from the viewpoint of more effectively reducing the feeling of tension during use while maintaining the friction-reducing effect of the film formed on the skin. , Glycyrrhizinates; more preferably pantenol, tocopherol acetate, glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate; particularly preferably glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate.

These (D) components may be used alone or in combination of two or more.

When the component (D) is contained in the external preparation for reducing skin friction of the present invention, the content thereof is not particularly limited, and examples thereof include 0.05 to 10% by weight. The content of the component (D) is preferably 0.05 to 8% by weight from the viewpoint of more effectively reducing the feeling of tension during use while maintaining the friction-reducing effect of the film formed on the skin. , More preferably 0.1 to 5% by weight.

(E) Plasticizer The external preparation for reducing skin friction of the present invention is a plasticizer (hereinafter referred to as “plasticizer”), if necessary, in order to impart good flexibility and skin adhesion to the film formed on the skin. (E) It may be referred to as a component).

The plasticizer used in the present invention is not particularly limited as long as it is pharmaceutically acceptable, but for example, vegetable oil, mono, di or tricarboxylic acid having 5 to 22 carbon atoms and one of 1 to 9 carbon atoms. Hyprate alcohol esters, terpenoids, polyhydric alcohols, glycerin fatty acid esters, mineral oils, polyethers, polyesters and the like can be mentioned.

Specific examples of vegetable oils include castor oil, cottonseed oil, soybean oil, sesame oil, almond oil, oyster oil, corn oil, olive oil, orange oil, chamomile oil, kehi oil, wheat germ oil, saflower oil, and perilla oil. , Citronella oil, pepper oil, sparemint oil, rice oil, butterfly oil, camellia oil, television oil, peppermint oil, rapeseed oil, peppermint oil, sunflower oil, sunflower oil, bergamot oil, palm oil, eucalyptus oil, lacquer oil, Examples include lavender oil, egg yolk oil, lemon oil, rose oil, funnel oil, and Roman chamomile oil. These vegetable oils may be used alone or in combination of two or more.

Specific examples of the ester of a mono, di or tricarboxylic acid having 5 to 22 carbon atoms and a monovalent alcohol having 1 to 9 carbon atoms include isopropyl palmitate, isopropyl myristate, isopropyl stearate, ethyl linoleate, and linoleic acid. Isopropyl, dimethyl phthalate, diethyl phthalate, dipropyl phthalate, dibutyl phthalate, dioctyl phthalate, diisobutyl adipate, diisopropyl adipate, diisononyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dibutyl sebacate, Examples thereof include triethyl citrate, tributyl citrate, and acetyltributyl citrate. These esters may be used alone or in combination of two or more.

Specific examples of terpenoids include camphor, menthol, borneol, cineole, anethole, limonene, eugenol, geraniol, and mint oil. These terpenoids may be used alone or in combination of two or more.

Specific examples of the polyhydric alcohol include propylene glycol, glycerin, and sorbitol. These polyhydric alcohols may be used alone or in combination of two or more.

Specific examples of the glycerin fatty acid ester include glyceryl monostearate, glycerin monooleate, glycerin monomyristate, decaglyceryl laurate, and medium-chain fatty acid triglyceride. These glycerin fatty acid esters may be used alone or in combination of two or more.

Specific examples of the mineral oil include silicone oil, liquid paraffin, petrolatum and the like. These mineral oils may be used alone or in combination of two or more.

Specific examples of the polyether include polyethylene glycol and the like.

Specific examples of the polyester include polyester adipic acid and the like.

Among these plasticizers, preferably vegetable oils, mono-, di- or tricarboxylic acids having 5 to 22 carbon atoms, esters of monohydric alcohols having 1 to 9 carbon atoms, terpenoids; more preferably castor oil, isopropyl palmitate, etc. Examples include isopropyl myristate and camphor.

In addition, the plasticizer has the advantage of improving the spreadability on the skin and the flexibility of the film of the external preparation for reducing skin friction, but when it is blended with the conventional external preparation for reducing skin friction, it causes contact with water. It contributed to the remarkable whitening of the preparation. In particular, vegetable oil (particularly castor oil) is one of the plasticizers that easily induce white turbidity. On the other hand, according to the present invention, even if a plasticizer such as vegetable oil is contained, the white turbidity caused by contact with water is effectively suppressed by containing the components (A) to (C) in combination. can do. In view of such effects of the present invention, examples of suitable plasticizers to be blended in the present invention include vegetable oils (particularly castor oil).

