JP2019537430A5 - - Google Patents
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- Publication number
- JP2019537430A5 JP2019537430A5 JP2019515986A JP2019515986A JP2019537430A5 JP 2019537430 A5 JP2019537430 A5 JP 2019537430A5 JP 2019515986 A JP2019515986 A JP 2019515986A JP 2019515986 A JP2019515986 A JP 2019515986A JP 2019537430 A5 JP2019537430 A5 JP 2019537430A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- oligonucleotide
- pmhc
- polynucleotide
- vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 171
- 108091008874 T cell receptors Proteins 0.000 claims description 168
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 167
- 108091033319 polynucleotide Proteins 0.000 claims description 160
- 239000002157 polynucleotide Substances 0.000 claims description 160
- 102000040430 polynucleotide Human genes 0.000 claims description 160
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 112
- 108091034117 Oligonucleotide Proteins 0.000 claims description 95
- 230000000295 complement effect Effects 0.000 claims description 66
- 210000004027 cell Anatomy 0.000 claims description 47
- 108020004999 messenger RNA Proteins 0.000 claims description 31
- 238000012163 sequencing technique Methods 0.000 claims description 22
- 238000001514 detection method Methods 0.000 claims description 16
- 239000000839 emulsion Substances 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 8
- 108020004414 DNA Proteins 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 4
- 238000011176 pooling Methods 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 108091093088 Amplicon Proteins 0.000 claims description 2
- 108091026890 Coding region Proteins 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 238000000151 deposition Methods 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 230000009258 tissue cross reactivity Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 230000035772 mutation Effects 0.000 description 9
- 230000003321 amplification Effects 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- 210000005259 peripheral blood Anatomy 0.000 description 6
- 239000011886 peripheral blood Substances 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 5
- 238000000684 flow cytometry Methods 0.000 description 4
- 230000002093 peripheral effect Effects 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000002934 lysing effect Effects 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 108020003589 5' Untranslated Regions Proteins 0.000 description 1
- 208000036832 Adenocarcinoma of ovary Diseases 0.000 description 1
- 108091008875 B cell receptors Proteins 0.000 description 1
- 230000003844 B-cell-activation Effects 0.000 description 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
- 229940045513 CTLA4 antagonist Drugs 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 244000287680 Garcinia dulcis Species 0.000 description 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 206010061328 Ovarian epithelial cancer Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000002619 cancer immunotherapy Methods 0.000 description 1
- 238000007621 cluster analysis Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 108091008915 immune receptors Proteins 0.000 description 1
- 102000027596 immune receptors Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000013394 immunophenotyping Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000001806 memory b lymphocyte Anatomy 0.000 description 1
- 208000013371 ovarian adenocarcinoma Diseases 0.000 description 1
- 201000006588 ovary adenocarcinoma Diseases 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2016/053598 | 2016-09-24 | ||
| PCT/US2016/053598 WO2017053905A1 (en) | 2015-09-24 | 2016-09-24 | Affinity-oligonucleotide conjugates and uses thereof |
| PCT/US2017/013274 WO2018057051A1 (en) | 2016-09-24 | 2017-01-12 | Affinity-oligonucleotide conjugates and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537430A JP2019537430A (ja) | 2019-12-26 |
| JP2019537430A5 true JP2019537430A5 (enExample) | 2020-02-20 |
| JP6929354B2 JP6929354B2 (ja) | 2021-09-01 |
Family
ID=57960826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515986A Expired - Fee Related JP6929354B2 (ja) | 2016-09-24 | 2017-01-12 | 親和性−オリゴヌクレオチドコンジュゲートおよびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP6929354B2 (enExample) |
| AU (1) | AU2017332495A1 (enExample) |
| BR (1) | BR112019005748A2 (enExample) |
| IL (1) | IL265471A (enExample) |
| WO (1) | WO2018057051A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP3592862A1 (en) * | 2017-03-08 | 2020-01-15 | California Institute of Technology | Pairing antigen specificity of a t cell with t cell receptor sequences |
| US20230183791A1 (en) * | 2017-03-24 | 2023-06-15 | National University Of Singapore | Methods For Multiplex Detection Of Molecules |
| US12049667B2 (en) | 2017-05-26 | 2024-07-30 | Abvitro Llc | High-throughput polynucleotide library sequencing and transcriptome analysis |
| EP3752832A1 (en) | 2018-02-12 | 2020-12-23 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| WO2019238939A1 (en) * | 2018-06-15 | 2019-12-19 | F. Hoffmann-La Roche Ag | A system for identification of antigens recognized by t cell receptors expressed on tumor infiltrating lymphocytes |
| WO2020068633A1 (en) * | 2018-09-24 | 2020-04-02 | Bristol-Myers Squibb Company | Barcoded peptide-mhc complexes and uses thereof |
| GB201816522D0 (en) * | 2018-10-10 | 2018-11-28 | Autolus Ltd | Methods and reagents for analysing nucleic acids from single cells |
| EP3899538A4 (en) * | 2018-12-18 | 2022-11-30 | MBL International Corp. | COMPOSITIONS OF PMHC OCCUPANCY STREPTAVIDIN OLIGO CONJUGATES |
| AU2020218446B2 (en) * | 2019-02-04 | 2023-05-25 | National University Corporation Ehime University | "CAR LIBRARY AND scFv MANUFACTURING METHOD |
| US12416037B2 (en) * | 2020-01-24 | 2025-09-16 | Vanderbilt University | Methods for identification of ligand-blocking antibodies and for determining antibody potency |
| US12449419B1 (en) | 2020-02-12 | 2025-10-21 | 10X Genomics, Inc. | Methods for detecting binding of peptide-MHC monomers to T cells |
| WO2021251867A1 (en) * | 2020-06-09 | 2021-12-16 | Simsen Diagnostics Ab, | Lymphocyte clonality determination |
| US12637706B2 (en) | 2022-03-23 | 2026-05-26 | 10X Genomics, Inc. | Methods and compositions related to microsphere surface gelation |
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-
2017
- 2017-01-12 AU AU2017332495A patent/AU2017332495A1/en not_active Abandoned
- 2017-01-12 JP JP2019515986A patent/JP6929354B2/ja not_active Expired - Fee Related
- 2017-01-12 BR BR112019005748A patent/BR112019005748A2/pt not_active Application Discontinuation
- 2017-01-12 WO PCT/US2017/013274 patent/WO2018057051A1/en not_active Ceased
-
2019
- 2019-03-19 IL IL265471A patent/IL265471A/en unknown
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