JP2019531255A5 - - Google Patents
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- JP2019531255A5 JP2019531255A5 JP2018566882A JP2018566882A JP2019531255A5 JP 2019531255 A5 JP2019531255 A5 JP 2019531255A5 JP 2018566882 A JP2018566882 A JP 2018566882A JP 2018566882 A JP2018566882 A JP 2018566882A JP 2019531255 A5 JP2019531255 A5 JP 2019531255A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- heterocyclyl
- substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 CC*(CC)c(cc1)cc(O2)c1C(c1c(*)cccc1)=C(C1=*c(ccc(N=O)c3)c3[U]1)C2=O Chemical compound CC*(CC)c(cc1)cc(O2)c1C(c1c(*)cccc1)=C(C1=*c(ccc(N=O)c3)c3[U]1)C2=O 0.000 description 1
- OIUWADICAXHIKH-UHFFFAOYSA-N OC(CCCNC(c1ccccc1C(c1cc(CCC2)c3N2CCCc3c1O1)=C(c2nc3ccccc3[s]2)C1=O)=O)=O Chemical compound OC(CCCNC(c1ccccc1C(c1cc(CCC2)c3N2CCCc3c1O1)=C(c2nc3ccccc3[s]2)C1=O)=O)=O OIUWADICAXHIKH-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021212730A JP2022050495A (ja) | 2016-09-30 | 2021-12-27 | 新規の蛍光色素およびバイオマーカーとしてのそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402635P | 2016-09-30 | 2016-09-30 | |
| US62/402,635 | 2016-09-30 | ||
| PCT/EP2017/074880 WO2018060482A1 (en) | 2016-09-30 | 2017-09-29 | New fluorescent dyes and their uses as biomarkers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021212730A Division JP2022050495A (ja) | 2016-09-30 | 2021-12-27 | 新規の蛍光色素およびバイオマーカーとしてのそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531255A JP2019531255A (ja) | 2019-10-31 |
| JP2019531255A5 true JP2019531255A5 (https=) | 2020-08-13 |
| JP7002478B2 JP7002478B2 (ja) | 2022-02-10 |
Family
ID=60268333
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566882A Active JP7002478B2 (ja) | 2016-09-30 | 2017-09-29 | 新規の蛍光色素およびバイオマーカーとしてのそれらの使用 |
| JP2021212730A Withdrawn JP2022050495A (ja) | 2016-09-30 | 2021-12-27 | 新規の蛍光色素およびバイオマーカーとしてのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021212730A Withdrawn JP2022050495A (ja) | 2016-09-30 | 2021-12-27 | 新規の蛍光色素およびバイオマーカーとしてのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10385214B2 (https=) |
| EP (2) | EP3974425B1 (https=) |
| JP (2) | JP7002478B2 (https=) |
| KR (2) | KR102582172B1 (https=) |
| CN (1) | CN109476654B (https=) |
| AU (2) | AU2017335223B2 (https=) |
| CA (1) | CA3026019C (https=) |
| ES (2) | ES2914688T3 (https=) |
| IL (2) | IL297749B2 (https=) |
| SG (1) | SG11201810633WA (https=) |
| WO (1) | WO2018060482A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
| GB201716931D0 (en) * | 2017-10-16 | 2017-11-29 | Illumina Cambridge Ltd | New fluorescent compounds and their use as biomarkers |
| CN112601825B (zh) * | 2018-07-09 | 2023-11-28 | 青岛华大智造科技有限责任公司 | 核酸测序方法 |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| WO2020178231A1 (en) | 2019-03-01 | 2020-09-10 | Illumina, Inc. | Multiplexed fluorescent detection of analytes |
| BR112020026528B1 (pt) | 2019-03-01 | 2024-02-15 | Illumina Cambridge Limited | Composto de cumarina substituído com amina exocíclica, nucleotídeo ou oligonucleotídeo, kit, método de sequenciamento e método para sintetizar o referido composto |
| CA3103636A1 (en) * | 2019-03-01 | 2020-09-10 | Illumina Cambridge Limited | Tertiary amine substituted coumarin compounds and their uses as fluorescent labels |
| NL2023327B1 (en) | 2019-03-01 | 2020-09-17 | Illumina Inc | Multiplexed fluorescent detection of analytes |
| JP2023510454A (ja) | 2019-11-27 | 2023-03-14 | イルミナ ケンブリッジ リミテッド | シクロオクタテトラエンを含有する色素及び組成物 |
| US11787831B2 (en) | 2020-06-22 | 2023-10-17 | Illumina Cambridge Limited | Nucleosides and nucleotides with 3′ acetal blocking group |
| US11981964B2 (en) * | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195196A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Alkylpyridinium coumarin dyes and uses in sequencing applications |
