JP2020073504A5 - - Google Patents
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- JP2020073504A5 JP2020073504A5 JP2019229640A JP2019229640A JP2020073504A5 JP 2020073504 A5 JP2020073504 A5 JP 2020073504A5 JP 2019229640 A JP2019229640 A JP 2019229640A JP 2019229640 A JP2019229640 A JP 2019229640A JP 2020073504 A5 JP2020073504 A5 JP 2020073504A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- antibody
- seq
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022019186A JP7492981B2 (ja) | 2013-08-01 | 2022-02-10 | 抗ｇａｒｐタンパク質及びその使用 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361861008P | 2013-08-01 | 2013-08-01 | |
| US61/861,008 | 2013-08-01 | ||
| EP13178958.8A EP2832747A1 (en) | 2013-08-01 | 2013-08-01 | Anti-GARP protein and uses thereof |
| EP13178958.8 | 2013-08-01 | ||
| EP14167425.9 | 2014-05-07 | ||
| EP14167425 | 2014-05-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530550A Division JP2016529892A (ja) | 2013-08-01 | 2014-08-01 | 抗ｇａｒｐタンパク質及びその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022019186A Division JP7492981B2 (ja) | 2013-08-01 | 2022-02-10 | 抗ｇａｒｐタンパク質及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020073504A JP2020073504A (ja) | 2020-05-14 |
| JP2020073504A5 true JP2020073504A5 (https=) | 2020-10-01 |
Family
ID=52431038
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530550A Withdrawn JP2016529892A (ja) | 2013-08-01 | 2014-08-01 | 抗ｇａｒｐタンパク質及びその使用 |
| JP2019229640A Pending JP2020073504A (ja) | 2013-08-01 | 2019-12-19 | 抗ｇａｒｐタンパク質及びその使用 |
| JP2022019186A Active JP7492981B2 (ja) | 2013-08-01 | 2022-02-10 | 抗ｇａｒｐタンパク質及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530550A Withdrawn JP2016529892A (ja) | 2013-08-01 | 2014-08-01 | 抗ｇａｒｐタンパク質及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022019186A Active JP7492981B2 (ja) | 2013-08-01 | 2022-02-10 | 抗ｇａｒｐタンパク質及びその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US10000572B2 (https=) |
| EP (2) | EP3786187A1 (https=) |
| JP (3) | JP2016529892A (https=) |
| KR (2) | KR102362609B1 (https=) |
| CN (2) | CN105658666B (https=) |
| AU (3) | AU2014298373B2 (https=) |
| BR (1) | BR112016002199B8 (https=) |
| CA (1) | CA2919765C (https=) |
| EA (1) | EA035550B1 (https=) |
| ES (1) | ES2860952T3 (https=) |
| IL (2) | IL243899B (https=) |
| MX (2) | MX377091B (https=) |
| NZ (1) | NZ717476A (https=) |
| SG (2) | SG10201800889SA (https=) |
| WO (1) | WO2015015003A1 (https=) |
| ZA (1) | ZA201601085B (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS61778B1 (sr) | 2013-05-06 | 2021-06-30 | Scholar Rock Inc | Kompozicije i postupci za modulaciju faktora rasta |
| ES2860952T3 (es) * | 2013-08-01 | 2021-10-05 | Univ Catholique Louvain | Proteína anti-garp y usos de la misma |
| WO2016125017A1 (en) * | 2015-02-03 | 2016-08-11 | Universite Catholique De Louvain | Anti-garp protein and uses thereof |
| US9708412B2 (en) | 2015-05-21 | 2017-07-18 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| JP2018529642A (ja) * | 2015-07-22 | 2018-10-11 | ホスピタル サント ジョアン デ デューＨｏｓｐｉｔａｌ Ｓａｎｔ Ｊｏａｎ Ｄｅ Ｄｅｕ | Ｃａｓｒを発現する癌（例えば神経芽腫）のための免疫療法 |
| DK3354729T5 (da) * | 2015-09-24 | 2024-09-30 | Daiichi Sankyo Co Ltd | Anti-garp-antistof |
| EP3383911B1 (en) * | 2015-12-02 | 2021-01-20 | STCube & Co. Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
