JP2019532092A5 - - Google Patents
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- Publication number
- JP2019532092A5 JP2019532092A5 JP2019522803A JP2019522803A JP2019532092A5 JP 2019532092 A5 JP2019532092 A5 JP 2019532092A5 JP 2019522803 A JP2019522803 A JP 2019522803A JP 2019522803 A JP2019522803 A JP 2019522803A JP 2019532092 A5 JP2019532092 A5 JP 2019532092A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- heteroatoms selected
- substituted
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662414158P | 2016-10-28 | 2016-10-28 | |
| US62/414,158 | 2016-10-28 | ||
| PCT/US2017/058645 WO2018081488A1 (en) | 2016-10-28 | 2017-10-27 | Heterobicyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532092A JP2019532092A (ja) | 2019-11-07 |
| JP2019532092A5 true JP2019532092A5 (OSRAM) | 2020-11-12 |
| JP7145850B2 JP7145850B2 (ja) | 2022-10-03 |
Family
ID=60263169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522803A Active JP7145850B2 (ja) | 2016-10-28 | 2017-10-27 | Ｉｌ－１２、ｉｌ－２３および／またはｉｆｎアルファ応答の調節剤として有用なヘテロ二環化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10781215B2 (OSRAM) |
| EP (1) | EP3532473B1 (OSRAM) |
| JP (1) | JP7145850B2 (OSRAM) |
| KR (1) | KR102477063B1 (OSRAM) |
| CN (1) | CN110114357B (OSRAM) |
| ES (1) | ES2895107T3 (OSRAM) |
| MA (1) | MA46620A (OSRAM) |
| WO (1) | WO2018081488A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL266109B2 (en) * | 2016-10-21 | 2025-05-01 | Nimbus Lakshmi Inc | Tyk2 inhibitors and uses thereof |
| TW201940483A (zh) | 2018-03-12 | 2019-10-16 | 美商艾伯維有限公司 | 酪胺酸激酶２介導的傳訊之抑制劑 |
| AR117177A1 (es) * | 2018-12-10 | 2021-07-14 | Lilly Co Eli | DERIVADOS DE 7-(METILAMINO)PIRAZOLO[1,5-A]PIRIMIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE IL-23 E INFa |
| CN111484480B (zh) * | 2019-01-29 | 2023-08-11 | 上海翰森生物医药科技有限公司 | 一种多环类衍生物抑制剂、其制备方法和应用 |
| JP7595582B2 (ja) | 2019-03-26 | 2024-12-06 | ベンティックス バイオサイエンシーズ，インク． | Ｔｙｋ２偽キナーゼリガンド |
| KR20220002488A (ko) | 2019-04-30 | 2022-01-06 | 셀진 코포레이션 | 아프레밀라스트 및 tyk2 억제제를 포함하는 조합 요법 |
| UA129894C2 (uk) | 2019-11-08 | 2025-09-03 | Вентукс Біосціенціс, Інк. | Ліганди псевдокінази tyk2 |
| US11697648B2 (en) * | 2019-11-26 | 2023-07-11 | Theravance Biopharma R&D Ip, Llc | Fused pyrimidine pyridinone compounds as JAK inhibitors |
| CN116283993B (zh) * | 2021-12-20 | 2024-05-03 | 艾立康药业股份有限公司 | 一种嘧啶类化合物及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7176214B2 (en) | 2003-05-21 | 2007-02-13 | Bristol-Myers Squibb Company | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same |
| WO2008135232A1 (en) * | 2007-05-02 | 2008-11-13 | Riccardo Cortese | Use and compositions of purine derivatives for the treatment of proliferative disorders |
| CL2008002319A1 (es) * | 2007-08-08 | 2009-01-02 | Mithkline Beecham Corp | Compuestos derivados de pirrolopirimidina; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer. |
| CA2720946C (en) * | 2008-04-07 | 2013-05-28 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| US8258144B2 (en) * | 2008-04-22 | 2012-09-04 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| CN104903301B (zh) * | 2012-11-08 | 2017-08-29 | 百时美施贵宝公司 | 可用于调节IL‑12、IL‑23和/或IFNα的烷基酰胺取代的嘧啶化合物 |
| TWI582077B (zh) | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| EP3080131B1 (en) * | 2013-12-10 | 2018-10-10 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
| KR20170003688A (ko) * | 2014-05-14 | 2017-01-09 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 단백질 탈아세틸화효소 억제제 및 이중 단백질 탈아세틸화효소-단백질 키나제 억제제로서의 헤테로사이클릭 하이드록삼산 및 그 이용 방법 |
| IL266109B2 (en) * | 2016-10-21 | 2025-05-01 | Nimbus Lakshmi Inc | Tyk2 inhibitors and uses thereof |
-
2017
- 2017-10-27 WO PCT/US2017/058645 patent/WO2018081488A1/en not_active Ceased
- 2017-10-27 JP JP2019522803A patent/JP7145850B2/ja active Active
- 2017-10-27 US US16/344,459 patent/US10781215B2/en active Active
- 2017-10-27 MA MA046620A patent/MA46620A/fr unknown
- 2017-10-27 CN CN201780080803.4A patent/CN110114357B/zh active Active
- 2017-10-27 EP EP17794645.6A patent/EP3532473B1/en active Active
- 2017-10-27 KR KR1020197014828A patent/KR102477063B1/ko active Active
- 2017-10-27 ES ES17794645T patent/ES2895107T3/es active Active
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