JP2019534321A5 - - Google Patents
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- JP2019534321A5 JP2019534321A5 JP2019537032A JP2019537032A JP2019534321A5 JP 2019534321 A5 JP2019534321 A5 JP 2019534321A5 JP 2019537032 A JP2019537032 A JP 2019537032A JP 2019537032 A JP2019537032 A JP 2019537032A JP 2019534321 A5 JP2019534321 A5 JP 2019534321A5
- Authority
- JP
- Japan
- Prior art keywords
- usp10
- biomarker
- aml
- activity
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101000809243 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 10 Proteins 0.000 claims description 167
- 101000748141 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 32 Proteins 0.000 claims description 163
- 102100038426 Ubiquitin carboxyl-terminal hydrolase 10 Human genes 0.000 claims description 163
- 238000000034 method Methods 0.000 claims description 129
- 239000000090 biomarker Substances 0.000 claims description 128
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 83
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 78
- 230000000694 effects Effects 0.000 claims description 78
- 239000003795 chemical substances by application Substances 0.000 claims description 75
- 238000012360 testing method Methods 0.000 claims description 50
- 239000003112 inhibitor Substances 0.000 claims description 46
- 238000002560 therapeutic procedure Methods 0.000 claims description 46
- 210000004027 cell Anatomy 0.000 claims description 40
- 239000000523 sample Substances 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 37
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims description 18
- 102000049850 human FLT3 Human genes 0.000 claims description 18
- 230000003463 hyperproliferative effect Effects 0.000 claims description 17
- 150000003384 small molecules Chemical group 0.000 claims description 16
- 230000030833 cell death Effects 0.000 claims description 13
- 108091033319 polynucleotide Proteins 0.000 claims description 12
- 102000040430 polynucleotide Human genes 0.000 claims description 12
- 239000002157 polynucleotide Substances 0.000 claims description 12
- 241000124008 Mammalia Species 0.000 claims description 10
- 230000004044 response Effects 0.000 claims description 10
- 238000010171 animal model Methods 0.000 claims description 8
- 239000002246 antineoplastic agent Substances 0.000 claims description 8
- 230000004083 survival effect Effects 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 238000001727 in vivo Methods 0.000 claims description 6
- 239000003550 marker Substances 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 230000002829 reductive effect Effects 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 239000012634 fragment Substances 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 241000894007 species Species 0.000 claims description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 4
- 108091023037 Aptamer Proteins 0.000 claims description 4
- 102000053642 Catalytic RNA Human genes 0.000 claims description 4
- 108090000994 Catalytic RNA Proteins 0.000 claims description 4
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims description 4
- 108091027967 Small hairpin RNA Proteins 0.000 claims description 4
- 108020004459 Small interfering RNA Proteins 0.000 claims description 4
- 101150020913 USP7 gene Proteins 0.000 claims description 4
- 102100021013 Ubiquitin carboxyl-terminal hydrolase 7 Human genes 0.000 claims description 4
- 108700011958 Ubiquitin-Specific Peptidase 7 Proteins 0.000 claims description 4
- 229940126752 Ubiquitin-specific protease 7 inhibitor Drugs 0.000 claims description 4
- 230000000692 anti-sense effect Effects 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 201000002687 childhood acute myeloid leukemia Diseases 0.000 claims description 4
- 239000013068 control sample Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 238000010362 genome editing Methods 0.000 claims description 4
- 102000046976 human USP10 Human genes 0.000 claims description 4
- 238000009396 hybridization Methods 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 230000002452 interceptive effect Effects 0.000 claims description 4
- 108091070501 miRNA Proteins 0.000 claims description 4
- 239000002679 microRNA Substances 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 230000001575 pathological effect Effects 0.000 claims description 4
- -1 piwiRNA Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 238000003753 real-time PCR Methods 0.000 claims description 4
- 108091092562 ribozyme Proteins 0.000 claims description 4
- 239000002924 silencing RNA Substances 0.000 claims description 4
- 239000004055 small Interfering RNA Substances 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 230000034994 death Effects 0.000 claims description 3
