JP2017171583A - External preparation for alleviating skin abrasion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external preparation for alleviating skin abrasions which can alleviate abrasions on the skin.SOLUTION: An external preparation comprises: at least one alcohol selected from the group consisting of monohydric alcohols having 1 to 4 carbon atoms and a benzyl alcohol; esters of monocarboxylic acids having 2 to 4 carbon atoms and monohydric alcohols having 1 to 5 carbon atoms; and nitrocellulose. The external preparation can form a coating on the skin which has high abrasion alleviating activity and can be used as an external preparation for alleviating skin abrasions.SELECTED DRAWING: None

Description

  The present invention relates to an external preparation for reducing skin friction. More specifically, this invention relates to the external preparation for skin friction reduction which can reduce the friction to skin by forming a film in skin.

  In daily life, the skin is stimulated by friction with external objects. Such skin irritation not only causes discomfort, but can also cause various symptoms on the skin. For example, symptoms caused by friction with the skin include symptoms such as rashes caused by squeezing underwear, bed slips, and shoe slips. In addition, when an accessory such as a ring is attached, it may be difficult to remove due to friction with the finger. Therefore, various methods for dealing with problems caused by friction applied to the skin have been proposed.

  For example, Patent Document 1 discloses that shoe rubbing can be prevented by using a foot cover (deformed sock) in which a friction imparting body is attached to the inner surface of the heel contact portion. However, in the body wearing tool such as Patent Document 1, since the skin part other than the part that receives physical stimulation due to friction is also covered, the feeling of use is bad, and the part where the body wearing tool is worn is bulky. There is.

  In addition, for example, in Patent Document 2, a seal in which a plurality of strip-shaped tape pieces are stuck and fixed in parallel with an appropriate interval on the surface of an adhesive layer formed on one surface of a sheet body, a skin region where shoe rubs have occurred It has been reported that it is possible to prevent shoe rubbing by sticking to the shoe. However, the sheet-like material as in Patent Document 2 is not flexible and is difficult to apply to a movable range such as a joint, and also has a feeling of tension (feeling that the skin is pulled) at the time of application, and a feeling of use is felt. There is a disadvantage of being bad.

  On the other hand, conventionally, a technique for reducing skin friction by directly forming a film on the skin is not known.

JP-A-10-292206 JP 2013-275614 A

  An object of the present invention is to provide an external preparation for reducing skin friction that can reduce friction on the skin.

  The present inventor has intensively studied to solve the above problems, and has arrived at a new idea of reducing skin friction by forming a film directly on the skin. And when earnestly examining about the external preparation which forms a film | membrane directly on skin, at least 1 sort (s) of alcohol selected from the group which consists of C1-C4 monohydric alcohol and benzyl alcohol, and C2-C2 An external preparation containing an ester of monocarboxylic acid of 4 and a monohydric alcohol having 1 to 5 carbon atoms and nitrocellulose can form a film having a high friction reducing action on the skin and is useful as an external preparation for reducing skin friction I found out. In addition, the present inventor has also found that by adding a specific component such as panthenol to the external preparation, the feeling of tension during use can be reduced and the usability can be improved. The present invention has been completed by further studies based on these findings.

That is, this invention provides the invention of the aspect hung up below.
Item 1. (A) at least one alcohol selected from the group consisting of a monohydric alcohol having 1 to 4 carbon atoms and benzyl alcohol, (B) a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms An external preparation for reducing skin friction, characterized by comprising an ester thereof and (C) nitrocellulose.
Item 2. The component (A) is at least one selected from the group consisting of ethanol, isopropanol, and benzyl alcohol, and the component (B) is at least one selected from the group consisting of ethyl acetate and butyl acetate. Item 2. An external preparation for reducing skin friction according to Item 1.
Item 3. Item (1) or (2) further includes (D) at least one selected from the group consisting of glycyrrhizic acids, tocopherols, panthenol, vitamin Cs, vitamin As, pyridoxines, allantoins, and azulenes. The external preparation for skin friction reduction as described.
Item 4. Item 4. The topical preparation for reducing skin friction according to any one of Items 1 to 3, which is used for preventing shoe rubs.

  The external preparation for reducing skin friction according to the present invention can suppress problems caused by friction applied to the skin by forming a film having a high friction reducing action on the skin.

