JP2019527681A - 脂肪酸アミド誘導体を含むパーソナルケア組成物 - Google Patents
脂肪酸アミド誘導体を含むパーソナルケア組成物 Download PDFInfo
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- 0 *C*CCCC=CCCCCCCCCCC=C(CCC(C[C@@](C=CC=C1)C1=C)C(*)=C)O Chemical compound *C*CCCC=CCCCCCCCCCC=C(CCC(C[C@@](C=CC=C1)C1=C)C(*)=C)O 0.000 description 5
- NJQHZENQKNIRSY-UHFFFAOYSA-N CCc1c[nH]cn1 Chemical compound CCc1c[nH]cn1 NJQHZENQKNIRSY-UHFFFAOYSA-N 0.000 description 1
- XLSZMDLNRCVEIJ-UHFFFAOYSA-N Cc1c[nH]cn1 Chemical compound Cc1c[nH]cn1 XLSZMDLNRCVEIJ-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2800/75—Anti-irritant
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
【化1】
【化2】
【選択図】なし
Description
R1は、H、C1〜C4アルキル、−CH2OH、−CH2(CH3)−OH、−[CH2]4−NH2、−CH2−CO2H、−[CH2]2−CO2H、
R3は、−CO2H;−CH2CO2H;−CH2CH2CO2Hである);
並びに
(ii)化粧料用に許容され得る担体
を含むパーソナルケア組成物を提供する。
R1は、H、C1〜C4アルキル、−CH2OH、−CH2(CH3)−OH、−[CH2]4−NH2、−CH2−CO2H、−[CH2]2−CO2H、
R3は、−CO2H;−CH2CO2H;−CH2CH2CO2Hである);
並びに
(ii)化粧料用に許容され得る担体
を含むパーソナルケア組成物を提供する。
スキンケア組成物:一部の実施形態では、本発明のスキンケア組成物にはまた、化粧料用に許容され得る担体も含められる。一部の実施形態では、パーソナルケア組成物がスキンケア組成物である場合、化粧料用に許容され得る担体は、式(1)の化合物が可溶性である担体である。一部の実施形態では、化粧料用に許容され得る担体は、40℃までの温度で液状である親油性担体である。
一部の実施形態では、本発明によるスキンケア組成物は:
a.すべての水溶性成分、例えば、保存料、増粘性ポリマー(グリセリン及び水があってもよい)を混合し;
b.混合物を70〜90℃の温度まで加熱し;
c.すべての油溶性成分と70〜90℃の温度にした式(1)の化合物とを混合し;
d.混合した油溶性成分を、加熱した水溶性成分の混合物に添加し、混合物を70〜90℃の温度に維持しながらアジテーションによって混合し;
e.混合物を、混合しながら室温まで冷却すること
により作製され得る。
一部の実施形態では、スキンケア組成物がヒトの皮膚に経表面的に適用される。一部の実施形態では、スキンケア組成物が:スキンコンディショニング、肌をなめらかにする、肌のシワ又は老化の低減、皮膚の炎症の低減、痒みの低減、シミの低減、日焼けの低減、及び肌の美白からなる群より選択される少なくとも1つの有益性をもたらすものである。
本発明の一部の実施形態による化合物がFAAHを阻害する能力を、Cayman Chemicals製の市販のキット(Caymanカタログ番号10005196)に開示された方法に従って調べた。このキットでは、AMC−アラキドノイルアミドを加水分解して蛍光性の生成物7−アミノ−4−メチルクマリン(AMC)の放出をもたらす組換えヒトFAAH酵素を使用する。フルオロフォアを蛍光により、340〜360nmの励起波長及び450〜465nmの発光波長を用いて検出した。アッセイは、https://www.caymanchem.com/pdfs/10005196.pdfに存在するウェブページに見出され得るキットマニュアルに記載のとおりに従った。
本発明の化合物の潜在的刺激性をゼイン溶解度試験法により、以下のとおりに測定した:
ゼイン測定は、0.5gのゼイン粉末を10mlの界面活性剤溶液中に添加して(2wt%で)界面活性剤−ゼイン−水混合物を得ることにより開始する。次いで混合物を15分間ボルテックス混合し、30分間放置して溶解平衡にし、3000rpmで20分間、遠心分離して未溶解ゼインを単離し、Milli−Q水でゆすぎ洗浄して界面活性剤残渣を取り除き、60℃の真空オーブン内で少なくとも48時間乾燥させて過剰の水を除去する。
0.5g
得られた結果を表2に示す。ゼイン溶解度(パーセンテージで示した場合)が大きいほど、化合物はより刺激性である。試験した化合物(化合物1、5、12、14、17及び18)は対照化合物(SLG、又はココグリシン)より低刺激性であった。化合物17及び18は15%〜20%の範囲のゼイン溶解度を示した。化合物1及び14は20%〜25%の範囲のゼイン溶解度を示した。化合物5及び12は30%〜35%の範囲のゼイン溶解度を示した。
本発明の化合物が組成物のUVAPF及びSPFを高める能力を、サンスクリーン剤アボベンゾンと本発明の化合物を含有している組成物のSPFを測定することにより調べ、対照組成物と比較した。