| CA3055555A1 (en) * | 2016-03-11 | 2017-09-14 | Scholar Rock, Inc. | Tgf.beta.1-binding immunoglobulins and use thereof |
| EP3436480A4 (en) | 2016-03-30 | 2019-11-27 | Musc Foundation for Research Development | METHOD FOR THE TREATMENT AND DIAGNOSIS OF CANCER BY TARGETING GLYCOPROTEIN A REPETITION PREDOMINANT (GARP) AND FOR EFFECTIVE IMMUNOTHERAPY ALONE OR IN COMBINATION |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| EP3493844A4 (en) | 2016-05-20 | 2021-03-24 | Harpoon Therapeutics Inc. | SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| CN110049773A (zh) * | 2016-07-14 | 2019-07-23 | 供石公司 | TGFβ抗体、方法和用途 |
| EP3568466A4 (en) | 2017-01-10 | 2020-07-15 | The General Hospital Corporation | TARGETED T CELLS WITH CYTOTOXICITY TO IMMUNOSUPPRESSIVE CELLS |
| US12378297B2 (en) | 2017-04-14 | 2025-08-05 | The General Hospital Corporation | Chimeric antigen receptor T cells targeting the tumor microenvironment |
| GB201707561D0 (en) | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
| EP3621994A4 (en) | 2017-05-12 | 2020-12-30 | Harpoon Therapeutics, Inc. | MESOTHELIN BINDING PROTEINS |
| MX2020003915A (es) | 2017-10-13 | 2020-10-08 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso. |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| AU2018383709B2 (en) | 2017-12-12 | 2025-09-11 | Pionyr Immunotherapeutics, Inc. | Anti-TREM2 antibodies and related methods |
| WO2019157533A1 (en) * | 2018-02-12 | 2019-08-15 | The General Hospital Corporation | Chimeric antigen receptors targeting the tumor microenvironment |
| KR102835308B1 (ko) | 2018-08-08 | 2025-07-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| US10815311B2 (en) | 2018-09-25 | 2020-10-27 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| US12459995B2 (en) * | 2018-10-16 | 2025-11-04 | Neuracle Science Co., Ltd. | Use of anti-FAM19A5 antibodies |
| AU2019412561A1 (en) | 2018-12-24 | 2021-08-12 | Sanofi | Multispecific binding proteins with mutant Fab domains |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| US20240190961A1 (en) * | 2019-10-25 | 2024-06-13 | Daiichi Sankyo Company, Limited | Combination of anti-garp antibody and immunomodulator |
| EP4058144A1 (en) | 2019-11-15 | 2022-09-21 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
| CA3166328A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| JP7511377B2 (ja) * | 2020-04-16 | 2024-07-05 | デンカ株式会社 | アデノウイルスの免疫測定方法及び免疫測定器具 |
| US20230192867A1 (en) | 2020-05-15 | 2023-06-22 | Bristol-Myers Squibb Company | Antibodies to garp |
| EP4161936A1 (en) | 2020-06-03 | 2023-04-12 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| TWI843503B (zh) | 2020-06-03 | 2024-05-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| KR20230035576A (ko) | 2020-07-07 | 2023-03-14 | 비온테크 에스이 | Hpv 양성 암 치료용 rna |
| WO2022116877A1 (en) | 2020-12-02 | 2022-06-09 | Shanghai Henlius Biotech, Inc. | ANTI-GARP/TGFβ ANTIBODIES AND METHODS OF USE |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| BR112023014319A2 (pt) * | 2021-01-18 | 2023-09-26 | Jiangxi Jemincare Group Co Ltd | Anticorpo contra a proteína garp e aplicação do mesmo |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| WO2022240879A1 (en) | 2021-05-11 | 2022-11-17 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| KR20240007233A (ko) | 2021-05-13 | 2024-01-16 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
