JP2019534883A5 - - Google Patents

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Publication number
JP2019534883A5
JP2019534883A5 JP2019519219A JP2019519219A JP2019534883A5 JP 2019534883 A5 JP2019534883 A5 JP 2019534883A5 JP 2019519219 A JP2019519219 A JP 2019519219A JP 2019519219 A JP2019519219 A JP 2019519219A JP 2019534883 A5 JP2019534883 A5 JP 2019534883A5
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JP
Japan
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acceptable salt
pharmaceutically acceptable
stereoisomer
item
substituted
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JP2019519219A
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English (en)
Japanese (ja)
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JP2019534883A (ja
JP7034152B2 (ja
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Priority claimed from PCT/US2017/055109 external-priority patent/WO2018067685A1/en
Publication of JP2019534883A publication Critical patent/JP2019534883A/ja
Publication of JP2019534883A5 publication Critical patent/JP2019534883A5/ja
Application granted granted Critical
Publication of JP7034152B2 publication Critical patent/JP7034152B2/ja
Active legal-status Critical Current
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JP2019519219A 2016-10-05 2017-10-04 小分子ampk活性化剤 Active JP7034152B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404592P 2016-10-05 2016-10-05
US62/404,592 2016-10-05
PCT/US2017/055109 WO2018067685A1 (en) 2016-10-05 2017-10-04 Small molecule ampk activators

Publications (3)

Publication Number Publication Date
JP2019534883A JP2019534883A (ja) 2019-12-05
JP2019534883A5 true JP2019534883A5 (https=) 2020-11-12
JP7034152B2 JP7034152B2 (ja) 2022-03-11

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ID=61832129

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019519219A Active JP7034152B2 (ja) 2016-10-05 2017-10-04 小分子ampk活性化剤

Country Status (8)

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US (2) US11040935B2 (https=)
EP (1) EP3522877B1 (https=)
JP (1) JP7034152B2 (https=)
KR (1) KR20190096949A (https=)
CN (1) CN110035745B (https=)
AU (1) AU2017340403B2 (https=)
RU (1) RU2766146C2 (https=)
WO (1) WO2018067685A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11040935B2 (en) 2016-10-05 2021-06-22 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule AMPK activators
EP4027987A4 (en) * 2019-09-10 2023-11-29 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods and materials for increasing level of phosphorylated ampk protein
CN111925345B (zh) * 2020-08-21 2023-09-29 上海科利生物医药有限公司 一种手性2-氨甲基四氢呋喃的制备方法
EP4479366A4 (en) * 2022-02-15 2026-03-25 Childrens Medical Ct Corp COMPOSITIONS AND METHODS RELATING TO THE INHIBITION OF ATP/P2X7R SIGNALING

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2547524A1 (de) * 1975-10-23 1977-04-28 Bayer Ag Disubstituierte phenolaether des 3-amino-2-hydroxypropans, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS5726653A (en) * 1980-05-09 1982-02-12 Ciba Geigy Ag Substituted phenyl ether
US4410472A (en) 1982-01-15 1983-10-18 Aluminum Company Of America Method for making spherical binderless pellets
US4552960A (en) 1983-06-20 1985-11-12 Eli Lilly And Company Fungicidal amines
DE4017019A1 (de) 1990-05-26 1991-11-28 Hoechst Ag Verwendung von substituierten ss-hydroxyethylaminen als potente hemmstoffe der exoenzyme von pilzen
TW205034B (https=) * 1990-09-13 1993-05-01 Pola Kasei Kogyo Kk
EP0533056A3 (en) 1991-09-14 1993-06-16 Hoechst Aktiengesellschaft Substituted aminopropanes, process for their preparation and their use as antimycotic agents
US5541204A (en) 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
WO2000073302A1 (en) * 1999-05-27 2000-12-07 3-Dimensional Pharmaceuticals, Inc. Oxazaheterocycles as protease inhibitors
AUPQ841300A0 (en) * 2000-06-27 2000-07-20 Fujisawa Pharmaceutical Co., Ltd. New aminoalcohol derivatives
US6395762B1 (en) * 2000-07-17 2002-05-28 American Home Products Corporation Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
CA2415932A1 (en) 2000-07-17 2002-01-24 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine pyrazinones as protease inhibitors
WO2003024953A1 (en) * 2000-08-10 2003-03-27 Nisshin Pharma Inc. Propanolamine derivative having 1,4-benzodioxane ring
AR035605A1 (es) 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
WO2002098832A1 (de) * 2001-06-05 2002-12-12 Merck Patent Gmbh Cf2o-verbrückte, axial substituierte cyclohexan-derivate
US20030158195A1 (en) 2001-12-21 2003-08-21 Cywin Charles L. 1,6 naphthyridines useful as inhibitors of SYK kinase
AU2003226094A1 (en) 2002-03-27 2003-10-13 Smithkline Beecham Corporation Compounds and methods
EP1754483A1 (en) * 2005-08-18 2007-02-21 Merck Sante Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them
JP2009536613A (ja) * 2006-04-07 2009-10-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を調節する化合物
ITMI20061581A1 (it) * 2006-08-04 2008-02-05 Univ Bari Ligandi del recettore beta-3 adrenergico e loro uso in terapia
JP2010527980A (ja) 2007-05-22 2010-08-19 プロシディオン・リミテッド 代謝障害を治療するための二環状アリールおよびヘテロアリール化合物
WO2010003084A2 (en) * 2008-07-02 2010-01-07 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US20100279997A1 (en) 2009-05-04 2010-11-04 Lindsay Burns Barbier Analgesic that binds filamin a
JP6566867B2 (ja) 2012-07-13 2019-08-28 ペイン セラピューティクス インコーポレイテッド 生きている患者でのアルツハイマー病アッセイ
ES2716049T3 (es) 2012-07-13 2019-06-07 Pain Therapeutics Inc Un método para inhibir la fosforilación de tau
EP2983473A4 (en) 2013-03-15 2016-11-23 Als Mountain Llc PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONINERGIC AGENT AND METHODS OF USING SAME
US9433604B2 (en) 2013-10-08 2016-09-06 Pain Therapeutics Inc. Method for inhibiting growth of cancer cells
US11040935B2 (en) 2016-10-05 2021-06-22 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule AMPK activators

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