EA035550B1 - АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С КОМПЛЕКСОМ hGARP/TGF-B1, И ИХ ПРИМЕНЕНИЕ - Google Patents

АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С КОМПЛЕКСОМ hGARP/TGF-B1, И ИХ ПРИМЕНЕНИЕ Download PDF

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EA035550B1
EA035550B1 EA201690314A EA201690314A EA035550B1 EA 035550 B1 EA035550 B1 EA 035550B1 EA 201690314 A EA201690314 A EA 201690314A EA 201690314 A EA201690314 A EA 201690314A EA 035550 B1 EA035550 B1 EA 035550B1
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Prior art keywords
antibody
seq
hgarp
human
tgf
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EA201690314A
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English (en)
Russian (ru)
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EA201690314A1 (ru
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Софи Лукас
Пьерр Кули
Юлиа Куэнде Вилласур
Лор Дюмутье
Жан-Кристоф Рено
Себастиан Ван Де Вонинг
Майкл Сондерс
Ханс Де Хард
Гитте Де Бук
Original Assignee
Юниверсите Католик Де Лувэн
Людвиг Инститьют Фор Кэнсер Рисерч Лтд.
Ардженкс Бвба
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Priority claimed from EP13178958.8A external-priority patent/EP2832747A1/en
Application filed by Юниверсите Католик Де Лувэн, Людвиг Инститьют Фор Кэнсер Рисерч Лтд., Ардженкс Бвба filed Critical Юниверсите Католик Де Лувэн
Publication of EA201690314A1 publication Critical patent/EA201690314A1/ru
Publication of EA035550B1 publication Critical patent/EA035550B1/ru

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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/54—F(ab')2
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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EA201690314A 2013-08-01 2014-08-01 АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С КОМПЛЕКСОМ hGARP/TGF-B1, И ИХ ПРИМЕНЕНИЕ EA035550B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361861008P 2013-08-01 2013-08-01
EP13178958.8A EP2832747A1 (en) 2013-08-01 2013-08-01 Anti-GARP protein and uses thereof
EP14167425 2014-05-07
PCT/EP2014/066650 WO2015015003A1 (en) 2013-08-01 2014-08-01 Anti-garp protein and uses thereof

Publications (2)

Publication Number Publication Date
EA201690314A1 EA201690314A1 (ru) 2016-07-29
EA035550B1 true EA035550B1 (ru) 2020-07-06

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EA201690314A EA035550B1 (ru) 2013-08-01 2014-08-01 АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С КОМПЛЕКСОМ hGARP/TGF-B1, И ИХ ПРИМЕНЕНИЕ

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US (5) US10000572B2 (https=)
EP (2) EP3786187A1 (https=)
JP (3) JP2016529892A (https=)
KR (2) KR102362609B1 (https=)
CN (2) CN105658666B (https=)
AU (3) AU2014298373B2 (https=)
BR (1) BR112016002199B8 (https=)
CA (1) CA2919765C (https=)
EA (1) EA035550B1 (https=)
ES (1) ES2860952T3 (https=)
IL (2) IL243899B (https=)
MX (2) MX377091B (https=)
NZ (1) NZ717476A (https=)
SG (2) SG10201800889SA (https=)
WO (1) WO2015015003A1 (https=)
ZA (1) ZA201601085B (https=)

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