One of these plasticizers may be used alone, or two or more of these plasticizers may be used in combination.

When the component (E) is contained in the external preparation for reducing skin friction of the present invention, the content thereof is not particularly limited, but is, for example, 1 to 40% by weight, preferably 2 to 30% by weight, more preferably. 3 to 20% by weight, particularly preferably 5 to 20% by weight.

Other Ingredients The external preparation for reducing skin friction of the present invention may further contain a solvent such as water, acetone, ethyl methyl ketone and diethyl ether, if necessary, as long as the effects of the present invention are not impaired. However, solvents other than the components (A) and (B) may impair the transparency of the film, or may cause the film to become cloudy or gel due to contact with water. Therefore, (A) and When a solvent other than the component (B) is blended, it is necessary to consider such characteristics. Furthermore, diethyl ether requires careful handling in manufacturing due to its high volatility and is ignitable, and can also cause solidification due to drying during storage, a peculiar odor, and the like. When blending ether, it is required to consider such characteristics. The content of the solvent other than the components (A) and (B) in the external preparation for reducing skin friction of the present invention is preferably, for example, about 4% by weight or less, particularly about 2% by weight or less.

Further, the external preparation for reducing skin friction of the present invention may contain a medicinal ingredient other than the ingredient (D), if necessary, as long as the effect of the present invention is not impaired. Examples of such medicinal ingredients include anti-inflammatory agents, local anesthetics, analgesics, antihistamines, bactericides, antifungal agents, vitamins, moisturizers, whitening agents, tissue repair agents, skin protectants, and keratin softeners. , Local stimulants, antipruritic agents, astringents, ultraviolet protective agents, silicon gels, active drug extracts, amino acids, minerals and the like.

In addition, the external preparation for reducing skin friction of the present invention is a thickener, a buffer, a chelating agent, an antioxidant, a stabilizer, an emulsifier, and a preservative, as necessary, as long as the effects of the present invention are not impaired. , Fragrances, refreshing agents, coloring agents, dispersants, fluidizing agents, thickening agents, thickeners, adsorbents, moisturizers, wetting agents, moisture-proofing agents, antistatic agents, etc. Good.

Method for manufacturing an external preparation for reducing skin friction The external preparation for reducing skin friction of the present invention comprises the above components (A) to (C), and if necessary, the above (D) component, other solvent, medicinal ingredient, and addition. It is prepared by mixing a desired amount of an agent or the like.

How to use the external preparation for reducing skin friction The external preparation for reducing skin friction of the present invention is used by applying it to a skin site to which friction is applied in order to reduce friction on the skin.

A film having a high friction-reducing effect is formed on the skin portion to which the external preparation for reducing skin friction of the present invention is applied, and the friction is reduced at the skin portion.

The skin site to which the external preparation for reducing skin friction of the present invention is applied is not particularly limited as long as it is a site where reduction of friction is required, and any of the upper limbs, lower limbs, chest, abdomen, back, waist, etc. It may be. Further, when the external preparation for reducing skin friction of the present invention contains the component (D), it can form a tough film that is hard to tear on the skin and has a reduced feeling of tension, so that the ankles and wrists can be formed. Even if it is applied to a range of motion with joints such as elbows, knees, and fingers, the back of the foot, the sole of the foot, and the heel, it is difficult to tear and it is possible to follow the movement of the body.

The external preparation for reducing skin friction of the present invention can be applied to various applications in which reduction of friction on the skin is required. For example, the external preparation for reducing skin friction of the present invention can prevent rashes by applying it to skin parts tightened by underwear, socks, etc., or prevent bedsores by applying it to skin parts where bedsores are likely to occur. be able to. In addition, the external preparation for reducing skin friction of the present invention can prevent shoe rubbing by being applied to the back of the foot, sole, toes, heel, etc., where shoe rubbing is likely to occur. Further, by applying the present invention to a finger or the like on which an accessory such as a ring is attached, friction between the accessory and the skin can be reduced and the attachment and detachment of the accessory can be facilitated.

