JP2019537582A5 - - Google Patents
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- JP2019537582A5 JP2019537582A5 JP2019522710A JP2019522710A JP2019537582A5 JP 2019537582 A5 JP2019537582 A5 JP 2019537582A5 JP 2019522710 A JP2019522710 A JP 2019522710A JP 2019522710 A JP2019522710 A JP 2019522710A JP 2019537582 A5 JP2019537582 A5 JP 2019537582A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- subject
- hearing loss
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 34
- 206010011878 Deafness Diseases 0.000 claims 11
- 230000001684 chronic effect Effects 0.000 claims 11
- 230000010370 hearing loss Effects 0.000 claims 11
- 231100000888 hearing loss Toxicity 0.000 claims 11
- 208000016354 hearing loss disease Diseases 0.000 claims 11
- SRHWORQGHZESJE-UHFFFAOYSA-N N-[1-(4,6-disulfonylcyclohex-2-en-1-yl)-2,2-dimethylpropylidene]hydroxylamine Chemical compound CC(C)(C)C(=NO)C1C=CC(CC1=S(=O)=O)=S(=O)=O SRHWORQGHZESJE-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 3
- 206010063602 Exposure to noise Diseases 0.000 claims 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 2
- 229960004308 acetylcysteine Drugs 0.000 claims 2
- 210000003030 auditory receptor cell Anatomy 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 238000004880 explosion Methods 0.000 claims 2
- 231100000573 exposure to toxins Toxicity 0.000 claims 2
- 210000004307 hair cells vestibular Anatomy 0.000 claims 2
- 230000014511 neuron projection development Effects 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 230000000946 synaptic effect Effects 0.000 claims 2
- 230000001720 vestibular Effects 0.000 claims 2
- JKRODHBGNBKZLE-YUMQZZPRSA-N (2s)-2-amino-5-[[(2r)-1-[(2-ethoxy-2-oxoethyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O JKRODHBGNBKZLE-YUMQZZPRSA-N 0.000 claims 1
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 claims 1
- 229930182818 D-methionine Natural products 0.000 claims 1
- DYEFUKCXAQOFHX-UHFFFAOYSA-N Ebselen Chemical compound [se]1C2=CC=CC=C2C(=O)N1C1=CC=CC=C1 DYEFUKCXAQOFHX-UHFFFAOYSA-N 0.000 claims 1
- 206010020559 Hyperacusis Diseases 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims 1
- 206010036626 Presbyacusis Diseases 0.000 claims 1
- 108700024319 S-ethyl glutathione Proteins 0.000 claims 1
- 208000009205 Tinnitus Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229950010033 ebselen Drugs 0.000 claims 1
- 239000002360 explosive Substances 0.000 claims 1
- 210000000067 inner hair cell Anatomy 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 210000002241 neurite Anatomy 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 210000002985 organ of corti Anatomy 0.000 claims 1
- 208000009800 presbycusis Diseases 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 210000000225 synapse Anatomy 0.000 claims 1
- 230000007470 synaptic degeneration Effects 0.000 claims 1
- 102000013498 tau Proteins Human genes 0.000 claims 1
- 108010026424 tau Proteins Proteins 0.000 claims 1
- 231100000886 tinnitus Toxicity 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662415101P | 2016-10-31 | 2016-10-31 | |
| US62/415,101 | 2016-10-31 | ||
| US201762488740P | 2017-04-22 | 2017-04-22 | |
| US62/488,740 | 2017-04-22 | ||
| US201762510596P | 2017-05-24 | 2017-05-24 | |
| US62/510,596 | 2017-05-24 | ||
| US201762550345P | 2017-08-25 | 2017-08-25 | |
| US62/550,345 | 2017-08-25 | ||
| PCT/US2017/058834 WO2018081614A1 (en) | 2016-10-31 | 2017-10-27 | Methods for enhancing synaptogenesis and neuritogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019537582A JP2019537582A (ja) | 2019-12-26 |
