JP2019530427A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019530427A5 JP2019530427A5 JP2018568216A JP2018568216A JP2019530427A5 JP 2019530427 A5 JP2019530427 A5 JP 2019530427A5 JP 2018568216 A JP2018568216 A JP 2018568216A JP 2018568216 A JP2018568216 A JP 2018568216A JP 2019530427 A5 JP2019530427 A5 JP 2019530427A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- pharmaceutical composition
- seq
- heavy chain
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- NFGXHKASABOEEW-UHFFFAOYSA-N (+)-methoprene Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 5
- 102000004965 antibodies Human genes 0.000 claims 30
- 108090001123 antibodies Proteins 0.000 claims 30
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 102000007584 Prealbumin Human genes 0.000 claims 10
- 108010071690 Prealbumin Proteins 0.000 claims 10
- 206010002023 Amyloidosis Diseases 0.000 claims 7
- 206010002022 Amyloidosis Diseases 0.000 claims 7
- 230000001404 mediated Effects 0.000 claims 7
- 239000012472 biological sample Substances 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 4
- 210000001519 tissues Anatomy 0.000 claims 3
- 206010064930 Age-related macular degeneration Diseases 0.000 claims 2
- 210000003403 Autonomic Nervous System Anatomy 0.000 claims 2
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 2
- 208000005846 Cardiomyopathy Diseases 0.000 claims 2
- 210000001508 Eye Anatomy 0.000 claims 2
- 230000035693 Fab Effects 0.000 claims 2
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 2
- 210000002216 Heart Anatomy 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 210000003734 Kidney Anatomy 0.000 claims 2
- 206010052774 Ligament disease Diseases 0.000 claims 2
- 208000002780 Macular Degeneration Diseases 0.000 claims 2
- 210000001428 Peripheral Nervous System Anatomy 0.000 claims 2
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 2
- 206010043234 Tendon disease Diseases 0.000 claims 2
- 201000008031 cardiomyopathy Diseases 0.000 claims 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 210000004369 Blood Anatomy 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 210000002381 Plasma Anatomy 0.000 claims 1
- 210000002966 Serum Anatomy 0.000 claims 1
- 208000005198 Spinal Stenosis Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 200000000009 stenosis Diseases 0.000 claims 1
- 230000036262 stenosis Effects 0.000 claims 1
- 239000004475 Arginine Substances 0.000 description 4
- 125000000511 arginine group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 4
- 229920001850 Nucleic acid sequence Polymers 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 230000003993 interaction Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/201,416 | 2016-07-02 | ||
| US15/201,416 US9879080B2 (en) | 2015-01-28 | 2016-07-02 | Anti-transthyretin antibodies |
| PCT/IB2017/053987 WO2018007923A2 (en) | 2016-07-02 | 2017-06-30 | Anti-transthyretin antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530427A JP2019530427A (ja) | 2019-10-24 |
| JP2019530427A5 true JP2019530427A5 (es) | 2020-08-13 |
| JP7016470B2 JP7016470B2 (ja) | 2022-02-07 |
Family
ID=59506312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568216A Active JP7016470B2 (ja) | 2016-07-02 | 2017-06-30 | 抗トランスサイレチン抗体 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3478715A2 (es) |
| JP (1) | JP7016470B2 (es) |
| WO (1) | WO2018007923A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10464999B2 (en) | 2015-01-28 | 2019-11-05 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US9879080B2 (en) | 2015-01-28 | 2018-01-30 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10633433B2 (en) | 2015-01-28 | 2020-04-28 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| BR112020006434A2 (pt) | 2017-10-06 | 2020-11-03 | Prothena Biosciences Limited | anticorpos anti-transtirretina |
| CU20200042A7 (es) | 2017-11-29 | 2021-03-11 | Prothena Biosciences Ltd | Formulación liofilizada de un anticuerpo monoclonal contra la transtirretina |
| AU2019374418A1 (en) | 2018-11-09 | 2021-06-24 | Neurimmune Ag | Patient-derived amyloid xenograft non-human animal model |
| US20230183329A1 (en) | 2020-05-12 | 2023-06-15 | Neurimmune Ag | Combination therapy for ttr amyloidosis |
| CA3239708A1 (en) | 2021-12-03 | 2023-06-08 | Aubin MICHALON | Novel potency assay for antibody-based drugs and useful means therefor |
