JP2019532982A - 相乗的抗酸化効果を有するフェノール化合物を含む組成物 - Google Patents
相乗的抗酸化効果を有するフェノール化合物を含む組成物 Download PDFInfo
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- JP2019532982A JP2019532982A JP2019522833A JP2019522833A JP2019532982A JP 2019532982 A JP2019532982 A JP 2019532982A JP 2019522833 A JP2019522833 A JP 2019522833A JP 2019522833 A JP2019522833 A JP 2019522833A JP 2019532982 A JP2019532982 A JP 2019532982A
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- composition
- present
- mangiferin
- isolate
- total weight
- Prior art date
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- Granted
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- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- PVXCGWNPDFFPOV-UHFFFAOYSA-M sodium;pyridine-4-carboxylate Chemical compound [Na+].[O-]C(=O)C1=CC=NC=C1 PVXCGWNPDFFPOV-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003436 stilbenoids Chemical class 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000006276 transfer reaction Methods 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
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- BURBOJZOZGMMQF-UHFFFAOYSA-N xanthoxylol Natural products C1=C(O)C(OC)=CC=C1C1C(COC2C=3C=C4OCOC4=CC=3)C2CO1 BURBOJZOZGMMQF-UHFFFAOYSA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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Abstract
Description
Claims (20)
- (a)マンギフェリンを含む単離物または抽出物と、
(b)フェルラ酸、
(c)ビタミンCおよび
(d)バイカリンのうちの少なくとも1つと、
を含む抗酸化組成物であって、前記マンギフェリンを含む単離物または抽出物とフェルラ酸およびビタミンCおよびバイカリンのうちの1つ以上とが、相乗的抗酸化活性を生じさせるのに十分な量で存在する、抗酸化組成物。 - (a)約0.01%〜約20%の、マンギフェリンを含む単離物または抽出物と、
(b)約0.01%〜約20%のフェルラ酸と、
(c)約0.01%〜約20%のビタミンCと、
を含む、請求項1に記載の組成物であって、全ての量は、前記組成物の総重量に基づいた重量パーセントである、組成物。 - (a)約0.01%〜約20%の、マンギフェリンを含む単離物または抽出物と、
(b)約0.01%〜約20%のフェルラ酸と、
(d)約0.01%〜約20%のバイカリンと、
を含む、請求項1に記載の組成物であって、全ての量は、前記組成物の総重量に基づいた重量パーセントである、組成物。 - (a)約0.01%〜約20%の、マンギフェリンを含む単離物または抽出物と、
(b)約0.01%〜約20%のフェルラ酸と、
を含む、請求項1に記載の組成物であって、全ての量は、前記組成物の総重量に基づいた重量パーセントである、組成物。 - (a)約0.01%〜約20%の、マンギフェリンを含む単離物または抽出物と、
(c)約0.01%〜約20%のビタミンCと、
を含む、請求項1に記載の組成物であって、全ての量は、前記組成物の総重量に基づいた重量パーセントである、組成物。 - (a)約0.01%〜約20%の、マンギフェリンを含む単離物または抽出物と、
(d)約0.01%〜約20%のバイカリンと、
を含む、請求項1に記載の組成物であって、全ての量は、前記組成物の総重量に基づいた重量パーセントである、組成物。 - 前記組成物は、皮膚への局所適用に適しており、ローション、セラム、ゲル、ミルク、フォーム、リキッドファンデーションまたはクリームの形態である、請求項1に記載の組成物。
- 少なくとも1種のハイドロトロープ(e)をさらに含む、請求項1に記載の組成物。
- 前記ハイドロトロープ(e)がカフェインまたはニコチンアミドである、請求項8に記載の組成物。
- 前記マンギフェリンを含む単離物または抽出物(a)は、前記組成物の総重量に基づいて約0.01重量%〜10重量%の量で存在する、請求項1に記載の組成物。
- 前記マンギフェリンを含む単離物または抽出物(a)は、前記組成物の総重量に基づいて約0.01重量%〜5重量%の量で存在する、請求項1に記載の組成物。
- フェルラ酸(b)およびバイカリン(d)のうちの1つ以上は、存在する場合、前記組成物の総重量に基づいて約0.01重量%〜10重量%の量で存在し、ビタミンC(c)は、存在する場合、前記組成物の総重量に基づいて約0.01重量%〜20重量%の量で存在する、請求項1に記載の組成物。
- フェルラ酸(b)およびバイカリン(d)のうちの1つ以上は、存在する場合、前記組成物の総重量に基づいて約0.01重量%〜5重量%の量で存在し、ビタミンC(c)は、存在する場合、前記組成物の総重量に基づいて約5重量%〜15重量%の量で存在する、請求項1に記載の組成物。
- マンギフェリン(a)は、マンゴー葉の抽出物として存在する、請求項1に記載の組成物。
- マンギフェリン(a)は、少なくとも約70%〜約90%以下の純度で存在する、請求項14に記載の組成物。
- 前記ハイドロトロープ(d)は、前記組成物の総重量に基づいて約0.01重量%〜約20重量%の量で存在する、請求項8に記載の組成物。
- (a)約0.5%の、マンギフェリンを含む単離物または抽出物と、
(b)約0.5%のフェルラ酸、
(c)約10%のビタミンCおよび
(d)約0.5%のバイカリンのうちの少なくとも1つと、