  Furthermore, in a preferred embodiment of the external preparation for reducing skin friction according to the present invention, it is possible to suppress a feeling of tension during use (feeling that the skin is pulled when a film is formed on the skin), so that the range of motion of joints and the like can be reduced. Even if applied to a range of motion such as a joint or to a foot, it can follow the movement of the body, and can be prevented from being torn or peeled off, giving a good feeling of use.

  The external preparation for reducing skin friction of the present invention comprises at least one alcohol selected from the group consisting of monohydric alcohols having 1 to 4 carbon atoms and benzyl alcohol (hereinafter also referred to as component (A)). , An ester of a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms (hereinafter also referred to as (B) component) and nitrocellulose (hereinafter referred to as (C) component) In some cases). Hereinafter, the external preparation for reducing skin friction according to the present invention will be described in detail.

(A) C1-C4 monohydric alcohol and / or benzyl alcohol The external preparation for reducing skin friction of the present invention is at least one selected from the group consisting of C1-C4 monohydric alcohols and benzyl alcohol. Containing alcohol.

  Although it does not restrict | limit especially about the kind of C1-C4 monohydric alcohol, For example, methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, and tert-butanol are mentioned.

  Among these alcohols, C2-C4 monohydric alcohol and benzyl alcohol are preferable, ethanol, isopropanol, n-butanol, and benzyl alcohol are more preferable, and ethanol, isopropanol, and benzyl alcohol are particularly preferable.

  In the external preparation for reducing skin friction according to the present invention, as the component (A), one kind of monohydric alcohol and benzyl alcohol having 1 to 4 carbon atoms may be used alone, or two or more kinds may be used in combination. May be used.

  From the viewpoint of forming a film having an even better friction reducing action on the skin, as a preferred embodiment of the component (A), a monohydric alcohol having 1 to 4 carbon atoms or a monohydric alcohol having 1 to 4 carbon atoms More preferably, a combination of at least one of ethanol and isopropanol, or a combination of at least one of ethanol and isopropanol and benzyl alcohol; particularly preferably a combination of isopropanol and benzyl alcohol. In particular, as component (A), when a monohydric alcohol having 1 to 4 carbon atoms and benzyl alcohol are used in combination, a film having an even better friction reducing action can be formed on the skin, and with water. It is possible to suppress the clouding and gelation of the film due to contact, and it is possible to provide good properties

  When (A) component is used in combination with monohydric alcohol having 1 to 4 carbon atoms and benzyl alcohol, these ratios are not particularly limited, but for example, 1 part by weight of monohydric alcohol having 1 to 4 carbon atoms The benzyl alcohol is 0.05 to 2 parts by weight, preferably 0.05 to 1.25 parts by weight, more preferably 0.05 to 0.77 parts by weight, still more preferably 0.06 to 0.56 parts by weight. Is mentioned.

  In the external preparation for reducing skin friction of the present invention, the content of the component (A) is not particularly limited, but is, for example, 10 to 70% by weight, preferably 15 to 65% by weight, and more preferably 18 to 60% by weight. Particularly preferred is 25 to 60% by weight. When the component (A) satisfies the above content, it becomes possible to form a film having a further excellent friction reducing action on the skin. Furthermore, when the component (A) contains the component (D) described later while satisfying the above content, it is possible to further reduce the feeling of tension during use.

(B) Ester of monocarboxylic acid having 2 to 4 carbon atoms and monohydric alcohol having 1 to 5 carbon atoms The external preparation for reducing skin friction according to the present invention comprises monocarboxylic acid having 2 to 4 carbon atoms and 1 to 1 carbon atoms. 5 esters with monohydric alcohols. “Ester of monocarboxylic acid having 2 to 4 carbon atoms and monohydric alcohol having 1 to 5 carbon atoms” means one molecule of monocarboxylic acid having 2 to 4 carbon atoms and one molecule of monohydric alcohol having 1 to 5 carbon atoms. Is an ester-bonded compound.

  Although it does not restrict | limit especially about the kind of C2-C4 monocarboxylic acid which comprises the said ester, For example, an acetic acid, lactic acid, propionic acid, a butyric acid etc. are mentioned. Among these monocarboxylic acids, the monocarboxylic acids having 2 or 3 carbon atoms are preferable, and acetic acid and lactic acid are more preferable.