| JP2019537582A5 true JP2019537582A5 (https=) | 2020-12-03 |
Family
ID=62020809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522710A Pending JP2019537582A (ja) | 2016-10-31 | 2017-10-27 | シナプス形成および神経突起形成を増強するための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10576125B2 (https=) |
| EP (1) | EP3532042A4 (https=) |
| JP (1) | JP2019537582A (https=) |
| CN (1) | CN110248650A (https=) |
| WO (1) | WO2018081614A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12076332B2 (en) | 2018-04-27 | 2024-09-03 | The Regents Of The University Of California | Treatment of lysosomal storage disorders |
| EP3784795A4 (en) | 2018-04-27 | 2022-01-19 | The Regents Of The University Of California | INHIBITION OF LIPOFUSCIN AGGREGATION BY MOLECULAR TWEEZERS |
| US20210137861A1 (en) * | 2018-05-03 | 2021-05-13 | Hough Ear Institute | Methods for reducing accumulated pathologic tau protein |
| AU2019339352B2 (en) * | 2018-09-12 | 2025-05-22 | Hough Ear Institute | Methods for treating hearing loss incident to cochlear implant surgery |
| EP3946601A1 (en) * | 2019-03-26 | 2022-02-09 | Tonix Pharma Holdings Limited | Salt forms of s-(n, n-diethylcarbamoyl)glutathione |
| US12390510B2 (en) | 2019-05-29 | 2025-08-19 | Massachusetts Eye And Ear Infirmary | Methods of treating sensorineural hearing loss using fibroblast growth factor 2 (FGF2) |
| CN112939823A (zh) * | 2019-12-10 | 2021-06-11 | 中国石油天然气股份有限公司 | 泥页岩抑制剂制备方法及抑制剂的应用 |
| WO2025245095A1 (en) * | 2024-05-20 | 2025-11-27 | Therapeutic Vision, Inc. | Method of preventing blast-induced loss of cochlear and vestibular hair cells and auditory spiral ganglion neurons |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5488145A (en) | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
| US6064064A (en) * | 1996-03-01 | 2000-05-16 | Fire Sentry Corporation | Fire detector |
| WO2000018407A1 (en) | 1998-09-25 | 2000-04-06 | Cephalon, Inc. | Methods for preventing/treating damage to sensory hair cells and cochlear neurons |
| KR20130097813A (ko) * | 2008-04-21 | 2013-09-03 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
| JP2012521984A (ja) * | 2009-03-27 | 2012-09-20 | モリーク ピーティーイー リミテッド | 細胞成長を促進するための治療 |
| CA2772097C (en) * | 2009-08-24 | 2019-04-30 | Hough Ear Institute | Methods for treating acute acoustic trauma |
| ES2893825T3 (es) * | 2011-02-04 | 2022-02-10 | Hough Ear Inst | Métodos de tratamiento de lesiones cerebrales |
| EP2872128B1 (en) | 2012-07-16 | 2020-02-19 | Cornell University | Nicotinamide riboside to treat hearing loss |
| CA2883896C (en) * | 2012-09-07 | 2023-03-07 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| JP6396438B2 (ja) * | 2013-06-04 | 2018-09-26 | アクチュラム・ライフ・サイエンス・アクチエボラーグ | トリアゾール化合物およびガンマセクレターゼモジュレーターとしてのその使用 |
| US20180256756A1 (en) * | 2015-09-18 | 2018-09-13 | Oklahoma Medical Research Foundation | Method of transporting an agent across blood-brain, blood-cochlear or blood-cerebrospinal fluid barrier |
-
2017
- 2017-10-27 CN CN201780078374.7A patent/CN110248650A/zh active Pending
- 2017-10-27 EP EP17866191.4A patent/EP3532042A4/en active Pending
- 2017-10-27 JP JP2019522710A patent/JP2019537582A/ja active Pending
- 2017-10-27 US US15/796,522 patent/US10576125B2/en active Active
- 2017-10-27 WO PCT/US2017/058834 patent/WO2018081614A1/en not_active Ceased
-
2020
- 2020-01-30 US US16/777,750 patent/US20200164021A1/en not_active Abandoned
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