JPS5878663A - Rapid drying film forming base agent - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a liquid or paste-like quick-drying film-forming base that is applied to a target surface such as the skin.

External medicines that are applied or pasted on the skin include:
There are various formulations such as ointments, plasters, poultices, and lotions, and these are widely used depending on the purpose of use, taking advantage of their respective advantages. Among these external medicines, for example, ointments and plasters tend to be sticky due to their formulation, and there is a risk that they may stain clothing or the like by coming into contact with it, or that the medicine may migrate from the affected area. Therefore, it is necessary to cover the affected area of the drug applicator with cloth, paper, or a synthetic resin film to prevent the staining and movement. In addition, for products that contain volatile components in their composition, such as poultices, in order to prevent the volatile components from evaporating quickly and maintain the medicinal efficacy over a long period of time, it is generally the case that the surface on which the drug is applied is covered with a cloth. , covering with paper or synthetic resin film, etc. In recent years, poultices and plasters have been commercially available in the form of sheets that are spread on a medicinal base cloth for ease of use, but these forms do not irritate the skin. A feeling of pressure or discomfort is unavoidable, and the process of spreading the drug is required, resulting in complicated manufacturing.

The present invention was developed in view of the above circumstances, and its purpose is to quickly dry when applied to the target surface such as the skin, and to form a stable film with elasticity on the applied surface after drying. The purpose is to provide a liquid or paste-like quick-drying film-forming base that has a saponification degree of 60 to 80 mol %, which has a compatibility of 1 with -valent lower alcohols,
Polyvinyl alcohol 5 with polymerization ff 300-1500
~25 weight duck, -valent lower alcohol 20~60 weight duck, ester gum α1~&θ weight 1% are contained in the base,
Furthermore, it is characterized by containing one or more of rosin, a homopolymer of dialkylaminoalkyl methacrylate, and a copolymer of dialkylaminoalkyl methacrylate and methyl methacrylate, if necessary.

Generally, the best solvent for polyvinyl alcohol is water, but polyvinyl alcohol with a low degree of saponification and polymerization is filterable even in aqueous solutions with high alcohol concentrations. However, when other substances such as medicinal ingredients are added, the physical properties become complex, and phenomena such as coagulation, aggregation, and syneresis are likely to occur, making it difficult to obtain a homogeneous phase. Furthermore, when a mixed-phase liquid in which polyvinyl alcohol is dissolved in an aqueous solution with a high alcohol concentration is applied to the skin or the like, a film of polyvinyl alcohol is formed on the applied surface as the aqueous alcohol solution evaporates. However, this film is very brittle by itself and is prone to cracking and peeling, making it difficult to put it to practical use.

As a result of various studies, the present inventor found that the degree of saponification was 60~gQ m
A mixed-phase liquid made by dissolving polyvinyl alcohol with a polymerization degree of 300 to 1500 in a high alcohol concentration aqueous solution and a small amount of ester gum will remain homogeneous even if other minute substances such as medicinal ingredients are added to it. The phase can be maintained, and the film formed on the coated surface after drying has high elasticity and adhesive strength, and will not crack even after a long period of time.
□It was found that it is extremely stable without causing any peeling or peeling. This film is stably formed even on bent parts such as joints, and is easily damaged by large kites. In particular, those in which one or more of the following are dissolved in the above-mentioned mixed-phase liquid together with ester gum: ,
When Kowa is applied to the skin, the adhesion and toughness of the film formed on the applied surface after drying are further improved, and the film does not peel off from its surrounding area even after a long period of time. Therefore, if a medicinal ingredient is added to this, for example,
Just by applying it, a film containing medicinal ingredients can be formed on the applied surface after drying, so there is no need to cover the drug-applied surface with cloth, paper, etc. as with conventional external drugs.
In addition, there is no need to spread the drug in advance, and the base fabric itself can be used as a base for external drugs.

The polyvinyl alcohol used in the quick-drying film-forming base of the present invention has a degree of saponification of 60 to 3Q mo1%, preferably 70±
5N31%, degree of polymerization 300-1500 preferably 500
Within the range of ±100, 5 to 25
It is appropriate to use heavy weight polyvinyl alcohol.If the amount of polyvinyl alcohol exceeds 25% by weight, the viscosity of the base will increase and it will be difficult to apply to the skin. The viscosity decreases, making it difficult to form a film after drying. - As the lower alcohol, for example, ethanol can be used, and the amount thereof is 20% based on the entire base.
It is appropriate to use ~60 weight duck. If the alcohol content exceeds 60% by weight, it may be dangerous to handle and cannot be put to practical use.If the alcohol content is less than 20% by weight, the dryness of the base will deteriorate. Ester gum gives elasticity and toughness to the film together with the above-mentioned polyvinyl alcohol, and is contained in the base material of the present invention in an amount of 0.1 to 3.0% by weight of the whole. In addition, when one or more of rosin, a homopolymer of dialkylaminoalkyl methacrylate, and a copolymer of dialkylaminoalkyl methacrylate and methyl methacrylate are contained in the range of α01 to 1.5% by weight, the film becomes sticky. This increases the strength (each) and increases the effectiveness of preventing peeling.

