CN108778234A - External preparation for mitigating skin friction - Google Patents
External preparation for mitigating skin friction Download PDFInfo
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- CN108778234A CN108778234A CN201780017659.XA CN201780017659A CN108778234A CN 108778234 A CN108778234 A CN 108778234A CN 201780017659 A CN201780017659 A CN 201780017659A CN 108778234 A CN108778234 A CN 108778234A
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- skin
- external preparation
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- friction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The purpose of the present invention is to provide the external preparations for mitigating skin friction, can mitigate the friction to skin.The external preparation includes selected from least one of the group being made of the monohydric alcohol of carbon atom number 1~4 and benzylalcohol alcohol, the monocarboxylic acid of carbon atom number 2~4 and ester and nitrocellulose formed by the monohydric alcohol of carbon atom number 1~5, the high overlay film of antifriction function can be formed on the skin, may be used as the external preparation for mitigating skin friction.
Description
Technical field
The present invention relates to the external preparations for mitigating skin friction.More particularly it relates to can by
Overlay film is formed on skin to mitigate the external preparation for mitigating skin friction of the friction to skin.
Background technology
In daily life, skin can be stimulated due to the friction with foreign objects.These not only can for the stimulation of skin
Sense of discomfort is generated, can also cause the various symptoms of skin sometimes.For example, as the symptom because of caused by the friction to skin, tool
There are the symptoms such as fash, bedsore and the shoes mill pin generated by underwear tension.In addition, when wearing the ornaments such as ring, sometimes because with
Friction between finger and be not easy to remove.Therefore, all the time, for uncomfortable because caused by applying friction on the skin,
Propose various countermeasures.
For example, Patent Document 1 discloses being equipped with the footmuff that friction provides body by using in heel contact portion inner face
(deformation socks) prevents shoes mill pin.But in the human body wearing utensil as patent document 1, rubbed caused object
It manages the skin part other than the position of stimulation to be also capped, it is poor that accordingly, there exist use feelings, in addition, having worn human body wearing device
The shortcomings that site volume of tool increases.
In addition, being formed by the one side of sheet body in adhesive level according to appropriate for example, being reported in patent document 2
Fixed multiple strip tape sheets are pasted spaced and parallelly, form sealing element, which is pasted onto to the skin for generating shoes mill pin
On position, being achieved in prevents shoes mill pin.But in patent document 2 there is shortage flexibility in such sheet article, it is difficult to suitable
For zone of action such as joints, moreover, having tight feeling (feeling that skin is pulled), the disadvantage of use feeling difference when pasting.
On the other hand, currently, it is still unknown by the people come the technology for mitigating skin friction by directly forming overlay film on the skin.
Existing technical literature
Patent document
Patent document 1：Japanese Unexamined Patent Publication 10-292206 bulletins
Patent document 2：Japanese Unexamined Patent Publication 2013-275614 bulletins
Invention content
Technical problems to be solved by the inivention
The purpose of the present invention is to provide the external preparations for mitigating skin friction for the friction that can mitigate to skin.
Technical teaching for solving the problem was
The present inventor concentrates on studies in order to solve the problem, is covered to contemplate by directly being formed on the skin
Film mitigates the new idea of skin friction.Also, the external preparation for directly forming overlay film on the skin is carried out with great concentration
Research, as a result, it has been found that, including former selected from least one of the group being made of the monohydric alcohol of carbon atom number 1~4 and benzylalcohol alcohol, carbon
The external preparation of ester and nitrocellulose formed by the monocarboxylic acid of subnumber 2~4 and the monohydric alcohol of carbon atom number 1~5 can be
It is formed on skin and mitigates the high overlay film of rubbing action, it is useful as the external preparation for mitigating skin friction.In addition, of the invention
People also found, further contains the special components such as panthenol class in the external preparation by making, can reduce tight feeling when use,
Improve use feeling.The present invention is further studied based on these discoveries and is completed repeatedly.
That is, the present invention provides the invention of following aspects.A kind of external preparations for mitigating skin friction of item 1., feature
It is, at least one of the group being made of the monohydric alcohol of carbon atom number 1~4 and benzylalcohol alcohol, (B) carbon atom is selected from containing (A)
The monocarboxylic acid of number 2~4 and ester and (C) nitrocellulose formed by the monohydric alcohol of carbon atom number 1~5.Item 2. is according to described in item 1
For mitigating the external preparation of skin friction, wherein (A) ingredient ethyl alcohol, isopropanol and benzylalcohol selected from being made of
At least one of group, and (B) ingredient is selected from least one of the group being made of ethyl acetate and butyl acetate.
External preparation for mitigate skin friction of the item 3. according to item 1 or 2, wherein further include (D) and be selected from by glycyrrhizic acid
In the group that class, tocopherols, panthenol class, vitamin c class, retinoid, pyridoxol class, allantoin class and Azulene class are constituted extremely
Few one kind.External preparation for mitigate skin friction of the item 4. according to any one of item 1~3, wherein for preventing shoes
Mill pin.
Invention effect
The external preparation for mitigating skin friction of the present invention can mitigate rubbing action height by being formed on the skin
Overlay film, to inhibit uncomfortable caused by applying friction on the skin.
