JP2019532011A5 - - Google Patents
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- JP2019532011A5 JP2019532011A5 JP2018506309A JP2018506309A JP2019532011A5 JP 2019532011 A5 JP2019532011 A5 JP 2019532011A5 JP 2018506309 A JP2018506309 A JP 2018506309A JP 2018506309 A JP2018506309 A JP 2018506309A JP 2019532011 A5 JP2019532011 A5 JP 2019532011A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- therapeutic agent
- patient
- chromosomal
- flt3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940124597 therapeutic agent Drugs 0.000 claims 37
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 25
- 230000002062 proliferating effect Effects 0.000 claims 25
- 230000005856 abnormality Effects 0.000 claims 23
- 230000002068 genetic effect Effects 0.000 claims 23
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 22
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 22
- 208000035475 disorder Diseases 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 10
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- 239000004480 active ingredient Substances 0.000 claims 6
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- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 claims 4
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- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 3
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- 238000007912 intraperitoneal administration Methods 0.000 claims 3
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 3
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 2
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- 241000124008 Mammalia Species 0.000 claims 2
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022031616A JP7536320B2 (ja) | 2016-11-02 | 2022-03-02 | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
| JP2024064106A JP2024096859A (ja) | 2016-11-02 | 2024-04-11 | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416475P | 2016-11-02 | 2016-11-02 | |
| US62/416,475 | 2016-11-02 | ||
| US15/799,684 | 2017-10-31 | ||
| PCT/US2017/059377 WO2018085292A1 (en) | 2016-11-02 | 2017-10-31 | Crenolanib for treating flt3 mutated proliferative disorders associated mutations |
| US15/799,684 US11078541B2 (en) | 2016-11-02 | 2017-10-31 | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031616A Division JP7536320B2 (ja) | 2016-11-02 | 2022-03-02 | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019532011A JP2019532011A (ja) | 2019-11-07 |
| JP2019532011A5 true JP2019532011A5 (https=) | 2020-06-25 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506309A Pending JP2019532011A (ja) | 2016-11-02 | 2017-10-31 | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
| JP2022031616A Active JP7536320B2 (ja) | 2016-11-02 | 2022-03-02 | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
| JP2024064106A Withdrawn JP2024096859A (ja) | 2016-11-02 | 2024-04-11 | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031616A Active JP7536320B2 (ja) | 2016-11-02 | 2022-03-02 | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
| JP2024064106A Withdrawn JP2024096859A (ja) | 2016-11-02 | 2024-04-11 | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11078541B2 (https=) |
| EP (1) | EP3359155A4 (https=) |
| JP (3) | JP2019532011A (https=) |
| KR (2) | KR20200079351A (https=) |
| CN (1) | CN108778276A (https=) |
| AU (1) | AU2017353925A1 (https=) |
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| US12534764B2 (en) | 2016-11-02 | 2026-01-27 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| EA201991078A1 (ru) * | 2016-11-02 | 2019-11-29 | Креноланиб для лечения пролиферативных расстройств, связанных с мутацией flt3 | |
| WO2018175746A1 (en) | 2017-03-24 | 2018-09-27 | Kura Oncology, Inc. | Methods for treating hematological malignancies and ewing's sarcoma |
| US12268690B2 (en) | 2018-07-27 | 2025-04-08 | Oregon Health & Science University | Treatments for mutations in acute myeloid leukemia |
| JP2022503792A (ja) * | 2018-09-26 | 2022-01-12 | クラ オンコロジー，インク． | メニン阻害剤を用いた血液悪性腫瘍の処置 |
| CN109678849A (zh) * | 2019-01-16 | 2019-04-26 | 北京悦康科创医药科技股份有限公司 | 一种抗癌药物的制备方法 |
| US11471451B2 (en) * | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN110531016B (zh) * | 2019-09-05 | 2021-08-31 | 合肥诺明药物安全研究有限公司 | 一种hyml-122血药浓度定量分析方法 |
| CA3186319A1 (en) * | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| WO2022019998A1 (en) | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| US11524006B2 (en) * | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| CN112921091B (zh) * | 2021-03-16 | 2022-01-21 | 南京先声医学检验实验室有限公司 | Flt3基因突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用 |
| JP2023063189A (ja) * | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
| CN115141886B (zh) * | 2022-06-28 | 2023-06-06 | 厦门艾德生物医药科技股份有限公司 | 一种基于高通量测序的髓系白血病基因突变检测的探针引物组及其应用 |
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| ATE303998T1 (de) | 2000-10-17 | 2005-09-15 | Merck & Co Inc | Oral aktive salze mit tyrosinkinaseaktivität |
| TWI238824B (en) | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
| WO2003024969A1 (en) | 2001-09-14 | 2003-03-27 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
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2017
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- 2017-10-31 CA CA3024012A patent/CA3024012A1/en active Pending
- 2017-10-31 US US15/799,684 patent/US11078541B2/en active Active
- 2017-10-31 KR KR1020207018302A patent/KR20200079351A/ko not_active Ceased
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- 2017-10-31 CN CN201780016669.1A patent/CN108778276A/zh active Pending
- 2017-10-31 KR KR1020187016693A patent/KR20180074792A/ko not_active Ceased
- 2017-10-31 JP JP2018506309A patent/JP2019532011A/ja active Pending
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- 2017-10-31 EP EP17866388.6A patent/EP3359155A4/en active Pending
- 2017-10-31 AU AU2017353925A patent/AU2017353925A1/en not_active Abandoned
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2019
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2021
- 2021-06-23 US US17/355,468 patent/US12404555B2/en active Active
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2022
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2024
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2025
- 2025-06-11 US US19/234,777 patent/US20250305063A1/en active Pending
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