JP2019532015A - 環状ペプチドを含むワクチン組成物、環状ペプチドに対する抗体又はそれを含む抗癌組成物 - Google Patents
環状ペプチドを含むワクチン組成物、環状ペプチドに対する抗体又はそれを含む抗癌組成物 Download PDFInfo
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Abstract
Description
i)TM4SF5が肝癌及び大腸癌などに発現されて癌の成長に影響を与え、
ii)TM4SF5のextracellular domain 2(EC2)に該当する環状ペプチドを合成して環状ペプチド−CpG−DNA−リポソーム複合体を製造してマウスに免疫すると、環状ペプチドに対する抗体が生成され、
iii)環状ペプチド−CpG−DNA−リポソーム複合体をワクチンとして用い、大腸癌(CT−26細胞を利用)の転移に対するワクチン効能を検証し、
iv)環状ペプチド−CpG−DNA−リポソーム複合体を免疫したマウスの脾臓細胞を融合したモノクローナル抗体を製造し、
v)マウスanti−TM4SF5モノクローナル抗体に基づいてヒト化されたanti−TM4SF5抗体を製造し、
vi)ヒト化されたanti−TM4SF5抗体の肝癌、大腸癌の抑制効能及び大腸癌の転移抑制効能を評価することに関する。
Claims (15)
- 配列表の第1配列及び配列表の第2配列で構成される群から選択されるアミノ酸配列からなるペプチド、
又は配列表の第1配列及び配列表の第2配列中の、3番目のシステインと26番目のシステインアミノ酸との間にジスルフィド結合で連結された環状ペプチドで構成される群から選択されるアミノ酸配列からなるペプチドを有効成分として含む、ワクチン組成物。 - 前記ペプチドワクチン組成物は、免疫刺激オリゴヌクレオチド及びリポソームに捕集されたことを特徴とする、請求項1に記載のペプチドワクチン組成物。
- 配列表の第1配列及び配列表の第2配列で構成される群から選択されるアミノ酸配列からなるペプチド、
又は配列表の第1配列及び配列表の第2配列中の、3番目のシステインと26番目のシステインアミノ酸との間にジスルフィド結合で連結された環状ペプチドで構成される群から選択されるアミノ酸配列からなるペプチドに対する抗体又はその抗原結合断片。 - 前記抗体は、配列表の第3配列又は第4配列からなるCDRH1、配列表の第5配列又は第6配列からなるCDRH2、及び配列表の第7配列又は第8配列からなるCDRH3の重鎖CDR(complementarity determining region)アミノ酸配列を有する重鎖可変領域と、
配列表の第9配列又は第10配列からなるCDRL1、配列表の第11配列又は第12配列からなるCDRL2、及び配列表の第13配列又は第14配列からなるCDRL3の軽鎖CDRアミノ酸配列を有する軽鎖可変領域とを含む、請求項3に記載の抗体又はその抗原結合断片。 - 前記重鎖可変領域は、配列表の第15配列又は第16配列のアミノ酸配列を有することを特徴とする、請求項4に記載の抗体又はその抗原結合断片。
- 前記軽鎖可変領域は、配列表の第17配列又は第18配列のアミノ酸配列を有することを特徴とする、請求項4に記載の抗体又はその抗原結合断片。
- 請求項4に記載の抗体又はその抗原結合断片の重鎖可変領域をコードする核酸分子。
- 前記核酸分子は、配列表の第19配列又は第20配列のヌクレオチド配列を有することを特徴とする、請求項7に記載の核酸分子。
- 請求項4に記載の抗体又はその抗原結合断片の軽鎖可変領域をコードする核酸分子。
- 前記核酸分子は、配列表の第21配列又は第22配列のヌクレオチド配列を有することを特徴とする、請求項9に記載の核酸分子。
- (a)請求項3乃至4のいずれか1項に記載の抗体又はその抗原結合断片の薬学的有効量と、(b)薬学的に許容される担体とを含む、癌の予防又は治療用薬学的組成物。
- 前記癌は、肝癌、大腸癌、膵臓癌、肺癌、胃癌、直腸癌、軟部組織肉腫(soft−tissue sarcoma)、結腸癌、十二指腸乳頭部上皮癌(carcinoma of the papilla vateri)、非内分泌肺腫瘍(nonendocrine lung tumor)及び気管支類癌腫(bronchial carcinoid tumor)で構成される群から選択されることを特徴とする、請求項11に記載の薬学的組成物。
- 前記組成物は、癌細胞の転移又は癌細胞の浸潤を抑制することを特徴とする、請求項11に記載の組成物。
- 請求項3乃至4のいずれか1項に記載の抗体又はその抗原結合断片を含む癌診断用キット。
- 前記癌は、肝癌、大腸癌、膵臓癌、肺癌、胃癌、直腸癌、軟部組織肉腫(soft−tissue sarcoma)、結腸癌、十二指腸乳頭部上皮癌(carcinoma of the papilla vateri)、非内分泌肺腫瘍(nonendocrine lung tumor)及び気管支類癌腫(bronchial carcinoid tumor)で構成される群から選択されることを特徴とする、請求項14に記載の診断用キット。
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PCT/KR2017/007407 WO2018034434A1 (ko) | 2016-08-17 | 2017-07-11 | 사이클릭 펩타이드를 포함하는 백신 조성물, 사이클릭 펩타이드에 대한 항체 또는 이를 포함하는 항암 조성물 |
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