  Further, the type of the monohydric alcohol having 1 to 5 carbon atoms constituting the ester is not particularly limited. For example, methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, tert -Butanol, benzyl alcohol, 1-pentanol, 3-methyl-1-butanol, 2-methyl-1-butanol, 2,2 dimethyl-1-propanol, 2-pentanol, 3-methyl-2-butanol, 3 -Pentanol, 2-methyl-2-butanol. Among these alcohols, preferably, methanol, ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol, benzyl alcohol, more preferably ethanol, n-propanol, isopropanol, n-butanol, 1-pentanol. Is mentioned.

  Specific examples of the ester include methyl acetate, ethyl acetate, propyl acetate (n-propyl acetate), isopropyl acetate, butyl acetate (n-butyl acetate), sec-butyl acetate, isobutyl acetate, pentyl acetate (acetate 1- Pentyl), ethyl lactate, butyl lactate, isoamyl acetate (3-methylbutyl acetate), ethyl butyrate, ethyl propionate and the like. Among these, from the viewpoint of forming a film having an even better friction reducing action on the skin, the ester is preferably ethyl acetate, butyl acetate, ethyl lactate; more preferably ethyl acetate, butyl acetate. Can be mentioned.

  In the external preparation for reducing skin friction according to the present invention, as the component (B), one of these esters may be used alone, or two or more thereof may be used in combination. For example, as the component (B), by using a combination of two or more esters having different boiling points, the film formation rate of the external preparation for reducing skin friction of the present invention can be appropriately adjusted. For example, when the ester having a boiling point of less than 100 ° C. (for example, ethyl acetate) and the ester having a boiling point of 100 ° C. or more (for example, butyl acetate) are used in combination, the ratio of the ester having a boiling point of less than 100 ° C. is set high. The film formation rate can be increased. If the ratio of the ester having a boiling point of less than 100 ° C. is set low, the film formation rate can be decreased.

  As a suitable example of the component (B), ethyl acetate and butyl acetate are used in combination, and 0.05 to 0.5 parts by weight, preferably 0.07 to 0.4 parts by weight of butyl acetate per 1 part by weight of ethyl acetate. Satisfying the ratio of parts by weight, more preferably 0.1 to 0.3 parts by weight. By using ethyl acetate and butyl acetate together at such a ratio, it is possible to form a film at an appropriate film formation rate when applied to the skin.

  In the external preparation for reducing skin friction of the present invention, the content of the component (B) is not particularly limited, and may be appropriately set according to the type of the component (B), the film formation speed to be provided, etc. For example, it is 25 to 65% by weight, preferably 25 to 60% by weight, and more preferably 35 to 55% by weight based on the total amount of the preparation.

  In the external preparation for reducing skin friction of the present invention, the ratio of the component (B) to the component (A) may be appropriately set within the range satisfying the contents of both of these components.For example, (A) The ratio which becomes 0.2-10 weight part of (B) component per 1 weight part of component is mentioned.

  The ratio of the component (B) to the component (A) is preferably 0, based on 1 part by weight of the component (A) from the viewpoint of forming a film having a further excellent friction reducing action on the skin. The ratio is 4 to 6 parts by weight, more preferably 0.4 to 5 parts by weight, particularly preferably 0.4 to 3.5 parts by weight, and still more preferably 0.6 to 1.8 parts by weight. . When satisfying such a ratio, in addition to being able to form a film having a further excellent friction reducing action on the skin, it is possible to suppress the clouding and gelation of the film due to contact with water, and to have good properties It can also be provided. Furthermore, when the component (D) described later is included while satisfying such a ratio, it is possible to reduce the feeling of tension even more effectively.

(C) Nitrocellulose The external preparation for reducing skin friction of the present invention contains nitrocellulose. Nitrocellulose serves as a base for the film formed on the skin.

  As long as the nitrocellulose used in the present invention can form a film on the skin, the molecular weight, nitrogen content and the like are not particularly limited.