Moreover, in a kind of preferred embodiment of the external preparation for mitigating skin friction of the present invention, due to that can press down
Tight feeling (feeling that skin is pulled when forming overlay film on the skin) when system uses, thus either it is used for the activities such as joint
Region, or suitable for zone of action and foots such as joints, the action of body can be followed, can inhibit damaged or peeled off,
To provide good use feeling.
Specific implementation mode
The external preparation for mitigating skin friction of the present invention is it is characterized in that, containing selected from by carbon atom number 1~4
Single carboxylic of at least one of the group that monohydric alcohol and benzylalcohol are constituted alcohol (in the following, being also shown as (A) ingredient sometimes), carbon atom number 2~4
Ester (in the following, being also shown as (B) ingredient sometimes) and nitrocellulose formed by monohydric alcohol of the acid with carbon atom number 1~5 (in the following,
Sometimes also it is shown as (C) ingredient).In the following, the external preparation for mitigating skin friction to the present invention is described in detail.
(A) monohydric alcohol and/or benzylalcohol of carbon atom number 1~4
The external preparation for mitigating skin friction of the present invention contains selected from the monohydric alcohol and benzylalcohol structure by carbon atom number 1~4
At at least one of group alcohol.
It for the type of the monohydric alcohol of carbon atom number 1~4, is not particularly limited, for example, can enumerate：Methanol, ethyl alcohol, just
Propyl alcohol, isopropanol, n-butanol, sec-butyl alcohol, isobutanol, the tert-butyl alcohol.
In these alcohol, preferably enumerate：The monohydric alcohol and benzylalcohol of carbon atom number 2~4, are further preferably enumerated：It is ethyl alcohol, different
Propyl alcohol, n-butanol and benzylalcohol, are particularly preferably enumerated：Ethyl alcohol, isopropanol and benzylalcohol.
In the present invention in mitigating the external preparation of skin friction, as (A) ingredient, can be used alone carbon atom
The monohydric alcohol of number 1~4 and one kind in benzylalcohol, it is two or more alternatively, it is also possible to be applied in combination.
From the viewpoint of forming the overlay film with more excellent mitigation rubbing action on the skin, as (A) ingredient
Preferred embodiment, can enumerate：The combination of the monohydric alcohol of carbon atom number 1~4 or the monohydric alcohol and benzylalcohol of carbon atom number 1~4；
Further preferably enumerate：At least one of ethyl alcohol and isopropanol or at least one of ethyl alcohol and isopropanol and benzylalcohol
Combination；Particularly preferably enumerate：The combination of isopropanol and benzylalcohol.1~4 monohydric alcohol of carbon atom number and benzylalcohol especially is being applied in combination
In the case of as (A) ingredient, it can be formed on the skin with the more excellent overlay film for mitigating rubbing action, moreover, can
To inhibit overlay film to generate muddy or gelation because being contacted with water, it can also be made to have good character.
In the case where the monohydric alcohol and benzylalcohol that carbon atom number 1~4 is applied in combination are used as (A) ingredient, their ratio does not have
There is special limitation, for example, can enumerate：Relative to the monohydric alcohol of 1 parts by weight carbon atom number 1~4, benzylalcohol is 0.05~2 parts by weight,
Preferably 0.05~1.25 parts by weight, more preferably 0.05~0.77 parts by weight, further preferably 0.06~0.56 parts by weight.
In the present invention in mitigating the external preparation of skin friction, the content of (A) ingredient to be not particularly limited, example
Such as, it can enumerate：10~70 weight %, preferably 15~65 weight %, further preferred 18~60 weight %, particularly preferred 25~60
Weight %.By making (A) ingredient meet above-mentioned content, can be formed on the skin with more excellent mitigation rubbing action
Overlay film.Moreover, in the case where (A) ingredient meets the content and includes aftermentioned (D) ingredient, can also more effectively drop
Tight feeling when low use.
(B) ester formed by monohydric alcohol of the monocarboxylic acid of carbon atom number 2~4 with carbon atom number 1~5
The monocarboxylic acid and carbon atom number 1~5 that the external preparation for mitigating skin friction of the present invention contains carbon atom number 2~4
Monohydric alcohol formed by ester." monocarboxylic acid of carbon atom number 2~4 and ester formed by the monohydric alcohol of carbon atom number 1~5 " refers to 1 point
The monohydric alcohol of the monocarboxylic acid of sub- carbon atom number 2~4 and 1 molecule carbon atom number 1~5 carries out compound made of ester bond bonding.
For the type of the monocarboxylic acid for the carbon atom number 2~4 for constituting above-mentioned ester, it is not particularly limited, for example, can enumerate：
Acetic acid, lactic acid, propionic acid, butyric acid etc..In these monocarboxylic acids, the monocarboxylic acid of carbon atom number 2 or 3 is preferably enumerated, it is further excellent
Elect acetic acid, lactic acid.
