JP2018505218A5 - - Google Patents
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- Publication number
- JP2018505218A5 JP2018505218A5 JP2017560462A JP2017560462A JP2018505218A5 JP 2018505218 A5 JP2018505218 A5 JP 2018505218A5 JP 2017560462 A JP2017560462 A JP 2017560462A JP 2017560462 A JP2017560462 A JP 2017560462A JP 2018505218 A5 JP2018505218 A5 JP 2018505218A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- solvate
- salt
- peritonitis
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000011282 treatment Methods 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 26
- 239000012453 solvate Substances 0.000 claims description 26
- 206010067125 Liver injury Diseases 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 21
- 206010034674 peritonitis Diseases 0.000 claims description 18
- 231100000439 acute liver injury Toxicity 0.000 claims description 17
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical group CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 15
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 8
- 239000013543 active substance Substances 0.000 claims description 7
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 6
- 229960004308 acetylcysteine Drugs 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 231100000753 hepatic injury Toxicity 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 239000001530 fumaric acid Substances 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 230000002458 infectious effect Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims description 3
- 239000003862 glucocorticoid Substances 0.000 claims description 3
- 229960005489 paracetamol Drugs 0.000 claims description 3
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 229940037128 systemic glucocorticoids Drugs 0.000 claims description 3
- 239000003053 toxin Substances 0.000 claims description 3
- 231100000765 toxin Toxicity 0.000 claims description 3
- 108700012359 toxins Proteins 0.000 claims description 3
- 229930186147 Cephalosporin Natural products 0.000 claims description 2
- 229930182555 Penicillin Natural products 0.000 claims description 2
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004098 Tetracycline Substances 0.000 claims description 2
- 125000003158 alcohol group Chemical group 0.000 claims description 2
- 229940126575 aminoglycoside Drugs 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 229940124587 cephalosporin Drugs 0.000 claims description 2
- 150000001780 cephalosporins Chemical class 0.000 claims description 2
- 239000003246 corticosteroid Substances 0.000 claims description 2
- 229960001334 corticosteroids Drugs 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 229940124307 fluoroquinolone Drugs 0.000 claims description 2
- -1 fluoroquinolones Chemical class 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 2
- 229940041033 macrolides Drugs 0.000 claims description 2
- 150000002960 penicillins Chemical class 0.000 claims description 2
- 229960001476 pentoxifylline Drugs 0.000 claims description 2
- 210000004303 peritoneum Anatomy 0.000 claims description 2
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims description 2
- 235000019364 tetracycline Nutrition 0.000 claims description 2
- 150000003522 tetracyclines Chemical class 0.000 claims description 2
- 229940040944 tetracyclines Drugs 0.000 claims description 2
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims description 2
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 208000019423 liver disease Diseases 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000008964 Chemical and Drug Induced Liver Injury Diseases 0.000 description 1
- 206010072268 Drug-induced liver injury Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562114304P | 2015-02-10 | 2015-02-10 | |
| US62/114,304 | 2015-02-10 | ||
| PCT/US2015/051467 WO2016130179A1 (en) | 2015-02-10 | 2015-09-22 | Cenicriviroc for the treatment of fibrosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020042730A Division JP2020111586A (ja) | 2015-02-10 | 2020-03-12 | 線維症の治療用のセニクリビロック |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505218A JP2018505218A (ja) | 2018-02-22 |
| JP2018505218A5 true JP2018505218A5 (https=) | 2018-10-25 |