| US20220195517A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Long stokes shift chromenoquinoline dyes and uses in sequencing applications |
| US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| CN114671842B (zh) * | 2020-12-24 | 2024-05-28 | 郑州思昆生物工程有限公司 | 一种荧光化合物及其制备方法、荧光修饰核苷酸、试剂盒 |
| KR20240009435A (ko) | 2021-05-20 | 2024-01-22 | 일루미나, 인코포레이티드 | 합성에 의한 시퀀싱을 위한 조성물 및 방법 |
| US20220403450A1 (en) | 2021-06-03 | 2022-12-22 | Illumina Software, Inc. | Systems and methods for sequencing nucleotides using two optical channels |
| EP4396376A1 (en) | 2021-09-01 | 2024-07-10 | Illumina, Inc. | Amplitude modulation for accelerated base calling |
| US20230183799A1 (en) | 2021-12-10 | 2023-06-15 | Illumina, Inc. | Parallel sample and index sequencing |
| AU2023236924A1 (en) | 2022-03-15 | 2024-10-24 | Illumina, Inc. | Paired-end sequencing |
| US20230304086A1 (en) | 2022-03-28 | 2023-09-28 | Illumina Cambridge Limited | Labeled avidin and methods for sequencing |
| AU2023246772A1 (en) | 2022-03-29 | 2024-01-18 | Illumina Inc. | Chromenoquinoline dyes and uses in sequencing |
| WO2023192900A1 (en) | 2022-03-31 | 2023-10-05 | Illumina Singapore Pte. Ltd. | Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis |
| US20230357845A1 (en) | 2022-03-31 | 2023-11-09 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
| CN119301275A (zh) | 2022-05-31 | 2025-01-10 | 伊路米纳有限公司 | 用于核酸测序的组合物和方法 |
| CN119604513A (zh) | 2022-06-28 | 2025-03-11 | 因美纳公司 | 含有稠合四环双硼杂环的荧光染料及其在测序中的用途 |
| US20240140939A1 (en) | 2022-09-30 | 2024-05-02 | Illumina Cambridge Limited | Compositions and methods for reducing photo damage during sequencing |
| WO2024137765A1 (en) | 2022-12-22 | 2024-06-27 | Illumina, Inc. | Transition-metal catalyst compositions and methods for sequencing by synthesis |
| CN119095982A (zh) | 2022-12-22 | 2024-12-06 | 伊路米纳有限公司 | 用于边合成边测序的钯催化剂组合物和方法 |
| CN119095984A (zh) | 2022-12-27 | 2024-12-06 | 伊路米纳有限公司 | 使用3'烯丙基封端的核苷酸的测序方法 |
| WO2024206407A2 (en) | 2023-03-29 | 2024-10-03 | Illumina, Inc. | Naphthalimide dyes and uses in nucleic acid sequencing |
| EP4689181A1 (en) | 2023-03-30 | 2026-02-11 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| WO2025049700A1 (en) | 2023-08-31 | 2025-03-06 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| WO2025061922A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Methods for sequencing |
| WO2025061942A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Sequencing error identification and correction |
| WO2025090596A1 (en) | 2023-10-26 | 2025-05-01 | Illumina, Inc. | 4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing |
| WO2025144716A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing |
| WO2025184226A1 (en) | 2024-02-28 | 2025-09-04 | Illumina, Inc. | Nucleotides with terminal phosphate capping |
| WO2025188906A1 (en) | 2024-03-08 | 2025-09-12 | Illumina, Inc. | Modified adenosine nucleotides |
| WO2025221895A1 (en) | 2024-04-19 | 2025-10-23 | Illumina, Inc. | Water soluble polymer scaffolds for dye labeling |
| WO2025230914A1 (en) | 2024-04-29 | 2025-11-06 | Illumina, Inc. | Nucleotides with enzyme-triggered self-immolative linkers for sequencing by synthesis |
| WO2026020407A1 (zh) * | 2024-07-25 | 2026-01-29 | 深圳华大智造科技股份有限公司 | 一种提高分辨率的分子探针、其修饰的核酸以及在基因测序中的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2411969A1 (de) * | 1974-03-13 | 1975-09-25 | Bayer Ag | Farbstofflaser |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| JP2002503954A (ja) | 1997-04-01 | 2002-02-05 | グラクソ、グループ、リミテッド | 核酸増幅法 |
| US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
