JP2019535292A - シグナル伝達改変タンパク質 - Google Patents

シグナル伝達改変タンパク質 Download PDF

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Publication number
JP2019535292A
JP2019535292A JP2019528055A JP2019528055A JP2019535292A JP 2019535292 A JP2019535292 A JP 2019535292A JP 2019528055 A JP2019528055 A JP 2019528055A JP 2019528055 A JP2019528055 A JP 2019528055A JP 2019535292 A JP2019535292 A JP 2019535292A
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cells
cell
protein
shp
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JP2019528055A
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English (en)
Japanese (ja)
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JP2019535292A5 (enExample
Inventor
ショーン コルドバ,
ショーン コルドバ,
エヴァンジェリア コカラキ,
エヴァンジェリア コカラキ,
ヴァニア バルダン,
ヴァニア バルダン,
サイモン トーマス,
サイモン トーマス,
マリア スタブロウ,
マリア スタブロウ,
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オートラス リミテッド
オートラス リミテッド
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Publication of JP2019535292A publication Critical patent/JP2019535292A/ja
Publication of JP2019535292A5 publication Critical patent/JP2019535292A5/ja
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70514CD4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/03Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048Protein-tyrosine-phosphatase (3.1.3.48)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70517CD8
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019528055A 2016-11-28 2017-11-27 シグナル伝達改変タンパク質 Withdrawn JP2019535292A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1620070.1A GB201620070D0 (en) 2016-11-28 2016-11-28 Signal transduction modifying protein
GB1620070.1 2016-11-28
PCT/GB2017/053555 WO2018096361A1 (en) 2016-11-28 2017-11-27 Signal transduction modifying protein

Publications (2)

Publication Number Publication Date
JP2019535292A true JP2019535292A (ja) 2019-12-12
JP2019535292A5 JP2019535292A5 (enExample) 2020-11-12

Family

ID=58073102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019528055A Withdrawn JP2019535292A (ja) 2016-11-28 2017-11-27 シグナル伝達改変タンパク質

Country Status (5)

Country Link
US (1) US20190309046A1 (enExample)
EP (1) EP3544995A1 (enExample)
JP (1) JP2019535292A (enExample)
GB (1) GB201620070D0 (enExample)
WO (1) WO2018096361A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023510893A (ja) * 2020-01-13 2023-03-15 広東泰禾製薬技術有限公司 抗腫瘍融合タンパク質及びその製造方法と使用
JP2023513752A (ja) * 2020-02-14 2023-04-03 ベイジン ヨンタイ ルイケ バイオテクノロジー カンパニー リミテッド 外部から導入された細胞シグナル伝達調節因子を過剰発現する免疫細胞及びその使用
JP2023524132A (ja) * 2020-05-07 2023-06-08 オートラス リミテッド 細胞

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201509413D0 (en) 2015-06-01 2015-07-15 Ucl Business Plc Fusion protein
GB201716728D0 (en) 2017-10-12 2017-11-29 Autolus Ltd Cell
US20210363217A1 (en) * 2018-06-19 2021-11-25 Autolus Limited Cell
CN108866004A (zh) * 2018-06-26 2018-11-23 奥妙生物技术(广州)有限公司 Shp-1敲除的t细胞及其构建方法
CN113543792A (zh) * 2019-03-08 2021-10-22 奥托路斯有限公司 包含工程化嵌合抗原受体和car调节剂的组合物和方法
JP2023503840A (ja) * 2019-11-14 2023-02-01 ルートヴィヒ インスティテュート フォー キャンサー リサーチ リミテッド 免疫療法のための組成物および方法
WO2022235832A1 (en) * 2021-05-06 2022-11-10 Ludwig Institute For Cancer Research Ltd Compositions and methods for immunotherapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002541845A (ja) 1999-04-16 2002-12-10 セルテック セラピューティックス リミテッド 合成膜貫通成分
GB201507119D0 (en) * 2015-04-27 2015-06-10 Ucl Business Plc Nucleic Acid Construct
GB201509413D0 (en) * 2015-06-01 2015-07-15 Ucl Business Plc Fusion protein
GB201514874D0 (en) * 2015-08-20 2015-10-07 Autolus Ltd Cell

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023510893A (ja) * 2020-01-13 2023-03-15 広東泰禾製薬技術有限公司 抗腫瘍融合タンパク質及びその製造方法と使用
JP7758279B2 (ja) 2020-01-13 2025-10-22 広東泰禾製薬技術有限公司 抗腫瘍融合タンパク質及びその製造方法と使用
JP2023513752A (ja) * 2020-02-14 2023-04-03 ベイジン ヨンタイ ルイケ バイオテクノロジー カンパニー リミテッド 外部から導入された細胞シグナル伝達調節因子を過剰発現する免疫細胞及びその使用
JP2023524132A (ja) * 2020-05-07 2023-06-08 オートラス リミテッド 細胞

Also Published As

Publication number Publication date
WO2018096361A1 (en) 2018-05-31
GB201620070D0 (en) 2017-01-11
US20190309046A1 (en) 2019-10-10
EP3544995A1 (en) 2019-10-02

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