JP2020037538A5 - - Google Patents

Info

Publication number

JP2020037538A5

JP2020037538A5 JP2018165890A JP2018165890A JP2020037538A5 JP 2020037538 A5 JP2020037538 A5 JP 2020037538A5 JP 2018165890 A JP2018165890 A JP 2018165890A JP 2018165890 A JP2018165890 A JP 2018165890A JP 2020037538 A5 JP2020037538 A5 JP 2020037538A5

Authority

JP

Japan

Prior art keywords

amino acid

activity

cap

ala

angiotensin converting

Prior art date

2018-09-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 230000000694 effects Effects 0.000 claims 48
• 125000003275 alpha amino acid group Chemical group 0.000 claims 34
• 102100035765 Angiotensin-converting enzyme 2 Human genes 0.000 claims 33
• 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 claims 33
• 108090000765 processed proteins & peptides Proteins 0.000 claims 31
• 102000004196 processed proteins & peptides Human genes 0.000 claims 25
• 229920001184 polypeptide Polymers 0.000 claims 24
• 125000000539 amino acid group Chemical group 0.000 claims 16
• 102000039446 nucleic acids Human genes 0.000 claims 12
• 108020004707 nucleic acids Proteins 0.000 claims 12
• 150000007523 nucleic acids Chemical class 0.000 claims 12
• 239000000758 substrate Substances 0.000 claims 11
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 239000000126 substance Substances 0.000 claims 7
• 125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 claims 6
• 238000007792 addition Methods 0.000 claims 6
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 6
• 238000012217 deletion Methods 0.000 claims 6
• 230000037430 deletion Effects 0.000 claims 6
• 238000003780 insertion Methods 0.000 claims 6
• 230000037431 insertion Effects 0.000 claims 6
• 102000004169 proteins and genes Human genes 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 238000006467 substitution reaction Methods 0.000 claims 5
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 4
• 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 claims 4
• 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 4
• 206010069351 acute lung injury Diseases 0.000 claims 4
• 230000015556 catabolic process Effects 0.000 claims 4
• 238000006731 degradation reaction Methods 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• -1 2-methylamino benzoyl Chemical group 0.000 claims 3
• BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 claims 3
• UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 3
• UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims 2
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
• 102100030988 Angiotensin-converting enzyme Human genes 0.000 claims 2
• 102000015427 Angiotensins Human genes 0.000 claims 2
• 108010064733 Angiotensins Proteins 0.000 claims 2
• 206010003504 Aspiration Diseases 0.000 claims 2
• 208000001528 Coronaviridae Infections Diseases 0.000 claims 2
• 102000004190 Enzymes Human genes 0.000 claims 2
• 108090000790 Enzymes Proteins 0.000 claims 2
• 206010016654 Fibrosis Diseases 0.000 claims 2
• 206010019280 Heart failures Diseases 0.000 claims 2
• 206010020772 Hypertension Diseases 0.000 claims 2
• 208000004852 Lung Injury Diseases 0.000 claims 2
• 208000019693 Lung disease Diseases 0.000 claims 2
• 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims 2
• 206010037423 Pulmonary oedema Diseases 0.000 claims 2
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
• 206010040047 Sepsis Diseases 0.000 claims 2
• 206010069363 Traumatic lung injury Diseases 0.000 claims 2
• 208000036142 Viral infection Diseases 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
• 230000004761 fibrosis Effects 0.000 claims 2
• 210000005003 heart tissue Anatomy 0.000 claims 2
• 206010022000 influenza Diseases 0.000 claims 2
• 231100000515 lung injury Toxicity 0.000 claims 2
• 244000005700 microbiome Species 0.000 claims 2
• 208000005333 pulmonary edema Diseases 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• 210000001519 tissue Anatomy 0.000 claims 2
• 230000009385 viral infection Effects 0.000 claims 2
• 241000588724 Escherichia coli Species 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 210000004102 animal cell Anatomy 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 238000003776 cleavage reaction Methods 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 235000021107 fermented food Nutrition 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 235000021067 refined food Nutrition 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 230000007017 scission Effects 0.000 claims 1