本発明の化合物が12 HSAの溶解度を高める能力を調べた。結果を表4に示す。観察結果は、視認可能な析出物(ppt)(不溶性12 HSAを示す)から不透明な溶液及び半透明の溶液を経て透明な溶液(12 HSAの溶解度の増大を示す)までに及ぶ。
Claims (15)
- 式(1)の化合物が抗炎症剤である、請求項1に記載の組成物。
- 式(1)の化合物が痒み抑制剤である、請求項1に記載の組成物。
- 式(1)の化合物が脂肪酸アミド加水分解酵素を阻害するものである、請求項1に記載の組成物。
- 式(1)の化合物が、共役リノール酸アミド誘導体、リシノール酸アミド誘導体、12−ヒドロキシステアリン酸アミド誘導体及びその混合物からなる群より選択される、請求項1に記載の組成物。
- 前記共役リノール酸アミド誘導体が:化合物1、化合物2、化合物3、化合物4、化合物5、化合物6、化合物7、化合物8、化合物9、化合物10、化合物11及びその混合物からなる群より選択される、請求項1に記載の組成物。
- 前記リシノール酸アミド誘導体が:化合物12、化合物13、化合物14及び化合物15並びにその混合物からなる群より選択される、請求項1に記載の組成物。
- 12−ヒドロキシステアリン酸アミド誘導体が:化合物16、化合物17、化合物18、化合物19及びその混合物からなる群より選択される、請求項1に記載の組成物。
- リーブオン組成物である、請求項1に記載の組成物。
- 有機系サンスクリーン剤をさらに含む、請求項1に記載の組成物。
- 前記有機系サンスクリーン剤が、p−メトキシ桂皮酸エチルヘキシル、アボベンゾン、オクチルサリチレート、テトラフタリリデンジカンファースルホン酸、ベンゾフェノン−4、ベンゾフェノン−3及びその混合物からなる群より選択される、請求項10に記載の組成物。
- PPAR活性化脂肪酸をさらに含む、請求項1に記載の組成物。
- 請求項1に記載の組成物を皮膚に、肌の見た目を改善するのに充分な量で適用することを含む、肌の見た目の改善方法。
- 請求項1に記載のパーソナルケア組成物を皮膚に、皮膚刺激性を低減させるのに充分な量で適用することを含む、皮膚刺激性を低減させる方法。
- 請求項1に記載のパーソナルケア組成物を皮膚に、肌乾燥を低減させるのに充分な量で適用することを含む、肌乾燥を低減させる方法。
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EP16181413.2 | 2016-07-27 | ||
EP16181413 | 2016-07-27 | ||
PCT/EP2017/064354 WO2018019463A1 (en) | 2016-07-27 | 2017-06-13 | Personal care compositions comprising fatty acid amide derivatives |
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JP2019527681A true JP2019527681A (ja) | 2019-10-03 |
JP6972098B2 JP6972098B2 (ja) | 2021-11-24 |
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US (1) | US11202743B2 (ja) |
EP (1) | EP3490524B1 (ja) |
JP (1) | JP6972098B2 (ja) |
CN (1) | CN109562043B (ja) |
BR (1) | BR112018077141B1 (ja) |
CA (1) | CA3030333A1 (ja) |
EA (1) | EA037720B1 (ja) |
MX (1) | MX2019000948A (ja) |
PH (1) | PH12018502686A1 (ja) |
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ZA (1) | ZA201900065B (ja) |
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US20200297606A1 (en) | 2020-09-24 |
EA201990084A1 (ru) | 2019-08-30 |
CA3030333A1 (en) | 2018-02-01 |
EP3490524A1 (en) | 2019-06-05 |
US11202743B2 (en) | 2021-12-21 |
WO2018019463A1 (en) | 2018-02-01 |
JP6972098B2 (ja) | 2021-11-24 |
CN109562043A (zh) | 2019-04-02 |
BR112018077141B1 (pt) | 2022-02-01 |
BR112018077141A2 (pt) | 2019-04-30 |
CN109562043B (zh) | 2022-04-08 |
PH12018502686A1 (en) | 2019-10-21 |
EA037720B1 (ru) | 2021-05-13 |
MX2019000948A (es) | 2019-06-10 |
EP3490524B1 (en) | 2021-10-13 |
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