In addition, the type of the monohydric alcohol for the carbon atom number 1~5 of the above-mentioned ester of composition, is not particularly limited, for example, can
It enumerates：Methanol, ethyl alcohol, normal propyl alcohol, isopropanol, n-butanol, sec-butyl alcohol, isobutanol, the tert-butyl alcohol, benzylalcohol, 1- amylalcohols, 3- methyl-
N-butyl alcohol, 2-methyl-1-butene alcohol, 2,2- dimethyl -1- propyl alcohol, 2- amylalcohols, 3- methyl -2- butanol, 3- amylalcohols, 2- methyl -2-
Butanol.In these alcohol, preferably enumerate：Methanol, ethyl alcohol, normal propyl alcohol, isopropanol, n-butanol, 1- amylalcohols, benzylalcohol, further
It is preferred that enumerating：Ethyl alcohol, normal propyl alcohol, isopropanol, n-butanol, 1- amylalcohols.
As above-mentioned ester, specifically, can enumerate：Methyl acetate, ethyl acetate, propyl acetate (n-propyl acetate), second
Isopropyl propionate, butyl acetate (n-butyl acetate), sec-butyl acetate, isobutyl acetate, pentyl acetate (acetic acid 1- pentyl esters), lactic acid
Ethyl ester, butyl lactate, isoamyl acetate (acetic acid 3- methylbutyl butenoates), ethyl butyrate, ethyl propionate etc..Wherein, from the skin
It is formed from the viewpoint of there is the more excellent overlay film for mitigating rubbing action, as above-mentioned ester, is preferably enumerated：Acetic acid second
Ester, butyl acetate, ethyl lactate；Further preferably enumerate：Ethyl acetate, butyl acetate.
In the present invention in mitigating the external preparation of skin friction, as (B) ingredient, can be used alone above-mentioned ester
In one kind, in addition can also be applied in combination two or more.For example, it is also possible to by the way that different two or more of boiling point are applied in combination
Ester is used as (B) ingredient, and the external preparation for mitigating skin friction to suitably adjust the present invention forms the speed of overlay film.Example
Such as, it is used in combination the above-mentioned ester that above-mentioned ester (for example, ethyl acetate) of the boiling point less than 100 DEG C and boiling point are 100 DEG C or more (for example, second
Acid butyl ester), if the ratio of the above-mentioned ester by boiling point less than 100 DEG C is configured higher, it can be expedited overlay film and form speed, if will
The ratio of above-mentioned ester of the boiling point less than 100 DEG C is configured relatively low, then can reduce overlay film and form speed.
As the preferred example of (B) ingredient, can enumerate：Ethyl acetate and butyl acetate is applied in combination, and meets following ratios
Rate：Relative to 1 weight part of ethylacetate, butyl acetate is 0.05~0.5 parts by weight, preferably 0.07~0.4 parts by weight, into one
Step is preferably 0.1~0.3 parts by weight.By according to such ratio and with ethyl acetate and butyl acetate, being coated on skin
When upper, speed can be formed with overlay film appropriate and form overlay film.
In the present invention in mitigating the external preparation of skin friction, the content of (B) ingredient to be not particularly limited,
Speed etc. is formed according to the type of (B) ingredient and the overlay film that should have to be appropriately arranged with, for example, can enumerate：Relative to the system
The total amount of agent is 25~65 weight %, preferably 25~60 weight %, further preferably 35~55 weight %.
In the present invention in mitigating the external preparation of skin friction, the ratio for (B) ingredient relative to (A) ingredient
Rate is appropriately arranged in the range of meeting both ingredients respective content, for example, following ratio can be enumerated：Relative to 1
Parts by weight (A) ingredient, (B) ingredient are 0.2~10 parts by weight.
From the viewpoint of forming the overlay film with more excellent mitigation rubbing action on the skin, as (B) ingredient
Relative to the ratio of (A) ingredient, following ratio can be enumerated：Relative to 1 parts by weight (A) ingredient, (B) ingredient is preferably 0.4~6 weight
Part is measured, further preferably 0.4~5 parts by weight, particularly preferably 0.4~3.5 parts by weight are still more preferably 0.6~1.8
Parts by weight.In the case where meeting ratio as above, it can be formed on the skin and mitigate covering for rubbing action with more excellent
Film can also make it have good character furthermore, it is possible to which overlay film is inhibited to generate muddy or gelation because being contacted with water.And
And the ratio as satisfaction and in the case of including aftermentioned (D) ingredient, it can also more effectively reduce tight feeling.
(C) nitrocellulose
The external preparation for mitigating skin friction of the present invention contains nitrocellulose.Nitrocellulose is as institute's shape on skin
At the base of overlay film work.
Then its molecular weight, nitrogen are contained as long as overlay film can be formed on the skin as the nitrocellulose for the present invention
Amount etc. is not particularly limited.
In addition, in the present invention in mitigating the external preparation of skin friction, guncotton can also to be used
(Pyroxyline) it is used as nitrocellulose.Guncotton is nitrocellulose made of solvent-soaked, specifically, can enumerate：
The mixture of the isopropanol of the nitrocellulose of 70 weight % or so and 30 weight % or so.In the present invention, as (C) at
Point, commercially available guncotton can also be used.As commercially available guncotton, specifically, can enumerate：T.N.C.Industrial Co.,
RS 1/32sec, RS 1/16sec, RS 1/8sec, RS 1/8L sec, RS 1/8H sec, RS 1/4sec, the RS of Ltd manufactures
1/4H sec, RS 1/2sec, RS 1sec, 5 RS~10~15sec of 6sec, RS, 15~20sec of RS, 30~40sec of RS,
60~80sec of RS, RS 120sec, RS 150sec, RS 300sec, RS 500sec, RS 800sec, RS 1200sec, RS
2000sec；The RS 1/16 of Korea CNC Ltd manufacture, RS 1/8, RS 1/4, RS 1/2, RS 1, RS 2, RS 5, RS 7,
RS 20, RS 60, RS 120, RS 500, RS 1000, RS 2000 etc..These can be used alone, and can also combine makes
With two or more.It should be noted that in the present invention, in the case where using guncotton as (C) ingredient, carbon that guncotton includes
The part of (A) ingredient described in the monohydric alcohol composition of atomicity 1~4.