| JP6676660B2 JP6676660B2 (ja) | 2020-04-08 |
Family
ID=56614560
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560462A Expired - Fee Related JP6676660B2 (ja) | 2015-02-10 | 2015-09-22 | 線維症の治療用のセニクリビロック |
| JP2020042730A Pending JP2020111586A (ja) | 2015-02-10 | 2020-03-12 | 線維症の治療用のセニクリビロック |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020042730A Pending JP2020111586A (ja) | 2015-02-10 | 2020-03-12 | 線維症の治療用のセニクリビロック |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20180110754A1 (https=) |
| EP (1) | EP3256124B1 (https=) |
| JP (2) | JP6676660B2 (https=) |
| KR (1) | KR20170113596A (https=) |
| CN (1) | CN107405403B (https=) |
| AU (1) | AU2015382376B2 (https=) |
| BR (1) | BR112017016388A2 (https=) |
| CA (1) | CA2975445A1 (https=) |
| ES (1) | ES2864767T3 (https=) |
| HK (1) | HK1247558A1 (https=) |
| IL (1) | IL253617A0 (https=) |
| MX (1) | MX2017010277A (https=) |
| RU (1) | RU2722641C2 (https=) |
| SG (1) | SG11201706028RA (https=) |
| WO (1) | WO2016130179A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20030329A1 (es) | 2001-08-08 | 2003-05-12 | Takeda Chemical Industries Ltd | Compuesto biciclico con actividad antagonista de ccr5 y produccion del mismo |
| JP6716568B2 (ja) | 2014-12-23 | 2020-07-01 | トビラ セラピューティクス， インコーポレイテッド | セニクリビロックの製造方法及び関連類似体 |
| JP2019520427A (ja) | 2016-06-21 | 2019-07-18 | トビラ セラピューティクス， インコーポレイテッド | 精製されたセニクリビロク及びセニクリビロク製造のための精製された中間体 |
| WO2022235440A1 (en) * | 2021-04-21 | 2022-11-10 | The United States Government As Represented By The Department Of Veterans Affairs | Method for treating traumatic brain injury, spinal cord injury, or stroke using small molecule inhibitors of ccr2 |
| CN116270633A (zh) * | 2023-03-03 | 2023-06-23 | 神经肌肉骨骼再生医学中心有限公司 | 马拉韦罗在制备治疗肌肉退行性疾病的药物中的用途 |
| CN119954974B (zh) * | 2025-04-09 | 2025-07-22 | 四川康德赛医疗科技有限公司 | 一种工程化巨噬细胞，其制备方法及抗纤维化的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2249027A (en) * | 1990-10-23 | 1992-04-29 | Fujisawa Pharmaceutical Co | Use of macrolide compounds for hepatic failure |
| PE20030329A1 (es) | 2001-08-08 | 2003-05-12 | Takeda Chemical Industries Ltd | Compuesto biciclico con actividad antagonista de ccr5 y produccion del mismo |
| WO2006059716A1 (ja) | 2004-12-03 | 2006-06-08 | Takeda Pharmaceutical Company Limited | 固形製剤 |
| US8148356B2 (en) * | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
| WO2013000922A1 (en) * | 2011-06-27 | 2013-01-03 | Universite Pierre Et Marie Curie (Paris 6) | Ccr2 antagonist peptides |
| JP6263815B2 (ja) * | 2013-03-05 | 2018-01-24 | 国立大学法人 岡山大学 | 細胞死抑制剤及びその製造方法 |
| CN105263498B (zh) * | 2013-05-15 | 2019-04-26 | 妥必徕疗治公司 | 赛尼克韦罗组合物及其制备和使用方法 |
| KR101669124B1 (ko) * | 2013-07-11 | 2016-10-25 | 서울대학교병원 | 인간 배아줄기세포에서 유래된 중간엽 줄기세포를 유효성분으로 함유하는 간섬유화 또는 간경화 예방 및 치료용 조성물 |
-
2015
- 2015-09-22 BR BR112017016388-8A patent/BR112017016388A2/pt not_active Application Discontinuation
- 2015-09-22 MX MX2017010277A patent/MX2017010277A/es unknown
- 2015-09-22 CN CN201580076576.9A patent/CN107405403B/zh not_active Expired - Fee Related
- 2015-09-22 WO PCT/US2015/051467 patent/WO2016130179A1/en not_active Ceased
- 2015-09-22 US US15/549,958 patent/US20180110754A1/en not_active Abandoned
- 2015-09-22 JP JP2017560462A patent/JP6676660B2/ja not_active Expired - Fee Related
- 2015-09-22 CA CA2975445A patent/CA2975445A1/en not_active Abandoned
- 2015-09-22 RU RU2017130289A patent/RU2722641C2/ru active
- 2015-09-22 SG SG11201706028RA patent/SG11201706028RA/en unknown
- 2015-09-22 EP EP15882259.3A patent/EP3256124B1/en not_active Not-in-force
- 2015-09-22 ES ES15882259T patent/ES2864767T3/es active Active
- 2015-09-22 HK HK18106984.5A patent/HK1247558A1/zh unknown
- 2015-09-22 KR KR1020177023821A patent/KR20170113596A/ko not_active Ceased
- 2015-09-22 AU AU2015382376A patent/AU2015382376B2/en not_active Expired - Fee Related
-
2017
- 2017-07-23 IL IL253617A patent/IL253617A0/en unknown
-
2019
- 2019-02-26 US US16/285,867 patent/US20190343806A1/en not_active Abandoned
-
2020
- 2020-03-12 JP JP2020042730A patent/JP2020111586A/ja active Pending
- 2020-06-03 US US16/891,979 patent/US20200360347A1/en not_active Abandoned
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