JP2019525905A5 - - Google Patents
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- Publication number
- JP2019525905A5 JP2019525905A5 JP2018567034A JP2018567034A JP2019525905A5 JP 2019525905 A5 JP2019525905 A5 JP 2019525905A5 JP 2018567034 A JP2018567034 A JP 2018567034A JP 2018567034 A JP2018567034 A JP 2018567034A JP 2019525905 A5 JP2019525905 A5 JP 2019525905A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- amino
- alkynyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C(O*)=O)NP(C)(*I)=* Chemical compound CC(C(O*)=O)NP(C)(*I)=* 0.000 description 21
- ZWVZJIPZOWYMCX-USPMSXPRSA-O CC(C(N1)=O)=CN([C@H](C2F)O[C@@H](CCO[P+](Oc3ccccc3)=O)C2O)C1=S Chemical compound CC(C(N1)=O)=CN([C@H](C2F)O[C@@H](CCO[P+](Oc3ccccc3)=O)C2O)C1=S ZWVZJIPZOWYMCX-USPMSXPRSA-O 0.000 description 1
- SHPYMWXCTNEIPY-BQELKBSMSA-O CC(C(N1)=S)=CN([C@H](C2F)O[C@@H](CO[P+](Oc3ccccc3)=O)C2=O)C1=S Chemical compound CC(C(N1)=S)=CN([C@H](C2F)O[C@@H](CO[P+](Oc3ccccc3)=O)C2=O)C1=S SHPYMWXCTNEIPY-BQELKBSMSA-O 0.000 description 1
- ZWNUAOJKWYAJSA-NUWAFVOYSA-N CC(C)OC([C@H](C)NP(CO[C@H](C)C[n]1c(N=CNC2N)c2nc1)(Oc1ccccc1)=O)=O Chemical compound CC(C)OC([C@H](C)NP(CO[C@H](C)C[n]1c(N=CNC2N)c2nc1)(Oc1ccccc1)=O)=O ZWNUAOJKWYAJSA-NUWAFVOYSA-N 0.000 description 1
- FNNKWUBMFPLFIB-KADSROQASA-N CC(C)OC([C@H](C)NP(OC[C@H]1SC[C@@H](N(C=CC(N)=N2)C2=O)O1)(Oc1ccccc1)=O)=O Chemical compound CC(C)OC([C@H](C)NP(OC[C@H]1SC[C@@H](N(C=CC(N)=N2)C2=O)O1)(Oc1ccccc1)=O)=O FNNKWUBMFPLFIB-KADSROQASA-N 0.000 description 1
- ZNTGUQABVFCVJH-JYNVWVNFSA-N CC(C)OC([C@H](C)N[PH-]([O-]c1ccccc1)(OC[C@@H](C(C1F)=O)O[C@@H]1N(C=C(C)C(N1)=O)C1=O)=O)=O Chemical compound CC(C)OC([C@H](C)N[PH-]([O-]c1ccccc1)(OC[C@@H](C(C1F)=O)O[C@@H]1N(C=C(C)C(N1)=O)C1=O)=O)=O ZNTGUQABVFCVJH-JYNVWVNFSA-N 0.000 description 1
- GBYPGNBWFIZONE-PKSJVXGASA-N CC(C)OC([C@H](C)[N]#CP(COCC[n]1c2ncnc(N)c2nc1)(Oc1ccccc1)=O)=O Chemical compound CC(C)OC([C@H](C)[N]#CP(COCC[n]1c2ncnc(N)c2nc1)(Oc1ccccc1)=O)=O GBYPGNBWFIZONE-PKSJVXGASA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077781A JP2022116024A (ja) | 2016-06-24 | 2022-05-10 | Ｂ型肝炎ウイルスの治療のためのホスホロアミデート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662354471P | 2016-06-24 | 2016-06-24 | |
| US62/354,471 | 2016-06-24 | ||
| PCT/US2017/038963 WO2017223421A1 (en) | 2016-06-24 | 2017-06-23 | Phosphoramidates for the treatment of hepatitis b virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077781A Division JP2022116024A (ja) | 2016-06-24 | 2022-05-10 | Ｂ型肝炎ウイルスの治療のためのホスホロアミデート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019525905A JP2019525905A (ja) | 2019-09-12 |
| JP2019525905A5 true JP2019525905A5 (enExample) | 2020-09-10 |
Family
ID=60783488
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567034A Pending JP2019525905A (ja) | 2016-06-24 | 2017-06-23 | Ｂ型肝炎ウイルスの治療のためのホスホロアミデート |
| JP2022077781A Withdrawn JP2022116024A (ja) | 2016-06-24 | 2022-05-10 | Ｂ型肝炎ウイルスの治療のためのホスホロアミデート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077781A Withdrawn JP2022116024A (ja) | 2016-06-24 | 2022-05-10 | Ｂ型肝炎ウイルスの治療のためのホスホロアミデート |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11364257B2 (enExample) |