In the present invention in mitigating the external preparation of skin friction, the content of (C) ingredient is with can shape on the skin
It is limit at overlay film, is not particularly limited, for example, can enumerate：3.5~14 weight %, preferably 5.6~11.2 weight % (make
In the case that guncotton is the mixture of the nitrocellulose of 70 weight % and the isopropanol of 30 weight %, contain as the guncotton
Amount, can enumerate：5~20 weight %, preferably 8~16 weight %).
(D) ingredient for the tight feeling that overlay film is formed by skin is reduced
In addition to the external preparation for mitigating skin friction of the present invention removes (A)~(C) ingredients, can also contain be selected from by
The group that Radix Glycyrrhizae acids, tocopherols, panthenol class, vitamin c class, retinoid, pyridoxol class, allantoin class and Azulene class are constituted
At least one of (in the following, being also shown as (D) ingredient sometimes).By containing these (D) ingredients, can reduce because of institute's shape on skin
At overlay film caused by tight feeling, that is, be used in the zone of action such as joint and foot, the activity of body can also be followed, can be with
Inhibit damaged, peel off.
Radix Glycyrrhizae acids is glycyrrhizic acid, its derivative and their salt, specifically, can enumerate：Glycyrrhizic acid, glycyrrhizic acid two
Potassium, glycyrrhizic acid monoammonium, enoxolone, enoxolone glyceride, enoxolone octadecane ester, enoxolone pyridoxol ester etc..?
In these Radix Glycyrrhizae acids, preferably enumerate：Glycyrrhizic acid, dipotassium glycyrrhizinate and enoxolone.These Radix Glycyrrhizae acids can individually make
With one kind, in addition can also be applied in combination two or more.
Tocopherols are tocopherol and its derivative, specifically, can enumerate：Alpha-tocopherol, betatocopherol, γ-fertility
Phenol, Delta-Tocopherol, alpha-tocotrienol, β-tocotrienols, γ-tocotrienols, δ-tocotrienols, tocopherol acetate
Ester, tocopheryl linoleate, dlo-tocopherol nicatinate, (linoleic acid/oleic acid) Renascin etc..It, can be excellent in these tocopherols
Elect Tocopherol acetate ester.These tocopherols can be used alone, and in addition can also be applied in combination two or more.
Panthenol class is panthenol, its derivative and their salt, specifically, can enumerate：Panthenol, pantothenic acid alcohol ethylether
(Pantothenyl ethyl ether), pantothenic acid alkali salt (such as calcium salt etc.), pantothenic acid alkali metal salt (such as sodium salt
Deng), acetyl group pantothenic acid alcohol ethylether etc..In these panthenol classes, panthenol is preferably enumerated.These panthenol classes can be used alone
In addition one kind can also be applied in combination two or more.
Vitamin c class is ascorbic acid, its derivative and their salt, specifically, can enumerate：It is ascorbic acid, anti-bad
Hematic acid monoalkyl ester (for example, ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid monoleate, four oneself
Base decyl alcohol acid ascorbyl ester etc.), ascorbic acid dialkyl ester is (for example, L-Ascorbic acid distearate, two palmitic acid of ascorbic acid
Ester, ascorbic acid dioleate), ascorbic acid trialkyl ester is (for example, ascorbic acid tristearate, three palm of ascorbic acid
Acid esters, ascorbic acid trioleate etc.) etc..These vitamin c class can be used alone, and in addition can also be applied in combination two
Kind or more.
Retinoid is vitamin A and its derivative, specifically, can enumerate：Retinol, retinene, vitamin A acid,
3-dehydroretinol, 3- dehydroretinals, 3- dehydrogenations vitamin A acid, hydrogenation retinol, retinol palmitate, propionic acid regard Huang
Alcohol ester, linoleic acid retinol ester, retinol acetate etc..These retinoids can be used alone, in addition can also group
It closes using two or more.
Vitamin B6 class is vitamin B6, its derivative and their salt, specifically, can enumerate：Pyridoxol, pyrrole are trembled
Aldehyde, pyridoxamine, their inorganic acid salt (for example, hydrochloride, sulfate, nitrate, hydrobromate, phosphate etc.) etc..These
Vitamin B6 class can be used alone, and in addition can also be applied in combination two or more.
Allantoin class is allantoin and its derivative, specifically, can enumerate：Allantoin, allantoin aluminium chloride, urine
Bursin hydroxy Al etc..These allantoin classes can be used alone, and in addition can also be applied in combination two or more.
