JP2020090440A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP2020090440A JP2020090440A JP2018226446A JP2018226446A JP2020090440A JP 2020090440 A JP2020090440 A JP 2020090440A JP 2018226446 A JP2018226446 A JP 2018226446A JP 2018226446 A JP2018226446 A JP 2018226446A JP 2020090440 A JP2020090440 A JP 2020090440A
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- Prior art keywords
- cpc
- scc
- composition
- oral composition
- sodium
- Prior art date
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- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 95
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims abstract description 75
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- JVOGSHDZLOJKKR-MXFMKSRJSA-I [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O Chemical compound [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O JVOGSHDZLOJKKR-MXFMKSRJSA-I 0.000 claims description 17
- 229910052802 copper Inorganic materials 0.000 claims description 17
- 239000010949 copper Substances 0.000 claims description 17
- 208000028169 periodontal disease Diseases 0.000 claims description 16
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 claims description 2
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Abstract
Description
項1.
銅クロロフィリンナトリウム及び塩化セチルピリジニウムを質量比1:1.2〜100又は1.2〜20:1で含有する、口腔用組成物。
項2.
抗歯周病のための口腔用組成物である、項1に記載の組成物。
項3.
抗歯周病が、歯周病進行抑制である、項2に記載の組成物。
項4.
銅クロロフィリンナトリウムを0.001〜0.1質量%含有する、項1〜3のいずれかに記載の組成物。
項5.
塩化セチルピリジニウムを0.005〜0.1質量%含有する、項1〜4のいずれかに記載の組成物。
P.g菌(P.gingivalis W83)をGAM培地にて培養し、吸光度(O.D(600))=1.0に調整した。当該菌液を10000rpmで遠心分離し、上清を回収した。回収した上清中にジンジパインが含まれる。各濃度に調整した銅クロロフィリンナトリウム(SCC)を、回収した上清と混合し、3分間放置した。3分後、PBSで100倍希釈したジンジパインの基質(Z−His−Glu−Lys−MCA又はZ−Phe−Arg−MCA;株式会社ペプチド研究所)と混合し、遮光して37℃1時間静置した。なお、Z−His−Glu−Lys−MCAはBenzyloxycarbonyl-L-Histidyl-L-Glutamyl-L-Lysine 4-methylcoumaryl-7-amide (Hydrochloride Form)であり、Lys−ジンジパイン(Kgp)活性により切断されて蛍光を発する試薬である。また、Z−Phe−Arg−MCAはBenzyloxycarbonyl-L-phenylalanyl-L-arginine 4-methylcoumaryl-7-amide (Hydrochloride Form)であり、Arg−ジンジパイン(Rgp)活性により切断されて蛍光を発する試薬である。1時間後、蛍光プレートリーダー(Gemini XPS)にて蛍光強度(励起光:380nm、放出光:440nm)を測定した。薬剤濃度が0μg/mLでの蛍光強度を100%になるように換算し、各濃度のSCCを処理した際のジンジパイン活性を算出した。なお、各濃度について検討はn=2で行い、算出する値は平均値とした。算出された値が小さいほど、ジンジパイン活性が抑制されたことを示す。結果を図1に示す。
上記と同様にして、SCC及びCPCを組み合わせて用いた際のP.g菌のジンジパイン活性の抑制効果を検討した。すなわち、次のようにして検討した。P.g菌(P.gingivalis W83)をGAM培地にて培養し、吸光度(O.D(600))=1.0に調整した。当該菌液を10000rpmで遠心分離し、上清を回収した。回収した上清中にジンジパインが含まれる。各濃度に調整した薬剤(銅クロロフィリンナトリウム(SCC)、塩化セチルピリジニウム(CPC)、及びその混合物)を、回収した上清と混合し、3分間放置した。3分後、PBSで100倍希釈したLys−ジンジパイン(Kgp)の基質(Z−Phe−Arg−MCA;株式会社ペプチド研究所)と混合し、遮光して37℃1時間静置した。1時間後、蛍光プレートリーダー(Gemini XPS)にて蛍光強度(励起光:380nm、放出光:440nm)を測定した。薬剤濃度が0μg/mLでの蛍光強度を100%になるように換算し、各濃度の薬剤を処理した際のジンジパイン活性を算出した。なお、各濃度について検討はn=2で行い、算出する値は平均値とした。算出された値が小さいほど、ジンジパイン活性が抑制されたことを示す。結果を表1にまとめて示す。
P.g菌(P.gingivalis W83)をGAM培地にて培養し、吸光度(O.D(600))=1.0に調整した。各処理濃度の倍の濃度に調整した薬剤(銅クロロフィリンナトリウム(SCC)、塩化セチルピリジニウム(CPC)、及びその混合物)を、調整した菌液と等量混合し、3分間放置した。3分後、当該薬剤及び菌液の混合液に、殺菌剤不活化PBS(0.07%レシチン+0.5%Tween 80)を1/10量加え、殺菌効果を停止させた。その後、GAM培地にの当該混合液を10倍量加え、37℃嫌気条件下で16時間培養した。培養後、吸光プレートリーダー(xMark マイクロプレートリーダー)にて培地の吸光度(O.D(600))を測定し、濁度を測定して殺菌効果を確認した。吸光度が小さいほど菌が増殖していないことから、吸光度が小さいほど殺菌効果が高いということができる。結果を表2にまとめて示す。
Claims (5)
- 銅クロロフィリンナトリウム及び塩化セチルピリジニウムを質量比1:1.2〜100又は1.2〜20:1で含有する、口腔用組成物。
- 抗歯周病のための口腔用組成物である、請求項1に記載の組成物。
- 抗歯周病が、歯周病進行抑制である、請求項2に記載の組成物。
- 銅クロロフィリンナトリウムを0.001〜0.1質量%含有する、請求項1〜3のいずれかに記載の組成物。
- 塩化セチルピリジニウムを0.005〜0.1質量%含有する、請求項1〜4のいずれかに記載の組成物。
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JP5402613B2 (ja) * | 2009-12-22 | 2014-01-29 | ライオン株式会社 | 歯磨組成物 |
JP5682264B2 (ja) * | 2010-11-30 | 2015-03-11 | ライオン株式会社 | 口腔用組成物及び歯周病原因菌の歯面付着抑制剤 |
JP2012131726A (ja) * | 2010-12-21 | 2012-07-12 | Lion Corp | 口腔用組成物及びアルジンジパイン活性阻害剤 |
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JP2006306768A (ja) * | 2005-04-27 | 2006-11-09 | Sunstar Inc | 口腔又は咽喉用殺菌組成物 |
JP2010018546A (ja) * | 2008-07-10 | 2010-01-28 | Nippon Zettoc Co Ltd | コラゲナーゼ阻害剤、皮膚外用剤、口腔用組成物及び食品 |
JP2016179967A (ja) * | 2015-03-25 | 2016-10-13 | サンスター株式会社 | 水系口腔用組成物 |
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