JP2019529563A5 - - Google Patents
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- Publication number
- JP2019529563A5 JP2019529563A5 JP2019537750A JP2019537750A JP2019529563A5 JP 2019529563 A5 JP2019529563 A5 JP 2019529563A5 JP 2019537750 A JP2019537750 A JP 2019537750A JP 2019537750 A JP2019537750 A JP 2019537750A JP 2019529563 A5 JP2019529563 A5 JP 2019529563A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- cancer
- compound according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 15
- 238000000034 method Methods 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 229940127121 immunoconjugate Drugs 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- -1 alkyl-X 2 Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940127084 other anti-cancer agent Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662398783P | 2016-09-23 | 2016-09-23 | |
| US62/398,783 | 2016-09-23 | ||
| PCT/US2017/052967 WO2018057897A1 (en) | 2016-09-23 | 2017-09-22 | Anti-cancer agents and preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019529563A JP2019529563A (ja) | 2019-10-17 |
| JP2019529563A5 true JP2019529563A5 (https=) | 2020-11-05 |
| JP7111722B2 JP7111722B2 (ja) | 2022-08-02 |
Family
ID=61690726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019537750A Active JP7111722B2 (ja) | 2016-09-23 | 2017-09-22 | 抗がん剤およびその調製方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10858371B2 (https=) |
| EP (1) | EP3515492B1 (https=) |
| JP (1) | JP7111722B2 (https=) |
| KR (1) | KR102646702B1 (https=) |
| CN (1) | CN109862916A (https=) |
| AU (1) | AU2017331260B2 (https=) |
| BR (1) | BR112019005885A2 (https=) |
| CA (1) | CA3037883A1 (https=) |
| DK (1) | DK3515492T3 (https=) |
| IL (1) | IL265521B2 (https=) |
| MA (1) | MA46291A (https=) |
| MX (1) | MX394670B (https=) |
| RU (1) | RU2019111768A (https=) |
| WO (1) | WO2018057897A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7111722B2 (ja) | 2016-09-23 | 2022-08-02 | パーデュー・リサーチ・ファウンデーション | 抗がん剤およびその調製方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901464A (fr) | 1943-01-23 | 1945-07-27 | Boehringer & Soehne Gmbh | Procédé d'obtention de vanilline |
| US7825267B2 (en) | 2006-09-08 | 2010-11-02 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Synthesis of FR901464 and analogs with antitumor activity |
| WO2009031999A1 (en) | 2007-09-07 | 2009-03-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Fr901464 and analogs with antitumor activity and method for their preparation |
| CN101417934B (zh) * | 2007-10-24 | 2012-04-18 | 国鼎生物科技股份有限公司 | 分离自牛樟芝萃取物的化合物 |
| NZ602675A (en) | 2008-03-18 | 2014-03-28 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| US8969405B2 (en) * | 2008-06-21 | 2015-03-03 | St. Jude Children's Research Hospital | Anticancer compounds and methods of making and using same |
| WO2013130882A1 (en) | 2012-02-28 | 2013-09-06 | Fred Hutchinson Cancer Research Center | Compositions and methods for treating cancer |
| MX340090B (es) * | 2012-11-05 | 2016-06-23 | Pfizer | Analogos de spliceostatina. |
| WO2014100367A1 (en) | 2012-12-21 | 2014-06-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Synthesis of fr901464 and analogs with antitumor activity |
| US20140274979A1 (en) | 2013-03-13 | 2014-09-18 | Golden Biotechnology Corporation | Method for the treatment of fatty liver disease |
| ES2955206T3 (es) | 2013-07-15 | 2023-11-29 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh | Derivados de espiroquinoxalina como inhibidores de la muerte celular regulada no apoptótica |
| KR102092569B1 (ko) * | 2013-09-17 | 2020-03-25 | 엘지디스플레이 주식회사 | 터치 스크린 일체형 디스플레이 장치와 이의 구동 방법 |
| CN113461705A (zh) * | 2013-11-19 | 2021-10-01 | 普渡研究基金会 | 抗癌剂及其制备 |
| AU2017277786A1 (en) * | 2016-06-08 | 2019-01-03 | William Marsh Rice University | Derivatives of Thailanstatin A, methods of treatment and methods of synthesis thereof |
| JP7111722B2 (ja) | 2016-09-23 | 2022-08-02 | パーデュー・リサーチ・ファウンデーション | 抗がん剤およびその調製方法 |
-
2017
- 2017-09-22 JP JP2019537750A patent/JP7111722B2/ja active Active
- 2017-09-22 KR KR1020197011144A patent/KR102646702B1/ko active Active
- 2017-09-22 US US16/335,378 patent/US10858371B2/en active Active
- 2017-09-22 IL IL265521A patent/IL265521B2/en unknown
- 2017-09-22 CA CA3037883A patent/CA3037883A1/en active Pending
- 2017-09-22 CN CN201780065546.7A patent/CN109862916A/zh active Pending
- 2017-09-22 AU AU2017331260A patent/AU2017331260B2/en active Active
- 2017-09-22 MA MA046291A patent/MA46291A/fr unknown
- 2017-09-22 MX MX2019003368A patent/MX394670B/es unknown
- 2017-09-22 DK DK17853991.2T patent/DK3515492T3/da active
- 2017-09-22 EP EP17853991.2A patent/EP3515492B1/en active Active
- 2017-09-22 WO PCT/US2017/052967 patent/WO2018057897A1/en not_active Ceased
- 2017-09-22 BR BR112019005885-0A patent/BR112019005885A2/pt unknown
- 2017-09-22 RU RU2019111768A patent/RU2019111768A/ru unknown
-
2020
- 2020-11-09 US US17/092,829 patent/US11851441B2/en active Active
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