| US6485944B1 (en) | 1997-10-10 | 2002-11-26 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| WO2000006770A1 (en) | 1998-07-30 | 2000-02-10 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| GB0002310D0 (en) | 2000-02-01 | 2000-03-22 | Solexa Ltd | Polynucleotide sequencing |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6391937B1 (en) | 1998-11-25 | 2002-05-21 | Motorola, Inc. | Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers |
| US6169185B1 (en) | 1999-02-25 | 2001-01-02 | Day-Glo Color Corp. | Ink jet printing inks |
| US6372813B1 (en) | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
| US6664061B2 (en) | 1999-06-25 | 2003-12-16 | Amersham Biosciences Ab | Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
| AU2001279244A1 (en) | 2000-08-09 | 2002-02-18 | Motorola, Inc. | The use and evaluation of a (2+2) photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
| PT3438116T (pt) | 2002-08-23 | 2021-03-23 | Illumina Cambridge Ltd | Nucleótidos identificados |
| WO2004018497A2 (en) | 2002-08-23 | 2004-03-04 | Solexa Limited | Modified nucleotides for polynucleotide sequencing |
| GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
| GB0326073D0 (en) | 2003-11-07 | 2003-12-10 | Solexa Ltd | Improvements in or relating to polynucleotide arrays |
| EP1701785A1 (en) | 2004-01-07 | 2006-09-20 | Solexa Ltd. | Modified molecular arrays |
| EP1888743B1 (en) | 2005-05-10 | 2011-08-03 | Illumina Cambridge Limited | Improved polymerases |
| GB0517097D0 (en) | 2005-08-19 | 2005-09-28 | Solexa Ltd | Modified nucleosides and nucleotides and uses thereof |
| USRE49362E1 (en) | 2006-05-18 | 2023-01-10 | Illumina Cambridge Limited | Dye compounds and the use of their labelled conjugates |
| EP2758475B1 (en) | 2011-09-23 | 2017-04-26 | Illumina Cambridge Limited | Dyes for labelling molecular ligands |
| CA2859660C (en) | 2011-09-23 | 2021-02-09 | Illumina, Inc. | Methods and compositions for nucleic acid sequencing |
| US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
| DK2964624T3 (en) | 2013-03-08 | 2017-04-03 | Illumina Cambridge Ltd | RHODAMINE COMPOUNDS AND USE AS FLUORESCING LABELS |
| WO2014139596A1 (en) | 2013-03-15 | 2014-09-18 | Illumina Cambridge Limited | Modified nucleosides or nucleotides |
| US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
-
2017
- 2017-09-28 US US15/719,216 patent/US10385214B2/en active Active
- 2017-09-29 SG SG11201810633WA patent/SG11201810633WA/en unknown
- 2017-09-29 EP EP21195809.5A patent/EP3974425B1/en active Active
- 2017-09-29 ES ES17794669T patent/ES2914688T3/es active Active
- 2017-09-29 WO PCT/EP2017/074880 patent/WO2018060482A1/en not_active Ceased
- 2017-09-29 CN CN201780042127.1A patent/CN109476654B/zh active Active
- 2017-09-29 IL IL297749A patent/IL297749B2/en unknown
- 2017-09-29 KR KR1020227041740A patent/KR102582172B1/ko active Active
- 2017-09-29 AU AU2017335223A patent/AU2017335223B2/en active Active
- 2017-09-29 KR KR1020187037385A patent/KR102473054B1/ko active Active
- 2017-09-29 ES ES21195809T patent/ES2988726T3/es active Active
- 2017-09-29 IL IL263871A patent/IL263871B2/en unknown
- 2017-09-29 EP EP17794669.6A patent/EP3519410B1/en active Active
- 2017-09-29 CA CA3026019A patent/CA3026019C/en active Active
- 2017-09-29 JP JP2018566882A patent/JP7002478B2/ja active Active
-
2019
- 2019-08-13 US US16/539,606 patent/US10844225B2/en active Active
-
2020
- 2020-11-17 US US16/950,705 patent/US11370920B2/en active Active
-
2021
- 2021-12-27 JP JP2021212730A patent/JP2022050495A/ja not_active Withdrawn
-
2022
- 2022-11-07 AU AU2022268273A patent/AU2022268273B2/en active Active
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