  In the external preparation for reducing skin friction according to the present invention, piroxylin can also be used as nitrocellulose. Piroxylin is obtained by moistening nitrocellulose in a solvent. Specifically, a mixture of about 70% by weight of nitrocellulose and about 30% by weight of isopropanol can be mentioned. In the present invention, commercially available piroxylin can also be used as the component (C). Specific examples of commercially available piroxylin include T.I. N. C. Industrial Co. , Ltd. RS 1/32 sec, RS 1/16 sec, RS 1/8 sec, RS 1/8 L sec, RS 1/8 H sec, RS 1/4 sec, RS 1/4 H sec, RS 1/2 sec, RS 1 sec, RS 5-6 sec, RS 10-15 sec, RS 15-20 sec, RS 30-40 sec, RS 60-80 sec, RS 120 sec, RS 150 sec, RS 300 sec RS 500 sec, RS 800 sec, RS 1200 sec, RS 2000 sec; RS 1/16, RS 1/8, RS 1/4, RS 1/2, RS 1, RS 2, RS 5 made by Korea CNC Ltd RS 7, RS 20, RS 60, RS 120, RS 500, RS 1000, RS 2000, and the like. These may be used alone or in combination of two or more. In the present invention, when piroxylin is used as the component (C), the monohydric alcohol having 1 to 4 carbon atoms contained in the piroxyline constitutes a part of the component (A).

  In the external preparation for reducing skin friction of the present invention, the content of the component (C) is not particularly limited as long as it can form a film on the skin, but is preferably, for example, 3.5 to 14% by weight, preferably 5.6 to 11.2% by weight (when using piroxylin which is a mixture of 70% by weight of nitrocellulose and 30% by weight of isopropanol, the content of piroxylin is 5 to 20% by weight, preferably 8 to 16% by weight. ).

(D) Ingredient for reducing the tension of the film formed on the skin The external preparation for reducing skin friction according to the present invention comprises glycyrrhizic acids, tocopherols, panthenols in addition to the components (A) to (C). , Vitamin Cs, Vitamin As, pyridoxines, allantoins, and azulenes (hereinafter also referred to as (D) component) may be contained. By containing these components (D), it is possible to reduce the feeling of tension due to the film formed on the skin, and to follow the movements of the body even if applied to the range of motion such as joints and feet, and torn or peel off Can be suppressed.

  Glycyrrhizic acids are glycyrrhizic acid, its derivatives, and salts thereof. Specifically, glycyrrhizic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, glycyrrhetinic acid glycerin, glycyrrhetinic acid stearyl, glycyrrhetinic acid pyridoxine Etc. Among these glycyrrhizic acids, glycyrrhizic acid, dipotassium glycyrrhizinate and glycyrrhetinic acid are preferable. These glycyrrhizic acids may be used alone or in combination of two or more.

  Tocopherols are tocopherol and its derivatives, specifically, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, Examples include tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, (linoleic acid / oleic acid) tocopherol and the like. Among these tocopherols, preferably, tocopherol acetate is used. These tocopherols may be used individually by 1 type, and may be used in combination of 2 or more type.

  Panthenols are panthenol, derivatives thereof, and salts thereof. Specifically, panthenol, pantothenyl ethyl ether, alkaline earth metal pantothenate (for example, calcium salt), alkali metal pantothenate Examples thereof include salts (for example, sodium salt), acetyl pantothenyl ethyl ether and the like. Of these panthenols, preferably, panthenol is used. These panthenols may be used individually by 1 type, and may be used in combination of 2 or more type.

  Vitamin Cs are ascorbic acid, its derivatives, and salts thereof. Specifically, ascorbic acid, ascorbic acid monoalkyl ester (for example, ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid monooleate) , Tetrahexyl decanoic acid ascorbyl, etc.), ascorbic acid dialkyl esters (eg, ascorbic acid distearate, ascorbic acid dipalmitate, ascorbic acid dioleate), ascorbic acid trialkyl esters (eg, ascorbic acid tristearate, ascorbic acid tripalmitate, ascorbine) Acid trioleate and the like). These vitamin Cs may be used individually by 1 type, and may be used in combination of 2 or more type.

  Vitamin A is vitamin A and derivatives thereof, specifically, retinol, retinal, retinoic acid, 3-dehydroretinol, 3-dehydroretinoal, 3-dehydroretinoic acid, hydrogenated retinol, retinol palmitate, Examples include retinol propionate, retinol linoleate, and retinol acetate. These vitamin As may be used individually by 1 type, and may be used in combination of 2 or more type.

