JP2019524798A5 - - Google Patents
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- Publication number
- JP2019524798A5 JP2019524798A5 JP2019506725A JP2019506725A JP2019524798A5 JP 2019524798 A5 JP2019524798 A5 JP 2019524798A5 JP 2019506725 A JP2019506725 A JP 2019506725A JP 2019506725 A JP2019506725 A JP 2019506725A JP 2019524798 A5 JP2019524798 A5 JP 2019524798A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- independently
- alkyl
- subject
- targeting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000008685 targeting Effects 0.000 claims description 43
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 229940079593 drug Drugs 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 18
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 230000001678 irradiating effect Effects 0.000 claims description 12
- 150000008052 alkyl sulfonates Chemical class 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 239000002243 precursor Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000012472 biological sample Substances 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000001475 halogen functional group Chemical group 0.000 claims description 6
- 125000005647 linker group Chemical group 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
- 125000001931 aliphatic group Chemical group 0.000 claims description 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 4
- 238000003776 cleavage reaction Methods 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 229910052711 selenium Inorganic materials 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 229960001972 panitumumab Drugs 0.000 claims description 2
- 125000006239 protecting group Chemical group 0.000 claims description 2
- 230000007017 scission Effects 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 claims description 2
- 229960000575 trastuzumab Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- -1 n- propyl Chemical group 0.000 claims 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662373666P | 2016-08-11 | 2016-08-11 | |
| US62/373,666 | 2016-08-11 | ||
| PCT/US2017/045694 WO2018031448A1 (en) | 2016-08-11 | 2017-08-07 | Near-ir light-cleavable conjugates and conjugate precursors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524798A JP2019524798A (ja) | 2019-09-05 |
| JP2019524798A5 true JP2019524798A5 (https=) | 2020-07-30 |
| JP7042254B2 JP7042254B2 (ja) | 2022-03-25 |
Family
ID=59656210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506725A Active JP7042254B2 (ja) | 2016-08-11 | 2017-08-07 | 近赤外光開裂性コンジュゲートおよびコンジュゲート前駆体 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10561729B2 (https=) |
| EP (1) | EP3496762A1 (https=) |
| JP (1) | JP7042254B2 (https=) |
| WO (1) | WO2018031448A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3655408B1 (en) | 2017-08-24 | 2021-07-14 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Conformational restriction of cyanine fluorophores in far-red and near-ir range |
| EP3752486A4 (en) * | 2018-02-15 | 2022-07-06 | Children's National Medical Center | Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems |
| AU2019325658B2 (en) | 2018-08-23 | 2024-02-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Water soluble novel cyanine fluorophore with tunable properties between near IR and SWIR region for in vivo imaging |
| WO2020179749A1 (ja) * | 2019-03-05 | 2020-09-10 | 国立大学法人東海国立大学機構 | 標的特異的複合体及びその用途 |
| US20210353151A1 (en) * | 2020-05-12 | 2021-11-18 | On Target Laboratories, LLC | Targeted fluorescent markers in combination with a flexible probe |
| WO2022050376A1 (ja) * | 2020-09-04 | 2022-03-10 | 国立大学法人東海国立大学機構 | 光を用いた薬物伝送方法、及び標的集積型複合体 |
| JPWO2022163807A1 (https=) * | 2021-01-29 | 2022-08-04 | ||
| CN115433356B (zh) * | 2022-03-11 | 2023-06-30 | 中国科学院精密测量科学与技术创新研究院 | 一种PEG修饰的氟化Cy7胶束及其合成方法和应用 |
| CN114573645A (zh) * | 2022-03-26 | 2022-06-03 | 常州大学 | 乳糖酸-新吲哚菁绿偶联物及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1065250B1 (en) | 1999-07-02 | 2004-12-08 | Visen Medical, Inc. | New fluorescent cyanine labels containing a sulfamido linker arm |
| US7198778B2 (en) | 2000-01-18 | 2007-04-03 | Mallinckrodt Inc. | Tumor-targeted optical contrast agents |
| US7556797B2 (en) | 2000-10-16 | 2009-07-07 | Mallinckrodt Inc. | Minimally invasive physiological function monitoring agents |
| US8188116B2 (en) | 2002-09-04 | 2012-05-29 | Vanderbilt University | Agents for therapy efficacy monitoring and deep tissue imaging |
| US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| US20080050316A1 (en) | 2006-08-24 | 2008-02-28 | Baylor College Of Medicine | Molecular imaging of epithelial cells in lymph |
| WO2009012109A2 (en) | 2007-07-13 | 2009-01-22 | Emory University | Cyanine-containing compounds for cancer imaging and treatment |
| WO2009023813A1 (en) | 2007-08-15 | 2009-02-19 | Applied Soil Water Technologies Llc | Metals recovery from mining heap leach ore |
| JP5515529B2 (ja) | 2009-09-04 | 2014-06-11 | 国立大学法人三重大学 | 近赤外光発光化合物、その合成法及びその発光法 |
| SG184224A1 (en) | 2010-03-24 | 2012-11-29 | Univ Singapore | Development of photostable near-ir cyanine dyes for in vivo imaging |
| WO2013036543A2 (en) | 2011-09-10 | 2013-03-14 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Molecular imaging of cancer cells in vivo |
| CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
| WO2014149069A1 (en) | 2013-03-15 | 2014-09-25 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| KR101494639B1 (ko) | 2013-05-15 | 2015-02-23 | 고려대학교 산학협력단 | 엽산 Cy7계 치료진단용 약물 전달 시스템 및 이것의 제조방법 |
| US10280307B2 (en) | 2014-11-05 | 2019-05-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Class of stable heptamethine cyanine fluorophores and biomedical applications thereof |
| WO2017027721A1 (en) | 2015-08-12 | 2017-02-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near-ir light-cleavable conjugates and conjugate precursors |
-
2017
- 2017-08-07 US US16/323,747 patent/US10561729B2/en active Active
- 2017-08-07 JP JP2019506725A patent/JP7042254B2/ja active Active
- 2017-08-07 EP EP17754556.3A patent/EP3496762A1/en not_active Withdrawn
- 2017-08-07 WO PCT/US2017/045694 patent/WO2018031448A1/en not_active Ceased
-
2019
- 2019-12-20 US US16/723,482 patent/US10874739B2/en active Active
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