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 206010027476 Metastases Diseases 0.000 claims description 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 230000000052 comparative effect Effects 0.000 claims description 2
- 239000002299 complementary DNA Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 210000003608 fece Anatomy 0.000 claims description 2
- 238000012165 high-throughput sequencing Methods 0.000 claims description 2
- 238000001794 hormone therapy Methods 0.000 claims description 2
- 238000007901 in situ hybridization Methods 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 238000002493 microarray Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 210000003097 mucus Anatomy 0.000 claims description 2
- 239000002853 nucleic acid probe Substances 0.000 claims description 2
- 230000036961 partial effect Effects 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 230000004043 responsiveness Effects 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 238000002626 targeted therapy Methods 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 238000011156 evaluation Methods 0.000 claims 1
- 238000013537 high throughput screening Methods 0.000 claims 1
- 101000607909 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Proteins 0.000 description 1
- 102100039865 Ubiquitin carboxyl-terminal hydrolase 1 Human genes 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022094297A JP2022116353A (ja) | 2016-09-20 | 2022-06-10 | Ｕｓｐ１０バイオマーカーおよびモジュレーターを用いたａｍｌの同定、評価、予防および処置のための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662397100P | 2016-09-20 | 2016-09-20 | |
| US62/397,100 | 2016-09-20 | ||
| PCT/US2017/052506 WO2018057618A1 (en) | 2016-09-20 | 2017-09-20 | Compositions and methods for identification, assessment, prevention, and treatment of aml using usp10 biomarkers and modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022094297A Division JP2022116353A (ja) | 2016-09-20 | 2022-06-10 | Ｕｓｐ１０バイオマーカーおよびモジュレーターを用いたａｍｌの同定、評価、予防および処置のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534321A JP2019534321A (ja) | 2019-11-28 |
| JP2019534321A5 true JP2019534321A5 (https=) | 2020-08-27 |
| JP7466308B2 JP7466308B2 (ja) | 2024-04-12 |
Family
ID=61690641
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019537032A Active JP7466308B2 (ja) | 2016-09-20 | 2017-09-20 | Ｕｓｐ１０バイオマーカーおよびモジュレーターを用いたａｍｌの同定、評価、予防および処置のための組成物および方法 |
| JP2022094297A Pending JP2022116353A (ja) | 2016-09-20 | 2022-06-10 | Ｕｓｐ１０バイオマーカーおよびモジュレーターを用いたａｍｌの同定、評価、予防および処置のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022094297A Pending JP2022116353A (ja) | 2016-09-20 | 2022-06-10 | Ｕｓｐ１０バイオマーカーおよびモジュレーターを用いたａｍｌの同定、評価、予防および処置のための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11136409B2 (https=) |
| EP (1) | EP3515559B1 (https=) |
| JP (2) | JP7466308B2 (https=) |
| AU (1) | AU2017332721B2 (https=) |
| CA (1) | CA3034643A1 (https=) |
| ES (1) | ES3033182T3 (https=) |
| WO (1) | WO2018057618A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| US20220125760A1 (en) * | 2019-02-14 | 2022-04-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of usp7 inhibitors for the treatment of acute myeloid leukemia (aml) |
| US12590087B2 (en) | 2019-04-30 | 2026-03-31 | Valo Health, Inc. | Inhibiting USP36 |
| EP3972589B1 (en) * | 2019-05-22 | 2024-07-03 | Merck Sharp & Dohme LLC | Natriuretic peptide receptor a agonists useful for the treatment of cardiometabolic diseases, kidney disease and diabetes |
| CN117427085A (zh) * | 2020-02-21 | 2024-01-23 | 中国科学院上海药物研究所 | 金诺芬等老药及其组合物在抗单正链rna病毒中的应用 |
| EP4110393A1 (en) * | 2020-02-28 | 2023-01-04 | Immunologik GmbH | Inhibitors of human deubiquitinases for the treatment of coronaviral infections |
| CN113838206B (zh) * | 2021-09-28 | 2023-05-16 | 南京工业大学 | 一种基于bim的假山瀑布三维设计方法 |
| CN113912595B (zh) * | 2021-10-12 | 2024-03-15 | 中国药科大学 | 一类含有噻唑或噻二唑结构的化合物及其应用 |
| CN114807233B (zh) * | 2022-05-05 | 2023-04-18 | 江苏省人民医院（南京医科大学第一附属医院） | 一种巨噬细胞特异性usp13过表达的重组腺相关病毒及其应用 |
| WO2024097876A1 (en) * | 2022-11-02 | 2024-05-10 | Board Of Regents, The University Of Texas System | Methods relating to optimizing therapy selection for acute myeloid leukemia |
| CN120131695B (zh) * | 2025-03-06 | 2026-02-06 | 浙江大学 | 金诺芬在制备治疗usp6基因重排及异常激活疾病药物中的应用 |
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-
2017
- 2017-09-20 EP EP17853809.6A patent/EP3515559B1/en active Active
- 2017-09-20 CA CA3034643A patent/CA3034643A1/en active Pending
- 2017-09-20 ES ES17853809T patent/ES3033182T3/es active Active
- 2017-09-20 WO PCT/US2017/052506 patent/WO2018057618A1/en not_active Ceased
- 2017-09-20 AU AU2017332721A patent/AU2017332721B2/en not_active Ceased
- 2017-09-20 JP JP2019537032A patent/JP7466308B2/ja active Active
- 2017-09-20 US US16/331,712 patent/US11136409B2/en active Active
-
2022
- 2022-06-10 JP JP2022094297A patent/JP2022116353A/ja active Pending
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