The method of applying the external preparation for reducing skin friction of the present invention to the skin is not particularly limited, and is, for example, application by a finger, direct application using the container mouth of a tube, application using a brush, a spatula, or the like. Any method may be used, but from the viewpoint of user convenience, application using a brush is preferable. Further, in order to enhance the convenience of the user, it is desirable that the external preparation for reducing skin friction of the present invention is provided in a container to which a brush is attached.

The present invention will be described in more detail with reference to Examples below, but the present invention is not limited thereto. In the following Examples, Comparative Examples, and Formulation Examples, pyroxylin (nitrocellulose: isopropyl alcohol weight ratio: 7: 3) was used as the nitrocellulose source.

Test Example 1: Evaluation of friction reducing effect 1. Preparation of External Preparation for Reducing Skin Friction An external preparation for reducing skin friction having the composition shown in Table 1 was prepared. Specifically, the components (A), (D), and (E) are stirred and mixed, and the component (C) is added to and dispersed, and then the component (B) is added and stirred uniformly. It was dissolved to obtain an external preparation for reducing skin friction (Examples 1 to 7).

2. Evaluation method of friction reduction effect 0.2 g of each skin friction reduction external preparation is applied to artificial skin (trade name "Bioskin", manufactured by Bulux Co., Ltd.) in a certain range (2 cm x 5 cm) and dried at room temperature for one day. A film was formed on the artificial skin. The coefficient of friction of the film formed on the artificial skin was measured using a friction tester KES-SE (manufactured by Kato Tech Co., Ltd.). The coefficient of friction was measured under a load of 25 g on the jig at a speed of 1 mm / sec, and the average coefficient of friction in the measurement range (20 mm) was obtained. A 10mm square piano wire was used as the jig sensor option.

For comparison, artificial skin to which no external preparation for reducing skin friction (Comparative Example 1) and adhesive plaster (trade name "Band-Aid Scratch Power Pad for Shoe Slip", manufactured by Johnson & Johnson Co., Ltd.) are attached. The friction coefficient was also measured on the skin adhesive plaster-attached surface (Comparative Example 2) under the same conditions as described above. Further, the relative value of the average friction coefficient measured in Examples 1 to 7 and Comparative Example 2 was also calculated, assuming that the average friction coefficient measured in Comparative Example 1 was 100.

3. 3. Evaluation Results Table 1 shows the obtained results. All of the external preparations for reducing skin friction (Examples 1 to 7) containing the components (A) to (C) were able to reduce the frictional force of the coated portion. Further, in addition to the components (A) to (C), the external preparation for skin friction reduction (Examples 1 to 5) containing the component (D) and / or the component (E) also has a friction reducing effect, and in particular. The friction reducing effect was high in the external preparations for reducing skin friction (Examples 1 and 3) containing glycyrrhetinic acid or tocopherol acetate. Further, in the external preparations for reducing skin friction (Examples 6 and 7) containing no component (E), a particularly excellent friction reducing effect was observed.

Test Example 2: Evaluation of tension 1. Preparation of External Preparation for Reducing Skin Friction An external preparation for reducing skin friction having the composition shown in Table 2 was prepared. Specifically, the components (A) and (D) are stirred and mixed, and the component (C) is added to and dispersed, and then the component (B) is added and uniformly stirred and dissolved to reduce skin friction. External preparations (Examples 6 to 14) were obtained.

2. Evaluation method of tension feeling A rubber string cut to 2 cm (trade name "Soft Rubber 8 Call", manufactured by Kai Corporation) is placed straight on the surface (0.5 cm x 1 cm) with 0.2 g of an external preparation for reducing skin friction. It was applied and dried at room temperature for about 2 hours to form a film. Next, starting from the center of the site where the external preparation for reducing skin friction was applied, fold the elastic cord so that one side of the elastic cord touches the other side, and then take a photo 3 seconds after releasing the hand. did. The angle formed by the elastic cord at the starting point (restoration angle of the elastic cord, the angle formed by the one side and the other side) was measured with a protractor. The average value of the three measurements is shown in the table. Further, the relative value of the average restoration angle of the elastic cord measured in Examples 7-14 was also calculated, assuming that the average restoration angle of the elastic cord measured in Example 6 was 100.