| EP4348260A2 (en) | 2021-06-03 | 2024-04-10 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| CA3225254A1 (en) | 2021-07-13 | 2023-01-19 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| US20240425571A1 (en) * | 2021-10-11 | 2024-12-26 | Ohio State Innovation Foundation | Glycoprotein a repetitions predominant (garp)-binding antibodies and uses thereof |
| WO2023107938A1 (en) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| US12122764B2 (en) | 2021-12-22 | 2024-10-22 | Gilead Sciences, Inc. | IKAROS zinc finger family degraders and uses thereof |
| KR20240123836A (ko) | 2021-12-22 | 2024-08-14 | 길리애드 사이언시즈, 인코포레이티드 | 이카로스 아연 핑거 패밀리 분해제 및 이의 용도 |
| GB202203269D0 (en) | 2022-03-09 | 2022-04-20 | Argenx Iip Bv | TGF-Beta antibodies |
| WO2023178181A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| JP2025526336A (ja) | 2022-07-22 | 2025-08-13 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ｔ細胞悪性腫瘍におけるバイオマーカー及びバイオターゲットとしてのｇａｒｐ |
| JP2025524957A (ja) | 2022-07-29 | 2025-08-01 | アッヴィ・バイオセラピューティクス・インコーポレイテッド | 抗ＧＡＲＰ－ＴＧＦ－β１／ＰＤ－１併用療法 |
| JP2026501506A (ja) | 2022-12-14 | 2026-01-16 | アステラス・ファーマ・ヨーロッパ・ベスローデン・フェンノートシャップ | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤並びに免疫チェックポイント阻害剤を含む併用療法 |
| AU2023409398A1 (en) | 2022-12-22 | 2025-06-05 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2024187051A1 (en) | 2023-03-07 | 2024-09-12 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| CR20250446A (es) | 2023-04-21 | 2025-12-02 | Gilead Sciences Inc | Inhibidores de prmt5 y usos de los mismos |
| CN121241070A (zh) * | 2023-06-05 | 2025-12-30 | 纯生物制剂股份有限公司 | 抗garp抗体和使用方法 |
| US20250154172A1 (en) | 2023-11-03 | 2025-05-15 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| WO2026033885A1 (en) | 2024-08-08 | 2026-02-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| TW202541837A (zh) | 2023-12-08 | 2025-11-01 | 日商安斯泰來製藥公司 | 含有結合至cldn18.2和cd3之雙特異性結合劑和穩定或增加cldn18.2表現之藥劑之組合療法 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| NZ298145A (en) * | 1994-12-29 | 1998-08-26 | Yamanouchi Pharma Co Ltd | Monoclonal antibodies having inhibitory effect on type ii phospholipase a2, proteins forming part thereof, cells producing them, dna encoding them, recombinant vector comprising the dna and medicament |
| CN1333274A (zh) * | 2000-07-07 | 2002-01-30 | 上海博德基因开发有限公司 | 一种新的多肽——人garp蛋白12.98和编码这种多肽的多核苷酸 |
| US7709610B2 (en) * | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
| US20070048785A1 (en) | 2004-06-09 | 2007-03-01 | Lin Laura L | Anti-IL-13 antibodies and complexes |
| WO2006103639A2 (en) | 2005-03-31 | 2006-10-05 | Case Western Reserve University | Methods and reagents for identifying/isolating t regulatory (treg) cells and for treating individuals |
| US20110086367A1 (en) | 2006-04-03 | 2011-04-14 | Medizinische Hochschule Hannover | Pharmaceuticals for influencing the reaction of the human immune system |
| CN103223165B (zh) * | 2007-08-24 | 2015-02-11 | 学校法人庆应义塾 | 肿瘤细胞所导致的免疫抑制的解除剂及使用该解除剂的抗肿瘤剂 |
| KR101557173B1 (ko) * | 2007-10-25 | 2015-10-05 | 더 스크립스 리서치 인스티튜트 | 박테리아에서의 쿼럼 센싱의 항체 매개성 파괴 |
| WO2009073163A1 (en) * | 2007-12-03 | 2009-06-11 | American Type Culture Collection (Atcc) | Avian influenza antibodies, compositions, and methods thereof |