  Vitamin B6 is vitamin B6, derivatives thereof, and salts thereof. Specifically, pyridoxine, pyridoxal, pyridoxamine, and inorganic acid salts thereof (for example, hydrochloride, sulfate, nitrate, hydrobromic acid) Salt, phosphate, etc.). These vitamin B6s may be used alone or in combination of two or more.

  Allantoins are allantoin and its derivatives, and specifically include allantoin, allantoin chlorohydroxyaluminum, allantoin hydroxyaluminum, and the like. These allantoins may be used individually by 1 type, and may be used in combination of 2 or more type.

  Azulene is azulene, derivatives thereof, and salts thereof. Specifically, azulene, guaiazulene, guaiazulene sulfonic acid, azulene sulfonic acid, sodium azulene sulfonate, 1,4-dimethyl-7-isopropylazulene- 3-sulfonic acid etc. are mentioned. These azulenes may be used individually by 1 type, and may be used in combination of 2 or more type.

  Among these components (D), pantenols and tocopherols are preferable from the viewpoint of more effectively reducing the feeling of tension during use while maintaining the friction reducing action of the film formed on the skin. More preferred are panthenol, tocopherol acetate, glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate; and particularly preferred are glycyrrhetinic acid, glycyrrhizic acid, and dipotassium glycyrrhizinate.

  These components (D) may be used alone or in combination of two or more.

  In the external preparation for reducing skin friction of the present invention, when the component (D) is contained, the content is not particularly limited, and examples thereof include 0.05 to 10% by weight. From the viewpoint of more effectively reducing the feeling of tension during use while maintaining the friction reducing action of the film formed on the skin, the content of the component (D) is preferably 0.05 to 8% by weight. More preferably, 0.1 to 5 weight% is mentioned.

(E) Plasticizer The external preparation for reducing skin friction according to the present invention is provided with a plasticizer (hereinafter, referred to as “plasticizer”) in order to impart good flexibility and skin adhesion to the film formed on the skin. (E) may also be indicated).

  The plasticizer used in the present invention is not particularly limited as long as it is pharmaceutically acceptable. For example, vegetable oil, mono-, di- or tricarboxylic acid having 5 to 22 carbon atoms and one having 1 to 9 carbon atoms can be used. Examples thereof include esters of hydric alcohols, terpenoids, polyhydric alcohols, glycerin fatty acid esters, mineral oils, polyethers, and polyesters.

  Specific examples of vegetable oils include castor oil, cottonseed oil, soybean oil, sesame oil, almond oil, fennel oil, corn oil, olive oil, orange oil, chamomile oil, cinnamon oil, wheat germ oil, safflower oil, and perilla oil. , Citronellor oil, pepper oil, spearmint oil, rice oil, clove oil, camellia oil, turpentine oil, spruce oil, rapeseed oil, mint oil, cedar oil, sunflower oil, bergamot oil, palm oil, eucalyptus oil, peanut oil, Lavender oil, egg yolk oil, lemon oil, rose oil, funnel oil, roman chamomile oil and the like can be mentioned. These vegetable oils may be used individually by 1 type, and may be used in combination of 2 or more type.

  Specific examples of esters of mono-, di- or tricarboxylic acids having 5 to 22 carbon atoms and monohydric alcohols having 1 to 9 carbon atoms include isopropyl palmitate, isopropyl myristate, isopropyl stearate, ethyl linoleate, linoleic acid Isopropyl, dimethyl phthalate, diethyl phthalate, dipropyl phthalate, dibutyl phthalate, dioctyl phthalate, diisobutyl adipate, diisopropyl adipate, diisononyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dibutyl sebacate, Examples include triethyl citrate, tributyl citrate, and acetyl tributyl citrate. These ester may be used individually by 1 type, and may be used in combination of 2 or more type.

  Specific examples of terpenoids include camphor, menthol, borneol, cineol, anethole, limonene, eugenol, geraniol, and mint oil. These terpenoids may be used individually by 1 type, and may be used in combination of 2 or more type.

  Specific examples of the polyhydric alcohol include propylene glycol, glycerin, sorbitol and the like. These polyhydric alcohols may be used individually by 1 type, and may be used in combination of 2 or more type.

