JP2010540541A5 - - Google Patents
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- Publication number
- JP2010540541A5 JP2010540541A5 JP2010527024A JP2010527024A JP2010540541A5 JP 2010540541 A5 JP2010540541 A5 JP 2010540541A5 JP 2010527024 A JP2010527024 A JP 2010527024A JP 2010527024 A JP2010527024 A JP 2010527024A JP 2010540541 A5 JP2010540541 A5 JP 2010540541A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- nhr
- formula
- halogen
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- -1 methylenecyclopropyl Chemical group 0.000 claims 3
- 101150009274 nhr-1 gene Proteins 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97576507P | 2007-09-27 | 2007-09-27 | |
| US98132207P | 2007-10-19 | 2007-10-19 | |
| PCT/US2008/076499 WO2009042444A2 (en) | 2007-09-27 | 2008-09-16 | Methods and compounds for treating retinol-related diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540541A JP2010540541A (ja) | 2010-12-24 |
| JP2010540541A5 true JP2010540541A5 (https=) | 2011-11-04 |
Family
ID=40512081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527024A Pending JP2010540541A (ja) | 2007-09-27 | 2008-09-16 | レチノール関連疾患を治療するための方法及び化合物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2205234A4 (https=) |
| JP (1) | JP2010540541A (https=) |
| KR (1) | KR20100097098A (https=) |
| CN (1) | CN101873852A (https=) |
| AU (1) | AU2008305303A1 (https=) |
| CA (1) | CA2699773A1 (https=) |
| IL (1) | IL204728A0 (https=) |
| WO (1) | WO2009042444A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009051244A1 (ja) | 2007-10-18 | 2009-04-23 | Takeda Pharmaceutical Company Limited | 複素環化合物 |
| US8853215B2 (en) | 2009-04-16 | 2014-10-07 | Takeda Pharmaceutical Company Limited | Derivatives of N-acyl-N′-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes |
| JP5951625B2 (ja) * | 2010-11-24 | 2016-07-13 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｃｏｌｕｍｂｉａ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎ Ｔｈｅ Ｃｉｔｙ Ｏｆ Ｎｅｗ Ｙｏｒｋ | 加齢性黄斑変性症およびシュタルガルト病の処置のための非レチノイドｒｂｐ４アンタゴニスト |
| WO2012074038A1 (ja) * | 2010-12-02 | 2012-06-07 | 第一三共株式会社 | 修飾１本鎖ポリヌクレオチド |
| US9333202B2 (en) | 2012-05-01 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease |
| US9938291B2 (en) | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
| US9944644B2 (en) | 2013-03-14 | 2018-04-17 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles their preparation and use |
| WO2014152018A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydrocyclopentapyrroles, their preparation and use |
| EP3495357B1 (en) | 2013-03-14 | 2021-05-05 | The Trustees of Columbia University in the City of New York | 4-phenylpiperidines, their preparation and use |
| SG11201608943VA (en) | 2014-04-30 | 2016-11-29 | Univ Columbia | Substituted 4-phenylpiperidines, their preparaiton and use |
| US9944596B2 (en) * | 2014-10-24 | 2018-04-17 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| KR102490156B1 (ko) | 2014-10-24 | 2023-01-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
| AU2021265838A1 (en) * | 2020-04-29 | 2022-10-20 | Saliogen Therapeutics, Inc. | Compositions and methods for treatment of inherited macular degeneration |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2526534A (en) * | 1948-07-03 | 1950-10-17 | Dow Chemical Co | Di-(aryloxy)-methanes |
| US4255152A (en) * | 1978-09-05 | 1981-03-10 | Ciba-Geigy Corporation | Process for the dyeing of hydrophobic fibres |
| JPS577480A (en) * | 1980-06-16 | 1982-01-14 | Sankyo Co Ltd | 4-alkoxy-6-phenoxymethyl-2-pyrone derivative |
| US7510710B2 (en) * | 2004-01-08 | 2009-03-31 | The Regents Of The University Of Colorado | Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor |
| WO2005092062A2 (en) * | 2004-03-19 | 2005-10-06 | Myriad Genetics, Inc. | Compounds for neurodegenerative disorders |
| WO2005116010A1 (en) * | 2004-05-26 | 2005-12-08 | Merck Frosst Canada Ltd. | Ep4 receptor agonist, compositions and methods thereof |
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2008
- 2008-09-16 CN CN200880107835A patent/CN101873852A/zh active Pending
- 2008-09-16 EP EP08834564A patent/EP2205234A4/en not_active Withdrawn
- 2008-09-16 KR KR1020107009129A patent/KR20100097098A/ko not_active Withdrawn
- 2008-09-16 JP JP2010527024A patent/JP2010540541A/ja active Pending
- 2008-09-16 CA CA2699773A patent/CA2699773A1/en not_active Abandoned
- 2008-09-16 AU AU2008305303A patent/AU2008305303A1/en not_active Abandoned
- 2008-09-16 WO PCT/US2008/076499 patent/WO2009042444A2/en not_active Ceased
-
2010
- 2010-03-25 IL IL204728A patent/IL204728A0/en unknown