|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US5057313A
(en)
|
1986-02-25 |
1991-10-15 |
The Center For Molecular Medicine And Immunology |
Diagnostic and therapeutic antibody conjugates
|
|
WO1987005330A1
(en)
|
1986-03-07 |
1987-09-11 |
Michel Louis Eugene Bergh |
Method for enhancing glycoprotein stability
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2, Inc., Danville, Calif. |
Geänderte antikörper.
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
WO1991000906A1
(en)
|
1989-07-12 |
1991-01-24 |
Genetics Institute, Inc. |
Chimeric and transgenic animals capable of producing human antibodies
|
|
AU638762B2
(en)
|
1989-10-05 |
1993-07-08 |
Optein Inc |
Cell-free synthesis and isolation of novel genes and polypeptides
|
|
US6657103B1
(en)
|
1990-01-12 |
2003-12-02 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
ATE139258T1
(de)
|
1990-01-12 |
1996-06-15 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9014932D0
(en)
|
1990-07-05 |
1990-08-22 |
Celltech Ltd |
Recombinant dna product and method
|
|
DK0585287T3
(da)
|
1990-07-10 |
2000-04-17 |
Cambridge Antibody Tech |
Fremgangsmåde til fremstilling af specifikke bindingsparelementer
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
CA2095633C
(en)
|
1990-12-03 |
2003-02-04 |
Lisa J. Garrard |
Enrichment method for variant proteins with altered binding properties
|
|
ES2287206T3
(es)
|
1991-03-01 |
2007-12-16 |
Dyax Corporation |
Proceso para el desarrollo de mini-proteinas de union.
|
|
WO1992018619A1
(en)
|
1991-04-10 |
1992-10-29 |
The Scripps Research Institute |
Heterodimeric receptor libraries using phagemids
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
US5348867A
(en)
|
1991-11-15 |
1994-09-20 |
George Georgiou |
Expression of proteins on bacterial surface
|
|
EP0617706B1
(en)
|
1991-11-25 |
2001-10-17 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
ATE249840T1
(de)
|
1991-12-13 |
2003-10-15 |
Xoma Corp |
Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung
|
|
JP3571337B2
(ja)
|
1992-02-11 |
2004-09-29 |
セル ジェネシス,インコーポレーテッド |
遺伝子標的現象による同型遺伝子接合
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
NZ255101A
(en)
|
1992-07-24 |
1997-08-22 |
Cell Genesys Inc |
A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor
|
|
US6664114B1
(en)
|
1992-08-03 |
2003-12-16 |
Sapidyne Instruments, Inc. |
Solid phase assay for detection of ligands
|
|
CA2145063A1
(en)
|
1992-09-22 |
1994-03-31 |
Cambridge Genetics Limited |
Recombinant viruses displaying a nonviral polypeptide on their external surface
|
|
US6054287A
(en)
|
1994-05-27 |
2000-04-25 |
Methodist Hospital Of Indiana, Inc. |
Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6091001A
(en)
|
1995-03-29 |
2000-07-18 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
EP0822830B1
(en)
|
1995-04-27 |
2008-04-02 |
Amgen Fremont Inc. |
Human anti-IL-8 antibodies, derived from immunized xenomice
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
US6699658B1
(en)
|
1996-05-31 |
2004-03-02 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
GB9712818D0
(en)
|
1996-07-08 |
1997-08-20 |
Cambridge Antibody Tech |
Labelling and selection of specific binding molecules
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
|
US6342220B1
(en)
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US20020029391A1
(en)
|
1998-04-15 |
2002-03-07 |
Claude Geoffrey Davis |
Epitope-driven human antibody production and gene expression profiling
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6833268B1
(en)
|
1999-06-10 |
2004-12-21 |
Abgenix, Inc. |
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
|
|
US6475220B1
(en)
|
1999-10-15 |