  Specific examples of the glycerin fatty acid ester include glyceryl monostearate, glyceryl monooleate, glyceryl monomyristic acid, decaglyceryl laurate, and medium-chain fatty acid triglycerides. These glycerin fatty acid esters may be used alone or in combination of two or more.

  Specific examples of the mineral oil include silicone oil, liquid paraffin, and petroleum jelly. These mineral oils may be used alone or in combination of two or more.

  Specific examples of the polyether include polyethylene glycol.

  Specific examples of the polyester include adipic acid polyester.

  Among these plasticizers, preferably, vegetable oils, esters of mono-, di- or tricarboxylic acids having 5 to 22 carbon atoms and monohydric alcohols having 1 to 9 carbon atoms, terpenoids; more preferably castor oil, isopropyl palmitate, Examples include isopropyl myristate and camphor.

  In addition, plasticizers have the advantage of improving the spreadability of the external preparation for reducing skin friction and the flexibility of the film, but when added to conventional external preparations for reducing skin friction, This was one of the factors causing significant clouding of the preparation. In particular, vegetable oil (particularly castor oil) is one of the plasticizers that easily induce clouding. On the other hand, according to the present invention, even when a plasticizer such as vegetable oil is contained, the clouding caused by contact with water is effectively suppressed by including the combination of the components (A) to (C). can do. In view of the effects of the present invention, vegetable oils (particularly castor oil) are listed as examples of suitable plasticizers to be blended in the present invention.

  These plasticizers may be used individually by 1 type, and may be used in combination of 2 or more type.

  In the external preparation for reducing skin friction according to the present invention, when the component (E) is contained, the content thereof is not particularly limited, but for example, 1 to 40% by weight, preferably 2 to 30% by weight, more preferably 3 to 20% by weight, particularly preferably 5 to 20% by weight.

Other Components The topical preparation for reducing skin friction according to the present invention may further contain a solvent such as water, acetone, ethyl methyl ketone, diethyl ether and the like, as necessary, as long as the effects of the present invention are not hindered. However, since solvents other than the components (A) and (B) may impair the transparency of the film or may easily cause clouding or gelation of the film due to contact with water, (A) and When blending a solvent other than the component (B), it is necessary to consider such characteristics. Furthermore, since diethyl ether is ignitable due to its high volatility, it must be handled with care in manufacturing, and it can cause solidification due to drying during storage, a characteristic odor, etc. When blending ether, it is required to consider such characteristics. The content of the solvent other than the components (A) and (B) in the external preparation for reducing skin friction of the present invention is preferably about 4% by weight or less, particularly about 2% by weight or less.

  Furthermore, the external preparation for reducing skin friction according to the present invention may contain a medicinal component other than the component (D) as necessary, as long as the effects of the present invention are not hindered. Examples of such medicinal ingredients include anti-inflammatory agents, local anesthetics, analgesics, antihistamines, bactericides, antifungal agents, vitamins, moisturizers, whitening agents, tissue repair agents, skin protectants, and keratin softeners. , Topical stimulants, antipruritics, astringents, ultraviolet protective agents, silicone gels, herbal extracts, amino acids, minerals and the like.

  Further, the external preparation for reducing skin friction of the present invention is a thickener, a buffer, a chelating agent, an antioxidant, a stabilizer, an emulsifier, an antiseptic, as necessary, as long as the effects of the present invention are not hindered. , Fragrances, refreshing agents, colorants, dispersants, fluidizing agents, thickening agents, thickeners, adsorbents, moisturizers, wetting agents, moisture-proofing agents, anti-static agents, etc. Good.

Method for producing external preparation for reducing skin friction The external preparation for reducing skin friction of the present invention comprises the above components (A) to (C), and if necessary, the above component (D), other solvents, medicinal components, and additives. It is prepared by mixing a desired amount of agent and the like.

Method for Using External Preparation for Reducing Skin Friction The external preparation for reducing skin friction of the present invention is used by applying to a skin site to which friction is applied in order to reduce friction against the skin.

  In the skin part to which the external preparation for reducing skin friction of the present invention is applied, a film having a high friction reducing action is formed, and friction is reduced in the skin part.