To produce the quick-drying film-forming base of the present invention, first, a high alcohol concentration aqueous solution consisting of a -valent lower alcohol and a small amount of purified water is prepared by hand, and the degree of saponification and polymerization are adjusted. Polyvinyl alcohol having a concentration within the above range is added and dissolved near the azeotropic point to obtain a mixed phase liquid of polyvinyl alcohol with a high alcohol concentration. In that case, glycerin and/or propylene glycol may be mixed with the high alcohol concentration aqueous solution as a humectant.

To this mixed phase liquid, a solution of ester gum in methyl salicylate is gradually added and mixed homogeneously. Next, if necessary, an alcoholic solution of rosin, an aqueous solution of dialkylaminoalkyl methacrylate homopolymer, and a solution of dialkylaminoalkyl methacrylate and methyl methacrylate are added. A base can be obtained by gradually adding a water dilution of the copolymer emulsion. Menthone in Hetsuka oil can also be used as a solvent for ester gum. The resulting base will be liquid or paste depending on the amount of polyvinyl alcohol.

Example 1 A mixed solution consisting of 16.45 parts of purified water, 503 parts of ethanol, and 1 part of glycerin was prepared (II) with a degree of saponification of 71 mo.
1%, 1 cup ff5so polyvinyl alcohol 15-0
of water in a dissolver equipped with a reflux condenser near the boiling point.
to obtain a high alcohol concentration mixed phase liquid (al) of polyvinyl alcohol.Separately, lbl ester gum α8
0.4 parts of rosin dissolved in 5 parts of ethanol (alg) 0.4 parts of rosin dissolved in 3 parts of methyl salicylate (alg) 30% emulsion of a copolymer of methylaminoethyl methacrylate and methyl methacrylate.
A mixed solution of 15 parts of polyvinyl alcohol mixed with 5.0 parts of purified water was prepared, and a high alcohol concentration mixed phase solution of the above polyvinyl alcohol (al, lbl
, lcl, and (dl) were mixed one after another, and finally ethanol was further added to make 100 parts to obtain a liquid quick-drying film-forming base. When this base was applied to the skin with fingers, the surface covered in a few tens of seconds. After drying, an elastic and transparent film was formed.This film was not easily damaged even by a large kite, and remained extremely stable without cracking or peeling even after 4 hours. It was something to do.

Example 2 Using the same method as in Example 1, prepare 1al of a high alcohol concentration mixed phase liquid of polyvinyl alcohol (IJ) from 12 parts of purified water, 50 parts of ethanol, 1 part of glycerin, and 11 parts of polyvinyl alcohol. Gum α
5 parts of methyl salicylate dissolved in 3.0 parts of methyl salicylate (cl) 0.3 parts of rosin dissolved in 5.0 parts of ethanol (at 0.15 parts of dimethylamino nibble methacrylate homopolymer dissolved in 6.0 parts of purified water) (e)
I! - 4.0 parts of menthol, 5.0 parts of peppermint oil,
a-Prepare 2.05 parts of camphor and add ibl, (cl, ldl) to the above mixed phase liquid 1al.
, tel were sequentially mixed to obtain a liquid quick-drying anti-inflammatory analgesic. When this anti-inflammatory analgesic was applied to the skin surface of the affected area, the surface dried and a film was formed within a few tens of seconds. This film did not peel off even when worn on clothes, and could exert an anti-inflammatory and analgesic effect for about 3 to 4 hours.

Example 3 The following materials were prepared to obtain an anti-inflammatory analgesic using Example 21: MA. Although the obtained anti-inflammatory analgesic was in the form of a paste, it could be expected to have the same effects as in Example 2.

(al 1650 parts of purified water, 49.3 parts of ethanol,
A high alcohol concentration mixed phase solution of polyvinyl alcohol (d) consisting of 15 parts of polyvinyl alcohol (saponification degree 71 mo1%, polymerization degree 500') and 1 part of glycerin (d) 0.8 parts of ester gum dissolved in 3 parts of methyl salicylate (cl) Rosin 04 parts dissolved in 5 parts of ethanol, 1 cll, /-3.0 parts of menthol, 4 parts of peppermint oil.
A mixture of 0 parts and 20 parts of a-camphor Patent applicant Watanabe Pharmaceutical Co., Ltd.

Claims (2)

[Claims] (1) polyvinyl alcohol with a degree of saponification of 60 to 80 times, which is compatible with a -valent lower alcohol, 5 to 25 weight percent of polyvinyl alcohol with a degree of polymerization of 300 to 1,500, and a 20 to 60 weight amount of a -valent lower alcohol; A quick-drying film-forming base containing 1 to 3.0% by weight of ester gum α. (2) Claims containing 0.01 to 1.5% by weight of one or more of rosin, a homopolymer of dialkylaminoalkyl methacrylate, and a copolymer of dialkylaminoalkyl methacrylate and methyl methacrylate. The quick-drying film-forming base according to item 1.