を含む組成物であって、全ての量は、前記組成物の総重量に基づいた重量パーセントであり、前記マンギフェリンを含む単離物または抽出物(a)とフェルラ酸(b)およびビタミンC(c)およびバイカリン(d)のうちの1つ以上とが、相乗的抗酸化活性を生じさせるのに十分な量で存在する、組成物。 - 抗酸化組成物を調製するための方法であって、相乗的抗酸化活性を生じさせるのに十分な量で、マンギフェリンを含む単離物または抽出物(a)と、(b)フェルラ酸、(c)ビタミンCおよびバイカリン(d)のうちの少なくとも1つと、を前記組成物に含めることを含む、方法。
- (e)1種以上の(a)〜(d)とは異なる追加的な抗酸化物質と、ハイドロトロープ(f)と、を前記組成物に含めることをさらに含む、請求項18に記載の方法であって、(a)と(b)〜(d)のうちの少なくとも1つとが、相乗的抗酸化活性を生じさせるのに十分な量で存在する、方法。
- 抗酸化組成物を含む美容調合物を調製するための方法であって、請求項1に記載の抗酸化組成物を前記調合物に含めることと、水性セラム、水中油型エマルジョンおよびシリコーン中水型エマルジョンのうちの1つを形成させるための1種以上の美容上許容される成分をさらに含めることと、を含む方法。
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US15/339,026 US10898420B2 (en) | 2016-10-31 | 2016-10-31 | Compositions containing phenolic compounds having synergistic antioxidant benefits |
US15/339,026 | 2016-10-31 | ||
PCT/US2017/059273 WO2018081790A1 (en) | 2016-10-31 | 2017-10-31 | Compositions containing phenolic compounds having synergistic antioxidant benefits |
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FR3111271B1 (fr) * | 2020-06-11 | 2022-08-05 | Oreal | Amélioration de la qualité de clarté et de sensation d’une formulation avec un extrait comprenant un antioxydant xanthone |
WO2022141375A1 (en) * | 2020-12-31 | 2022-07-07 | L'oreal | Composition for caring for kertatin materials |
US20230165778A1 (en) | 2021-11-29 | 2023-06-01 | The Procter & Gamble Company | Method of Improving the Appearance of Skin |
US20230165768A1 (en) | 2021-11-29 | 2023-06-01 | The Procter & Gamble Company | Skin care composition |
AU2022396550A1 (en) * | 2021-11-29 | 2024-03-28 | The Procter & Gamble Company | Method for treating post-acne marks |
CN116327629A (zh) * | 2023-02-24 | 2023-06-27 | 华熙生物科技股份有限公司 | 具有抗氧化作用的组合物及其用途 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002000244A (ja) * | 2000-06-27 | 2002-01-08 | Ogawa & Co Ltd | 食品の香味劣化抑制剤並びに抑制方法 |
JP2002180081A (ja) * | 2000-12-14 | 2002-06-26 | Ogawa & Co Ltd | シトラールの劣化臭生成抑制剤および劣化臭生成抑制方法 |
US20050048008A1 (en) * | 2003-08-29 | 2005-03-03 | Bioderm Research | Antiaging Cosmetic Delivery Systems |
JP2010502755A (ja) * | 2006-09-12 | 2010-01-28 | ハイナン ディーズ ドラッグ リサーチ コーポレーション リミテッド | 2型糖尿病及び2型糖尿病慢性合併症の治療作用を持つ薬物組成物 |
CN101721400A (zh) * | 2008-10-13 | 2010-06-09 | 青岛启元生物技术有限公司 | 阿魏酸在增加某些药物的药效作用及其用途 |
JP2011504470A (ja) * | 2007-11-22 | 2011-02-10 | ハイナン ディーズ ドラッグ リサーチ コーポレーション リミテッド | 新規なマンゴー配糖体カルシウム塩、その製造方法及びその使用 |
CN103784356A (zh) * | 2012-10-29 | 2014-05-14 | 伽蓝(集团)股份有限公司 | 芒果活性部位在制备抗氧化化妆品中的应用 |
ES2464192A1 (es) * | 2012-11-30 | 2014-05-30 | Universidad De Cádiz | Extractos fenólicos de Mangifera indica Linn, procedimiento de obtención y usos. |
CN104434655A (zh) * | 2014-11-20 | 2015-03-25 | 云南人羞花化妆品有限公司 | 一种三七粉底霜及其制备方法 |
JP2015533169A (ja) * | 2012-10-12 | 2015-11-19 | ロレアル | 少なくとも一種のフラボノイド及びフェルラ酸を含む化粧品組成物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9602837A (es) | 1994-11-25 | 1997-06-28 | Rocher Yves Biolog Vegetale | Composiciones cosmeticas o farmaceuticas que contienen mangiferina o sus derivados. |
CN1977855A (zh) | 2005-12-09 | 2007-06-13 | 海南盛科天然药物研究院有限公司 | 含芒果苷的药用组合物及其制备方法 |