| EP2238170B1 (en) * | 2008-01-31 | 2016-11-23 | INSERM - Institut National de la Santé et de la Recherche Médicale | Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity |
| GB2461546B (en) * | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
| WO2010022341A1 (en) | 2008-08-21 | 2010-02-25 | The United State Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of enriching and using regulatory t cells |
| EP2977386A1 (en) | 2012-08-31 | 2016-01-27 | Argen-X Nv | Method for producing antibody molecules having inter-species, intra-target cross-reactivity |
| RS61778B1 (sr) * | 2013-05-06 | 2021-06-30 | Scholar Rock Inc | Kompozicije i postupci za modulaciju faktora rasta |
| EP2832747A1 (en) | 2013-08-01 | 2015-02-04 | Université Catholique de Louvain | Anti-GARP protein and uses thereof |
| ES2860952T3 (es) | 2013-08-01 | 2021-10-05 | Univ Catholique Louvain | Proteína anti-garp y usos de la misma |
| WO2016125017A1 (en) | 2015-02-03 | 2016-08-11 | Universite Catholique De Louvain | Anti-garp protein and uses thereof |
| DK3354729T5 (da) | 2015-09-24 | 2024-09-30 | Daiichi Sankyo Co Ltd | Anti-garp-antistof |
| CN110049773A (zh) | 2016-07-14 | 2019-07-23 | 供石公司 | TGFβ抗体、方法和用途 |
-
2014
- 2014-08-01 ES ES14748185T patent/ES2860952T3/es active Active
- 2014-08-01 US US14/908,368 patent/US10000572B2/en active Active
- 2014-08-01 KR KR1020167005677A patent/KR102362609B1/ko active Active
- 2014-08-01 NZ NZ717476A patent/NZ717476A/en unknown
- 2014-08-01 MX MX2016001356A patent/MX377091B/es active IP Right Grant
- 2014-08-01 EP EP20201515.2A patent/EP3786187A1/en not_active Withdrawn
- 2014-08-01 KR KR1020227004383A patent/KR20220025174A/ko not_active Ceased
- 2014-08-01 JP JP2016530550A patent/JP2016529892A/ja not_active Withdrawn
- 2014-08-01 EP EP14748185.7A patent/EP3027650B1/en active Active
- 2014-08-01 BR BR112016002199A patent/BR112016002199B8/pt active IP Right Grant
- 2014-08-01 EA EA201690314A patent/EA035550B1/ru not_active IP Right Cessation
- 2014-08-01 CA CA2919765A patent/CA2919765C/en active Active
- 2014-08-01 CN CN201480043607.6A patent/CN105658666B/zh active Active
- 2014-08-01 AU AU2014298373A patent/AU2014298373B2/en active Active
- 2014-08-01 SG SG10201800889SA patent/SG10201800889SA/en unknown
- 2014-08-01 SG SG11201600741SA patent/SG11201600741SA/en unknown
- 2014-08-01 CN CN202110765205.9A patent/CN113583128A/zh active Pending
- 2014-08-01 WO PCT/EP2014/066650 patent/WO2015015003A1/en not_active Ceased
-
2016
- 2016-01-29 MX MX2019011952A patent/MX2019011952A/es unknown
- 2016-02-01 IL IL243899A patent/IL243899B/en active IP Right Grant
- 2016-02-02 US US15/013,706 patent/US20160251438A1/en not_active Abandoned
- 2016-02-17 ZA ZA2016/01085A patent/ZA201601085B/en unknown
-
2018
- 2018-05-09 US US15/975,493 patent/US10604579B2/en active Active
-
2019
- 2019-03-29 US US16/370,822 patent/US10822424B2/en active Active
- 2019-11-18 AU AU2019268046A patent/AU2019268046A1/en not_active Abandoned
- 2019-12-19 JP JP2019229640A patent/JP2020073504A/ja active Pending
-
2020
- 2020-02-14 US US16/791,937 patent/US11230603B2/en active Active
- 2020-07-16 IL IL276106A patent/IL276106A/en unknown
-
2021
- 2021-12-03 AU AU2021277761A patent/AU2021277761A1/en not_active Abandoned
-
2022
- 2022-02-10 JP JP2022019186A patent/JP7492981B2/ja active Active
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