JP2019524098A - 非分裂細胞のゲノム編集のための方法と組成物 - Google Patents
非分裂細胞のゲノム編集のための方法と組成物 Download PDFInfo
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- JP2019524098A JP2019524098A JP2019501985A JP2019501985A JP2019524098A JP 2019524098 A JP2019524098 A JP 2019524098A JP 2019501985 A JP2019501985 A JP 2019501985A JP 2019501985 A JP2019501985 A JP 2019501985A JP 2019524098 A JP2019524098 A JP 2019524098A
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
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- Cell Biology (AREA)
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- Hospice & Palliative Care (AREA)
- Virology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022159696A JP7493563B2 (ja) | 2016-07-15 | 2022-10-03 | 分裂細胞または非分裂細胞のゲノム編集のための方法と組成物 |
| JP2024082104A JP2024119833A (ja) | 2016-07-15 | 2024-05-20 | 非分裂細胞のゲノム編集のための方法と組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662363164P | 2016-07-15 | 2016-07-15 | |
| US62/363,164 | 2016-07-15 | ||
| PCT/US2017/042151 WO2018013932A1 (en) | 2016-07-15 | 2017-07-14 | Methods and compositions for genome editing in non-dividing cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022159696A Division JP7493563B2 (ja) | 2016-07-15 | 2022-10-03 | 分裂細胞または非分裂細胞のゲノム編集のための方法と組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019524098A true JP2019524098A (ja) | 2019-09-05 |
| JP2019524098A5 JP2019524098A5 (OSRAM) | 2020-08-20 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019501985A Pending JP2019524098A (ja) | 2016-07-15 | 2017-07-14 | 非分裂細胞のゲノム編集のための方法と組成物 |
| JP2022159696A Active JP7493563B2 (ja) | 2016-07-15 | 2022-10-03 | 分裂細胞または非分裂細胞のゲノム編集のための方法と組成物 |
| JP2024082104A Pending JP2024119833A (ja) | 2016-07-15 | 2024-05-20 | 非分裂細胞のゲノム編集のための方法と組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022159696A Active JP7493563B2 (ja) | 2016-07-15 | 2022-10-03 | 分裂細胞または非分裂細胞のゲノム編集のための方法と組成物 |
| JP2024082104A Pending JP2024119833A (ja) | 2016-07-15 | 2024-05-20 | 非分裂細胞のゲノム編集のための方法と組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11674158B2 (OSRAM) |
| EP (2) | EP3485023B1 (OSRAM) |
| JP (3) | JP2019524098A (OSRAM) |
| AU (1) | AU2017295898B2 (OSRAM) |
| CA (1) | CA3030587A1 (OSRAM) |
| WO (1) | WO2018013932A1 (OSRAM) |
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| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
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| JP6929791B2 (ja) | 2015-02-09 | 2021-09-01 | デューク ユニバーシティ | エピゲノム編集のための組成物および方法 |
| WO2017053879A1 (en) | 2015-09-24 | 2017-03-30 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| EP3365356B1 (en) | 2015-10-23 | 2023-06-28 | President and Fellows of Harvard College | Nucleobase editors and uses thereof |
| WO2017095967A2 (en) | 2015-11-30 | 2017-06-08 | Duke University | Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use |
| EP3433363A1 (en) | 2016-03-25 | 2019-01-30 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| AU2017295898B2 (en) | 2016-07-15 | 2023-08-17 | Salk Institute For Biological Studies | Methods and compositions for genome editing in non-dividing cells |
| EP4275747A3 (en) | 2016-07-19 | 2024-01-24 | Duke University | Therapeutic applications of cpf1-based genome editing |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
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| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
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| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
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| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
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| US11959094B2 (en) | 2024-04-16 |
| US20190225991A1 (en) | 2019-07-25 |
| EP3485023C0 (en) | 2023-11-15 |
| US20230399663A1 (en) | 2023-12-14 |
| JP2024119833A (ja) | 2024-09-03 |
| AU2017295898A1 (en) | 2019-02-21 |
| EP4321623A3 (en) | 2024-05-15 |
| JP7493563B2 (ja) | 2024-05-31 |
| EP3485023B1 (en) | 2023-11-15 |
| JP2023092453A (ja) | 2023-07-03 |
| WO2018013932A1 (en) | 2018-01-18 |
| US11674158B2 (en) | 2023-06-13 |
| US20240409961A1 (en) | 2024-12-12 |
| CA3030587A1 (en) | 2018-01-18 |
| EP4321623A2 (en) | 2024-02-14 |
| AU2017295898B2 (en) | 2023-08-17 |
| EP3485023A1 (en) | 2019-05-22 |
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