Azulene class is Azulene, its derivative and their salt, specifically, can enumerate：Azulene, is cured at Kessazulen (Guaiazulene)
Create Azulene sulfonic acid, Azulene sulfonic acid, sodium azulenesulfonate, Isosorbide-5-Nitrae-dimethyl -7- isopropyl Azulene -3- sulfonic acid etc..These Azulene classes can be used alone
In addition one kind can also be applied in combination two or more.
In these (D) ingredients, it is formed by the mitigation rubbing action of overlay film from maintenance skin, while more effectively dropping
From the viewpoint of tight feeling when low use, preferably enumerate：Panthenol class, tocopherols, Radix Glycyrrhizae acids；Further preferably lift
Go out：Panthenol, Tocopherol acetate ester, enoxolone, glycyrrhizic acid, dipotassium glycyrrhizinate；Particularly preferably enumerate：Enoxolone, glycyrrhizic acid,
Dipotassium glycyrrhizinate.
These (D) ingredients can be used alone, and in addition can also be applied in combination two or more.
In the present invention in mitigating the external preparation of skin friction, containing (D) ingredient, content not to have
There is special limitation, for example, 0.05~10 weight % can be enumerated.The mitigation rubbing action of overlay film is formed by from maintenance skin,
From the viewpoint of more effectively reducing tight feeling when using simultaneously, as the content of (D) ingredient, preferably enumerate：0.05~8
Weight %, is further preferably enumerated：0.1~5 weight %.
(E) plasticizer
The good flexibility of overlay film and skin attachment are formed by skin in order to assign, of the invention rubs for mitigating skin
The external preparation of wiping can also include plasticizer (in the following, being also shown as (E) ingredient sometimes) as needed.
Plasticizer used in the present invention is then not particularly limited, example as long as being pharmaceutically acceptable substance
Such as, it can enumerate：Ester formed by the monohydric alcohol of vegetable oil, the mono-, di- of carbon atom number 5~22 or tricarboxylic acids with carbon atom number 1~9,
Terpene, polyalcohol, fatty acid glyceride, mineral oil, polyethers, polyester etc..
As vegetable oil, specifically, can enumerate：Castor oil, cottonseed oil, soybean oil, sesame oil, apricot kernel oil, fennel oil,
Corn oil, orange oil, oil of chamomile, cinnamon oil, wheat-germ oil, safflower oil, perilla herb oil, citronella oil, oil of ginger, stays olive oil
Blue sesame oil, rice bran oil, caryophyllus oil, camellia oil, turpentine oil, bitter orange oil, rapeseed oil, peppermint oil, cedar oil, sunflower oil, bergamot
(bergamot) oil, coconut oil, eucalyptus oil, peanut oil, lavender oil, egg oil, lemon oil, attar of rose, turkey red oil, Luo Mayang
Chamomile oil etc..These vegetable oil can be used alone, and in addition can also be applied in combination two or more.
As ester formed by the mono-, di- or tricarboxylic acids of carbon atom number 5~22 and the monohydric alcohol of carbon atom number 1~9, it is specific and
Speech, can enumerate：Isopropyl palmitate, isopropyl myristate, isopropyl stearate, ethyl linoleate, linoleic acid isopropyl ester, neighbour
Rutgers, diethyl phthalate, dipropyl phthalate, dibutyl phthalate, phthalic acid
Dioctyl ester, diisobutyl adipate, diisopropyl adipate, diisononyl adipate, dioctyl adipate, decanedioic acid diethyl
Ester, diisopropyl sebacate, dibutyl sebacate, triethyl citrate, tributyl citrate, acetyl tributyl citrate
Deng.These esters can be used alone, and in addition can also be applied in combination two or more.
As terpene, specifically, can enumerate：Camphor, menthol, borneol, Cineole, anethole, limonene, clove tree
Phenol, geraniol, peppermint oil etc..These terpenes can be used alone, and in addition can also be applied in combination two or more.
As polyalcohol, specifically, can enumerate：Propylene glycol, glycerine, D-sorbite etc..These polyalcohols can be independent
Using one kind, in addition can also be applied in combination two or more.
As fatty acid glyceride, specifically, can enumerate：Glycerin monostearate, glyceryl monooleate, single nutmeg
Acid glyceride, ten glyceride of lauric acid, MCT Oil etc..These fatty acid glycerides can be used alone one
Kind, it in addition can also be applied in combination two or more.
As mineral oil, specifically, can enumerate：Silicone oil, atoleine, vaseline etc..These mineral oil can be independent
Using one kind, in addition can also be applied in combination two or more.
As polyethers, specifically, polyethylene glycol etc. can be enumerated.
As polyester, specifically, adipate polyester etc. can be enumerated.
In these plasticizer, preferably enumerate：Vegetable oil, the mono-, di- of carbon atom number 5~22 or tricarboxylic acids and carbon atom
Ester, terpene formed by the monohydric alcohol of number 1~9；Further preferably enumerate：Castor oil, isopropyl palmitate, myristic acid isopropyl
Ester, camphor.
Although being improved in addition, plasticizer has for mitigating the external preparation of skin friction ductility and overlay film on the skin
Flexibility the advantages of, if but cooperation it is existing in mitigating the external preparation of skin friction, become cause preparation because
A factor of significant muddiness is contacted and generated with water.Especially vegetable oil (especially castor oil) is to be easy to cause above-mentioned muddiness
One of plasticizer.In contrast, can also include institute by combination even if containing plasticizer such as vegetable oil according to the present invention
(A)~(C) ingredient is stated to effectively inhibit the muddiness generated because being contacted with water.In view of the effect of the present invention as above, as with
The example for closing preferred plasticizer in the present invention can enumerate vegetable oil (especially castor oil).
