JP2019535292A5 - - Google Patents

Info

Publication number

JP2019535292A5

JP2019535292A5 JP2019528055A JP2019528055A JP2019535292A5 JP 2019535292 A5 JP2019535292 A5 JP 2019535292A5 JP 2019528055 A JP2019528055 A JP 2019528055A JP 2019528055 A JP2019528055 A JP 2019528055A JP 2019535292 A5 JP2019535292 A5 JP 2019535292A5

Authority

JP

Japan

Prior art keywords

domain

modified protein

signaling

protein according

signal transduction

Prior art date

2017-11-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
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• 102000035118 modified proteins Human genes 0.000 claims description 43
• 108091005573 modified proteins Proteins 0.000 claims description 43
• 230000019491 signal transduction Effects 0.000 claims description 23
• 230000011664 signaling Effects 0.000 claims description 21
• 150000007523 nucleic acids Chemical group 0.000 claims description 20
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims description 16
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims description 16
• 239000012528 membrane Substances 0.000 claims description 16
• 230000004807 localization Effects 0.000 claims description 14
• 239000008194 pharmaceutical composition Substances 0.000 claims description 14
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 12
• 238000000034 method Methods 0.000 claims description 9
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 8
• 108020004707 nucleic acids Proteins 0.000 claims description 8
• 102000039446 nucleic acids Human genes 0.000 claims description 8
• 201000010099 disease Diseases 0.000 claims description 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
• 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 6
• 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 6
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 6
• 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 6
• 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 6
• 102000014400 SH2 domains Human genes 0.000 claims description 6
• 108050003452 SH2 domains Proteins 0.000 claims description 6
• 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 claims description 6
• 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 claims description 6
• 102100021657 Tyrosine-protein phosphatase non-receptor type 6 Human genes 0.000 claims description 6
• 101710128901 Tyrosine-protein phosphatase non-receptor type 6 Proteins 0.000 claims description 6
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 6
• 230000037361 pathway Effects 0.000 claims description 6
• 150000001413 amino acids Chemical class 0.000 claims description 5
• 239000003112 inhibitor Substances 0.000 claims description 4
• 230000002265 prevention Effects 0.000 claims description 4
• 102000034285 signal transducing proteins Human genes 0.000 claims description 4
• 108091006024 signal transducing proteins Proteins 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 230000001404 mediated effect Effects 0.000 claims description 3
• 101000628535 Homo sapiens Metalloreductase STEAP2 Proteins 0.000 claims description 2
• 102100026711 Metalloreductase STEAP2 Human genes 0.000 claims description 2
• 206010028980 Neoplasm Diseases 0.000 claims description 2
• 102000007607 Non-Receptor Type 11 Protein Tyrosine Phosphatase Human genes 0.000 claims description 2
• 108010032107 Non-Receptor Type 11 Protein Tyrosine Phosphatase Proteins 0.000 claims description 2
• 102000002001 Non-Receptor Type 6 Protein Tyrosine Phosphatase Human genes 0.000 claims description 2
• 108010015793 Non-Receptor Type 6 Protein Tyrosine Phosphatase Proteins 0.000 claims description 2
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 2
• 201000011510 cancer Diseases 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims description 2
• 230000002401 inhibitory effect Effects 0.000 claims description 2
• 230000035772 mutation Effects 0.000 claims description 2
• 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
• 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
• 238000006467 substitution reaction Methods 0.000 claims description 2
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 3
• 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 238000001890 transfection Methods 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000007498 myristoylation Effects 0.000 description 1
• 102000004169 proteins and genes Human genes 0.000 description 1
• 108090000623 proteins and genes Proteins 0.000 description 1
• 230000002463 transducing effect Effects 0.000 description 1