CN101062044B (zh) | 2006-04-28 | 2010-12-08 | 深圳海王药业有限公司 | 一种含高浓度虎杖苷的药物组合物 |
CN101019877A (zh) | 2007-03-22 | 2007-08-22 | 广西中医学院 | 可溶性芒果苷包合物及其制备方法 |
CN101647794B (zh) * | 2009-09-11 | 2012-09-19 | 天津中医药大学 | 芒果叶中裂环芒果苷及含有裂环芒果苷的芒果叶提取物的用途 |
US20120230930A1 (en) * | 2011-03-08 | 2012-09-13 | Corstjens Hugo A | Methods For Activating Caspase-14 Expression In Human Skin |
US9107853B2 (en) | 2012-10-12 | 2015-08-18 | L'oreal S.A. | Compositions containing phenolic compounds and hydrotropes for cosmetic use |
WO2014059228A1 (en) * | 2012-10-12 | 2014-04-17 | L'oreal | Cosmetic compositions containing at least one hydrotrope and at least one active compound |
WO2014075866A2 (en) | 2012-11-16 | 2014-05-22 | Unilever N.V. | A skin lightening composition |
BR102013007969A2 (pt) | 2013-04-03 | 2014-11-11 | Isp Do Brasil Ltda | Composições cosméticas e uso de ciclodextrina |
CN103462975A (zh) | 2013-09-24 | 2013-12-25 | 昆明理工大学 | 芒果苷与碱性环糊精的包合物 |
-
2016
- 2016-10-31 US US15/339,026 patent/US10898420B2/en active Active
-
2017
- 2017-10-31 CN CN201780067705.7A patent/CN110446487B/zh active Active
- 2017-10-31 ES ES17804706T patent/ES2892299T3/es active Active
- 2017-10-31 KR KR1020197014742A patent/KR102503410B1/ko active IP Right Grant
- 2017-10-31 JP JP2019522833A patent/JP7236995B2/ja active Active
- 2017-10-31 WO PCT/US2017/059273 patent/WO2018081790A1/en unknown
- 2017-10-31 EP EP17804706.4A patent/EP3532023B1/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002000244A (ja) * | 2000-06-27 | 2002-01-08 | Ogawa & Co Ltd | 食品の香味劣化抑制剤並びに抑制方法 |
JP2002180081A (ja) * | 2000-12-14 | 2002-06-26 | Ogawa & Co Ltd | シトラールの劣化臭生成抑制剤および劣化臭生成抑制方法 |
US20050048008A1 (en) * | 2003-08-29 | 2005-03-03 | Bioderm Research | Antiaging Cosmetic Delivery Systems |
JP2010502755A (ja) * | 2006-09-12 | 2010-01-28 | ハイナン ディーズ ドラッグ リサーチ コーポレーション リミテッド | 2型糖尿病及び2型糖尿病慢性合併症の治療作用を持つ薬物組成物 |
JP2011504470A (ja) * | 2007-11-22 | 2011-02-10 | ハイナン ディーズ ドラッグ リサーチ コーポレーション リミテッド | 新規なマンゴー配糖体カルシウム塩、その製造方法及びその使用 |
CN101721400A (zh) * | 2008-10-13 | 2010-06-09 | 青岛启元生物技术有限公司 | 阿魏酸在增加某些药物的药效作用及其用途 |
JP2015533169A (ja) * | 2012-10-12 | 2015-11-19 | ロレアル | 少なくとも一種のフラボノイド及びフェルラ酸を含む化粧品組成物 |
CN103784356A (zh) * | 2012-10-29 | 2014-05-14 | 伽蓝(集团)股份有限公司 | 芒果活性部位在制备抗氧化化妆品中的应用 |
ES2464192A1 (es) * | 2012-11-30 | 2014-05-30 | Universidad De Cádiz | Extractos fenólicos de Mangifera indica Linn, procedimiento de obtención y usos. |
CN104434655A (zh) * | 2014-11-20 | 2015-03-25 | 云南人羞花化妆品有限公司 | 一种三七粉底霜及其制备方法 |
Non-Patent Citations (1)
Title |
---|
LAI TENG LING: "Standardised Mangifera indica extract is an ideal ", FOOD CHEMISTRY, vol. 113, JPN6021043016, 8 September 2008 (2008-09-08), pages 1154 - 1159, ISSN: 0004827508 * |
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EP3532023A1 (en) | 2019-09-04 |
ES2892299T3 (es) | 2022-02-03 |
CN110446487A (zh) | 2019-11-12 |
KR20190082242A (ko) | 2019-07-09 |
WO2018081790A1 (en) | 2018-05-03 |
KR102503410B1 (ko) | 2023-02-23 |
CN110446487B (zh) | 2022-07-29 |
US10898420B2 (en) | 2021-01-26 |
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