These plasticizer can be used alone, and in addition can also be applied in combination two or more.
In the present invention in mitigating the external preparation of skin friction, containing (E) ingredient, content not to have
There is special limitation, for example, can enumerate：1~40 weight %, preferably 2~30 weight %, further preferred 3~20 weight %, especially
It is preferred that 5~20 weight %.
Other ingredients
The external preparation for mitigating skin friction of the present invention can be as needed in the range for the effect for not interfering the present invention
Inside further include water, acetone, ethyl methyl ketone, diethyl ether equal solvent.But have can for the solvent in addition to (A) and (B) ingredient
The transparency of overlay film can be damaged, or is easy to cause muddiness and the gelation of overlay film therefore to remove in cooperation because contacting with water
(A) it and in the case of the solvent other than (B) ingredient, needs to consider the characteristic.Moreover, diethyl ether catching fire caused by high volatile
Property and be noted that in addition in manufacturing operation, it is also possible to become dry during storage due to generate solidification, distinctive smell etc.
The reason of, therefore, in the case where coordinating diethyl ether, need to consider these characteristics.It is rubbed as the present invention for mitigating skin
The content of solvent in the external preparation of wiping in addition to (A) and (B) ingredient, for example, it is preferable to for the left and right 4 weight % or less, especially
The left and right preferably 2 weight % or less.
Moreover, the external preparation for mitigating skin friction of the present invention can be as needed in the effect for not interfering the present invention
Include the medicinal ingredient in addition to (D) ingredient in the range of fruit.As such medicinal ingredient, for example, can enumerate：Anti-inflammatory agent,
Local anesthetic, analgesic, antihistaminic, fungicide, antifungal agent, vitamins, moisturizer, whitening agent, tissue repair agent,
Derma-Guard, keratolytic, local irritant, antipruritic, astringent, ultraviolet screener, silica gel, herb extracts, ammonia
Base acids, minerals class etc..
In addition, the external preparation for mitigating skin friction of the present invention can be as needed in the effect for not interfering the present invention
Include following additives in the range of fruit：Thickener, buffer, chelating agent, antioxidant, stabilizer, emulsifier, preservative,
Fragrance, colorant, dispersant, fluidizing reagent, thickening agent, thickener, adsorbent, moisturizer, wetting agent, anti-blushing agent, resists freshener
Electrostatic agent etc..
Manufacturing method for the external preparation for mitigating skin friction
The present invention for mitigating the external preparation of skin friction by making above-mentioned (A)~(C) ingredient and used as needed
Above-mentioned (D) ingredient, other solvents, medicinal ingredient, additive etc. are mixed according to aequum and are prepared.
Application method for the external preparation for mitigating skin friction
The present invention's is applied in the skin part of friction and uses for mitigating the external preparation of skin friction by being coated on, with
Mitigate the friction to skin.
In the skin part for the external preparation for mitigating skin friction for being coated with the present invention, is formed and mitigate rubbing action
High overlay film mitigates the friction at the skin part.
Skin part for the external preparation for mitigating skin friction for being applicable in the present invention, as long as rubbing to require to mitigate
The position of wiping, then be not particularly limited, and can be any parts such as upper limb, lower limb, chest, abdomen, back, waist.In addition,
In the case of containing (D) ingredient, the external preparation for mitigating skin friction of the invention can form not fragile on the skin
Damage, it is unusually strong, and the overlay film of tight feeling is reduced, therefore it is articulate to be used in the tool such as ankle, wrist, elbow, knee, finger
Zone of action, instep, foot bottom, heel etc., are not easy to breakage, can follow the activity of body.
The external preparation for mitigating skin friction of the present invention can be used for the various of friction of the requirement mitigation to skin
Purposes.For example, the present invention's is used to mitigate the skin that the external preparation of skin friction can be used for being tied tight by underwear or socks etc.
Position is to prevent fash, or for easy ting produce the skin part of bedsore with pre- counteracting bedsores.In addition, the present invention's is used to mitigate skin
The external preparation of skin friction can be used for being easy instep, sole, toe, heel of shoes mill pin etc. to prevent shoes mill pin.Moreover, this
The finger etc. that invention can be used for wearing the ornaments such as ring makes ornaments be easy to take to mitigate the friction between ornaments and skin
Under.
For by the method for external preparation coating on the skin for mitigating skin friction of the present invention, not limiting especially
System, for example, can be following method etc.：Using finger coating, directly it is coated with using the oral area of tubular container, using bristle or is scraped
The coatings such as knife, it is preferable to use bristle is coated with from the viewpoint of the convenience of user.In addition, in order to improve user just
Profit, the external preparation for mitigating skin friction of the invention are preferably accommodated in the container of bristle and provide.
Embodiment
In the following, show that embodiment carries out more specific description to the present invention, but the present invention is not limited thereto.It needs to illustrate
It is in following embodiment, comparative example and Formulation Example, as nitrocellulose source, to use guncotton (nitrocellulose: isopropyl
The weight ratio of alcohol is 7: 3).