  The skin site to which the external preparation for skin friction reduction of the present invention is applied is not particularly limited as long as friction is required, and any of upper limbs, lower limbs, chest, abdomen, back, waist, etc. It may be. In addition, the external preparation for reducing skin friction according to the present invention, when it contains the component (D), can form a film that is hard to tear on the skin and has a reduced feeling of tension. Even when applied to a range of motion with joints such as elbows, knees, fingers, etc., the back of the foot, the bottom of the foot, the heel, etc., it is difficult to break and can follow the movement of the body.

  The external preparation for reducing skin friction of the present invention can be applied to various uses in which reduction of friction against the skin is required. For example, the external preparation for reducing skin friction according to the present invention prevents rash by applying it to a skin site that is tightened by underwear or socks, or prevents bed slipping by applying it to a skin site that easily causes bed slippage. be able to. In addition, the external preparation for reducing skin friction of the present invention can be prevented from rubbing by applying it to the soles, soles, toes, heels and the like where the rubbing of shoes is likely to occur. Furthermore, the present invention can be applied to a finger or the like on which an accessory such as a ring is attached, thereby reducing friction between the accessory and the skin and facilitating attachment / detachment of the accessory.

  The method for applying the external preparation for reducing skin friction of the present invention to the skin is not particularly limited, and for example, by finger application, direct application using a tube container mouth, application using a brush or spatula, etc. Although it may be a method, application using a brush is preferable from the viewpoint of user convenience. In order to enhance the convenience for the user, the external preparation for reducing skin friction according to the present invention is preferably provided by being housed in a container with a brush attached.

  EXAMPLES The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to these examples. In the following Examples, Comparative Examples, and Formulation Examples, piroxylin (nitrocellulose: isopropyl alcohol weight ratio is 7: 3) was used as the nitrocellulose source.

Test Example 1: Evaluation of friction reducing action Preparation of external preparation for reducing skin friction An external preparation for reducing skin friction having the composition shown in Table 1 was prepared. Specifically, the components (A), (D), and (E) are stirred and mixed, and then the component (C) is added and dispersed therein, and then the component (B) is added and stirred uniformly. It melt | dissolved and the external preparation (Examples 1-7) for skin friction reduction was obtained.

2. Evaluation Method of Friction Reduction Action Apply 0.2 g of each external preparation for skin friction reduction to artificial skin (trade name “Bio Skin”, manufactured by Beaulux Co., Ltd.) in a certain range (2 cm × 5 cm) and dry at room temperature for one day. Thus, a film was formed on the artificial skin. The friction coefficient of the film formed on the artificial skin was measured using a friction tester KES-SE (manufactured by Kato Tech Co., Ltd.). The friction coefficient was measured by setting a speed of 1 mm / sec under a load of 25 g on the jig, and obtaining an average friction coefficient in the measurement range (20 mm). A 10mm square piano wire was used for the jig sensor option.

  For comparison, an artificial skin (Comparative Example 1) to which an external preparation for reducing skin friction was not applied and an adhesive bandage (trade name “Band-Aid Scratch Powerpad Shoe Displacement”, manufactured by Johnson & Johnson Co., Ltd.) were applied. The coefficient of friction was also measured under the same conditions as above for the skin adhesive bandage (Comparative Example 2). Moreover, the average friction coefficient measured in Comparative Example 1 was set to 100, and the relative values of the average friction coefficients measured in Examples 1 to 7 and Comparative Example 2 were also calculated.

3. Evaluation results Table 1 shows the results obtained. All of the external preparations for reducing skin friction (Examples 1 to 7) containing the components (A) to (C) were able to reduce the frictional force of the application part. In addition, in the preparation for external use for reducing skin friction (Examples 1 to 5) containing the component (D) and / or the component (E) in addition to the components (A) to (C), the friction reducing action is recognized, The friction reducing action of the external preparation for skin friction reduction (Examples 1 and 3) containing glycyrrhetinic acid or tocopherol acetate was high. Furthermore, in the external preparation for skin friction reduction (Examples 6 and 7) containing no component (E), particularly excellent friction reducing action was observed.

Test Example 2: Evaluation of the tension feeling Preparation of external preparation for reducing skin friction An external preparation for reducing skin friction having the composition shown in Table 2 was prepared. Specifically, components (A) and (D) are stirred and mixed, and then component (C) is added and dispersed, and then component (B) is added and uniformly stirred and dissolved to reduce skin friction. External preparations (Examples 6 to 14) were obtained.