In this evaluation method, the larger the restoration angle, the greater the shape-retaining characteristics of the film formed on the rubber string, and the greater the feeling of tension on the skin, and the smaller the restoration angle, the greater the shape retention characteristic of the film formed on the rubber string. It shows that the shape-retaining property of the film is small and the feeling of tension on the skin is small.

3. 3. Evaluation Results Table 3 shows the obtained results. From this result, in the external preparations for reducing skin friction containing the component (D) in addition to the components (A) to (C) (Examples 7 to 14), the external preparation for reducing skin friction not containing the component (D) was used. Compared with the preparation (Example 6), the restoration angle of the rubber string was smaller, and the feeling of tension could be reduced. In particular, the external preparations for reducing skin friction (Examples 9 to 12) containing glycyrrhetinic acid as the component (D) were remarkably excellent in the effect of reducing the feeling of tension.

Test Example 3: Evaluation of Shoe Rubbing Preventing Effect The external preparation for reducing skin friction (Examples 1, 2, 4 and 6) prepared in Test Examples 1 and 2 was evaluated for the shoe rubbing preventing effect. Specifically, for 6 subjects who own shoes that are prone to slipping when worn, each external preparation for reducing skin friction is applied with a brush to the part (skin) that is prone to slipping, and then the shoes are worn. I wore it and had him go out for a day (8 hours). After that, the presence or absence of slippage of shoes was observed in each subject.

In any of the external preparations for reducing skin friction (Examples 1, 2, 4 and 6), no slippage was observed in the subjects, and the slippage could be prevented by the friction reduction effect. More specifically, in the external preparation for reducing skin friction of Example 6, the friction reducing effect was high and the slippage of the shoes could be prevented, but the skin was slightly stretched, and the film formed on the skin was formed during walking. It was difficult to follow the movement of the foot, and there was a tendency for it to tear a little. On the other hand, the external preparations for reducing skin friction of Examples 1, 2 and 4 were excellent in the balance between the friction reducing effect and the skin tension reducing effect, and were particularly excellent in the shoe slip prevention effect. After the test using the external preparation for reducing skin friction was completed, the same test as above was performed except that the external preparation for reducing skin friction was not applied. As a result, 3 of the subjects showed symptoms of slippage. It was.

Formulation Examples The external preparations for reducing skin friction having the compositions shown in Tables 3 and 4 were produced in the same manner as in "1. Preparation of external preparations for reducing skin friction" described in Test Example 1. When the obtained external preparation for reducing skin friction was evaluated in the same manner as in Test Examples 1 and 2, the friction reducing effect was high and the tension reducing effect was excellent.

Claims (4)

(A) At least one alcohol selected from the group consisting of monovalent alcohols having 1 to 4 carbon atoms and benzyl alcohol, (B) monocarboxylic acids having 2 to 4 carbon atoms and monovalent alcohols having 1 to 5 carbon atoms. And (C) nitrocellulose, (D) glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, glycerin glycyrrhetinate, stearyl glycyrrhetinate, pyridoxin glycyrrhetinate , tocopherol , α-tocopherol, β - tocopherol, .gamma.-tocopherol, .delta.-tocopherol, alpha-tocotrienol, beta-tocotrienol, .gamma.-tocotrienol, .delta.-tocotrienol, tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, (linoleic acid / oleic acid) tocopherol, Pa Ntenoru, External use for reducing skin friction, which comprises at least one selected from the group consisting of pantothenyl ethyl ether, alkaline earth metal pantothenate, alkali metal pantothenate, and acetyl pantothenyl ethyl ether. Formulation. The component (A) is at least one selected from the group consisting of ethanol, isopropanol, and benzyl alcohol, and the component (B) is at least one selected from the group consisting of ethyl acetate and butyl acetate. The external preparation for reducing skin friction according to claim 1. The external preparation for reducing skin friction according to claim 1 or 2, further comprising at least one selected from the group consisting of vitamin Cs, vitamin As, pyridoxines, allantoins, and azulene. The external preparation for reducing skin friction according to any one of claims 1 to 3, which is for preventing shoe rubbing.