| WO2024105062A1 (en) | 2022-11-15 | 2024-05-23 | Neurimmune Ag | Methods for treating or preventing transthyretin-mediated amyloidosis |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH652145A5 (de) | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| US4634666A (en) | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| EP0832981A1 (en) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2 Inc | Geänderte antikörper. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE185601T1 (de) | 1990-07-10 | 1999-10-15 | Cambridge Antibody Tech | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| EP0746609A4 (en) | 1991-12-17 | 1997-12-17 | Genpharm Int | NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5914349A (en) | 1994-01-10 | 1999-06-22 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| DE19539493A1 (de) | 1995-10-24 | 1997-04-30 | Thomae Gmbh Dr K | Starker homologer Promotor aus Hamster |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| CA2625839A1 (en) | 1999-02-05 | 2000-08-10 | Samsung Electronics Co., Ltd. | Image texture retrieving method and apparatus thereof |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| EP1539233B1 (en) | 2001-07-12 | 2011-04-27 | FOOTE, Jefferson | Super humanized antibodies |
| WO2003057838A2 (en) | 2001-12-28 | 2003-07-17 | Abgenix, Inc. | Antibodies against the muc18 antigen |
| EP1567652B1 (de) | 2002-11-29 | 2007-08-22 | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG | Neue neomycin-phosphotransferase-gene und verfahren zur selektion von hochproduzierenden rekombinanten zellen |
| DE10338531A1 (de) | 2003-08-19 | 2005-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Reklonierung von Produktionszellen |
| PL1820022T3 (pl) | 2004-11-10 | 2009-11-30 | Boehringer Ingelheim Pharma | Zastosowanie analizy metodą cytometrii przepływowej w optymalizacji strategii dla banków komórek jajnika chińskiego chomika |
| EP2021340B1 (en) | 2006-04-21 | 2014-07-23 | The Government Of The United States, As Represented by The Secretary Of Health And Human Services | Beta-amyloid pet imaging agents |
| US20080124760A1 (en) | 2006-07-26 | 2008-05-29 | Barbara Enenkel | Regulatory Nucleic Acid Elements |
| EP2099823B2 (en) | 2006-12-01 | 2022-02-09 | Seagen Inc. | Variant target binding agents and uses thereof |
| MY148472A (en) | 2007-03-02 | 2013-04-30 | Boehringer Ingelheim Pharma | Improvement of protein production |
| EP2031064A1 (de) | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Steigerung von Proteintitern |
| US9534048B2 (en) * | 2012-08-24 | 2017-01-03 | University Health Network | Antibodies to TTR and methods of use |
| EP2953970A4 (en) * | 2013-02-08 | 2016-06-29 | Misfolding Diagnostics Inc | TRANSTYRETIN ANTIBODIES AND USES THEREOF |
| TWI718121B (zh) * | 2015-01-28 | 2021-02-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
-
2017
- 2017-06-30 WO PCT/IB2017/053987 patent/WO2018007923A2/en unknown
- 2017-06-30 JP JP2018568216A patent/JP7016470B2/ja active Active
- 2017-06-30 EP EP17746543.2A patent/EP3478715A2/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019530427A5 (es) | ||
| US20210332117A1 (en) | Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies | |
| JP2019530428A5 (es) | ||
| JP6234511B2 (ja) | アルファシヌクレインを認識するヒト化抗体 | |
| JP2019532617A5 (es) | ||
| AU2016323447B2 (en) | Anti-pro/latent-Myostatin antibodies and uses thereof | |
| CN103384682B (zh) | 结合il‑17a和il‑17f的抗体分子 | |
| JP2018506277A5 (es) | ||
| JP2020536532A5 (es) | ||
| CN103097415A (zh) | 针对肌生成抑制素6的人源化抗原结合蛋白 | |
| JP2018509889A5 (es) | ||
| TW201029662A (en) | Novel antigen binding proteins | |
| CN103145840A (zh) | Il-12/p40结合蛋白 | |
| TW201031421A (en) | IL-1 binding proteins | |
| CN108367075A (zh) | 4-1bb结合蛋白及其用途 | |
| JP2018510617A5 (es) | ||
| RU2014150433A (ru) | Улучшенные антитела антагонисты против gdf-8 и их применения | |
| TW201333039A (zh) | 雙可變域免疫球蛋白及其用途 | |
| CN108055848A (zh) | 抗pacap抗体及其用途 | |
| CN104744591A (zh) | β淀粉样蛋白结合蛋白 | |
| RU2015136078A (ru) | Антитело против с5 и способ предупреждения и лечения обусловленных комплементом заболеваний | |
| JP2016500656A (ja) | 代謝性疾患及び心臓血管疾患を治療するためのｔｏｌｌ様受容体３アンタゴニスト | |
| JP2013508292A5 (es) | ||
| WO2019207513A1 (en) | Use of anti-family with sequence similarity 19, member a5 antibodies for the treatment of neuropathic pain | |
| CN106795223A (zh) | 针对Fcγ受体IIB及Fcε受体的新型抗体 |