| EP (1) | EP3474863A4 (enExample) |
| JP (2) | JP2019525905A (enExample) |
| KR (1) | KR20190057277A (enExample) |
| CN (1) | CN109689065A (enExample) |
| AU (1) | AU2017281531A1 (enExample) |
| BR (1) | BR112018076913A2 (enExample) |
| CA (1) | CA3029315A1 (enExample) |
| EA (1) | EA201990059A1 (enExample) |
| IL (1) | IL263859B2 (enExample) |
| PH (1) | PH12018550207A1 (enExample) |
| SG (1) | SG11201811316YA (enExample) |
| WO (1) | WO2017223421A1 (enExample) |
| ZA (1) | ZA201900156B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3233878B1 (en) * | 2014-12-15 | 2025-09-03 | Emory University | Phosphoramidates for the treatment of hepatitis b virus |
| EP3752511A4 (en) * | 2018-01-10 | 2021-12-29 | Nucorion Pharmaceuticals, Inc. | Phosphor(n)amidatacetal and phosph(on)atalcetal compounds |
| CA3096264A1 (en) * | 2018-04-12 | 2019-10-17 | Modis Therapeutics Inc. | Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools |
| WO2020045628A1 (ja) * | 2018-08-31 | 2020-03-05 | ダイキン工業株式会社 | 核酸アナログ及び抗ｂ型肝炎ウイルス剤 |
| US11166976B2 (en) | 2018-11-08 | 2021-11-09 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| WO2020103929A1 (zh) * | 2018-11-23 | 2020-05-28 | 正大天晴药业集团股份有限公司 | 低聚核苷酸及前体药物 |
| EP3999519A4 (en) | 2019-07-17 | 2023-08-16 | Nucorion Pharmaceuticals, Inc. | CYCLIC DEOXYRIBONUCLEOTIDE COMPOUNDS |
| CN110642910B (zh) * | 2019-09-02 | 2020-10-30 | 南开大学 | 胸苷衍生物及其制备方法和用途 |
| EP4037706A4 (en) * | 2019-10-02 | 2023-09-13 | University of Washington | Compositions and methods for treatment of hepatitis b virus infection |
| CN111087421B (zh) * | 2019-12-24 | 2022-10-18 | 南京正大天晴制药有限公司 | 一种用于手性药物合成的磷酰胺化合物的制备方法 |
| US20230183282A1 (en) * | 2020-04-02 | 2023-06-15 | The Regents Of The University Of Michigan | Remdesivir and remdesivir analogs, solutions, and nanoparticle, liposomal, and microparticle compositions for treating viral infections |
| CN113493481B (zh) * | 2020-04-08 | 2025-02-18 | 北京君科华元医药科技有限公司 | 单磷酸恩替卡韦丙氨酰胺酚酯及其医药用途 |
| WO2021253376A1 (zh) * | 2020-06-19 | 2021-12-23 | 南京正大天晴制药有限公司 | 一种用于手性药物合成的磷酰胺化合物的制备方法 |
| WO2022251594A1 (en) * | 2021-05-27 | 2022-12-01 | Antios Therapeutics, Inc. | Pharmacokinetics and dose-related improvments in subjects treated with phosphoramidate clevudine prodrugs |
| WO2022256490A2 (en) * | 2021-06-03 | 2022-12-08 | Antios Therapeutics, Inc. | Improved synthesis of phosphoramidates for the treatment of hepatitis b virus |
| CN113501853B (zh) * | 2021-09-13 | 2021-12-07 | 南京颐媛生物医学研究院有限公司 | 4-硫代尿嘧啶脱氧核苷磷酸酯及其抗病毒药物用途 |
| CA3243401A1 (en) * | 2022-01-28 | 2023-08-03 | Glaxosmithkline Ip Dev Ltd | Polytherapy for the treatment of hepatitis B virus infections |
| CN115260263B (zh) * | 2022-05-23 | 2025-02-21 | 浙江扬厉医药技术有限公司 | 烷基硫芳基克拉夫定磷酰胺类化合物及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687931A (en) | 1970-03-19 | 1972-08-29 | Syntex Corp | Halogenated purine and pyrimidine nucleosides and process therefor |