2002-11-05 |
Whiteside Biomechanics, Inc. |
Spinal cable system
|
|
US7560534B2
(en)
|
2000-05-08 |
2009-07-14 |
Celldex Research Corporation |
Molecular conjugates comprising human monoclonal antibodies to dendritic cells
|
|
ES2405944T3
(es)
|
2000-11-30 |
2013-06-04 |
Medarex, Inc. |
Ácidos nucleicos que codifican las secuencias de inmunoglobulina humana reorganizadas a partir de ratones transcromoscómicos transgénicos
zadas
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US6997863B2
(en)
|
2001-07-25 |
2006-02-14 |
Triton Biosystems, Inc. |
Thermotherapy via targeted delivery of nanoscale magnetic particles
|
|
US7074175B2
(en)
|
2001-07-25 |
2006-07-11 |
Erik Schroeder Handy |
Thermotherapy via targeted delivery of nanoscale magnetic particles
|
|
WO2003025020A1
(en)
|
2001-09-13 |
2003-03-27 |
Institute For Antibodies Co., Ltd. |
Method of constructing camel antibody library
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
PT1527100E
(pt)
|
2002-03-29 |
2009-08-25 |
Schering Corp |
Anticorpos monoclonais humanos para interleucina-5 e métodos e composições compreendendo os mesmos
|
|
WO2006128690A1
(en)
*
|
2005-06-01 |
2006-12-07 |
Micromet Ag |
Anti-il2 antibodies
|
|
JP5248314B2
(ja)
*
|
2005-06-03 |
2013-07-31 |
メッツォ ペーパー インコーポレイテッド |
木材の機械解繊のための方法と装置
|
|
EP1987065A4
(en)
|
2006-02-16 |
2010-01-20 |
Nascent Biolog Inc |
METHOD FOR IMPROVING THE IMMUNE FUNCTION AND METHOD FOR PREVENTING OR TREATING DISEASES IN MAMMALS
|
|
JP2009542592A
(ja)
|
2006-07-06 |
2009-12-03 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Il−2媒介性免疫応答の有効性を高める組成物および方法
|
|
US8926976B2
(en)
|
2009-09-25 |
2015-01-06 |
Xoma Technology Ltd. |
Modulators
|
|
CU23734A1
(es)
|
2009-11-27 |
2011-11-15 |
Centro Inmunologia Molecular |
Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas
|
|
KR20200070407A
(ko)
|
2010-11-12 |
2020-06-17 |
넥타르 테라퓨틱스 |
Il-2 부분 및 중합체의 접합체
|
|
ES2694564T3
(es)
|
2011-02-10 |
2018-12-21 |
Roche Glycart Ag |
Polipéptidos de interleucina-2 mutantes
|
|
MY171135A
(en)
|
2011-06-03 |
2019-09-27 |
Xoma Technology Ltd |
Antibodies specific for tgf-beta
|
|
WO2013177187A2
(en)
|
2012-05-22 |
2013-11-28 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-pk il-2 and therapeutic agents
|
|
WO2014100014A1
(en)
|
2012-12-17 |
2014-06-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
Super-2 complexes with antibody to augment il-2 therapy
|
|
WO2014108748A1
(en)
|
2013-01-10 |
2014-07-17 |
Freescale Semiconductor, Inc. |
Packet processing architecture and method therefor
|
|
WO2015109212A1
(en)
*
|
2014-01-17 |
2015-07-23 |
Pfizer Inc. |
Anti-il-2 antibodies and compositions and uses thereof
|
|
EA201992609A1
(ru)
|
2014-02-06 |
2020-03-04 |
Ф.Хоффманн-Ля Рош Аг |
Слитые белки, содержащие интерлейкин-2, и их применения
|
|
WO2015164815A1
(en)
|
2014-04-24 |
2015-10-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Superagonists, partial agonists and antagonists of interleukin-2
|
|
CN106604932B
(zh)
*
|
2014-07-10 |
2024-12-10 |
苏黎世大学 |
人白细胞介素-2的免疫刺激单克隆抗体
|
|
MA40094B1
(fr)
|
2014-08-06 |
2022-05-31 |
Univ Miami |
Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
|
|
DK3186283T3
(da)
|
2014-08-29 |
2020-03-02 |
Hoffmann La Roche |
Kombinationsbehandling med tumormålrettede IL-2- immuncytokinervarianter og antistoffer mod humant PD-L1
|
|
CN115636880A
(zh)
*
|
2015-10-23 |
2023-01-24 |
辉瑞有限公司 |
抗il-2抗体及其组合物和用途
|
|
WO2017122130A1
(en)
*
|
2016-01-11 |
2017-07-20 |
Novartis Ag |
Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof
|
|
MX2019003543A
(es)
*
|
2016-09-28 |
2019-06-17 |
Xoma Us Llc |
Anticuerpos que se fijan al interleucina-2 y sus usos.
|