Test example 1：Mitigate the evaluation of rubbing action
1. the preparation of the external preparation for mitigating skin friction
Prepare the composition external preparation as shown in Table 1 for mitigating skin friction.Specifically, making (A) ingredient, (D) ingredient
And (E) ingredient is stirred and is mixed, and after adding (C) ingredient thereto and it being made to disperse, (B) ingredient is added, stirring evenly makes it
Dissolving, obtains the external preparation (Examples 1 to 7) for mitigating skin friction.
2. mitigating the evaluation method of rubbing action
The external preparation 0.2g for respectively being used to mitigate skin friction is coated on artificial skin (trade name " Bioskin ", Co., Ltd.
Beaulax manufacture) on a certain range (2cm × 5cm) in, it is drying for one day at room temperature, overlay film is formed on artificial skin.It uses
Friction fremitus tester KES-SE (manufacture of katotech Co., Ltd.) measures the friction coefficient that overlay film is formed by artificial skin.
On fixture, under the load of 25g, it is set as 1mm/ seconds speed, measures friction coefficient, acquires the flat of measurement range (20mm)
Equal friction coefficient.It should be noted that using the piano wire of 10mm square in the sensor options of fixture.
In addition, as a comparison, to it is uncoated for mitigate skin friction external preparation artificial skin (comparative example 1) and
The artificial of adhesive bandage (trade name " BAND-AID KIZU POWER PAD shoes mill pins use ", Johnson & Johnson Co., Ltd.'s manufacture) is pasted
The adhesive surface (comparative example 2) of the adhesive bandage of skin measures friction coefficient with condition same as above.In addition, with comparative example 1
Measured average friction coefficient is 100, also calculates the phase of average friction coefficient measured in Examples 1 to 7 and comparative example 2
To value.
3. evaluation result
The obtained results are shown in tables 1.External preparation (the embodiment 1 for mitigating skin friction containing (A)~(C) ingredients
~7) frictional force of coating part can be mitigated.In addition, also containing (D) ingredient and/or (E) ingredient in addition to (A)~(C) ingredients
The external preparation (Examples 1 to 5) for mitigating skin friction also observe mitigation rubbing action, especially contain Radix Glycyrrhizae time
The mitigation rubbing action of the external preparation (embodiment 1 and 3) for mitigating skin friction of acid or Tocopherol acetate ester is very high.And
And the external preparation (embodiment 6 and 7) for mitigating skin friction without containing (E) ingredient observes especially excellent mitigation
Rubbing action.
[table 1]
#1：The amount for the isopropanol that the amount of isopropanol of each isopropanol content to be added is included with the guncotton added adds up to.
#2：The amount for the nitrocellulose that each nitrocellulose cellulose content includes for the guncotton that is added.
Test example 2：The evaluation of tight feeling
1. the preparation of the external preparation for mitigating skin friction
Prepare the composition external preparation as shown in Table 2 for mitigating skin friction.Specifically, making (A) ingredient and (D) ingredient
It stirs and mixes, after adding (C) ingredient thereto and it being made to disperse, (B) ingredient is added, stirs evenly and makes it dissolve, obtain
External preparation (embodiment 6~14) for mitigating skin friction.
2. the evaluation method of tight feeling
Under straight condition, in the rubber rope for being cut into 2cm, (trade name " Soft rubber 8cord ", shellfish print Co. Ltd. system
Make) surface (0.5cm × 1cm) on external preparation 0.2g of the coating for mitigating skin friction, drying at room temperature about 2 hours, shape
At overlay film.Then, using be coated with the external preparation for mitigating skin friction position central part as starting point, with rubber rope
Then the mode foldable rubber rope contacted on one side with another side unclamps hand, photo is shot after 3 seconds.Rubber is measured using protractor
Rope is formed by angle in the starting point (recovery angle, described one side and the another side of rubber rope are formed by angle).It will
The average value measured three times is shown in table.In addition, the average recovery angle of the rubber rope measured in embodiment 6 is set as 100, also
Calculate the relative value of the average recovery angle of the rubber rope measured in embodiment 7~14.
In this evaluation method, it is bigger to restore angle, then it represents that the shape retention properties of overlay film are formed by rubber rope
Bigger, the tight feeling on skin is bigger, it is smaller to restore angle, then it represents that the shape retention properties of overlay film are formed by rubber rope
Smaller, the tight feeling on skin is smaller.
3. evaluation result
The obtained results are shown in tables 3.It can be seen from this result that with the external application for mitigating skin friction not comprising (D) ingredient
Preparation (embodiment 6) is compared, and the external preparation for mitigating skin friction of (D) ingredient is also contained in addition to (A)~(C) ingredients
The recovery angle of the rubber rope of (embodiment 7~14) becomes smaller, and reduces tight feeling.In particular, contain enoxolone as (D) at
The tight feeling reducing effect of the external preparation (embodiment 9~12) for mitigating skin friction divided is especially excellent.
[table 2]
#1：The amount for the isopropanol that the amount of isopropanol of each isopropanol content to be added is included with the guncotton added adds up to.
#2：The amount for the nitrocellulose that each nitrocellulose cellulose content includes for the guncotton that is added.