| US5587362A (en) | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| US20040229839A1 (en) | 2003-05-14 | 2004-11-18 | Biocryst Pharmaceuticals, Inc. | Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| EP1827460A4 (en) | 2004-12-09 | 2012-03-14 | Univ Minnesota | NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT |
| WO2006133092A1 (en) | 2005-06-07 | 2006-12-14 | Yale University | Methods of treating cancer and other conditions or disease states using lfmau and ldt |
| WO2007056596A2 (en) | 2005-11-09 | 2007-05-18 | Wayne State University | Phosphoramidate derivatives of fau |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| CN102046626A (zh) | 2008-04-23 | 2011-05-04 | 吉里德科学公司 | 用于抗病毒治疗的carba-核苷类似物 |
| EA026341B9 (ru) | 2010-03-31 | 2021-12-27 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | Кристаллическая форма нуклеозидфосфорамидата |
| SG188497A1 (en) | 2010-09-22 | 2013-05-31 | Alios Biopharma Inc | Substituted nucleotide analogs |
| WO2012078416A2 (en) | 2010-12-06 | 2012-06-14 | Rfs Pharma, Llc | Monophosphate prodrugs of dapd and analogs thereof |
| EP2734535A4 (en) | 2011-07-19 | 2014-10-22 | Nanjing Molecular Res Inc | 2 ', 3'-DIDEOXY-2'-ALPHA-FLUOR-2'-BETA-C-METHYL NUCLEOSIDE AND PRODRUGS THEREOF |
| WO2014070771A1 (en) | 2012-10-29 | 2014-05-08 | Rfs Pharma, Llc | Pyrimidine nucleotides and their monophosphate prodrugs for treatment of viral infections and cancer |
| US20140140951A1 (en) | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-Alanine Ester of Rp-Nucleoside Analog |
| EP2970357B1 (en) | 2013-03-13 | 2025-01-01 | Idenix Pharmaceuticals LLC | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| CA2909270A1 (en) * | 2013-04-12 | 2014-10-16 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of hcv |
| EP3233878B1 (en) | 2014-12-15 | 2025-09-03 | Emory University | Phosphoramidates for the treatment of hepatitis b virus |
-
2017
- 2017-06-23 EA EA201990059A patent/EA201990059A1/ru unknown
- 2017-06-23 BR BR112018076913-4A patent/BR112018076913A2/pt not_active IP Right Cessation
- 2017-06-23 EP EP17816278.0A patent/EP3474863A4/en not_active Withdrawn
- 2017-06-23 CN CN201780050071.4A patent/CN109689065A/zh active Pending
- 2017-06-23 US US16/312,756 patent/US11364257B2/en active Active
- 2017-06-23 JP JP2018567034A patent/JP2019525905A/ja active Pending
- 2017-06-23 SG SG11201811316YA patent/SG11201811316YA/en unknown
- 2017-06-23 KR KR1020197002039A patent/KR20190057277A/ko not_active Ceased
- 2017-06-23 AU AU2017281531A patent/AU2017281531A1/en not_active Abandoned
- 2017-06-23 WO PCT/US2017/038963 patent/WO2017223421A1/en not_active Ceased
- 2017-06-23 CA CA3029315A patent/CA3029315A1/en active Pending
-
2018
- 2018-12-20 PH PH12018550207A patent/PH12018550207A1/en unknown
- 2018-12-20 IL IL263859A patent/IL263859B2/en unknown
-
2019
- 2019-01-09 ZA ZA2019/00156A patent/ZA201900156B/en unknown
-
2022
- 2022-05-06 US US17/738,435 patent/US20220280542A1/en not_active Abandoned
- 2022-05-10 JP JP2022077781A patent/JP2022116024A/ja not_active Withdrawn
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