2. Evaluation method of the feeling of tension 0.2 g of an external preparation for reducing skin friction on the surface (0.5 cm × 1 cm) in a straight state with a rubber string cut to 2 cm (trade name “Soft Rubber 8 Coal”, manufactured by Kaiin Co., Ltd.) It was applied and dried at room temperature for about 2 hours to form a film. Next, starting from the center of the site where the external preparation for reducing skin friction was applied, the rubber cord was folded so that one side of the rubber cord was in contact with the other side, and then the hand was released and a photo was taken 3 seconds later did. The angle formed by the elastic band at the starting point (the elastic band restoring angle, the angle formed by the one side and the other side) was measured with a protractor. The average of three measurements is shown in the table. Moreover, the average restoration angle of the elastic band measured in Example 6 was set to 100, and the relative value of the average elastic restoration angle of the elastic band measured in Examples 7 to 14 was also calculated.

  In this evaluation method, the larger the restoration angle, the greater the shape retention characteristics of the film formed on the rubber string, and the greater the feeling of tension on the skin, and the smaller the restoration angle, the more the film is formed on the rubber string. It shows that the shape retention property of the film is small and the feeling of tension on the skin is small.

3. Evaluation results Table 3 shows the obtained results. From this result, in addition to the components (A) to (C), in the external preparation for reducing skin friction (Examples 7 to 14) containing the component (D), the external preparation for reducing skin friction that does not contain the component (D) Compared to the preparation (Example 6), the restoration angle of the elastic band was small, and the feeling of tension could be reduced. In particular, the external preparation for reducing skin friction (Examples 9 to 12) containing glycyrrhetinic acid as the component (D) was remarkably superior in reducing the tension feeling.

Test Example 3: Evaluation of Shoe Rubbing Prevention Effect The topical skin friction reducing external preparations (Examples 1, 2, 4 and 6) prepared in Test Examples 1 and 2 were evaluated for shoe rub preventing effect. Specifically, for 6 subjects who own shoes that easily slip off when worn, each topical preparation for reducing skin friction is applied to a portion (skin) that tends to slip off with a brush and dried. I wore it and went out for a day (8 hours). Thereafter, the presence or absence of shoe slipping in each subject was observed.

  In any of the external preparations for reducing skin friction (Examples 1, 2, 4 and 6), no shoe slip was observed in the test subject, and the shoe slip was prevented by the friction reducing effect. More specifically, the preparation for external use for reducing skin friction of Example 6 has a high friction reducing effect and can prevent shoe slipping, but it feels a slight skin tension and the film formed on the skin is walking. It was difficult to follow the movements of the feet, and a tendency to break somewhat. On the other hand, the external preparations for reducing skin friction of Examples 1, 2, and 4 were excellent in the balance between the friction reducing action and the skin tension reducing action, and particularly excellent in preventing shoe slippage. After the test using the external preparation for reducing skin friction, the test was conducted in the same manner as above except that the external preparation for reducing skin friction was not applied. It was.

Formulation Examples External preparations for reducing skin friction having the compositions shown in Tables 3 and 4 were produced in the same manner as in “1. Preparation of external preparation for reducing skin friction” described in Test Example 1. The obtained external preparation for reducing skin friction was evaluated in the same manner as in Test Examples 1 and 2. As a result, the effect of reducing friction was high and the effect of reducing the feeling of tension was excellent.

Claims (4)

  (A) at least one alcohol selected from the group consisting of a monohydric alcohol having 1 to 4 carbon atoms and benzyl alcohol, (B) a monocarboxylic acid having 2 to 4 carbon atoms and a monohydric alcohol having 1 to 5 carbon atoms An external preparation for reducing skin friction, characterized by comprising an ester thereof and (C) nitrocellulose.   The component (A) is at least one selected from the group consisting of ethanol, isopropanol, and benzyl alcohol, and the component (B) is at least one selected from the group consisting of ethyl acetate and butyl acetate. The external preparation for skin friction reduction according to claim 1, wherein   Furthermore, (D) including at least one selected from the group consisting of glycyrrhizic acids, tocopherols, panthenols, vitamin Cs, vitamin As, pyridoxines, allantoins, and azulenes. An external preparation for reducing skin friction described in 1.   The external preparation for reducing skin friction according to any one of claims 1 to 3, which is used for preventing shoe rubs.