Test example 3：Prevent the evaluation of shoes mill pin effect
To preparing external preparation (embodiment 1,2,4 and 6) pre- for mitigating skin friction in the test example 1 and 2
Anti- shoes mill pin effect is evaluated.Specifically, held using six put on after be easy shoes mill pins shoes subject as object,
It is respectively used to mitigate the external preparation of skin friction in part (skin) coating for being easy shoes mill pin using bristle and makes it dry it
Afterwards, shoes are put on and go out 1 day (8 hours).Then, observe whether each subject generates shoes mill pin.
In the external preparation (embodiment 1,2,4 and 6) for being completely used for mitigating skin friction, subject does not observe shoes
Mill pin can prevent shoes mill pin by mitigating friction effect.More specifically, embodiment 6 for mitigating the outer of skin friction
It is high with the mitigation rubbing action of preparation, shoes mill pin can be prevented, but dermal sensation is formed on skin and covered to slight tight feeling
The activity of foot when film is not easy to follow walking, it is seen that be slightly easy damaged tendency.On the other hand, embodiment 1,2 and 4 for subtracting
Balance between the effect of the tight feeling for mitigating rubbing action and reducing skin of the external preparation of light skin friction is good, in advance
Anti- shoes mill pin effect is especially excellent.It should be noted that after the test using the external preparation for mitigating skin friction,
In addition to being not coated with this and being used to mitigate the external preparation of skin friction, tested same as abovely, as a result three in subject
Name observes shoes mill pin symptom.
Formulation Example
Using with " preparation of 1. external preparation for mitigating skin friction " identical method described in the test example 1,
External preparation of the manufacture composition as shown in table 3 and 4 for mitigating skin friction.To obtaining in the same manner as above-mentioned test example 1 and 2
The external preparation for mitigating skin friction evaluated, it is high as a result to mitigate rubbing action, reduces the excellent effect of tight feeling.
[table 3]
#1：The amount for the isopropanol that the amount of isopropanol of each isopropanol content to be added is included with the guncotton added adds up to.
#2：The amount for the nitrocellulose that each nitrocellulose cellulose content includes for the guncotton that is added.
[table 4]
#1：The amount for the isopropanol that the amount of isopropanol of each isopropanol content to be added is included with the guncotton added adds up to.
#2：The amount for the nitrocellulose that each nitrocellulose cellulose content includes for the guncotton that is added.
Claims (4)
1. a kind of external preparation for mitigating skin friction, which is characterized in that contain：(A) it is selected from by carbon atom number 1~4
The monocarboxylic acid and the one of carbon atom number 1~5 of at least one of the group that monohydric alcohol and benzylalcohol are constituted alcohol, (B) carbon atom number 2~4
Ester formed by first alcohol and (C) nitrocellulose.
2. according to claim 1 for mitigating the external preparation of skin friction, wherein (A) ingredient be selected from by
At least one of the group that ethyl alcohol, isopropanol and benzylalcohol are constituted, and, (B) ingredient is selected from by ethyl acetate and acetic acid fourth
At least one of the group that ester is constituted.
3. the external preparation according to claim 1 or 2 for mitigating skin friction, wherein further include (D) and be selected from
It is made of Radix Glycyrrhizae acids, tocopherols, panthenol class, vitamin c class, retinoid, pyridoxol class, allantoin class and Azulene class
At least one of group.
4. the external preparation described in any one of claim 1 to 3 for mitigating skin friction, wherein it is used for pre-
Anti- shoes mill pin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016056178A JP6775976B2 (en) | 2016-03-18 | 2016-03-18 | Topical preparation for reducing skin friction |
| JP2016-056178 | 2016-03-18 | ||
| PCT/JP2017/010918 WO2017159852A1 (en) | 2016-03-18 | 2017-03-17 | External preparation for reducing friction on skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108778234A true CN108778234A (en) | 2018-11-09 |
| CN108778234B CN108778234B (en) | 2022-02-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780017659.XA Active CN108778234B (en) | 2016-03-18 | 2017-03-17 | External preparation for reducing skin friction |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6775976B2 (en) |
| CN (1) | CN108778234B (en) |
| WO (1) | WO2017159852A1 (en) |
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| JP6968589B2 (en) * | 2017-06-26 | 2021-11-17 | 小林製薬株式会社 | Film-forming external preparation |
| JP7048221B2 (en) * | 2017-06-26 | 2022-04-05 | 小林製薬株式会社 | Film-forming external preparation |
| JP2020083818A (en) * | 2018-11-27 | 2020-06-04 | 英昌化学工業株式会社 | Spray for forming protective film on skin surface |
| JP7241527B2 (en) * | 2018-12-20 | 2023-03-17 | 小林製薬株式会社 | Film-forming external preparation |
| JP7241529B2 (en) * | 2018-12-20 | 2023-03-17 | 小林製薬株式会社 | Film-forming external preparation |
| JP7241528B2 (en) * | 2018-12-20 | 2023-03-17 | 小林製薬株式会社 | Film-forming external preparation |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2017159852A1 (en) | 2017-09-21 |
| JP6775976B2 (en) | 2020-10-28 |
| JP2017171583A (en) | 2017-09-28 |
| CN108778234B (en) | 2022-02-08 |
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